Jornal Brasileiro de Reproducao Assistida最新文献_第2页

Exploration of Herbal Medicinal Plants and Formulations Available for the Treatment of PCOS: A review. 治疗多囊卵巢综合征的草药植物及其制剂的研究进展。

IF 1.9

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-07-30 DOI: 10.5935/1518-0557.20250006

Arjoo Babhare, Deweshri Nandurkar, Kishor Danao, Amol Warokar, Ujwala Mahajan

{"title":"Exploration of Herbal Medicinal Plants and Formulations Available for the Treatment of PCOS: A review.","authors":"Arjoo Babhare, Deweshri Nandurkar, Kishor Danao, Amol Warokar, Ujwala Mahajan","doi":"10.5935/1518-0557.20250006","DOIUrl":"10.5935/1518-0557.20250006","url":null,"abstract":"Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrine disorder with the underlying consequence of ovarian cysts, anovulation, and endocrine variation affecting women. According to the World Health Organization (WHO) estimation over 116 million women (3.4%) are affected by PCOS worldwide. It is typified by polycystic ovaries, hyperandrogenism, and ovulatory dysfunction. Pharmacological interventions that treat symptoms but may have fewer side effects are frequently used in conventional treatments. As a result, interest in herbal medicinal plants and formulations as additional or alternative PCOS therapies is developing. This review explores the safety and efficacy of various herbal remedies traditionally used in the management of PCOS. Each of the herbs mentioned in this review offers unique benefits. This review gives a comprehensive idea about PCOS, its causes and symptoms. It also explores formulations like capsules, tablets, syrups, and nano drug delivery system medicines for PCOS. According to studies, these herbal medicines can improve insulin resistance, lower testosterone levels and restore menstrual regularity while causing fewer negative effects than conventional therapy.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"367-377"},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical validation and experiences of the microfluidics sperm selection device ZyMōt™ for standard IVF. 用于标准试管婴儿的微流体精子选择装置ZyMōt™的临床验证和经验。

IF 1.9

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-07-30 DOI: 10.5935/1518-0557.20240104

Emma Adolfsson, Johanna Ingberg, Emma Igersten, Therese Bohlin

{"title":"Clinical validation and experiences of the microfluidics sperm selection device ZyMōt™ for standard IVF.","authors":"Emma Adolfsson, Johanna Ingberg, Emma Igersten, Therese Bohlin","doi":"10.5935/1518-0557.20240104","DOIUrl":"10.5935/1518-0557.20240104","url":null,"abstract":"Objective: Clinical validation of sperm selection device ZyMōt™ for standard IVF.Methods: The pre-clinical validation of ZyMōt™ included several steps. First, split semen preparation compared density gradient centrifugation (DGC) to ZyMōt™ with primary outcome fraction and absolute number of progressive motile sperm. Second, sibling oocytes were fertilized with sperms prepared with DGC and sperms selected by ZyMōt™, primary endpoint fertilization rate, utility rate, embryo development pace quality. After this, DGC was replaced by ZyMōt™, first without centrifugation steps, and then with a five-minute centrifugation step and subsequent media change prior to gamete co-incubation. Endpoint was assessment of key performance indicators against previous results using DGC for standard IVF.Results: ZyMōt™ resulted in purer sperm selection compared to DGC (fraction progressive motile sperm 97.2±3.1% vs. 83.0±14.1%, p<0.01). Fertilization of sibling oocytes resulted in similar fertilization rates and utility rates, and no differences in embryo development pace or quality. However, after changing sperm selection protocol from DGC to ZyMōt™ for standard IVF for all fresh semen samples with motile sperm, the fertilization rates and utility rates were significantly reduced, and cases of total failure of fertilization increased substantially. Adding five-minute centrifugation and media change after centrifugation to the sperm selection protocol restored fertilization rate, including total failure of fertilization rate, to normal.Conclusions: To conclude, the ZyMōt™ sperm selection device is suitable for standard IVF only after inclusion of five minutes centrifugation and subsequent media change prior to gamete co-incubation.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"244-250"},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of quercetin on obesity and reproduction through the expression of genes involved in the hypothalamus-pituitary-gonadal axis. 槲皮素通过下丘脑-垂体-性腺轴相关基因的表达对肥胖和生殖的影响。

IF 1.9

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-07-30 DOI: 10.5935/1518-0557.20240097

Elaheh Shams, Dina Zohrabi, Ozra Omrani, Mohammad Hossein Sanati, Maryam Karimi-Dehkordi, Nasrin Yazdanpanahi, Fatemeh Khademi Moghadam, Vahid Zarezade

{"title":"The effect of quercetin on obesity and reproduction through the expression of genes involved in the hypothalamus-pituitary-gonadal axis.","authors":"Elaheh Shams, Dina Zohrabi, Ozra Omrani, Mohammad Hossein Sanati, Maryam Karimi-Dehkordi, Nasrin Yazdanpanahi, Fatemeh Khademi Moghadam, Vahid Zarezade","doi":"10.5935/1518-0557.20240097","DOIUrl":"10.5935/1518-0557.20240097","url":null,"abstract":"Objective: Quercetin is a flavonoid compound extracted from fruits and plants and is used as a natural antioxidant to prevent or treat a variety of diseases such as cancer, obesity, chronic inflammation, and reproductive system dysfunction. The aim of this study was to investigate the effects of quercetin on obesity and ovarian tissue by analyzing the expression of genes involved in the hypothalamus-pituitary-gonadal axis, including ob-Rb, ob-Ra, and brain-derived neurotrophic factor (Bdnf), neuropeptide Y (NPY), and Kisspeptin (Kiss-1).Methods: In this experimental study, female rats were divided into three groups, and the effect of quercetin with doses of 50 and 100 mg/kg on weight and BMI was investigated. Also, the gene expression was assessed using the real-time PCR technique. The estrogen, progesterone, FSH, and LH were assessed using the chemiluminescence technique. The diameter and number of different types of follicles, corpus luteum, and blood vessels in mice were investigated. The growth indicators of the children, including the number, weight, and height and head width of the born children, were checked.Results: Quercetin caused a decrease in BMI, a significant increase in the expression of ob-Rb, ob-Ra, and Bdnf genes, a significant decrease in the expression of NPY and Kiss-1 genes, and led to an increase in sex hormones. Quercetin improved follicular indices and increased the number of mouse embryos.Conclusions: Probably, quercetin affects the hypothalamus-pituitary-gonadal axis by changing the expression of genes, and it helps to reduce obesity and increase fertility and better function of the reproductive system.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"211-218"},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the day 3 transfer strategy for POSEIDON patients. POSEIDON患者第3天转移策略分析。

IF 1.9

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-07-30 DOI: 10.5935/1518-0557.20240111

Jakub Wyroba, Joanna Kochan

{"title":"Analysis of the day 3 transfer strategy for POSEIDON patients.","authors":"Jakub Wyroba, Joanna Kochan","doi":"10.5935/1518-0557.20240111","DOIUrl":"10.5935/1518-0557.20240111","url":null,"abstract":"Objective: The aim of the study was to analyze the effectiveness of the day 3 ET strategy, and the morphology of the transferred embryos, in patients from POSEIDON and non-POSEIDON groups.Methods: 600 cycles of patients meeting the POSEIDON criteria and 600 non-POSEIDON cycles were analyzed to determine the proportion of cycles with an ET on days 3 or 5, or FET. Then we reviewed 330 day 3 ETs to compared the developmental stage, morphology, zona pellucida thickness and implantation potential of embryos transferred on day 3 from POSEIDON and non-POSEIDON patients.Results: Most cycles of POSEIDON patients end with ET on day 3 (42%) or without transfer (37%). In contrast, most cycle of non-POSEIDON patients end with FET (44%) and just 9% is canceled. The lowest percentage of embryos at the morula stage was recorded in POSEIDON groups III (10%) and IV (9%). The average number of cells in embryos was comparable in all groups. The largest percentage of top-quality embryos (grade A) were in POSEIDON group I (47%) .The highest implantation potential were observed in the non-POSEIDON group <35Y (28%), and in POSEIDON groups I (28%) and III (26%). The highest incidence of miscarriage was recorded in all POSEIDON and non-POSEIDON groups that included patients who were ≥35 years of age.Conclusions: The day 3 ET strategy still seems optimal for POSEIDON patients. The prognosis depends on which Poseidon group the patient is in. The best prognosis is for group I and the worst for group IV.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"298-305"},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dydrogesterone is an eligible tool to suppress LH surge in assisted reproduction technologies (ART) cycles. 地屈孕酮是抑制辅助生殖技术（ART）周期中LH激增的合适工具。

IF 1.9

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-07-30 DOI: 10.5935/1518-0557.20250003

Marcelo Marinho de Souza, Maria do Carmo Borges de Souza, Roberto de Azevedo Antunes, Ana Luíza Barbeitas, Verônica de Almeida Raupp, Ana Luísa Bruno Marinho de Souza, Layna Almeida Barbosa da Silva, Ana Cristina Allemand Mancebo, Flávia Fernandes Sequeira

{"title":"Dydrogesterone is an eligible tool to suppress LH surge in assisted reproduction technologies (ART) cycles.","authors":"Marcelo Marinho de Souza, Maria do Carmo Borges de Souza, Roberto de Azevedo Antunes, Ana Luíza Barbeitas, Verônica de Almeida Raupp, Ana Luísa Bruno Marinho de Souza, Layna Almeida Barbosa da Silva, Ana Cristina Allemand Mancebo, Flávia Fernandes Sequeira","doi":"10.5935/1518-0557.20250003","DOIUrl":"10.5935/1518-0557.20250003","url":null,"abstract":"Objective: To evaluate Dydrogesterone's effectiveness in PPOS protocols for IVF/ICSI or oocyte cryopreservation, focusing on LH surge suppression and metaphase II oocyte yield.Methods: A retrospective, comparative, single-center study of 550 IVF/ICSI and 186 oocyte cryopreservation cycles was conducted from January 2018 to December 2020. Exclusion criteria included endometriosis, previous ovarian surgery, ovarian insufficiency, and abnormal FSH/LH levels. Patients received either Follitropin delta (Rekovelle®) or Menotropin (Menopur®). LH surge blockade was achieved with GnRH antagonist (Cetrotide®) or DYG (Duphaston®). Primary outcome was incidence of premature LH surge; secondary outcomes included follicle size on hCG day, metaphase II oocytes, cancelled cycles, and OHSS. ANCOVA analyses were used, with partial squared Eta as the effect size index.Results: Premature LH peak with early follicular rupture occurred in 2 cases in Group 1 (Ant) and 3 cases in Group 2 (DYG), without statistical significance. LH levels on trigger day showed no difference (Ant: 2.63 - SD 1.15 vs. DYG: 2.47 - SD 1.22). Oocyte maturation at metaphase II (MII) stage was similar (6.28 - SD 4.72 vs. 6.71 - SD 4.53). Follicle size differed: fewer follicles ≥ 18 mm in Ant group (3.33 - SD 2.06 vs. 4.19 - SD 2.53; p=0.001), but more 15-17 mm follicles (p=0.024). No moderate to severe OHSS occurred in patients with AMH >3 ng/mL.Conclusions: DYG is an eligible tool for IVF/ICSI cycles intended to freeze-all and oocyte preservation, embryo banking, and preventing OHSS in patients with high AMH levels.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"317-322"},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prednisolone at a therapeutic dose is not detrimental to mouse oocyte competence. 治疗剂量的强的松龙对小鼠卵母细胞的能力没有损害。

IF 1.9

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-07-30 DOI: 10.5935/1518-0557.20240108

Shruthivishali Muthukumar, Vijeta Shetty, Akshatha Daddangadi, Satish Kumar Adiga, Shubhashree Uppangala

{"title":"Prednisolone at a therapeutic dose is not detrimental to mouse oocyte competence.","authors":"Shruthivishali Muthukumar, Vijeta Shetty, Akshatha Daddangadi, Satish Kumar Adiga, Shubhashree Uppangala","doi":"10.5935/1518-0557.20240108","DOIUrl":"10.5935/1518-0557.20240108","url":null,"abstract":"Objective: To examine the impact of PRDL on mouse oocyte developmental competence.Methods: This study was conducted on 6-8-week-old female Swiss albino mice in which different doses of PRDL were administered for three days during superovulation. Oocytes were assessed for quality, and subsequently, embryos derived from these oocytes were evaluated at the blastocyst stage. Simultaneously, oocytes were also exposed to PRDL during in vitro maturation and examined for their spindle and activation potential.Results: Compared to control group, the total cell number of blastocysts in the PRDL group increased. Nevertheless, the incidence of apoptosis was comparable between the groups. However, direct exposure at 10 µM significantly increased spindle abnormalities compared to those in the control group (p<0.05).Conclusions: Short-term PRDL exposure at a therapeutic dose is not detrimental to oocyte developmental potential in vitro. Although the current study confirmed the safety of PRDL in a mouse model, further studies involving long-term exposure are warranted, as patients receive PRDL treatment for extended periods of time.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"289-297"},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A shorter pre-vitrification equilibration time for laser-collapsed human blastocysts is associated with a lower miscarriage rate in ART treatments. 激光塌陷的人囊胚较短的玻璃化前平衡时间与ART治疗中较低的流产率有关。

IF 1.9

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-07-30 DOI: 10.5935/1518-0557.20250013

Romualdo Sciorio, Liuguang Zhang, Yuhu Li, Ning Li

{"title":"A shorter pre-vitrification equilibration time for laser-collapsed human blastocysts is associated with a lower miscarriage rate in ART treatments.","authors":"Romualdo Sciorio, Liuguang Zhang, Yuhu Li, Ning Li","doi":"10.5935/1518-0557.20250013","DOIUrl":"10.5935/1518-0557.20250013","url":null,"abstract":"Objective: Frozen embryo transfer in humans, especially at the blastocyst stage, provides a valid alternative to fresh embryo transfer. However, protocols for blastocyst vitrification are not yet standardized; for example, exposure to the first equilibration solution before vitrification commonly ranges from 2-3 minutes at 37°C or 2-15 minutes at room temperature. This study compared the clinical and neonatal outcomes involving vitrified-warmed blastocysts.Methods: The main aim of this prospective study was to compare the clinical and neonatal outcomes for 831 warmed blastocysts, returned in 585 frozen embryo transfers with two exposure times to the equilibration solution at room temperature: (A) 7-8 minutes and (B) 9-10 minutes.Results: The patients' characteristics were comparable between the two groups with no significant difference in their mean age, the average number of blastocysts transferred, basal Follicle Stimulating Hormone, body mass index (BMI), infertility duration, primary infertility, or endometrial thickness. The survival and clinical pregnancy rates of the vitrified-warmed laser collapsed blastocysts were not different between the two groups. The overall miscarriage rate was significantly lower in the 7-8 minute compared to the 9-10-minute equilibration group (A: 7.6% versus B: 14.2%, p<0.05). Live birth, multiple gestation and neonatal outcomes were similar between the two groups.Conclusions: Our results indicate that the equilibration time can affect the efficiency of the cryopreservation process of human blastocysts.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"323-332"},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective Serotonin Reuptake Inhibitors (SSRIs): Effects on male fertility. 选择性血清素再摄取抑制剂（SSRIs）：对男性生育能力的影响。

IF 1.9

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-07-30 DOI: 10.5935/1518-0557.20240109

Raisa Arruda de Oliveira, Suellen Casado Dos Santos, Vera Lúcia de Menezes Lima, Luana Nayara Gallego Adami

{"title":"Selective Serotonin Reuptake Inhibitors (SSRIs): Effects on male fertility.","authors":"Raisa Arruda de Oliveira, Suellen Casado Dos Santos, Vera Lúcia de Menezes Lima, Luana Nayara Gallego Adami","doi":"10.5935/1518-0557.20240109","DOIUrl":"10.5935/1518-0557.20240109","url":null,"abstract":"Selective Serotonin Reuptake Inhibitors are the most prescribed class of medications in cases of depression. This article discusses the main findings on their effects on male fertility, considering semen parameters and sperm function. This systematic review of the literature delves into the adverse effects of the main SSRIs on male fertility. The software package PRISMA was used to organize the search using keywords related to the research question. The search yielded a total of 125 studies. After the abstracts were read, 18 articles were selected for further analysis. The review ultimately included ten articles about the adverse effects of this class of antidepressants on male fertility, which included decreases in serum testosterone levels, reduced sperm production, decreased sperm reserves in the epididymis, and increased sperm transit time in the tail of the epididymis. The articles included in this review indicated that this class of antidepressants may have adverse effects on male fertility. However, a randomized clinical trial is needed to evaluate the mechanisms of spermatogenic failure and the underlying causes of these effects.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"351-358"},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydatidiform Mole and coexisting fetus following intrauterine insemination: a case report. 宫内人工授精后葡萄胎并发胎儿1例。

IF 1.9

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-07-30 DOI: 10.5935/1518-0557.20250011

Cynthia Lopes Pereira de Borborema, Eduardo Oliveira Pacheco, Aley Talans, Lucas Rios Torres, Angela Hissae Motoyama Caiado, Felipe Lazar Junior, Ulysses Dos Santos Torres, Giuseppe D'Ippolito

{"title":"Hydatidiform Mole and coexisting fetus following intrauterine insemination: a case report.","authors":"Cynthia Lopes Pereira de Borborema, Eduardo Oliveira Pacheco, Aley Talans, Lucas Rios Torres, Angela Hissae Motoyama Caiado, Felipe Lazar Junior, Ulysses Dos Santos Torres, Giuseppe D'Ippolito","doi":"10.5935/1518-0557.20250011","DOIUrl":"10.5935/1518-0557.20250011","url":null,"abstract":"Gestational trophoblastic diseases (GTD) comprise a heterogeneous group of disorders arising from genetic anomalies occurring during fertilization in twin pregnancies and often may be associated with assisted reproductive techniques. An exceedingly rare presentation of GTD is a twin pregnancy hydatidiform mole with a co-existing fetus, condition which may be an important cause of complications for the mother and the fetus. A 36-year-old woman (G2, P0, A1) underwent a friendly controlled ovarian stimulation (COS) followed by intrauterine insemination (IUI) for assisted reproductive purposes, resulting in a twin pregnancy initially characterized by two gestational sacs. However, one sac failed to progress and instead degenerated into molar trophoblastic disease, while the other sustained a normal fetus with regular growth. At 33 weeks gestation, the patient developed preeclampsia, necessitating delivery via cesarean section at a tertiary care facility. Reproductive-assisted procedures may be linked to cases of trophoblastic disease. Additionally, the presence of cystic lesions warrants a wide differential diagnosis, with magnetic resonance imaging serving as a valuable tool for accurate assessment and differentiation of structures.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"403-406"},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Infertility and Medically Assisted Reproduction Treatments on Female Sexuality. 不孕不育和医学辅助生殖治疗对女性性行为的影响。

IF 1.9

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-07-30 DOI: 10.5935/1518-0557.20240100

Badra Bannour, Darine Salem, Rania Bannour, Omar Khalil Ben Saad, Imen Bannour

{"title":"Impact of Infertility and Medically Assisted Reproduction Treatments on Female Sexuality.","authors":"Badra Bannour, Darine Salem, Rania Bannour, Omar Khalil Ben Saad, Imen Bannour","doi":"10.5935/1518-0557.20240100","DOIUrl":"10.5935/1518-0557.20240100","url":null,"abstract":"Objective: To evaluate the impact of infertility and Medically Assisted Procreation (MAP) on female sexuality. Human sexuality presents a multifaceted complexity, shaped by diverse factors and individual intricacies. Infertility and assisted reproductive treatments entail a prolonged and arduous journey, amplifying pre-existing sexual dysfunctions and serving as a rigorous trial of the affected women's sexuality and the resilience of couples.Methods: This is a prospective descriptive comparative study with an analytical section, involving 140 female participants: 70 with infertility undergoing assisted reproductive technology (ART) treatment, and 70 who are fertile and had no prior history of conceiving problems. The evaluation of the sexual function of the two groups was conducted using the Female Sexual Function Index (FSFI) score.Results: The infertile group exhibited a higher level of marital adjustment compared to the fertile cohort. A majority of participants within the infertile cohort (51.4%) presented with primary infertility and (48.6%) experiencing secondary infertility. A marginal elevation in the frequency of sexual intercourse among infertile participants was observed. The mean global score of female sexual function was (21.57±3.36) in the infertile group, which was significantly lower compared to (24.46±1.97) in the fertile group. Notably, both scores fell within the criteria for high risk of sexual dysfunction. The difference between the two groups was significant for all dimensions of FSFI.Conclusions: Infertility and its treatments pose challenges to female sexuality, often leading to sexual dysfunction. Thus, counseling and sexological support are crucial during treatment.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"251-257"},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0