Jornal Brasileiro de Reproducao Assistida最新文献

{"title":"Impact of Infertility and Medically Assisted Reproduction Treatments on Female Sexuality.","authors":"Badra Bannour, Darine Salem, Rania Bannour, Omar Khalil Ben Saad, Imen Bannour","doi":"10.5935/1518-0557.20240100","DOIUrl":"https://doi.org/10.5935/1518-0557.20240100","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of infertility and Medically Assisted Procreation (MAP) on female sexuality. Human sexuality presents a multifaceted complexity, shaped by diverse factors and individual intricacies. Infertility and assisted reproductive treatments entail a prolonged and arduous journey, amplifying pre-existing sexual dysfunctions and serving as a rigorous trial of the affected women's sexuality and the resilience of couples.</p><p><strong>Methods: </strong>This is a prospective descriptive comparative study with an analytical section, involving 140 female participants: 70 with infertility undergoing assisted reproductive technology (ART) treatment, and 70 who are fertile and had no prior history of conceiving problems. The evaluation of the sexual function of the two groups was conducted using the Female Sexual Function Index (FSFI) score.</p><p><strong>Results: </strong>The infertile group exhibited a higher level of marital adjustment compared to the fertile cohort. A majority of participants within the infertile cohort (51.4%) presented with primary infertility and (48.6%) experiencing secondary infertility. A marginal elevation in the frequency of sexual intercourse among infertile participants was observed. The mean global score of female sexual function was (21.57±3.36) in the infertile group, which was significantly lower compared to (24.46±1.97) in the fertile group. Notably, both scores fell within the criteria for high risk of sexual dysfunction. The difference between the two groups was significant for all dimensions of FSFI.</p><p><strong>Conclusions: </strong>Infertility and its treatments pose challenges to female sexuality, often leading to sexual dysfunction. Thus, counseling and sexological support are crucial during treatment.</p>","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical validation and experiences of the microfluidics sperm selection device ZyMōt™ for standard IVF.","authors":"Emma Adolfsson, Johanna Ingberg, Emma Igersten, Therese Bohlin","doi":"10.5935/1518-0557.20240104","DOIUrl":"https://doi.org/10.5935/1518-0557.20240104","url":null,"abstract":"<p><strong>Objective: </strong>Clinical validation of sperm selection device ZyMōt™ for standard IVF.</p><p><strong>Methods: </strong>The pre-clinical validation of ZyMōt™ included several steps. First, split semen preparation compared density gradient centrifugation (DGC) to ZyMōt™ with primary outcome fraction and absolute number of progressive motile sperm. Second, sibling oocytes were fertilized with sperms prepared with DGC and sperms selected by ZyMōt™, primary endpoint fertilization rate, utility rate, embryo development pace quality. After this, DGC was replaced by ZyMōt™, first without centrifugation steps, and then with a five-minute centrifugation step and subsequent media change prior to gamete co-incubation. Endpoint was assessment of key performance indicators against previous results using DGC for standard IVF.</p><p><strong>Results: </strong>ZyMōt™ resulted in purer sperm selection compared to DGC (fraction progressive motile sperm 97.2±3.1% vs. 83.0±14.1%, p<0.01). Fertilization of sibling oocytes resulted in similar fertilization rates and utility rates, and no differences in embryo development pace or quality. However, after changing sperm selection protocol from DGC to ZyMōt™ for standard IVF for all fresh semen samples with motile sperm, the fertilization rates and utility rates were significantly reduced, and cases of total failure of fertilization increased substantially. Adding five-minute centrifugation and media change after centrifugation to the sperm selection protocol restored fertilization rate, including total failure of fertilization rate, to normal.</p><p><strong>Conclusions: </strong>To conclude, the ZyMōt™ sperm selection device is suitable for standard IVF only after inclusion of five minutes centrifugation and subsequent media change prior to gamete co-incubation.</p>","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in behaviors toward acceptance of donor egg, sperm, and embryo in Northern Thai infertile couples.","authors":"Kanyapat Taechapeti, Sorawit Piriyasakmontri, Supitchaya Phatai, Tanyaporn Maraka, Usanee Sanmee","doi":"10.5935/1518-0557.20240042","DOIUrl":"10.5935/1518-0557.20240042","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the behavior towards the acceptance of donor egg, donor sperm, and donor embryo of Northern Thai infertile couples, separated between men and women.</p><p><strong>Methods: </strong>A cross-sectional study was conducted at the CMEx Fertility Center, Chiang Mai, Thailand. The questionnaires consisted of sociodemographic questions and the acceptance of couples toward donor egg, sperm and embryo. The couples filled in the answers separately.</p><p><strong>Results: </strong>A total of 250 infertile couples were assessed. There were no differences in the acceptance rate of donor egg, sperm and embryo between the men and the women. Male acceptance rates were 25.6%, 18.8%, and 18.8%, respectively; while female acceptance rates were 24.4%, 18.4%, and 19.2%, respectively. Most couples (over 70%) concordantly rejected the donation program. Around 10% of couples had discordant answers. The concordance accepted for couples for donor egg, sperm and embryo was only 20%, 13.2%, and 14.8%. Older people and those who had been infertile for a longer period were significantly more likely to accept donation programs.</p><p><strong>Conclusions: </strong>There is no difference concerning the acceptance of donor gametes and embryo among men and women. Most participants reject the utilization of donor programs, the overall acceptance rate is relatively low. This may indicate the need for more adequate information and education for the community to enhance prevention programs rather than focus on the treatment with donor gametes or embryos.</p>","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"554-557"},"PeriodicalIF":1.8,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of HOXA10 and HOXA11 in the endometrium of infertile patients with chronic endometritis.","authors":"Ana Carolina Mendonça Hissa de Sá, Luiz Felipe Bittencourt de Araujo, Mylena Zuim Sanson, Tamyres Souza Garcia Alvim Ranzato, Amanda Rezende Passarelli Tostes, Ivan Andrade de Araujo Penna","doi":"10.5935/1518-0557.20240035","DOIUrl":"10.5935/1518-0557.20240035","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to evaluate the impact of CE on the expression of HOXA10 and HOXA11 during the late proliferative phase in the endometrium of infertile women.</p><p><strong>Methods: </strong>A prospective, translational cohort study was conducted in partnership with the Hospital Universitário Antônio Pedro in Niterói and the Clínica Ginendo in Rio de Janeiro after approval by the Ethics Committee. The patients were selected to participate in the study after showing an indication for hysteroscopy. All participants were divided into three groups: infertile women with endometritis (n=10), infertile women without endometritis (n=17) and fertile women without endometritis (n=10). At hysteroscopy, two endometrial samples were obtaneid, with one sent for histopathological examination per the gynecologist's request and the other used for immunohistochemistry procedures to evaluate the expression of CD138, HOXA10 and HOXA11. CD138 was used to confirm the diagnosis of CE. The analysis of HOXA10 and HOXA11 was performed using the HScoring method for immunohistochemistry with polyclonal antibodies.</p><p><strong>Results: </strong>Women with and without endometritis had lower HOXA10 and HOXA11 expression values than women in the control group (fertile women without endometritis).</p><p><strong>Conclusions: </strong>The expression of HOXA10 and HOXA11 during the proliferative phase is not significantly different between infertile women with endometritis and infertile women without endometritis. Translational studies with a larger number of patients should be performed.</p>","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"530-534"},"PeriodicalIF":1.8,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Presentations - Abstracts of the 28th Annual Congress of the SBRA. Florianópolis/SC - Brazil, 2024.","authors":"","doi":"10.5935/1518-0557.20240062","DOIUrl":"10.5935/1518-0557.20240062","url":null,"abstract":"","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"701-707"},"PeriodicalIF":1.8,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of single dose of gonadotropin-releasing hormone agonist injection in frozen-thawed embryo transfer on pregnancy outcomes: A systematic review and meta-analysis.","authors":"Pongpawan Chienvichai, Natpat Jansaka, Usanee Sanmee, Kittipat Charoenkwan","doi":"10.5935/1518-0557.20240054","DOIUrl":"10.5935/1518-0557.20240054","url":null,"abstract":"<p><p>This systematic review and meta-analysis of randomized controlled trials aimed to evaluate the effect of a single-dose gonadotropin-releasing hormone agonist administration in the frozen-thawed embryo transfer cycle on pregnancy outcomes. A literature search was strategically conducted using PubMed, EMBASE, and the Cochrane Controlled Trials Register. The primary outcome was the clinical pregnancy rate. The secondary outcomes combined chemical pregnancy rate, implantation rate, ongoing pregnancy rate, live birth rate, miscarriage rate, and extrauterine pregnancy rate. Out of the 1594 citations that were found, only six met the criteria for being included in the meta-analysis. The clinical pregnancy rate was higher in the treatment group than in the control group (52.05% vs. 47.29%; p=0.04; RR=1.09; 95% CI=1.00-1.18). According to subgroup analysis based on the natural cycle, the clinical pregnancy rate with the agonist administration is significantly higher (43.75% vs. 27.35%; p=0.01; RR=1.6; 95% CI=1.10-2.32). However, there was no difference between the groups in terms of artificial cycles (p=0.80; 95% CI=0.96-1.20). The secondary outcomes did not show significant differences. We concluded that supplementing with a single dose of gonadotrophin-releasing hormone agonist can marginally increase the clinical pregnancy rate, particularly in the natural cycle. Other pregnancy outcomes do not improve with the treatment.</p>","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"691-700"},"PeriodicalIF":1.8,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142477378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring uterine contractility frequency in infertile population: A comparative study among different control groups with and without a C-section defect.","authors":"Juan Carlos Castillo, Maria Martínez-Moya, Ana Fuentes, Belen Moliner, María Gonzalez, Andrea Bernabeu, Rafael Bernabeu","doi":"10.5935/1518-0557.20240037","DOIUrl":"10.5935/1518-0557.20240037","url":null,"abstract":"<p><strong>Objective: </strong>Women undergoing IVF who have had a previous c-section (CS) have a lower live birth rate than those with a previous vaginal delivery. However, the precise underlying mechanisms need clarification. Does a previous CS affect the pattern of uterine contractility?.</p><p><strong>Methods: </strong>Prospective evaluation in patients undergoing frozen blastocyst embryo transfer in medicated endometrial preparation cycles. Twenty patients were included in groups: A/nulliparous. B/previous vaginal delivery. C/ previous CS without a niche, whereas fifteen patients were recruited in group D (CS and a niche). Patients employed estradiol compounds and 800 mg vaginal progesterone. A 3D-scan was performed the transfer-day where uterine contractility/minute was recorded.</p><p><strong>Results: </strong>Baseline characteristics (age, BMI, smoking, endometrial thickness) were similar. Mean frequency of uterine contractions/minute was similar between groups (1.15, 1.01, 0.92, and 1.21 for groups A, B, C, and D, respectively). There was a slight increase in the number of contractions in patients with a sonographic niche versus controls, not reaching statistical significance (p=0.48). No differences were observed when comparing patients with a previous C-section (regardless of the presence of a niche) to those without a C-section, either nulliparous (p=0.78) or with a previous vaginal delivery (p=0.80). The frequency of uterine contractions was similar between patients who achieved a clinical pregnancy and those who did not (1.19 vs. 1.02 UC/min, p=0.219, respectively).</p><p><strong>Conclusions: </strong>Our study found no significant difference in the frequency of uterine contractility between patients with or without a previous C-section or sonographic diagnosed niche. Further investigation is necessary to understand the physiological mechanisms affecting implantation in patients with isthmocele.</p>","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"543-548"},"PeriodicalIF":1.8,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential impacts of ambient PM2.5 exposure on sperm quality in northern Thailand.","authors":"Aram Thapsamuthdechakorn, Tawiwan Pantasri, Usanee Sanmee, Tanarat Muangmool, Pareeya Somsak, Pannarai Somboonchai, Jamjit Doungpunta","doi":"10.5935/1518-0557.20240051","DOIUrl":"10.5935/1518-0557.20240051","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the correlation between ambient particulate matter 2.5 (PM2.5) concentration and sperm quality among northern Thai men exposed to the seasonal air pollution from the agricultural burning process.</p><p><strong>Methods: </strong>The demographic data and semen analysis of Thai men living in Chiang Mai, Thailand, who visited the infertile clinic were collected. The correlation test between the monthly amount of PM2.5 and sperm quality was carried out.</p><p><strong>Results: </strong>From 2017 to 2021, 1,109 Thai men visited the Infertile Clinic. The correlation test between PM2.5 and sperm quality in years with a better climate revealed a weak positive correlation between the mean PM2.5 and percentage of progressive motile sperm and normal morphology (r=0.08, p=0.05 and r=0.1, p=0.02). However, there was a negative correlation between the mean PM2.5 and sperm concentration, progressive motility and normal sperm morphology during the years with a higher amount of ambient PM2.5, and especially PM2.5 exposure 3 months before semen collection (r=-0.12, p=0.01, r=-0.11, p=0.003, r=-0.15, p=0.004).</p><p><strong>Conclusions: </strong>Exposure to a high amount of PM2.5 air pollution negatively affects sperm quality.</p>","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"558-564"},"PeriodicalIF":1.8,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of COVID-19 on the male reproductive system.","authors":"Abzal Kystaubayev, Askhan Abzalbekov, Bakyt Ramazanova, Vyacheslav Lokshin, Muhammed Iskakov","doi":"10.5935/1518-0557.20240048","DOIUrl":"10.5935/1518-0557.20240048","url":null,"abstract":"<p><strong>Objective: </strong>The relevance of the study is determined by the deepening understanding of the global consequences of the coronavirus pandemic, which affect not only lung health but also a wide range of other body systems. In light of new data on the long-term effects of coronavirus infection, this study is highly significant. The purpose of this study is to investigate the impact of coronavirus infection on the male reproductive system and assess its potential influence on male fertility to refine the mechanisms of damage and provide recommendations for medical care.</p><p><strong>Methods: </strong>The study utilised a combination of methods, including a meta-analysis of medical organisation databases, analysis of clinical cases, representative sample method, and quantitative survey method. These approaches allowed for a comprehensive and multifaceted view of the problem.</p><p><strong>Results: </strong>The samples of sperm showed a noticeable decrease in progressive motility, sperm concentration, and volume, especially in patients with moderate and severe symptoms of COVID-19, whereas patients with mild symptoms only experienced a decrease in progressive motility and overall sperm motility. The survey identified symptoms of male reproductive system dysfunction after recovering from COVID-19. Predominant symptoms included decreased libido (15%), impotence (13%), and infections of the genital organs (12%). Most surveyed men lacked sufficient awareness of other aspects of male reproductive health, including infections, genetic defects, chronic diseases, and available medical services.</p><p><strong>Conclusions: </strong>As a result of the study, it was concluded that coronavirus infection can have a negative impact on the male reproductive system. The practical value of this study lies in improving approaches to medical care for men who have recovered from COVID-19 and creating preventive programmes.</p>","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"604-610"},"PeriodicalIF":1.8,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low ovarian responders produce more progesterone per follicle than normal and high responders.","authors":"Alfredo Cortés-Vazquez, Alfredo Leonardo Cortés-Algara, Daniel Moreno-García, Johnny S Younis","doi":"10.5935/1518-0557.20240043","DOIUrl":"10.5935/1518-0557.20240043","url":null,"abstract":"<p><strong>Objective: </strong>Late follicular premature progesterone rise is a complex phenomenon encountered during assisted reproductive technology (ART) treatments; different etiologies can occur in the same patient. Low ovarian responders may be the best example, since higher FSH doses and ovarian aging-related changes may interact and generate a premature progesterone rise. This study aims to explore the correlation between progesterone levels on hCG day and the progesterone-to-follicle index and compare the progesterone-to-follicle index according to ovarian response.</p><p><strong>Methods: </strong>We performed a retrospective, observational, analytic, cross-sectional, and cohort study at the Reproductive Endocrinology Department at Centro Médico Nacional 20 de November between January 2015 to January 2020. After verifying for normalcy, a Spearman Rho, Principal Component Analysis, and a simple linear regression model were performed. Treatment cycles were classified according to their ovarian response. Low-ovarian responders were classified according to the Bologna Criteria. Then an ANOVA test was performed to compare each group.</p><p><strong>Results: </strong>Our results show that the progesterone-to-follicle index correlates best with progesterone levels on hCG day. Comparing all the ovarian responses, low ovarian responders have the highest progesterone-to-follicle index of the four groups.</p><p><strong>Conclusions: </strong>Low ovarian responders produce more progesterone per follicle than regular and high responders.</p>","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"549-553"},"PeriodicalIF":1.8,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}