Jornal Brasileiro de Reproducao Assistida最新文献

Differential significance of Seminal Cell-Free DNA Levels, Oxidative Stress, and Sperm Characteristic between Infertile Men with Non-obstructive and obstructive Azoospermia. 非梗阻性和梗阻性无精子症男性不育患者精子无细胞DNA水平、氧化应激和精子特征的差异意义

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-05-29 DOI: 10.5935/1518-0557.20250007

Davoud Javidmehr, Farzaneh Fesahat, Fatemeh Hassani, Ali Reza Talebi, Abdolhossein Shahverdi

{"title":"Differential significance of Seminal Cell-Free DNA Levels, Oxidative Stress, and Sperm Characteristic between Infertile Men with Non-obstructive and obstructive Azoospermia.","authors":"Davoud Javidmehr, Farzaneh Fesahat, Fatemeh Hassani, Ali Reza Talebi, Abdolhossein Shahverdi","doi":"10.5935/1518-0557.20250007","DOIUrl":"https://doi.org/10.5935/1518-0557.20250007","url":null,"abstract":"Objective: The levels of cfDNA in the semen samples of infertile men and its relationship with the level of oxidative stress, antioxidant capacity and lipid peroxidation were investigated.Methods: Total 100 semen samples were obtained from infertile men with abnormal sperm parameters (oligoasthenospermia (n=10), oligoteratozoospermia (n=10), oligoasthenoteratozoospermia (n=10), and non-obstructive azoospermia (n=50)) and normozoospermic men. cfDNA was extracted and quantified by qPCR. Different markers related to the oxidant and antioxidant status as well as oxidative stress were measured in the seminal plasma samples of the study groups.Results: cfDNAs content in the oligoasthenoteratozoospermia group was significantly higher than those in the controls. A significant decrease in cfDNAs was observed in the azoospermia group compared to the controls. There was a significant increase in malondialdehyde and other oxidant related markers in all patient groups rather than the normal individuals. In contrast, seminal plasma samples of all patients with abnormal semen parameters showed a significant reduction in the levels of factors associated with antioxidant capacity compared to the controls.Conclusions: This study highlights the direct link between elevated cfDNA levels, oxidative stress, and impaired sperm parameters in men with azoospermia and oligospermia. Current data underscore the potential competence of cfDNA and oxidative stress as diagnostic tools to classify the severity of male infertility and abnormalities related to semen parameters. Our findings emphasize the importance of antioxidant therapy as an efficient strategy to reduce oxidative damage, enhance sperm quality, and improve reproductive outcomes for male partners of couples with infertility.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technical laboratory procedures faced on many oocytes picked up in vitro fertilization cycles. 技术实验室程序面临的许多卵母细胞捡起在体外受精周期。

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-05-29 DOI: 10.5935/1518-0557.20250015

Christina Morishima, Nilka Fernandes Donadio, Luiz Henrique Gebrim, Tatiana Carvalho S Bonetti

{"title":"Technical laboratory procedures faced on many oocytes picked up in vitro fertilization cycles.","authors":"Christina Morishima, Nilka Fernandes Donadio, Luiz Henrique Gebrim, Tatiana Carvalho S Bonetti","doi":"10.5935/1518-0557.20250015","DOIUrl":"https://doi.org/10.5935/1518-0557.20250015","url":null,"abstract":"Objective: The accumulation of cryopreserved embryos in assisted reproductive technology (ART) centers is an important point of discussion for the clinical and scientific community. This study conducted a survey to explore in vitro laboratories' approaches to handling oocytes and embryos in the face of an ovarian hyperresponse.Methods: We invited ART centers whose laboratories were registered in the National Embryo Production System (2018) to answer an online multiple-choice questionnaire. A total of 57 ART centers participated.Results: Most of the ART centers were private (92.9%) and about half of them were considered medium/large business, performing at least 30 IVF cycles per month. The ART centers were asked what their concept of ovarian hyper-responsiveness was, and 76% considered more than 15-20 oocytes retrieved. Faced with an ovarian hyper-responsiveness, the main practice reported was injecting all mature oocytes and vitrifying all developed blastocysts (53%), followed by a practice of freezing half of the oocytes and injecting other half of the oocytes (35%). 9% alternated between these two protocols.Conclusions: Injection of all oocytes followed by embryos cryopreservation is the most common approach when high order number of oocytes is collected, despite it generating many surplus embryos. The findings of this study underscore the necessity for updated consensus on the management and production of embryos, considering the multifaceted considerations involved, as laboratory efficiency and costs. The decision in such cases should focus on the balance of priorities of having a healthy newborn and the responsibility for the fate of surplus embryos.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the Relationship Between Clinical Features and the Sonographic Appearance of the Ovaries with the Delta Neutrophil Index in Polycystic Ovary Syndrome. 多囊卵巢综合征临床特征与卵巢超声表现及中性粒细胞指数关系的探讨。

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-05-29 DOI: 10.5935/1518-0557.20250014

Uğurcan Zorlu, Batuhan Turgay, Sezer Nil Yılmazer-Zorlu, Mohammad İbrahim Halilzade, İnci Halilzade, Hakan Raşit Yalçın

{"title":"Investigation of the Relationship Between Clinical Features and the Sonographic Appearance of the Ovaries with the Delta Neutrophil Index in Polycystic Ovary Syndrome.","authors":"Uğurcan Zorlu, Batuhan Turgay, Sezer Nil Yılmazer-Zorlu, Mohammad İbrahim Halilzade, İnci Halilzade, Hakan Raşit Yalçın","doi":"10.5935/1518-0557.20250014","DOIUrl":"https://doi.org/10.5935/1518-0557.20250014","url":null,"abstract":"Objective: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder in women of reproductive age, characterized by metabolic, reproductive, and inflammatory disturbances. This study aimed to investigate the relationship between clinical features, the sonographic appearance of the ovaries, and the Delta Neutrophil Index (DNI) in women with PCOS.Methods: This retrospective study included 60 women diagnosed with PCOS and 60 healthy controls. Clinical, laboratory, and ultrasonographic data were collected and analyzed. The Delta Neutrophil Index (DNI), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and ultrasonographic parameters, including ovarian stroma/total area ratio, and ovarian volume, were compared between the groups.Results: The study found that DNI, NLR, and PLR were significantly higher in the PCOS group compared to the control group, indicating a chronic low-grade inflammatory state. Significant differences were also observed in ovarian stroma/total area ratio, and ovarian volume between the groups. Additionally, a statistically significant relationship between acne and DNI was found in the PCOS group, while other symptoms such as infertility, hirsutism, and hair loss did not show a significant correlation with DNI.Conclusions: This study demonstrates a clear relationship between elevated inflammatory markers and ovarian morphology in PCOS. The findings suggest that inflammation plays a significant role in the pathophysiology of PCOS, underscoring the importance of incorporating anti-inflammatory treatment strategies in the clinical management of the disease.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A shorter pre-vitrification equilibration time for laser-collapsed human blastocysts is associated with a lower miscarriage rate in ART treatments. 激光塌陷的人囊胚较短的玻璃化前平衡时间与ART治疗中较低的流产率有关。

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-05-29 DOI: 10.5935/1518-0557.20250013

Romualdo Sciorio, Liuguang Zhang, Yuhu Li, Ning Li

{"title":"A shorter pre-vitrification equilibration time for laser-collapsed human blastocysts is associated with a lower miscarriage rate in ART treatments.","authors":"Romualdo Sciorio, Liuguang Zhang, Yuhu Li, Ning Li","doi":"10.5935/1518-0557.20250013","DOIUrl":"https://doi.org/10.5935/1518-0557.20250013","url":null,"abstract":"Objective: Frozen embryo transfer in humans, especially at the blastocyst stage, provides a valid alternative to fresh embryo transfer. However, protocols for blastocyst vitrification are not yet standardized; for example, exposure to the first equilibration solution before vitrification commonly ranges from 2-3 minutes at 37°C or 2-15 minutes at room temperature. This study compared the clinical and neonatal outcomes involving vitrified-warmed blastocysts.Methods: The main aim of this prospective study was to compare the clinical and neonatal outcomes for 831 warmed blastocysts, returned in 585 frozen embryo transfers with two exposure times to the equilibration solution at room temperature: (A) 7-8 minutes and (B) 9-10 minutes.Results: The patients' characteristics were comparable between the two groups with no significant difference in their mean age, the average number of blastocysts transferred, basal Follicle Stimulating Hormone, body mass index (BMI), infertility duration, primary infertility, or endometrial thickness. The survival and clinical pregnancy rates of the vitrified-warmed laser collapsed blastocysts were not different between the two groups. The overall miscarriage rate was significantly lower in the 7-8 minute compared to the 9-10-minute equilibration group (A: 7.6% versus B: 14.2%, p<0.05). Live birth, multiple gestation and neonatal outcomes were similar between the two groups.Conclusions: Our results indicate that the equilibration time can affect the efficiency of the cryopreservation process of human blastocysts.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphokinetic behavior in embryos leading to biochemical pregnancy. 胚胎的形态动力学行为导致生化妊娠。

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-05-29 DOI: 10.5935/1518-0557.20250010

Amanda Setti, Daniela Braga, Patricia Guilherme, Assumpto Iaconelli, Edson Borges

{"title":"Morphokinetic behavior in embryos leading to biochemical pregnancy.","authors":"Amanda Setti, Daniela Braga, Patricia Guilherme, Assumpto Iaconelli, Edson Borges","doi":"10.5935/1518-0557.20250010","DOIUrl":"https://doi.org/10.5935/1518-0557.20250010","url":null,"abstract":"Objective: It has been observed that faster developmental kinetics are linked with a higher number of embryo cells, improved blastocyst development, and increased rates of implantation and pregnancy. However, the embryonic morphokinetics' predictive value for biochemical pregnancy (BP) outcomes has been minimally investigated. The objective of this study was to investigate whether embryos leading to BP behave morphokinetically differently than those leading to positive or negative pregnancy result.Methods: This case-control study performed in a private university-affiliated IVF center, included 1248 transferred embryos from 753 women undergoing ICSI cycles between March 2019 and April 2022. Patients were split into three groups according to the pregnancy outcome: Biochemical Group (n=30 cycles/54 transferred embryos), consisting of patients with a BP; Positive Group (n=255 cycles/444 transferred embryos), consisting of patients with a positive pregnancy result (clinical pregnancy); and Negative Group (n=468 cycles/750 transferred embryos), consisting of patients with a negative pregnancy result. Kinetic markers from the point of insemination were recorded in the EmbryoScope incubator.Results: Embryos resulting in BP behaved similarly to those embryos resulting in a clinical pregnancy. Embryos resulting in a negative pregnancy showed significantly slower embryo development and KIDScore ranking compared to both Biochemical and Positive groups.Conclusions: Embryos that resulted in a BP did not display evidence of abnormal morphokinetics on time-lapse imaging. Further research is needed to identify factors that can predict and prevent biochemical pregnancy.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does flying after embryo transfer impact implantation? 胚胎移植后飞行是否影响着床？

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-05-29 DOI: 10.5935/1518-0557.20250005

João Antonio Dias, Carlos Roberto Izzo, Georges Fassolas, Luiz Fernando Henrique, Denis Schapira Wajman

{"title":"Does flying after embryo transfer impact implantation?","authors":"João Antonio Dias, Carlos Roberto Izzo, Georges Fassolas, Luiz Fernando Henrique, Denis Schapira Wajman","doi":"10.5935/1518-0557.20250005","DOIUrl":"https://doi.org/10.5935/1518-0557.20250005","url":null,"abstract":"Objective: To explore whether post-embryo transfer (ET) air travel affects in vitro fertilization (IVF) outcomes, addressing the growing concern in medical tourism where patients frequently travel for fertility treatments.Methods: This retrospective study was conducted at a private fertility clinic in São Paulo, Brazil, and included 2,135 embryo transfers performed between January 2019 and March 2022. Patients were divided into two groups: individuals who presumably traveled by airplane after ET (Group 2) and those who did not (Group 1). Data were analyzed for demographics, embryo transfer characteristics, and IVF outcomes. Relative risk was estimated using Poisson regression models, adjusting for age and treatment reasons. Significance was set at p<0.05.Results: 17.94% of patients traveled by plane post-ET. No significant differences were found between the groups in terms of pregnancy (Group 1: 61.99%, Group 2: 62.14%, p=0.94), implantation (Group 1: 34.58%, Group 2: 38.65%, p=0.28), or miscarriage rates (Group 1: 28.51%, Group 2: 32.50%, p=0.32). A sub-analysis of single embryo transfers and top embryos also showed no statistical differences.Conclusions: Post-ET air travel did not negatively impact IVF treatment outcomes. Further prospective studies are recommended to confirm these findings.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploration of Herbal Medicinal Plants and Formulations Available for the Treatment of PCOS: A review. 治疗多囊卵巢综合征的草药植物及其制剂的研究进展。

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-05-15 DOI: 10.5935/1518-0557.20250006

Arjoo Babhare, Deweshri Nandurkar, Kishor Danao, Amol Warokar, Ujwala Mahajan

{"title":"Exploration of Herbal Medicinal Plants and Formulations Available for the Treatment of PCOS: A review.","authors":"Arjoo Babhare, Deweshri Nandurkar, Kishor Danao, Amol Warokar, Ujwala Mahajan","doi":"10.5935/1518-0557.20250006","DOIUrl":"https://doi.org/10.5935/1518-0557.20250006","url":null,"abstract":"Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrine disorder with the underlying consequence of ovarian cysts, anovulation, and endocrine variation affecting women. According to the World Health Organization (WHO) estimation over 116 million women (3.4%) are affected by PCOS worldwide. It is typified by polycystic ovaries, hyperandrogenism, and ovulatory dysfunction. Pharmacological interventions that treat symptoms but may have fewer side effects are frequently used in conventional treatments. As a result, interest in herbal medicinal plants and formulations as additional or alternative PCOS therapies is developing. This review explores the safety and efficacy of various herbal remedies traditionally used in the management of PCOS. Each of the herbs mentioned in this review offers unique benefits. This review gives a comprehensive idea about PCOS, its causes and symptoms. It also explores formulations like capsules, tablets, syrups, and nano drug delivery system medicines for PCOS. According to studies, these herbal medicines can improve insulin resistance, lower testosterone levels and restore menstrual regularity while causing fewer negative effects than conventional therapy. .","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective Serotonin Reuptake Inhibitors (SSRIs): Effects on male fertility. 选择性血清素再摄取抑制剂（SSRIs）：对男性生育能力的影响。

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-05-15 DOI: 10.5935/1518-0557.20240109

Raisa Arruda de Oliveira, Suellen Casado Dos Santos, Vera Lúcia de Menezes Lima, Luana Nayara Gallego Adami

{"title":"Selective Serotonin Reuptake Inhibitors (SSRIs): Effects on male fertility.","authors":"Raisa Arruda de Oliveira, Suellen Casado Dos Santos, Vera Lúcia de Menezes Lima, Luana Nayara Gallego Adami","doi":"10.5935/1518-0557.20240109","DOIUrl":"https://doi.org/10.5935/1518-0557.20240109","url":null,"abstract":"Selective Serotonin Reuptake Inhibitors are the most prescribed class of medications in cases of depression. This article discusses the main findings on their effects on male fertility, considering semen parameters and sperm function. This systematic review of the literature delves into the adverse effects of the main SSRIs on male fertility. The software package PRISMA was used to organize the search using keywords related to the research question. The search yielded a total of 125 studies. After the abstracts were read, 18 articles were selected for further analysis. The review ultimately included ten articles about the adverse effects of this class of antidepressants on male fertility, which included decreases in serum testosterone levels, reduced sperm production, decreased sperm reserves in the epididymis, and increased sperm transit time in the tail of the epididymis. The articles included in this review indicated that this class of antidepressants may have adverse effects on male fertility. However, a randomized clinical trial is needed to evaluate the mechanisms of spermatogenic failure and the underlying causes of these effects.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychosocial aspects of infertility and the impact of assisted reproductive techniques - a comprehensive review. 不孕症的社会心理方面和辅助生殖技术的影响-全面审查。

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-04-30 DOI: 10.5935/1518-0557.20250002

Beatriz Ribeiro Neto, Márcia Barreiro, António Tomé, Emídio Vale-Fernandes

{"title":"Psychosocial aspects of infertility and the impact of assisted reproductive techniques - a comprehensive review.","authors":"Beatriz Ribeiro Neto, Márcia Barreiro, António Tomé, Emídio Vale-Fernandes","doi":"10.5935/1518-0557.20250002","DOIUrl":"https://doi.org/10.5935/1518-0557.20250002","url":null,"abstract":"This review examines the impact of Assisted Reproductive Technology (ART) on prospective parents and born children, as well as their parental relationships, considering their emotional and social context. Specific situations are analyzed, such as gynecological pathologies and heterologous treatments, such as the ROPA (Reception of Oocytes from Partner) method, and the use of gestational surrogacy, which have particular psychosocial impacts. Infertility affects approximately one-third of the global population, leading many to seek ART, which have grown in popularity over the decades. In addition to clinical concerns, the psychosocial impact of these techniques has received increasing attention, given the implications for mental health and family relationships. Based on a narrative review methodology, it analyzes experimental and observational studies on the topic, seeking to understand and evaluate the impact of ART techniques. The results highlight the emotional and ethical complexity associated with treatment decisions, from the decision to engage to these treatments to the psychosocial implications of the different available options. Anxiety and depression are common responses to the challenges faced during treatment, affecting both direct beneficiaries and their interpersonal relationships. Gestational surrogacy and heterologous treatments add layers of complexity. Regarding the impact on parental relationships and the development of children conceived through these methods, it is concluded that, despite concerns, children conceived through ART have the potential to grow and thrive as well as naturally conceived ones. This review emphasizes the importance of an inclusive and holistic approach to treating infertility, recognizing that parenthood goes beyond biological conception.´P)I?J: '+-.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ovarian response and outcomes of in vitro fertilization cycles in transgender men: Report of three cases with a live birth. 变性男性体外受精周期的卵巢反应和结果：三例活产病例报告。

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-04-30 DOI: 10.5935/1518-0557.20240114

Laura Maria Almeida Maia, Leci Veiga Caetano Amorim, Cassia Maria Avelar, Victoria Furquim Werneck Marinho, Erica Becker de Sousa Xavier, Aline R Lorenzon, Ricardo Mello Marinho, João Pedro Junqueira Caetano

{"title":"Ovarian response and outcomes of in vitro fertilization cycles in transgender men: Report of three cases with a live birth.","authors":"Laura Maria Almeida Maia, Leci Veiga Caetano Amorim, Cassia Maria Avelar, Victoria Furquim Werneck Marinho, Erica Becker de Sousa Xavier, Aline R Lorenzon, Ricardo Mello Marinho, João Pedro Junqueira Caetano","doi":"10.5935/1518-0557.20240114","DOIUrl":"https://doi.org/10.5935/1518-0557.20240114","url":null,"abstract":"In vitro fertilization (IVF) treatments have broadened to cover a variety of scenarios, including those involving transgender individuals or couples who wish to become parents, posing new challenges for the field of reproductive medicine. While there are limited reports of successful IVF births involving transgender men, concerns remain regarding the impact of long-term testosterone use on ovarian function, oocyte and embryo quality and IVF reproductive outcomes. This study details a case series of three trans men and cis women couples at a fertility clinic, resulting in one live birth. The couples underwent IVF with frozen blastocyst-stage embryos transferred to the cis women partners. The trans men, aged 32, 35, and 38, received ovarian stimulation with gonadotropins and dydrogesterone for pituitary suppression, and a GnRH agonist for final oocyte maturation. All had been on 250 mg of testosterone and paused treatment to resume menstrual cycles before IVF. Eggs were fertilized with donor sperm, and despite a lower-than-expected response to stimulation after short-term testosterone discontinuation, high-quality blastocysts were produced, leading to two pregnancies. Given the uncertainty regarding the long-term effects of testosterone on overall fertility, patients should be advised to consider cryopreservation before starting gender-affirming hormone therapy. Our case reports contribute to the knowledge in this area, highlighting the feasibility of oocyte collection, embryo development, pregnancies, and births in these individuals even after prolonged use of testosterone.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0