Jornal Brasileiro de Reproducao Assistida最新文献_第4页

Symptom assessment related to the menstrual cycle to predict endometriosis and adenomyosis in university students. 与月经周期相关的症状评估预测大学生子宫内膜异位症和子宫腺肌症。

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-03-12 DOI: 10.5935/1518-0557.20240091

Beatriz Memória Feitosa, Cristiano César Rodrigues Augusto Gonçalves, Beatriz Vieira Cavalcante, André Lucas Grangeiro de Sá Barreto Lima, Caroline Martins de Souza, Larissa Brandão Joventino, Edward Araujo Júnior, Marcelo Borges Cavalcante

{"title":"Symptom assessment related to the menstrual cycle to predict endometriosis and adenomyosis in university students.","authors":"Beatriz Memória Feitosa, Cristiano César Rodrigues Augusto Gonçalves, Beatriz Vieira Cavalcante, André Lucas Grangeiro de Sá Barreto Lima, Caroline Martins de Souza, Larissa Brandão Joventino, Edward Araujo Júnior, Marcelo Borges Cavalcante","doi":"10.5935/1518-0557.20240091","DOIUrl":"10.5935/1518-0557.20240091","url":null,"abstract":"Objective: To assess the prevalence of self-reported symptoms of endometriosis and adenomyosis among university students and identify potential predictors of these diseases among these symptoms.Methods: This cross-sectional study was conducted at a private university in northeastern Brazil. The students were asked to complete an electronic questionnaire using a Google Form link. Participants were asked about general information, the menstrual cycle, and bleeding symptoms. The electronic questionnaire results were compared between two groups: students who self-reported endometriosis/adenomyosis (ENDO/ADENO) and students who self-reported no endometriosis/adenomyosis (NO ENDO/ADENO).Results: Four (2.9%) students self-reported adenomyosis alone, 26 (18.6%) students self-reported endometriosis alone, and two (1.4%) students self-reported an associated diagnosis of endometriosis and adenomyosis. Participants were divided into two groups: ENDO/ADENO (n=32) and NO ENDO/ADENO (n=108). Participants in the ENDO/ADENO group reported more severe dysmenorrhea, worsening dysmenorrhea in the last 12 months, frequent absence from class, dyspareunia, and dysuria. Worsening dysmenorrhea was a predictor of endometriosis/adenomyosis in university female students (odds ratio = 5.73; 95% confidence interval, 1.91-17.22, p=0.002).Conclusions: The assessment of menstrual cycle symptoms can be used as a screening tool for patients at risk of endometriosis/adenomyosis. The progressive worsening of dysmenorrhea in the last 12 months was a predictor of endometriosis/adenomyosis diagnosis.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"127-135"},"PeriodicalIF":1.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced 3Dimentional engineered microenvironment to improve of in vitro spermatogenesis: narrative review. 先进的三维工程微环境提高体外精子发生：述评。

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-03-12 DOI: 10.5935/1518-0557.20240077

Masoud Ghorbani, Roya Hassani, Mohammad Reza Nourani, Vahabodin Goodarzi

{"title":"Advanced 3Dimentional engineered microenvironment to improve of in vitro spermatogenesis: narrative review.","authors":"Masoud Ghorbani, Roya Hassani, Mohammad Reza Nourani, Vahabodin Goodarzi","doi":"10.5935/1518-0557.20240077","DOIUrl":"10.5935/1518-0557.20240077","url":null,"abstract":"Induction of in vitro spermatogenesis may be helpful in the treatment of infertility in azoospermic individuals and those undergoing chemotherapy. Different cultivation systems have been implemented to achieve this aim. This review study aimed to investigate the application of three-dimensional culture in the induction of in vitro spermatogenesis. Relevant studies published in English were identified using PubMed using a range of search terms related to the core focus on tissue engineering of male reproductive systems, in vitro spermatogenesis, germ cell preservation, 3D culture systems for in vitro spermatogenesis, a 3D culture of testis tissue with were last updated in end of 2023. Searches were not restricted to a particular time frame or species, although the emphasis within the review is on regenerative medicine in mammalian male fertility preservation and in vitro spermatogenesis. Spermatogenesis is one of the most complicated cellular differentiation processes in the body. Significant attempts have been made to control spermatogenesis to drive differentiation of male germ stem cells toward mature sperm. Current research efforts focus on providing appropriate microenvironmental conditions to support the process of in vitro spermatogenesis by applying the principles of cell transplantation, material science, and bioengineering. Regenerative medicine may open a new avenue to patients for restoration and maintenance of normal function in spermatogenesis. The techniques reviewed are still in development, and this paper can become the primary reference for a large body of scientists developing advanced tissue engineering for male germ cells or developing the next generation of reproductive medicine.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"160-166"},"PeriodicalIF":1.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improvement of ovarian function in a premature ovarian failure mouse model using Vitex agnus-castus extract. 牡荆提取物对卵巢早衰小鼠卵巢功能的改善作用。

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-03-12 DOI: 10.5935/1518-0557.20240101

Zeinab Soleimany, Fatemeh Siadat, Mona Farhadi, Zeinab Sadat Mirshaby, Zahra Sanadgol, Hossein Eyni

{"title":"Improvement of ovarian function in a premature ovarian failure mouse model using Vitex agnus-castus extract.","authors":"Zeinab Soleimany, Fatemeh Siadat, Mona Farhadi, Zeinab Sadat Mirshaby, Zahra Sanadgol, Hossein Eyni","doi":"10.5935/1518-0557.20240101","DOIUrl":"10.5935/1518-0557.20240101","url":null,"abstract":"Objective: Premature ovarian failure (POF) leads to infertility. Numerous researchers have endeavored to enhance ovarian function through antioxidant interventions. Extract from Vitex agnus-castus (VAC) has demonstrated a protective effect. Therefore, the objective of this study was to investigate the amelioration of ovarian function following VAC treatment in a POF mouse model.Methods: In this investigation, 30 female NMRI mice were categorized into control, POF model (cyclophosphamide 120 mg/kg I.P), and experimental groups (100, 300, and 500 of VAC extract). Parameters such as body weight, vaginal smears, and follicular evaluation were examined. FSH, estradiol levels, free radicals, and the expression of the FMR1 gene were assessed.Results: The microscopic assessment revealed that POF induced morphological alterations in ovarian tissue, whereas VAC treatment significantly ameliorated ovarian tissue conditions. The follicles number exhibited a significant reduction in the POF group; however, VAC led to an increase in follicular count and elevated estradiol levels in the treatment groups. Serum FSH levels displayed an elevation in the POF group, whereas the treatment groups exhibited a substantial reduction in FSH levels compared to the POF group. The expression of the FMR1 gene demonstrated upregulation in the POF group compared to the control group (p<0.05). Moreover, this expression significantly decreased in the 500-dose VAC group compared to the POF group (p<0.001). ROS generation exhibited a significant increase in the POF group, which was conversely mitigated in all experimental groups.Conclusions: Our findings underscore the potential of this extract to ameliorate POF symptoms, however, further investigations are needed.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"117-126"},"PeriodicalIF":1.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of Pregnancy after Artificial Insemination in Women with Polycystic Ovary Syndrome. 多囊卵巢综合征患者人工授精后妊娠的预测因素。

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-02-21 DOI: 10.5935/1518-0557.20240095

Tânia Moreira, Carla Leal, Márcia Barreiro, António Tomé, Emídio Vale-Fernandes

{"title":"Predictors of Pregnancy after Artificial Insemination in Women with Polycystic Ovary Syndrome.","authors":"Tânia Moreira, Carla Leal, Márcia Barreiro, António Tomé, Emídio Vale-Fernandes","doi":"10.5935/1518-0557.20240095","DOIUrl":"https://doi.org/10.5935/1518-0557.20240095","url":null,"abstract":"Objective: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, being one of the main causes of infertility. Anti-Müllerian hormone (AMH) is an important marker of ovarian reserve and has been proposed as an alternative criterion for the diagnosis of PCOS. This study verifies whether AMH and body mass index (BMI) values are predictors of pregnancy in infertile women with PCOS undergoing artificial insemination (AI), a less invasive and painless technique of assisted reproductive technologies (ART).Methods: This retrospective observational study involved 220 women with PCOS who underwent AI between 2010 and 2022. Participants were categorized into three groups based on BMI and serum AMH levels. To categorize the three AMH classes, the 25th (4.08ng/mL) and 75th (8.99ng/mL) AMH percentiles were defined as cut-offs, and the words 'low', 'middle', and 'high' were utilized to define the groups.Results: There was a tendency towards a decrease in reproductive outcomes (number of inseminations with positive human-chorionic gonadotropin, number of live births, and number of term births) with an increase in the BMI value. All of these outcomes were also slightly higher in women with 'middle' AMH levels compared to women with 'low' and 'high' AMH. However, none of these results were statistically significant.Conclusions: This study suggests BMI may be an important predictive factor for pregnancy and there appears to be a range of biological normality for AMH values, where 'low' and 'high' levels of this hormone could constitute a marker of poor reproductive prognosis, in women with PCOS undergoing AI.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apolipoprotein A1: A potential biomarker in the secretome of euploid and aneuploid human embryos. 载脂蛋白A1：整倍体和非整倍体人类胚胎分泌组的潜在生物标志物。

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-02-21 DOI: 10.5935/1518-0557.20240106

Mitra Arianmanesh, Fatemeh Hassani, Leila Karimian, Poopak Eftekhari Yazdi, Bahar Movaghar, Bita Ebrahimi, Mostafa Fakhri, Mojtaba Rezazadeh Valojerdi

{"title":"Apolipoprotein A1: A potential biomarker in the secretome of euploid and aneuploid human embryos.","authors":"Mitra Arianmanesh, Fatemeh Hassani, Leila Karimian, Poopak Eftekhari Yazdi, Bahar Movaghar, Bita Ebrahimi, Mostafa Fakhri, Mojtaba Rezazadeh Valojerdi","doi":"10.5935/1518-0557.20240106","DOIUrl":"https://doi.org/10.5935/1518-0557.20240106","url":null,"abstract":"Objective: Morphologic assessment of an embryo is a valuable indicator for determining embryo health; however, it does not provide information on the chromosomal status of an embryo. Therefore, this study aimed to investigate the levels of Apolipoprotein A1 secreted by day-5 embryos in the spent media of euploid and aneuploid human embryos.Methods: This study utilized 131 spent culture media samples from 22 infertile couples who were referred to the fertility clinic of Royan Institute. Following ovulation induction, retrieved oocytes were fertilized by intracytoplasmic sperm injection. For pre-implantation genetic diagnosis, embryos were frozen and thawed on days 2 to 3 and a single blastomere was isolated from each embryo for the assessment of chromosomal abnormalities by fluorescence in situ hybridization. Five days after fertilization, the levels of Apolipoprotein A1 were determined in the spent media of normal embryos, aneuploid embryos (with chromosome abnormalities), and the control group (medium without any embryos) using enzyme-linked immunosorbent assay.Results: The Apolipoprotein A1 levels in the secretome of euploid cleavage-arrested embryos were significantly lower than those in the control group (p<0.04). However, Apolipoprotein A1 levels increased significantly in groups of euploid blastocysts, aneuploid cleavage-arrested embryos, aneuploid morulae, and aneuploid blastocysts compared to the control group (p<0.04). Furthermore, the Apolipoprotein A1 levels in the spent media of euploid early blastocysts were significantly higher compared to euploid hatching blastocysts and aneuploid blastocysts in the early, mid, and late stages (p<0.03).Conclusions: This study highlights the significant potential of Apolipoprotein A1 as a developmental bi-omarker to distinguish between euploid and aneuploid embryos.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perception of fertility, quality of life, and depression in women undergoing assisted reproductive treatment. 接受辅助生殖治疗的妇女对生育能力、生活质量和抑郁的感知。

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-02-21 DOI: 10.5935/1518-0557.20240103

Gisleine Verlang Lourenço, Vania Naomi Hirakata, Paula Barros Terraciano, Pietra Giron, Tania Marques, Eduardo Pandolfi Passos

{"title":"Perception of fertility, quality of life, and depression in women undergoing assisted reproductive treatment.","authors":"Gisleine Verlang Lourenço, Vania Naomi Hirakata, Paula Barros Terraciano, Pietra Giron, Tania Marques, Eduardo Pandolfi Passos","doi":"10.5935/1518-0557.20240103","DOIUrl":"https://doi.org/10.5935/1518-0557.20240103","url":null,"abstract":"Objective: To investigate perception of (in)fertility, fertility-related quality of life, and depression in women undergoing assisted reproductive treatment.Methods: Cross-sectional study, quantitative approach. The research sample comprised 89 women participating in the assisted reproduction program at the Hospital de Clínicas de Porto Alegre (HCPA) outpatient clinic. Data collection took place between August 2016 and January 2018. The tools used in the study were the Fertility Quality of Life (FertiQoL) questionnaire, Fertility Problem Inventory (FPI), Beck Depression Inventory (BDI), and a questionnaire on sociodemographic data.Results: The mean total FertiQoL score was 66.5 ± 14.5, and it was significantly associated with depression and formal education; on average, patients with depression had a score difference of -10.7 (95CI%: -17.5;-3.8) compared to those without depression. Patients with depression reported a lower quality of life compared to those without depression in the social, treatment environment, and total treatment subscales. On the mind/body subscale, those meeting BDI criteria for depression scored 13.4 points lower on average than respondents without depression (p<0.001). The highest-scoring FPI dimension was conjugal and sexual relationship (4.5±0.79). The FPI dimensions social relationships (r= -0.77; p<0.01), conjugal and sexual relationship (r= 0.67; p<0.01), and maternity/paternity (r= -0.65; p<0.01) correlated with FertiQoL total score.Conclusions: Women with depression who are in assisted reproductive treatment endorse lower fertility-related quality of life than their peers without depression. Assisted reproduction providers should be aware of the multiple factors involved and offer psychosocial care before, during, and after treatment.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of COVID-19 vaccination on serum levels of anti-Müllerian hormone in women of reproductive age. COVID-19疫苗接种对育龄妇女血清抗<s:1>勒氏杆菌激素水平的影响

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-02-21 DOI: 10.5935/1518-0557.20240098

Fernanda Godoy Cabral de Oliveira, Renato de Oliveira, Bianca Bianco, Michel Soane, Cláudia Fideles, Nathalia Saraiva, Denise Christofolini, Caio Parente Barbosa

{"title":"The effect of COVID-19 vaccination on serum levels of anti-Müllerian hormone in women of reproductive age.","authors":"Fernanda Godoy Cabral de Oliveira, Renato de Oliveira, Bianca Bianco, Michel Soane, Cláudia Fideles, Nathalia Saraiva, Denise Christofolini, Caio Parente Barbosa","doi":"10.5935/1518-0557.20240098","DOIUrl":"https://doi.org/10.5935/1518-0557.20240098","url":null,"abstract":"Objective: To evaluate the effects of COVID-19 vaccination (AstraZeneca® and CoronaVac®) on anti-Müllerian hormone (AMH) levels in threatened women.Methods: Retrospective cohort study evaluating serum AMH before and up to three vaccination doses against COVID-19 between 2021 and 2022 at FMABC. Statistical analysis presented in Stata 14. Clinical variables were described by absolute and relative frequency, in addition to measures of central tendency and dispersion. Shapiro-Wilk test for normality. Continuous variables compared within the group using the Friedman test and, between groups, Mann-Whitney U tests (non-parametric); Chi-square and Fisher's exact tests, for categorical variables, with p<0.05.Results: Median age of the 38 volunteers was 24 years (p25-75: 22-30) and AMH levels (ng/dl) at times 0, 1, 2 and 3 median (95% CI) were, respectively, 4.6(3.5-6); 4(2.3-5); 4.3(3-5); 4.9(2.6-6.3), p=0.726. Likewise, there was no statistically significant difference in the assessments between subgroups aged <35 and ≥35 years old and with and without exposure to COVID-19 in relation to AMH values.Conclusions: The vaccination against COVID-19 with the AstraZeneca® and CoronaVac® vaccines did not indicate any damage to anti-Müllerian hormone values in women of reproductive age.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the day 3 transfer strategy for POSEIDON patients. POSEIDON患者第3天转移策略分析。

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-02-21 DOI: 10.5935/1518-0557.20240111

Jakub Wyroba, Joanna Kochan

{"title":"Analysis of the day 3 transfer strategy for POSEIDON patients.","authors":"Jakub Wyroba, Joanna Kochan","doi":"10.5935/1518-0557.20240111","DOIUrl":"https://doi.org/10.5935/1518-0557.20240111","url":null,"abstract":"Objective: The aim of the study was to analyze the effectiveness of the day 3 ET strategy, and the morphology of the transferred embryos, in patients from POSEIDON and non-POSEIDON groups.Methods: 600 cycles of patients meeting the POSEIDON criteria and 600 non-POSEIDON cycles were analyzed to determine the proportion of cycles with an ET on days 3 or 5, or FET. Then we reviewed 330 day 3 ETs to compared the developmental stage, morphology, zona pellucida thickness and implantation potential of embryos transferred on day 3 from POSEIDON and non-POSEIDON patients.Results: Most cycles of POSEIDON patients end with ET on day 3 (42%) or without transfer (37%). In contrast, most cycle of non-POSEIDON patients end with FET (44%) and just 9% is canceled. The lowest percentage of embryos at the morula stage was recorded in POSEIDON groups III (10%) and IV (9%). The average number of cells in embryos was comparable in all groups. The largest percentage of top-quality embryos (grade A) were in POSEIDON group I (47%) .The highest implantation potential were observed in the non-POSEIDON group <35Y (28%), and in POSEIDON groups I (28%) and III (26%). The highest incidence of miscarriage was recorded in all POSEIDON and non-POSEIDON groups that included patients who were ≥35 years of age.Conclusions: The day 3 ET strategy still seems optimal for POSEIDON patients. The prognosis depends on which Poseidon group the patient is in. The best prognosis is for group I and the worst for group IV.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of quercetin on obesity and reproduction through the expression of genes involved in the hypothalamus-pituitary-gonadal axis. 槲皮素通过下丘脑-垂体-性腺轴相关基因的表达对肥胖和生殖的影响。

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-02-21 DOI: 10.5935/1518-0557.20240097

Elaheh Shams, Dina Zohrabi, Ozra Omrani, Mohammad Hossein Sanati, Maryam Karimi-Dehkordi, Nasrin Yazdanpanahi, Fatemeh Khademi Moghadam, Vahid Zarezade

{"title":"The effect of quercetin on obesity and reproduction through the expression of genes involved in the hypothalamus-pituitary-gonadal axis.","authors":"Elaheh Shams, Dina Zohrabi, Ozra Omrani, Mohammad Hossein Sanati, Maryam Karimi-Dehkordi, Nasrin Yazdanpanahi, Fatemeh Khademi Moghadam, Vahid Zarezade","doi":"10.5935/1518-0557.20240097","DOIUrl":"https://doi.org/10.5935/1518-0557.20240097","url":null,"abstract":"Objective: Quercetin is a flavonoid compound extracted from fruits and plants and is used as a natural antioxidant to prevent or treat a variety of diseases such as cancer, obesity, chronic inflammation, and reproductive system dysfunction. The aim of this study was to investigate the effects of quercetin on obesity and ovarian tissue by analyzing the expression of genes involved in the hypothalamus-pituitary-gonadal axis, including ob-Rb, ob-Ra, and brain-derived neurotrophic factor (Bdnf), neuropeptide Y (NPY), and Kisspeptin (Kiss-1).Methods: In this experimental study, female rats were divided into three groups, and the effect of quercetin with doses of 50 and 100 mg/kg on weight and BMI was investigated. Also, the gene expression was assessed using the real-time PCR technique. The estrogen, progesterone, FSH, and LH were assessed using the chemiluminescence technique. The diameter and number of different types of follicles, corpus luteum, and blood vessels in mice were investigated. The growth indicators of the children, including the number, weight, and height and head width of the born children, were checked.Results: Quercetin caused a decrease in BMI, a significant increase in the expression of ob-Rb, ob-Ra, and Bdnf genes, a significant decrease in the expression of NPY and Kiss-1 genes, and led to an increase in sex hormones. Quercetin improved follicular indices and increased the number of mouse embryos.Conclusions: Probably, quercetin affects the hypothalamus-pituitary-gonadal axis by changing the expression of genes, and it helps to reduce obesity and increase fertility and better function of the reproductive system.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elective fertility preservation before and after the Covid-19 pandemic outbreak. Covid-19大流行爆发前后的选择性生育保留。

IF 1.8

Jornal Brasileiro de Reproducao Assistida Pub Date : 2025-01-28 DOI: 10.5935/1518-0557.20240078

Nivin Samara, Tal Israeli, Tal Shahar, Sagi Levi, Shimi Barda, Asnat Groutz, Foad Azem, Hadar Amir

{"title":"Elective fertility preservation before and after the Covid-19 pandemic outbreak.","authors":"Nivin Samara, Tal Israeli, Tal Shahar, Sagi Levi, Shimi Barda, Asnat Groutz, Foad Azem, Hadar Amir","doi":"10.5935/1518-0557.20240078","DOIUrl":"https://doi.org/10.5935/1518-0557.20240078","url":null,"abstract":"Objective: To compare the number and outcomes of elective fertility preservation (FP) before and after the Covid-19 outbreak.Methods: This retrospective study of 574 women who underwent elective FP between 01/2017-12/2021 included 123 women who underwent the procedure before and 451 who underwent it after the Covid-19 outbreak. The change in the number of women who underwent the procedure each month before and after the pandemic was calculated. The ovarian stimulation outcomes were compared between the two groups.Results: The post-Covid-19 group included significantly more single women compared to the pre-Covid-19 group (93.8% vs. 91.1%, p = 0.024). A progestin-primed ovarian stimulation protocol was followed only among the women in the post-Covid-19 group (18.8% vs. 0%, p<0.001), and their gonadotropin dose was significantly lower than that of the women in the pre-Covid-19 group (3164.6±842.87 mIU/mL vs. 3426.5±1080.63 mIU/mL, p=0.014). There were no significant group differences in ovarian stimulation duration (p=0.069), peak estradiol level (p=0.606), number of retrieved and mature oocytes (p=0.545 and p=0.364, respectively), oocyte maturity rate (p=0.719) or the number of women who cryopreserved embryos (p=0.861). High levels of basal FSH and low antral follicle counts correlated negatively with the total numbers of retrieved and mature oocytes.Conclusions: A rapid and sustained increase in elective FP after the outbreak of the Covid-19 pandemic that significantly surpassed pre-pandemic levels was observed. There was no significant difference in FP outcomes between the two time periods.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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