Larissa P Borlina Beltrami, Paula Teixeira Marques, Francisco Jaime Lopes Barbosa, Viviane H Flumignan Zetola, Marcos Christiano Lange, Raffael Massuda
{"title":"Functional impairment and post-stroke depression: a 6-month longitudinal study.","authors":"Larissa P Borlina Beltrami, Paula Teixeira Marques, Francisco Jaime Lopes Barbosa, Viviane H Flumignan Zetola, Marcos Christiano Lange, Raffael Massuda","doi":"10.47626/2237-6089-2022-0589","DOIUrl":"https://doi.org/10.47626/2237-6089-2022-0589","url":null,"abstract":"<p><strong>Background: </strong>In recent decades, considerable advances have been made in the treatment of acute ischemic stroke (IS) and its prevention. However, even after treatment, approximately two-thirds of patients with IS have some degree of disability that requires rehabilitation, along with an increased possibility of developing psychiatric disorders, particularly depression.</p><p><strong>Objective: </strong>To determine the predictors of post-stroke depression in a 6-month period in patients with IS.</p><p><strong>Method: </strong>Ninety-seven patients with IS without previous depression were included in the study. The study protocol was applied during hospitalization and at 30, 90, and 180 days after hospital discharge. A binary logistic regression was then used. Age, sex, marital status, occupation, education, thrombolysis, National Institute of Health Stroke Scale, modified Rankin scale (mRS) score, Barthel index, and Mini-Mental State Examination score were included as independent variables.</p><p><strong>Results: </strong>Of the 97 patients, 24% of patients developed post-stroke depression. In the longitudinal follow-up, an mRS score of > 0 was the lone significant predictor of depression development (odds ratio = 5.38; 95% confidence interval: 1.25-23.12; p < 0.05).</p><p><strong>Conclusion: </strong>Our results showed that in patients without previous depression, functional impairment of any degree has a 5-fold greater chance of leading to depression development in the first 6 months post-stroke as compared to that in patients without functional impairment.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9248976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M da Mota Gomes, Lucio Lage Gonçalves, Elie Cheniaux, Antonio E Nardi
{"title":"King George III of England and Queen Maria I of Portugal: bipolar disorder and prince regents as common features of their reigns.","authors":"M da Mota Gomes, Lucio Lage Gonçalves, Elie Cheniaux, Antonio E Nardi","doi":"10.47626/2237-6089-2021-0315","DOIUrl":"10.47626/2237-6089-2021-0315","url":null,"abstract":"<p><strong>Abstract: </strong>Humanity is sporadically subjected to leaders with deviant behavior, ego problems, or psychiatric disorders, potentially leading to social instability. Bipolar disorder is not common in all populations, but, coincidentally, studies suggest that it affected two sovereigns that were contemporaries, King George III of England, who died 201 years ago, and Queen Maria I of Portugal, who died 205 years ago. They lived during a time when Europe was in turmoil with the French Revolution and Napoleonic Wars, which also coincided with the rise of psychiatry. Both monarchs were forced to have prince regents rule in their place, due to their emotional decline, and they shared the same medical consultant, Francis Willis.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":"45 ","pages":"e20210315"},"PeriodicalIF":2.6,"publicationDate":"2023-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9493082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lauro Miranda Demenech, Marlos Rodrigues Domingues, Rosângela Mattos Muller, Vera Regina Levien, Samuel Carvalho Dumith
{"title":"Internet addiction and depressive symptoms: a dose-response effect mediated by levels of physical activity.","authors":"Lauro Miranda Demenech, Marlos Rodrigues Domingues, Rosângela Mattos Muller, Vera Regina Levien, Samuel Carvalho Dumith","doi":"10.47626/2237-6089-2021-0279","DOIUrl":"10.47626/2237-6089-2021-0279","url":null,"abstract":"<p><strong>Introduction: </strong>There are several negative impacts on the physical and mental health of people presenting internet addiction, including development of mood disorders, such as depression.</p><p><strong>Objective: </strong>The aim of the study was to evaluate the association between internet addiction and depressive symptoms, as well as to test the mediating role of physical activity in this association.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with undergraduate students from three universities (one private and two public institutions) in southern Brazil. Depressive symptoms were measured with the Beck Depression Inventory (BDI-21), internet addiction with the Internet Addiction Test (IAT-20), and physical activity with the International Physical Activity Questionnaire (IPAQ - short version). Poisson regression and the Karlson-Holm-Breen mediation method were used for statistical analyses.</p><p><strong>Results: </strong>We observed a dose-response relationship between internet addiction and depressive symptoms. Levels of physical activity mediated the association between moderate internet addiction and depressive symptoms, accounting for 10.7% of the effect observed.</p><p><strong>Conclusion: </strong>Internet addiction can be detrimental to individuals' health, contributing to development of depressive symptoms. Along with psychological and pharmacological therapies, prescription of physical activities is recommended.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":"45 ","pages":"e20210279"},"PeriodicalIF":2.6,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10871458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Victória Machado Scheibe, Augusto Mädke Brenner, Gianfranco Rizzotto de Souza, Reebeca Menegol, Pedro Armelim Almiro, Neusa Sica da Rocha
{"title":"The Eysenck Personality Questionnaire Revised - Abbreviated (EPQR-A): psychometric properties of the Brazilian Portuguese version.","authors":"Victória Machado Scheibe, Augusto Mädke Brenner, Gianfranco Rizzotto de Souza, Reebeca Menegol, Pedro Armelim Almiro, Neusa Sica da Rocha","doi":"10.47626/2237-6089-2021-0342","DOIUrl":"10.47626/2237-6089-2021-0342","url":null,"abstract":"<p><strong>Introduction: </strong>The Eysenck Personality Questionnaire Revised - Abbreviated (EPQR-A) consists of 24 items for assessment of the three fundamental personality traits (psychoticism, extraversion, and neuroticism) and a validity scale (lie scale). Our objectives were to assess the psychometric properties of a version of this instrument culturally adapted for Brazil.</p><p><strong>Method: </strong>321 participants were recruited using a non-probabilistic method.</p><p><strong>Results: </strong>Internal consistencies ranged from minimally acceptable to respectable, except for the psychoticism domain. Higher neuroticism scores were associated with higher depression and anxiety scores, higher extraversion scores were associated with lower levels of depression symptoms, and higher psychoticism scores were associated with higher levels of depression symptoms.</p><p><strong>Conclusion: </strong>Our findings describe sustainable psychometric properties for the Brazilian Portuguese version of EPQR-A.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":"45 ","pages":"e20210342"},"PeriodicalIF":2.6,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10132824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rubens José Loureiro, Flavio Takemi Kataoka, Thiago Wendt Viola, Gisele Iesbich Vargas, Breno Sanvicente-Vieira, Rodrigo Grassi-Oliveira, Bruno Kluwe-Schiavon
{"title":"Decision-making under risk and theory of mind in adolescent offenders in provisional deprivation of liberty.","authors":"Rubens José Loureiro, Flavio Takemi Kataoka, Thiago Wendt Viola, Gisele Iesbich Vargas, Breno Sanvicente-Vieira, Rodrigo Grassi-Oliveira, Bruno Kluwe-Schiavon","doi":"10.47626/2237-6089-2020-0155","DOIUrl":"https://doi.org/10.47626/2237-6089-2020-0155","url":null,"abstract":"<p><strong>Introduction: </strong>Delinquent behaviors are risky behaviors that increase during puberty and reach their highest peak in late adolescence. It has been proposed that poor decision-making and theory of mind (ToM) are key cognitive processes implicated with delinquency during adolescence, affecting evaluation of risks and impairing appreciation of social norms. Nevertheless, it is not yet clear whether adolescent offenders who are subjected to provisional deprivation of liberty due to conflict with the law (adolescents in conflict with the law [ACL]) might, in fact, present a specific profile with regard to these cognitive processes.</p><p><strong>Objectives: </strong>To assess deliberative decision-making and ToM among adolescents in conflict with the law and adolescents not in conflict with the law.</p><p><strong>Methods: </strong>The sample comprised 62 participants: ACL (n = 29) and a control group (CG) (n = 33). ToM was assessed with the Reading the Mind in the Eyes Test (RMET) and decision-making was assessed with the Columbia Card Task (CCT). Substance use, callous-unemotional traits, childhood maltreatment, and intelligence quotient (IQ) were also assessed.</p><p><strong>Results: </strong>ACL had more ToM errors for negative mental states in comparison to CG, but not for error rates concerning neutral and positive mental states. With regards to decision-making, our results suggest that ACL group members did not vary their behavior based on the available information and that the risk information had an opposite effect on the number of cards chosen (risk-taking behavior) when compared to CG.</p><p><strong>Conclusion: </strong>These findings have important implications for development of interventions for these adolescents, suggesting that they tend to learn little from negative outcomes and have reduced capacity to process negative emotions.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":"44 ","pages":"e20200155"},"PeriodicalIF":2.6,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9172825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mario Simjanoski, Aidan McIntyre, Flavio Kapczinski, Taiane de Azevedos Cardoso
{"title":"Cognitive impairment in bipolar disorder in comparison to mild cognitive impairment and dementia: a systematic review.","authors":"Mario Simjanoski, Aidan McIntyre, Flavio Kapczinski, Taiane de Azevedos Cardoso","doi":"10.47626/2237-6089-2021-0300","DOIUrl":"https://doi.org/10.47626/2237-6089-2021-0300","url":null,"abstract":"<p><strong>Objective: </strong>To conduct a systematic review to describe cognitive abilities in bipolar disorder (BD) in comparison to cognitive abilities in mild cognitive impairment (MCI) and dementia.</p><p><strong>Methods: </strong>A literature search was performed with no year or language restrictions. The search yielded 1,461 articles, with 1,261 remaining after removal of duplicates, five of which were suitable for the systematic review: two for the comparison between BD and MCI and three comparing BD and dementia.</p><p><strong>Results: </strong>Analyses from our systematic review showed that euthymic individuals with BD present impairments in cognitive domains such as attention and executive functioning, motor skills, conceptual thinking, and visuo-spatial abilities that are equally severe as or more severe than the impairments observed in individuals with MCI. In contrast, studies comparing BD and dementia indicated that Alzheimer's disease (AD) dementia and behavioral variant frontotemporal dementia (bvFTD) both showed greater cognitive deficits than BD during euthymia, whereas BD during a mood episode demonstrated higher cognitive impairments than bvFTD.</p><p><strong>Conclusion: </strong>Findings from our systematic review suggest that cognitive impairments in euthymic BD fall into a range between the impairments seen in MCI and those seen in dementia. More studies are needed to analyze these comparisons, while also focusing on comparing different clinical stages of BD with MCI and dementia to analyze the progression of the clinical course and cognitive dysfunction in BD.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":"44 ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9185734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicholas Tze Ping Pang, Vincent Chung Sheng Tio, Amardeep Singh Bhupendar Singh, Mathias Wen Leh Tseu, Wendy Diana Shoesmith, Muhammad Aklil Abd Rahim, Mohd Amiruddin Mohd Kassim
{"title":"Efficacy of a single-session online ACT-based mindfulness intervention among undergraduates in lockdown during the COVID-19 pandemic.","authors":"Nicholas Tze Ping Pang, Vincent Chung Sheng Tio, Amardeep Singh Bhupendar Singh, Mathias Wen Leh Tseu, Wendy Diana Shoesmith, Muhammad Aklil Abd Rahim, Mohd Amiruddin Mohd Kassim","doi":"10.47626/2237-6089-2020-0172","DOIUrl":"https://doi.org/10.47626/2237-6089-2020-0172","url":null,"abstract":"<p><strong>Introduction: </strong>COVID-19 has trickle-down psychological effects on multiple strata of society, particularly university students. Apart from the worry of contracting or spreading COVID-19, Malaysian university students were also locked down on their campuses, suffering significant psychological distress. Hence, an online mindfulness intervention was proposed to alleviate psychological distress and improve psychological flexibility and mindfulness.</p><p><strong>Methods: </strong>This was a quasi-experimental study with university students as participants. Intervention group participants were instructed to complete online questionnaires which covered basic demographics and instruments assessing depression, anxiety, stress, mindfulness, psychological flexibility, and fear of COVID-19 before and after the one-hour intervention. The control group also completed before and after questionnaires and were subsequently crossed over to the intervention group. Repeated measures ANOVA was conducted to assess time*group effects.</p><p><strong>Results: </strong>118 participants were involved in this study. There were significant differences in anxiety (F(1,116) = 34.361, p < 0.001, partial eta-squared = 0.229) and psychological flexibility between the two groups (F(1,116) = 11.010, p = 0.001, partial eta-squared = 0.087), while there were no differences in depression, stress, mindfulness, or fear of COVID-19.</p><p><strong>Conclusion: </strong>The results of this study corroborate the efficacy of online single-session mindfulness therapy as a viable short-term psychological intervention under financial and time constraints. Since university students are in the age group with the highest incidence of depressive and anxiety disorders, it is crucial to utilize resources to address as many students as possible to ensure maximum benefit.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":"44 ","pages":"e20200172"},"PeriodicalIF":2.6,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9177660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Testing the efficacy of group cognitive-behavioral therapy for pathological internet use among undergraduates in Nigeria.","authors":"Moses Onyemaechi Ede, Chinedu Ifedi Okeke, Janet N Igbo, Eucheria Aye","doi":"10.47626/2237-6089-2021-0348","DOIUrl":"10.47626/2237-6089-2021-0348","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to examine the effect of group cognitive-behavioral therapy (GCBT) on pathological internet use (PIU).</p><p><strong>Method: </strong>The study applied a group randomized controlled trial design to assign participants to intervention and control groups. A total of 40 college students aged 18 to 30 who were pathological internet users (PIUs) participated in this study and were randomly assigned to treatment and control groups. Participants completed a self-report scale entitled the Problematic Internet Use Scale (PIUS) at three time points. The intervention lasted 8 weeks. The data collected were statistically analyzed using repeated-measures analysis of variance (ANOVA).</p><p><strong>Results: </strong>The results showed that GCBT has significant efficacy, decreasing the symptoms of PIU among the GCBT participants compared to those in the control group and that the improvements were maintained at follow-up. We also found a significant interaction effect by time for PIU.</p><p><strong>Conclusion: </strong>From the study findings, we can conclude that GCBT has significant benefit for mitigating the severity of PIU in college students. Therefore, mental health professionals are encouraged to explore the benefits of GCBT in treating symptoms associated with PIU in school settings and beyond.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":"45 1","pages":"e20210348"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9930133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Flávia de Moraes, Angelica de Baumont, Carolina Blaya Dreher, Gustavo Gauer, Gisele Gus Manfro
{"title":"Psychiatric outcomes and overall functioning in healthcare students during the first wave of the COVID-19 pandemic: a cross-sectional study.","authors":"Flávia de Moraes, Angelica de Baumont, Carolina Blaya Dreher, Gustavo Gauer, Gisele Gus Manfro","doi":"10.47626/2237-6089-2021-0416","DOIUrl":"https://doi.org/10.47626/2237-6089-2021-0416","url":null,"abstract":"<p><strong>Introduction: </strong>There is evidence that the coronavirus disease 2019 (COVID-19) pandemic impacted students on health care courses, including evidence of associations between anxiety or depression and inadequate coping mechanisms or unhealthy habits. However, little is known about possible predictors of mental health or psychiatric symptoms in Brazilian health care students during this period.</p><p><strong>Objective: </strong>To evaluate possible factors associated with anxiety and depressive symptoms, used to measure psychiatric outcomes, and quality of life, used as a parameter of overall functionality, in Brazilian students on health care courses during the COVID-19 pandemic.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with Brazilian students on health care courses from May to December 2020. Participants were recruited through social media and answered a 71-item open online questionnaire exploring demographic characteristics and personal behavior during the pandemic, anxiety, depression, and quality of life. We searched for variables potentially associated with psychiatric symptoms and mental health in these individuals using Poisson regression models.</p><p><strong>Results: </strong>Multivariate models showed depression and anxiety were associated with poor quality of life and medication abuse was associated with greater anxiety and poor quality of life. Psychotherapy was an effective coping strategy for anxiety and meditation or mindfulness practice and physical activity improved the students' quality of life.</p><p><strong>Conclusions: </strong>Our study presents important information about the factors associated with psychological impacts of the COVID-19 pandemic and strategies for coping with them that should be helpful to reflect on and for designing appropriate interventions.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":"45 ","pages":"e20210416"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9983417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bidirectionality of smoking and depression in adolescents: a systematic review.","authors":"Mudassir Farooqui, Samra Shoaib, Humera Afaq, Syed Quadri, Fatima Zaina, Aqsa Baig, Ayesha Liaquat, Zoona Sarwar, Atif Zafar, Sana Younus","doi":"10.47626/2237-6089-2021-0429","DOIUrl":"https://doi.org/10.47626/2237-6089-2021-0429","url":null,"abstract":"<p><strong>Introduction: </strong>Recently, evidence has been accumulating that both smoking and mental health disorders are continuously increasing among adolescents. This systematic review elucidates the research into evidence of the direction of the association and risk factors influencing the relationship between smoking and depression. We also highlight recent studies on the effects of electronic cigarettes and developments on the association between depression and smoking.</p><p><strong>Methods: </strong>A literature search was conducted on databases including PubMed, Ovid Medline, EMBASE, and PsycINFO and in relevant neurology and psychiatry journals. Terms used for electronic searches included smoking, tobacco, cigarettes; depression; adolescent, youth; direction. Relevant information was then utilized to synthesize findings on the association between smoking and depression among adolescent population.</p><p><strong>Results: </strong>The initial database searches yielded 2,738 related articles. After screening and cross-referencing, duplicate articles, articles published in languages other than English, and studies on animals, social and lifestyle factors, mood disorders, and substance use were excluded. Of these, a total of 122 publications only focusing on smoking and depression in the adolescent population were selected for synthesis in this qualitative systemic review. These include 110 original research articles, eight meta-analyses and reviews, and four reports and websites.</p><p><strong>Conclusion: </strong>The relationship between smoking and depression in the literature does not reflect the cause-effect relationship. The lack of evidence on the direction of the association may reflect futile study designs, confounding factors and/or use of indirect measures of depression and quantification of smoking. Future prospective randomized studies should target elucidation of the causal association.</p>","PeriodicalId":46305,"journal":{"name":"Trends in Psychiatry and Psychotherapy","volume":"45 ","pages":"e20210429"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10073999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}