在冷冻解冻胚胎移植中注射单剂量促性腺激素释放激素激动剂对妊娠结局的影响:系统回顾和荟萃分析。

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY
Pongpawan Chienvichai, Natpat Jansaka, Usanee Sanmee, Kittipat Charoenkwan
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引用次数: 0

摘要

这项随机对照试验的系统综述和荟萃分析旨在评估在冷冻-解冻胚胎移植周期中使用单剂量促性腺激素释放激素激动剂对妊娠结局的影响。研究人员利用 PubMed、EMBASE 和 Cochrane 对照试验注册中心进行了文献检索。主要结果是临床妊娠率。次要结果包括化学妊娠率、植入率、持续妊娠率、活产率、流产率和宫外孕率。在找到的 1594 篇引文中,只有 6 篇符合纳入荟萃分析的标准。治疗组的临床妊娠率高于对照组(52.05% 对 47.29%;P=0.04;RR=1.09;95% CI=1.00-1.18)。根据基于自然周期的亚组分析,使用激动剂的临床妊娠率明显更高(43.75% 对 27.35%;P=0.01;RR=1.6;95% CI=1.10-2.32)。但在人工周期方面,两组之间没有差异(P=0.80;95% CI=0.96-1.20)。次要结果未显示出明显差异。我们的结论是,补充单剂量的促性腺激素释放激素激动剂可略微提高临床妊娠率,尤其是在自然周期。其他妊娠结果并不会随着治疗的进行而改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of single dose of gonadotropin-releasing hormone agonist injection in frozen-thawed embryo transfer on pregnancy outcomes: A systematic review and meta-analysis.

This systematic review and meta-analysis of randomized controlled trials aimed to evaluate the effect of a single-dose gonadotropin-releasing hormone agonist administration in the frozen-thawed embryo transfer cycle on pregnancy outcomes. A literature search was strategically conducted using PubMed, EMBASE, and the Cochrane Controlled Trials Register. The primary outcome was the clinical pregnancy rate. The secondary outcomes combined chemical pregnancy rate, implantation rate, ongoing pregnancy rate, live birth rate, miscarriage rate, and extrauterine pregnancy rate. Out of the 1594 citations that were found, only six met the criteria for being included in the meta-analysis. The clinical pregnancy rate was higher in the treatment group than in the control group (52.05% vs. 47.29%; p=0.04; RR=1.09; 95% CI=1.00-1.18). According to subgroup analysis based on the natural cycle, the clinical pregnancy rate with the agonist administration is significantly higher (43.75% vs. 27.35%; p=0.01; RR=1.6; 95% CI=1.10-2.32). However, there was no difference between the groups in terms of artificial cycles (p=0.80; 95% CI=0.96-1.20). The secondary outcomes did not show significant differences. We concluded that supplementing with a single dose of gonadotrophin-releasing hormone agonist can marginally increase the clinical pregnancy rate, particularly in the natural cycle. Other pregnancy outcomes do not improve with the treatment.

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来源期刊
CiteScore
3.30
自引率
6.70%
发文量
56
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