Trends in Psychiatry and Psychotherapy最新文献

{"title":"Psychometric properties of the Death Anxiety Scale for adult chronic patients.","authors":"Ximena Palacios-Espinosa, Ricardo Sánchez Pedraza, Ana-María Gómez-Carvajal, Juan Sebastián Botero-Meneses, Diana María Escallón, Diego Armando Leal","doi":"10.47626/2237-6089-2023-0630","DOIUrl":"10.47626/2237-6089-2023-0630","url":null,"abstract":"<p><strong>Objectives: </strong>Death anxiety (DA) is a predictor of exacerbation of both physical and psychological symptoms of chronic diseases. Therefore, having short and easy-to-apply instruments to assess the presence of DA and adopting a multidisciplinary approach to address it are important. This study analyzes the psychometric properties of the Death Anxiety Scale (DAS), originally developed by Donald Templer, in a Colombian population of adult patients diagnosed with a chronic disease.</p><p><strong>Methods: </strong>The original instrument was linguistically, conceptually, and culturally adapted to Colombian Spanish to be subsequently administered to 301 adult patients with chronic diseases.</p><p><strong>Results: </strong>The exploratory factor analysis revealed a three-factor structure, which explained 47% of variance. Internal consistency was demonstrated (Cronbach's alpha: 0.71; McDonald's omega: 0.76; Guttman's lambda 6 [G6]: 0.74; greatest lower bound: 0.54). A correlation coefficient of 0.64 was found between the total score of the DAS and the Beck Anxiety Inventory (BAI).</p><p><strong>Conclusion: </strong>When comparing the results with the versions of the DAS in Spanish from Mexico and Spain, variability in the psychometric properties was observed. Language cannot therefore be assumed to be a guarantee of the reliability and validity of the instrument.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20230630"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9776830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concealing, tolerating, and adjusting to emotions in obsessive-compulsive and anxiety disorders: a cross-sectional study.","authors":"Carla P Loureiro, Emma M Thompson, Luana D Laurito, Maria E Moreira-de-Oliveira, Rafaela V Dias, Gabriela B de Menezes, Leonardo F Fontenelle","doi":"10.47626/2237-6089-2023-0652","DOIUrl":"10.47626/2237-6089-2023-0652","url":null,"abstract":"<p><strong>Objective: </strong>Although research has shown that mood and anxiety disorders manifest disturbed emotion regulation, it is unclear whether anxiety disorders differ from each other in terms of their emotion regulation strategies. In the present study, we investigated whether patients with anxiety disorders present different affective styles.</p><p><strong>Methods: </strong>We assessed the affective styles of 32 obsessive-compulsive disorder (OCD) patients, 29 social anxiety disorder (SAD) patients, 29 panic disorder (PD) patients, and 20 healthy controls using the Affective Style Questionnaire (ASQ). A multivariate analysis of covariance (MANCOVA) was conducted to compare affective styles across groups (OCD, SAD, PD, and control), while controlling for depression, anxiety symptoms, and age.</p><p><strong>Results: </strong>The MANCOVA revealed a significant, small-medium, main effect of diagnostic group on affective styles. The planned contrasts revealed that OCD and SAD patients reported significantly lower scores for \"tolerance\" (ASQ-T) compared to the healthy controls. There were no differences between the PD group and healthy controls.</p><p><strong>Conclusion: </strong>Our findings provide evidence that individuals with OCD and SAD have difficulty tolerating strong emotions existing in the present moment in an open and non-defensive way.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20230652"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9923448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication non-adherence in depression: a systematic review and metanalysis.","authors":"Roseane Dorte Halkjaer-Lassen, Walter S Gonçalves, Bruno R Gherman, Evandro S F Coutinho, Antonio E Nardi, Maria A A Peres, José Carlos Appolinario","doi":"10.47626/2237-6089-2023-0680","DOIUrl":"10.47626/2237-6089-2023-0680","url":null,"abstract":"<p><strong>Objective: </strong>Medication non-adherence is frequently reported in patients with major depressive disorder (MDD). The objective of this review is to consolidate data on the prevalence of non-adherence to antidepressant in MDD.</p><p><strong>Methods: </strong>A systematic review with meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline and the protocol was registered in International Prospective Register of Systematic Reviews (PROSPERO) under the number CRD42021199987. Studies assessing medication adherence in MDD were searched in PubMed/MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and PsycINFO. The data extraction was performed by two independents authors. Meta-analysis used random effects model and performed a subgroup analysis.</p><p><strong>Results: </strong>From the articles retrieved, 11 studies were considered eligible for the final analysis. Most of them assessed non-adherence by self-report scales, followed by Pharmacy Dispensation Records, Monitoring Events Medication System (MEMS), and blood tests. The pooled proportion of non-adherence was 42% (95% confidence interval [95%CI] 30-54), but heterogeneity was very large (I² = 99%).</p><p><strong>Conclusion: </strong>Data from the selected studies suggests that a high number of individuals with MDD do not adequately take their medication as prescribed. The high heterogenicity of measures used for the assessment of adherence may have impacted the great variability of the results. The results suggest it is necessary that health care professionals should address this issue in order to achieve a better treatment outcome in major depression.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20230680"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139404738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and suitability of adding short-term psychodynamic psychotherapy (STPP) to pharmacotherapy in patients with depressive disorders: a systematic review.","authors":"Gabriele Di Salvo, Camilla Perotti, Valerio Ricci, Giuseppe Maina, Gianluca Rosso","doi":"10.47626/2237-6089-2023-0764","DOIUrl":"10.47626/2237-6089-2023-0764","url":null,"abstract":"<p><strong>Objective: </strong>Recent guidelines on depressive disorders suggest a combination of antidepressants and psychotherapy in case of moderate to severe symptomatology. While cognitive behavioral therapy (CBT) and interpersonal therapy (ITP) are the most investigated interventions, psychodynamic psychotherapies have been less explored. The aim of this paper is to systematically review literature data on the efficacy of short-term psychodynamic psychotherapy (STPP) in combination with antidepressants in the treatment of depressive disorders, focusing on both short and long-term results and on potential moderators that could influence its effectiveness.</p><p><strong>Methods: </strong>This systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Databases searched were PubMed, Ovid, Scopus, and Cochrane Library, from inception to August 2023.</p><p><strong>Results: </strong>Adding STPP to medications in the first 6 months of treatment did not influence remission rates, but did improve acceptability, work adjustment, interpersonal relationships, social role functioning, hospitalization rates, and cost-effectiveness. After 12 months, a significant difference in remission rates arose, favoring combined therapy. From a long-term perspective, adding STPP to pharmacotherapy reduced the recurrence rate by almost 50%. STPP has proven to be more effective in longer depressive episodes, in more severe depression, and in patients with a history of childhood abuse. However, STPP had no impact on major depressive disorder (MDD) with comorbid obsessive-compulsive disorder (OCD).</p><p><strong>Conclusions: </strong>Combining STPP with antidepressants appeared to be helpful from both short-term and long-term perspectives. Still, there are few rigorous studies with large samples and further research is needed to identify which subgroups of patients may benefit more from STPP.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20230764"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140866110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of acceptance and commitment therapy for distress, emotion regulation, and self-compassion in patients with cardiovascular disease: a randomized clinical trial.","authors":"Arash Fattahi, Fatemeh Mazini, Nasrin Jaberghaderi, Fatemeh Rajabi, Mehdi Derakhshani, Mohammad Laki","doi":"10.47626/2237-6089-2023-0685","DOIUrl":"10.47626/2237-6089-2023-0685","url":null,"abstract":"<p><strong>Objective: </strong>Cardiovascular patients experience various psychological problems due to the conditions caused by their disease, making it worse if left untreated. The purpose of the current study was to evaluate the effects of acceptance and commitment therapy (ACT) on distress, emotion regulation, and self-compassion in patients with cardiovascular disease.</p><p><strong>Methods: </strong>This study was a randomized clinical trial with pre-test, post-test, and 2-month and 4-month follow-up periods accompanying a control group and an experimental group. Patients filled out questionnaires at four stages; a Depression, Anxiety, and Stress Scale (DASS-21), an Emotion Regulation Questionnaire (ERQ), and a Self-Compassion Scale (SCS). The experimental group underwent a treatment protocol based on ACT. Data were then analyzed using SPSS-25 with repeated measures analysis of variance (ANOVA).</p><p><strong>Results: </strong>ACT significantly reduced depression, anxiety, and stress, enhanced self-compassion, and improved emotion regulation in cardiac patients. Between-subjects (group) partial Eta squared (η²) for depression, anxiety, stress, reappraisal, suppression, and self-compassion were 0.61, 0.64, 0.66, 0.62, 0.66, and 0.65, respectively. Treatment efficacy was maintained at the 2-month and 6-month follow-up visits.</p><p><strong>Conclusion: </strong>The results of this study suggest that treating cardiac patients' psychological problems in an ACT-focused manner may have an impact on how well they respond to their treatment.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20230685"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10338518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haloperidol versus second-generation antipsychotics on the cognitive performance of individuals with schizophrenia and related disorders: pairwise meta-analysis of randomized controlled trials.","authors":"Daniel Prates Baldez, Tais Boeira Biazus, Francisco Diego Rabelo-da-Ponte, Guilherme Pedro Nogaro, Dayane Santos Martins, João Pedro Soledade Signori, Vanessa Gnielka, Ives Cavalcante Passos, Letícia Sanguinetti Czepielewski, Maurício Kunz","doi":"10.47626/2237-6089-2023-0664","DOIUrl":"10.47626/2237-6089-2023-0664","url":null,"abstract":"<p><strong>Objective: </strong>Despite previous literature, the superiority of second-generation antipsychotics (SGAs) relative to first-generation antipsychotics - especially haloperidol - on cognitive management in schizophrenia is still controversial. Thus, we aimed to compare the effects of haloperidol versus SGAs on the cognitive performance of individuals with schizophrenia or related disorders.</p><p><strong>Methods: </strong>We conducted an updated systematic review and nine pairwise meta-analyses of double-blinded randomized controlled trials published up to October 30th, 2022, using MEDLINE, Web of Science, and Embase.</p><p><strong>Results: </strong>Twenty-eight trials were included, enrolling 1,932 individuals. Compared to SGAs, haloperidol performed worse on cognitive composite (mean difference [MD] -0.13; 95% confidence interval [95%CI] -0.33 to -0.03), processing speed (MD -0.17; 95%CI -0.28 to -0.07), attention (MD -0.14; 95%CI -0.26 to -0.02), motor performance (MD -0.17; 95%CI -0.31 to -0.03), memory and verbal learning (MD -0.21; 95%CI -0.35 to -0.08), and executive function (MD -0.27; 95%CI -0.43 to -0.11). In contrast, there were no significant differences between SGAs and haloperidol on working memory (MD 0.10; 95%CI -0.08 to 0.27), visual learning (MD 0.08; 95%CI -0.05 to 0.21), social cognition (MD 0.29; 95%CI -0.30 to 0.88), and visuoconstruction (MD 0.17; 95%CI -0.04 to 0.39).</p><p><strong>Conclusion: </strong>Haloperidol had poorer performance in global cognition and in some cognitive domains, but with small effect sizes. Therefore, it was not possible to conclude that haloperidol is certainly worse than SGAs in the long-term cognitive management of schizophrenia.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20230664"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10239536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives on mental health amid the crisis of climate refugees.","authors":"Larissa Junkes, Antonio E Nardi","doi":"10.47626/2237-6089-2024-0931","DOIUrl":"10.47626/2237-6089-2024-0931","url":null,"abstract":"","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20240931"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142477357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes on risky drinking after the COVID-19 outbreak in Brazil: results from three consecutive web surveys.","authors":"Luisa Alencar Santos Lage, Fátima Smith Erthal, Marcelo Ribeiro-Alves, Aline Furtado Bastos, Vicent Balanzá-Martinez, Flavio Kapczinski, Raquel B De Boni","doi":"10.47626/2237-6089-2023-0686","DOIUrl":"10.47626/2237-6089-2023-0686","url":null,"abstract":"<p><strong>Objective: </strong>Risky drinking (RD) is associated with an increased risk of chronic and infectious diseases, injuries, and violence. This study aimed to assess changes in RD in Brazil after coronavirus disease 2019 (COVID-19) outbreak, both overall and among individuals with self-reported chronic diseases and mental health disorders.</p><p><strong>Methods: </strong>We conducted three independent, anonymous web surveys in Brazil including adult participants: Survey 1 (S1) (April/2020, n = 19,257), S2 (August/2020, n = 1,590), and S3 (January/2021, n = 859). Participants were recruited through adapted snowball sampling and sponsored social network advertisements. RD was assessed using the Alcohol Use Disorder Identification Test-Concise (AUDIT-C), designed to identify individuals at risk of alcohol-related problems. Logistic regression analyses with bootstrapping (B = 2,000) were performed, with stratification by sex, age, education, employment, household size, and the presence of chronic and mental health conditions, as well as lifestyle factors, to address sample imbalances.</p><p><strong>Results: </strong>The estimated prevalence of RD was 45.8% (95% confidence interval [95%CI] 45.5-46.1) in S1, 35.3% (95%CI 34.9-35.6) in S2, and 33.7% (95%CI 33.3-34.0) in S3. Participants with chronic diseases consistently presented lower RD prevalence across all three surveys, compared to those without such conditions. Conversely, individuals with mental health disorders presented higher RD prevalence than those without such diagnoses in S1 and S2, but not in S3.</p><p><strong>Conclusion: </strong>Despite the decrease in RD prevalence, monitoring of alcohol consumption trends remains essential for shaping effective public health policies. Additionally, the observed variations among individuals reporting chronic and mental health disorders highlight the need for targeted interventions in future crises.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20230686"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139404737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic insights into biology of bipolar disorder: implications for health complexity and mortality.","authors":"Paola Rampelotto Ziani, Marco Antônio de Bastiani, Pietra Paiva Alves, Pedro Henrique da Rosa, Tainá Schons, Giovana Mezzomo, Ellen Scotton, Flávio Kapczinski, Adriane R Rosa","doi":"10.47626/2237-6089-2024-0820","DOIUrl":"10.47626/2237-6089-2024-0820","url":null,"abstract":"<p><strong>Objective: </strong>The present study has the following objectives: 1) identify differentially expressed proteins and pathways in blood samples of bipolar disorder (BD) compared to healthy controls (HC) by employing high-throughput proteomics and bioinformatics; and 2) characterize disease-related molecular signatures through in-depth analysis of the differentially expressed proteins and pathways.</p><p><strong>Methods: </strong>Blood samples from patients with BD (n = 10) classified into high (BD+) or poor functioning (BD-), based on functional and cognitive status, and HC (n = 5) were analyzed using mass spectrometry-based proteomic analysis. Bioinformatics was performed to detect biological processes, pathways, and diseases related to BD.</p><p><strong>Results: </strong>Eight proteins exclusively characterized the molecular profile of patients with BD+ compared to HC, while 26 altered proteins were observed in the BD- group. These altered proteins were mainly enriched in biological processes related to lipid metabolism, complement system and coagulation cascade, and cardiovascular diseases; all these changes were more prominent in the BD- group.</p><p><strong>Conclusion: </strong>These findings may represent systemic alterations that occur with the progression of the illness and a possible link between BD and medical comorbidities. Such comprehensive understanding provides valuable insights for targeted interventions, addressing mental and physical health aspects in subjects with BD. Despite these promising findings, further research is warranted, encompassing larger sample cohorts and incorporating biological validation through molecular biology methods.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20240820"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated factors of burnout among health sciences students in Spain: a systematic review.","authors":"Zoila María Olmos-Bravo, Joan Vicent Sánchez-Ortí, Eugenio H Grevet, Vicent Balanzá-Martínez","doi":"10.47626/2237-6089-2024-0805","DOIUrl":"10.47626/2237-6089-2024-0805","url":null,"abstract":"<p><strong>Objective: </strong>There is growing concern about the occurrence of burnout syndrome in university students worldwide. This systematic review aimed to estimate the prevalence of burnout syndrome and its associated factors among health sciences students (HSS) in Spain.</p><p><strong>Methods: </strong>Five databases (MEDLINE/PubMed, PsycINFO, EMBASE, Dialnet and MEDES) were searched up to January 5, 2023, adhering to PRISMA guidelines. Quantitative studies reporting the prevalence of burnout syndrome among HSS in Spanish universities were considered. The reference lists of the selected studies were hand searched. Data were extracted from peer-reviewed articles.</p><p><strong>Results: </strong>Twenty-six studies were included with a total of 14,437 HSS. Most studies included nursing students (k = 11), followed by medicine students (k = 8), psychology students (k = 5), dental students (k = 2), physiotherapy students (k = 1) and pharmacy students (k = 1). Overall, study quality was fair. The most widely used instrument was the Maslach Burnout Inventory. The mean prevalence of burnout was 35.3% (k = 11 studies). However, rates varied widely between studies, which may be due to methodological differences. Inconsistent associations were found with gender and year of study. The relationship of burnout with academic and mental-health related variables was consistent across studies. Personal attributes, such as higher resilience, are likely protective against burnout.</p><p><strong>Conclusion: </strong>Burnout appears to be prevalent among HSS in Spain, and may be affected by academic, mental health and personality factors. Identifying risk and protective factors for burnout could help to develop preventive and management strategies to ultimately reduce its negative consequences in this population.</p><p><strong>Systematic review registration: </strong>PROSPERO (CRD42023387460).</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20240805"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}