Sarah Prates, Mariana Troesch, Rafaela Magalhães-Britto, Caroline Dallalana, Paula Studart-Bottó, Gabriela Léda-Rêgo, Juliana Socorro-Casqueiro, Stella Sarmento, Ângela Miranda-Scippa
{"title":"Diagnosis of mental disorders in caregivers of patients with bipolar disorder: a gap in the scientific literature.","authors":"Sarah Prates, Mariana Troesch, Rafaela Magalhães-Britto, Caroline Dallalana, Paula Studart-Bottó, Gabriela Léda-Rêgo, Juliana Socorro-Casqueiro, Stella Sarmento, Ângela Miranda-Scippa","doi":"10.47626/2237-6089-2024-0882","DOIUrl":"10.47626/2237-6089-2024-0882","url":null,"abstract":"<p><strong>Objective: </strong>Caregivers appear to experience mental health implications related to their role in supporting patients with bipolar disorder (BD). This study aimed to review the literature assessing the presence of not only psychiatric symptoms but also mental disorders and personality disorders in caregivers of patients with BD.</p><p><strong>Methods: </strong>This is a narrative review. Articles were searched in some online databases, including PubMed, Embase, Web of Science, PsychINFO, Lilacs, and SciELO up to June 2024. Inclusion criteria comprised articles in any language, focusing on primary caregivers of patients with BD, and quantitative studies evaluating the presence of mental disorder, personality disorder, or psychiatric symptoms in this caregiver group.</p><p><strong>Results: </strong>The review encompassed 15 articles. Only two studies utilized appropriate diagnostic instruments for assessing mental disorder, and no article evaluated personality disorder. Prevalence of caregiver's psychiatric symptoms and mental disorder was found to be higher compared to the general population.</p><p><strong>Conclusion: </strong>The lack of studies employing diagnostic assessment tools for mental disorder in these individuals may impede timely access to treatment, affecting both the caregiver's health and the clinical course of patients with BD. This study provides an updated overview of research on caregivers of patients with BD, despite the limitation of not being a systematic review. Further studies employing diagnostic assessments on caregivers are essential to gain deeper insights into this critical topic.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20240882"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leandro L Ferreira, Antonio E Nardi, Laiana A Quagliato
{"title":"Are parents with bipolar disorder at higher risk of having offspring with ADHD? A systematic review.","authors":"Leandro L Ferreira, Antonio E Nardi, Laiana A Quagliato","doi":"10.47626/2237-6089-2024-0797","DOIUrl":"10.47626/2237-6089-2024-0797","url":null,"abstract":"<p><strong>Objective: </strong>The offspring of parents with bipolar disorder (BD) and with attention deficit hyperactivity disorder (ADHD) have a higher risk of having the same condition. Both disorders also share psychopathological symptoms; however, little is known about their genetic overlap. To examine whether the offspring of parents with BD have a greater chance of being affected by ADHD, we conducted a systematic review.</p><p><strong>Methods: </strong>From inception to August 12, 2024, we searched the PubMed, SciELO, PsycInfo and Cochrane databases. We included studies if they investigated the association of parental bipolar disorder with offspring outcomes and made a proper investigation of disorders using validated instruments based on the Diagnostic Statistical Manual of Mental Disorders (DSM) or the International Classification of Diseases (ICD) criteria. Studies were excluded if: parents were under 18 years old or over 70; did not report original data; systematic reviews; in vitro studies; with an animal model; offspring older than 17 years of age or with any comorbid diagnosis with ADHD. To assess risk of bias, two authors independently used the Newcastle-Ottawa Scale quality assessment tool.</p><p><strong>Results: </strong>23 articles met the inclusion criteria. The majority of the studies reported that the offspring of parents with BD were at higher risk for ADHD. Particularly, in all case-control studies, the risk of ADHD was higher in the case group than the control group.</p><p><strong>Conclusion: </strong>The current studies are yet heterogeneous and literature did not uncover the biological correlation of these disorders regarding genetic, biochemical, neuroimaging and neuropsychological aspects.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20240797"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maiara da Silva Martins, Victor Matheus Lopes Martinez, Thiago Lucchina Pinto, Luis Eduardo Wearick-Silva, Thiago Wendt Viola
{"title":"Symptoms of depression and lifestyle in adolescents: a network analysis.","authors":"Maiara da Silva Martins, Victor Matheus Lopes Martinez, Thiago Lucchina Pinto, Luis Eduardo Wearick-Silva, Thiago Wendt Viola","doi":"10.47626/2237-6089-2024-0873","DOIUrl":"10.47626/2237-6089-2024-0873","url":null,"abstract":"<p><strong>Objective: </strong>Life experiences that promote or attenuate depression have been studied primarily in adults. Therefore, we investigated the association between lifestyle factors and symptoms of depression in adolescents.</p><p><strong>Methods: </strong>A cross-sectional study was carried out in Brazilians. Data from 93 individuals were analyzed out of the 150 invited participants (age 14.2±1.8, 67.74% girls). Lifestyle habits (SMILE-C), physical activity and sitting time (IPAQ), as well as symptoms of depression (DASS-21) were evaluated. A network analysis was performed using the EBIC-LASSO model, with the expected influence as a centrality parameter.</p><p><strong>Results: </strong>The lifestyle domains with the highest expected influence were diet and nutrition (1.423), walking (1.126) and stress management (1.015). The variables with the highest direct partial negative correlation with depression were social support (-0.307) and moderate-vigorous physical activity (-0.244), suggesting a bidirectional relationship between these variables with lower symptoms of depression.</p><p><strong>Conclusion: </strong>Specific lifestyle areas such as social support, physical activity and nutrition appear to impact other healthy habits while reducing teen depressive symptoms.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20240873"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juliana Socorro-Casqueiro, Vitor Almeida, Gabriela Léda-Rêgo, Paula Studart-Bottó, Mariana Troesch, Sarah Prates, Stella Sarmento, Caroline Dallalana, Ângela Miranda-Scippa
{"title":"Sexual function in patients with bipolar disorder type I evaluated in symptomatic remission: a cross-sectional study.","authors":"Juliana Socorro-Casqueiro, Vitor Almeida, Gabriela Léda-Rêgo, Paula Studart-Bottó, Mariana Troesch, Sarah Prates, Stella Sarmento, Caroline Dallalana, Ângela Miranda-Scippa","doi":"10.47626/2237-6089-2023-0778","DOIUrl":"10.47626/2237-6089-2023-0778","url":null,"abstract":"<p><strong>Objective: </strong>Bipolar disorder (BD) is a chronic pathology that is associated with several impairments throughout a patient's life, including decreased sexual function. Despite the importance in quality of life (QoL), functionality and medication adherence, it is still little investigated in these patients. The objective of this study was to compare the sexual function of patients with Bipolar Disorder type I (BD-I), in remission, with healthy controls (HCs) and to investigate the clinical and socio-demographic characteristics associated with sexual function in these individuals. Also, to assess the QoL in patients with and without sexual dysfunction (SD).</p><p><strong>Methods: </strong>Cross-sectional study with 132 patients with BD-I in euthymic phase and 61 HCs from an outpatient clinic. All the participants were evaluated through the Arizona Sexual Scale (ASEX) and the brief version of the World Health Organization Quality of Life Assessment (WHOQoL-BREF). The patients with BD-I were compared with the HCs. The patients were divided into two groups: the ones diagnosed with SD and the ones without it.</p><p><strong>Results: </strong>The patients with BD-I had higher rates of SD (42.4%) compared to the HCs (16.4%) (OR 3.67, 95%CI 1.55-8.67; p = 0.003). SD in patients was associated with being women (p = 0.001), older age (p = 0.003) and having a longer duration of untreated illness (p = 0.010). Patients with SD had worse QoL scores compared to those without SD.</p><p><strong>Conclusion: </strong>Patients with BD-I have a high prevalence of SD and this was associated with worse QoL scores in all domains.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20230778"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandre Martins Valença, Fabiana Estrela Silveira Bethlem, Gustavo Carvalho de Oliveira, Antonio Geraldo da Silva, Lisieux Elaine de Borba Telles, Antonio Egidio Nardi
{"title":"Evaluation of criminal responsibility in a patient with fetal alcohol syndrome and intellectual disability.","authors":"Alexandre Martins Valença, Fabiana Estrela Silveira Bethlem, Gustavo Carvalho de Oliveira, Antonio Geraldo da Silva, Lisieux Elaine de Borba Telles, Antonio Egidio Nardi","doi":"10.47626/2237-6089-2024-0924","DOIUrl":"10.47626/2237-6089-2024-0924","url":null,"abstract":"","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20240924"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jair de Jesus Mari, Naomar Almeida-Filho, Flávio Kapczinski, Antonio Nardi
{"title":"The S20 Brazilian Mental Health Report.","authors":"Jair de Jesus Mari, Naomar Almeida-Filho, Flávio Kapczinski, Antonio Nardi","doi":"10.47626/2237-6089-2024-0981","DOIUrl":"10.47626/2237-6089-2024-0981","url":null,"abstract":"","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20240981"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142477358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Autism spectrum disorder and personality disorders: differential diagnosis or comorbidity?","authors":"Tiago Figueiredo, Leonardo Caixeta","doi":"10.47626/2237-6089-2025-1104","DOIUrl":"10.47626/2237-6089-2025-1104","url":null,"abstract":"<p><strong>Objective: </strong>The clinical overlap between autism spectrum disorder (ASD) and personality disorders (PDs) poses significant diagnostic challenges. Shared features - such as social communication difficulties, rigidity, and emotional dysregulation - often lead to misdiagnosis or delayed diagnosis, especially in adults and underrepresented populations (e.g., women).</p><p><strong>Methods: </strong>This narrative review synthesizes current evidence on the differential diagnosis and comorbidity of ASD and PDs to guide clinical practice.</p><p><strong>Results: </strong>Findings highlight substantial symptom overlap, particularly in social cognition and emotional regulation. For instance, both ASD and schizotypal PD may exhibit social withdrawal, while ASD and borderline PD share impulsivity and identity disturbances - though with distinct etiologies (neurodevelopmental vs. trauma-related).</p><p><strong>Conclusions: </strong>Clinicians must adopt a developmental perspective to disentangle ASD from PDs, integrating longitudinal history, neuropsychological testing, and multidisciplinary evaluations. Future research should prioritize biomarker-based diagnostics and tailored interventions for comorbid presentations.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20251104"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Emotion comprehension and sociocognitive skills in children with high functioning autism spectrum disorders.","authors":"Vitoria Santos Santana, Josemar Marchezan, Denise Bisolo Scheibe, Joana Bücker","doi":"10.47626/2237-6089-2024-0863","DOIUrl":"10.47626/2237-6089-2024-0863","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare sociocognitive skills and emotion comprehension between children with autism spectrum disorder (ASD) and children with neurotypical development.</p><p><strong>Methods: </strong>This quantitative, cross-sectional, controlled study involved 19 children in each group, matched by age (6-12 years) and sex. The assessments examined cognitive aspects (Intelligence Quotient was assessed using the Vocabulary and Matrix Reasoning subtests; working memory using the digit span and letter-number sequencing subtests; attention using the Continuous Performance Test - Identical Pairs; and executive functions using the Trail Making Test), social functions (Children's Social Skills, Behavior Problems, and Academic Competence Inventory), and emotion comprehension (language was assessed using the Strange Stories Test; emotional facial expressions using the digital emotion comprehension test; emotional/affective prosody using the Profiling Elements of Prosody in Speech-Communication - Brazilian Portuguese adapted version).</p><p><strong>Results: </strong>The group with ASD exhibited better performance in executive functions (p = 0.02). However, they lagged the control group in social skills (p = 0.04), behavior problems (p = 0.03), and emotion comprehension (language, facial expressions, and prosody) (all p < 0.05).</p><p><strong>Conclusion: </strong>The findings indicate that children with ASD have diminished performance in social skills and emotion comprehension compared to children with neurotypical development. Therefore, the development of technologies and/or therapeutic interventions that address these deficits among children with ASD is recommended.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":"e20240863"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marcos Hortes N Chagas, Livio Rodrigues Leal, Natalia Mota de Souza, Rebeca Mendes P Pessoa
{"title":"Prevalence of mental disorders according to DSM-5 in older adults living in the community: a cross-sectional study.","authors":"Marcos Hortes N Chagas, Livio Rodrigues Leal, Natalia Mota de Souza, Rebeca Mendes P Pessoa","doi":"10.47626/2237-6089-2025-1206","DOIUrl":"https://doi.org/10.47626/2237-6089-2025-1206","url":null,"abstract":"<p><strong>Introduction: </strong>Population aging in Brazil has important implications for public health, including an increased prevalence of mental disorders. Few Brazilian studies have assessed these conditions in community-dwelling older adults using DSM-5 criteria.</p><p><strong>Objective: </strong>To determine the prevalence of mental disorders in older adults according to DSM-5 diagnostic criteria.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 267 older adults living in the catchment area of a Primary Health Care Unit in São Paulo State. Structured clinical evaluations based on DSM-5 were conducted by trained psychiatrists. Frequencies were calculated, and logistic regression analyses examined associations with sex, age, and education.</p><p><strong>Results: </strong>The prevalence of any current mental disorder was 74.2%, with 46.8% presenting two or more diagnoses. The most frequent disorders were generalized anxiety disorder (17.6%), depressive disorders (13.5%), and neurocognitive disorders (34.0%). Female sex was associated with greater odds of generalized anxiety disorder (OR=2.3; 95% CI: 1.12-4.74; p=0.032) and marginally with major depression (OR=2.02; 95% CI: 0.93-4.42; p=0.077). Older age was associated with both mild (OR=1.06; 95% CI: 1.02-1.11; p=0.005) and major neurocognitive disorders (OR=1.06; 95% CI: 1.00-1.12; p=0.037), whereas lower education was associated with major neurocognitive disorder (OR=0.75; 95% CI: 0.59-0.95; p=0.019).</p><p><strong>Conclusions: </strong>The prevalence of mental disorders in community-dwelling older adults was high, particularly for anxiety, depression, and neurocognitive disorders. These findings highlight the need for screening and mental health strategies targeting this population, especially in primary care settings.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The association between loot boxes and gambling in children and adolescents.","authors":"Pedro Fernández, Laiana Quagliato","doi":"10.47626/2237-6089-2025-1217","DOIUrl":"https://doi.org/10.47626/2237-6089-2025-1217","url":null,"abstract":"<p><strong>Background: </strong>With increased screen time among children and adolescents, concerns about the impact of loot boxes (LB) on gambling behaviors have grown. LBs, often included in video games as purchasable items with randomized rewards, resemble gambling mechanics, raising concerns about potential risks for youth.</p><p><strong>Methods: </strong>This systematic review collected and analyzed all available studies on LB use and gambling in individuals under 18 years old. A literature search was conducted using Cochrane, SciELO, and PubMed databases up to March 30, 2024. The inclusion criteria focused on peer-reviewed empirical studies examining the association between LBs and gambling behaviors in minors, while studies on unrelated gambling behaviors or those involving adults were excluded.</p><p><strong>Results: </strong>From 74 initial articles, 4 studies met the inclusion criteria. Findings consistently showed a positive association between LB engagement and gambling tendencies in adolescents. Results indicate that adolescents involved with LBs are at a higher risk of problematic gambling behaviors, with gender differences also observed, as male adolescents showed higher engagement with LBs and gambling risks.</p><p><strong>Conclusions: </strong>The review suggests a clear association between LB use and gambling behaviors in youth, with potential for LBs to act as a \"gateway\" to gambling. The findings highlight the need for regulatory actions, including age restrictions and educational efforts to protect youth from these risks. Further research with representative samples is necessary to deepen understanding of the LB-gambling link in young populations.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}