Current Hypertension Reviews最新文献

{"title":"Elevated Hypertension Risk among Mexican Patients with Hemophilia.","authors":"Maximiliano Correa Lara, Jaime García Chavez, Erika Martinez Hernandez","doi":"10.2174/0115734021369234250830084508","DOIUrl":"10.2174/0115734021369234250830084508","url":null,"abstract":"<p><strong>Introduction: </strong>Epidemiological evidence suggests that people with hemophilia (PWH) have a higher prevalence of comorbidities compared to the general population. However, the incidence and risk of comorbidities, particularly hypertension, among Mexican PWH remain underexplored.</p><p><strong>Methods: </strong>We conducted a retrospective cross-sectional study on adult PWH at a major hemophilia treatment center in Mexico. The objective was to determine the prevalence of comorbidities, with a focus on hypertension, by comparing PWH to a control group and assessing the impact of hemophilia severity.</p><p><strong>Results: </strong>A total of 223 PWH were evaluated. Patients with mild hemophilia had a higher likelihood of being overweight (OR 2.77, 95% CI: 1.397-5.496), those with moderate hemophilia also had a higher likelihood of being overweight (OR 2.42, 95% CI: 1.129-5.189), and those with severe hemophilia showed an increased risk of hypertension (OR 1.46, 95% CI: 1.006-2.119). A simple linear regression analysis revealed a weak association between coagulation factor activity and body mass index (p = 0.235, R² = 0.006).</p><p><strong>Discussion: </strong>The increased odds of hypertension in severe hemophilia and the lack of age as a significant confounder support the hypothesis that hemophilia-specific factors contribute to this elevated risk. The existing literature suggests that chronic inflammation stemming from recurrent joint bleeds and subsequent arthropathy can lead to vascular changes. Recent evidence of elevated pro-inflammatory markers in PWH further strengthens this link, indicating a systemic inflammatory state that extends beyond the joints and may impact cardiovascular regulation.</p><p><strong>Conclusion: </strong>This first retrospective cross-sectional study on Mexican PWH supports findings from other populations, indicating an elevated risk of hypertension and overweight in these patients, independent of obesity or diabetes mellitus. Further studies are warranted to elucidate the pathophysiological mechanisms driving this association.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"42-50"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mechanisms and Treatment Approaches of Oxidative Stress and Inflammation in the Development of Chronic Kidney Disease.","authors":"Rishi Kant, Prashanjit Roy, Amandeep Kaur, Princy Rs, Sourabh Kosey, Saurabh Kumar, Ranjeet Kumar","doi":"10.2174/0115734021411649251121111135","DOIUrl":"10.2174/0115734021411649251121111135","url":null,"abstract":"<p><p>The article investigates the crucial roles of oxidative stress and inflammation in the progression of Chronic Kidney Disease (CKD), a condition that poses an increasing global health burden. An imbalance between reactive oxygen species (ROS) and antioxidant defenses leads to mitochondrial damage, which subsequently triggers endothelial dysfunction and promotes kidney fibrosis. CKD symptoms are further exacerbated by inflammation, driven by uremic toxins and cytokine activity. The article highlights NF-κB and Nrf2 as key signaling pathways that regulate these networks. Additionally, it examines how cardiovascular disease, mineral-bone disorder, and cognitive decline emerge as clinical consequences of inflammatory and oxidative tissue damage. Therapeutic strategies for CKD are categorized into three main approaches: antioxidants and antiinflammatory medications, SGLT2 inhibitors, and bardoxolone methyl. The article also emphasizes non-pharmacological interventions, including behavioral modifications, dietary adjustments, probiotic use, and modulation of the gut microbiota. Finally, it discusses emerging research on biomarker development, precision medicine techniques, and genetic therapies aimed at improving CKD detection, management, and treatment outcomes.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"266-278"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Profile and Outcome of Hypertensive Emergencies: A Prospective Observational Study.","authors":"Mohd Israr, Mohd Ashraf, Ashaq Hussain Parrey, Mohd Ismail","doi":"10.2174/0115734021422131260213102217","DOIUrl":"10.2174/0115734021422131260213102217","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Hypertensive emergencies are among the most common life-threatening acute medical conditions encountered in clinical practice. They are characterized by a sudden, severe elevation of blood pressure (systolic ≥180 mmHg and/or diastolic ≥120 mmHg) in association with acute target organ damage, leading to significant short-term mortality and long-term morbidity. In low- and middle-income regions, delayed detection, poor treatment adherence, and limited health infrastructure amplify this burden. This prospective observational study aimed to evaluate the clinical profile, organ involvement, and in-hospital outcomes of patients admitted with hypertensive emergencies to a tertiary care centre in northern India.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We enrolled 300 consecutive patients aged ≥18 years who fulfilled the diagnostic criteria for hypertensive emergencies over two years (Oct 2022-Sep 2024) at the Government Medical College, Srinagar. Demographics, medical history, presenting symptoms, blood pressure trends, target organ damage, laboratory and imaging findings, treatment measures, and outcomes were recorded. Statistical analysis was performed using SPSS v29.0 and R software, with categorical variables compared using the chi-square or Fisher's exact test, and statistical significance set at p&lt;0.05.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of the 300 patients (58% men, 42% women), the predominant age group was 60-69 years (28%). Neurological involvement was the most frequent manifestation, with intracerebral haemorrhage and ischemic stroke occurring in 48% and 19% patients, respectively. Cardiac complications included left ventricular failure (15.7 %) and myocardial infarction (11.3 %). Fundoscopic changes indicative of hypertensive retinopathy were observed in 39% of the patients, and microalbuminuria was present in 28.3% of the patients. A significant proportion (72.3%) had known hypertension, although 42.4% reported poor treatment adherence. Serial monitoring revealed a consistent reduction in both systolic and diastolic pressures with prompt treatment initiation. Despite aggressive management, the in-hospital mortality rate was 21.7%, largely attributable to intracerebral hemorrhage.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;This study underscores the high burden of neurological, cardiac, and renal complications in hypertensive emergencies, with intracerebral hemorrhage emerging as the most frequent manifestation, in contrast to Western patterns, where ischemic events predominate. These findings highlight the impact of delayed diagnosis, limited access to emergency care, and suboptimal BP control. The high prevalence of target organ damage reflects chronic, uncontrolled hypertension and predicts adverse outcomes. Strengthening community screening, ensuring effective treatment adherence, and improving acute care capacity are essential for reducing mortality and morbidity in resource-limited settings.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/str","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"301-308"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preface.","authors":"Guido Grassi","doi":"10.2174/0115734021474321260130103450","DOIUrl":"https://doi.org/10.2174/0115734021474321260130103450","url":null,"abstract":"","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":"22 1","pages":"iv"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148303466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthostatic Hypotension in Older Adults: A Narrative Review of Causes, Drug Impacts, and Management Strategies.","authors":"Vishal Bhati, Payal Mittal","doi":"10.2174/0115734021380889250919160828","DOIUrl":"10.2174/0115734021380889250919160828","url":null,"abstract":"<p><strong>Introduction: </strong>Orthostatic hypotension (OH) is a prevalent disorder among the elderly, characterized by a marked decrease in blood pressure upon standing. It impacts 10-30% of elderly individuals and is linked to falls, cognitive deterioration, and cardiovascular issues. The primary factors include aging, autonomic dysfunction, and pharmaceutical usage.</p><p><strong>Methods: </strong>This narrative review consolidates and examines contemporary research regarding the etiology, pharmacological effects, diagnosis, and treatment of orthostatic hypotension in elderly adults. A systematic technique was not employed; rather, expert analysis of the existing literature was utilized to distill essential ideas.</p><p><strong>Results: </strong>OH in the elderly is frequently complex. Frequently involved drugs encompass diuretics, β-blockers, calcium channel blockers, ACE inhibitors, antidepressants, and antiparkinsonian therapies. These medications, within the framework of age-associated physiological alterations, elevate the risk of orthostatic hypotension. The diagnosis relies on monitoring blood pressure during changes in posture. Non-pharmacological interventions, including water, sodium consumption, compression garments, and physical movements, constitute first-line therapies. In chronic instances, pharmacological treatments such as midodrine, droxidopa, and fludrocortisone may be employed, albeit with vigilant monitoring due to potential deleterious effects.</p><p><strong>Discussion: </strong>OH significantly affects the autonomy and quality of life of elderly individuals. Medication- induced orthostatic hypotension is frequently disregarded, particularly in the context of polypharmacy. Customized management, encompassing drug evaluation and integrated therapy approaches, is crucial. Clinical monitoring and regular orthostatic evaluations are essential for prompt diagnosis and management.</p><p><strong>Conclusion: </strong>Effective OH management requires a personalized, multidisciplinary approach. Future research should focus on identifying reliable diagnostic biomarkers and developing individualized treatment algorithms to improve patient outcomes and support healthy aging.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"1-15"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonadherence, Clinic Inertia, and Ineffective Adherence in Antihypertensive Treatment in Latin America.","authors":"Luis Alcocer","doi":"10.2174/0115734021393935251103110508","DOIUrl":"10.2174/0115734021393935251103110508","url":null,"abstract":"<p><p>Arterial hypertension (HTN) is the leading modifiable risk factor for cardiovascular diseases in Latin America; however, control rates remain inadequate. Two primary contributors to this public health crisis are nonadherence to antihypertensive treatment and clinical inertia. Nonadherence rates in the region range from 14% to 94%, while clinical inertia, defined as healthcare providers' failure to escalate or modify treatment, when necessary, further complicates the issue. The interplay between these two factors creates a self-perpetuating cycle that leads to poorly controlled hypertension, increased morbidity and mortality, and a greater economic burden. A primary concern is \"ineffective adherence\", which occurs when patients follow prescribed treatments but do not achieve desired outcomes. This phenomenon is primarily driven by medical inertia and affects a significant proportion of cases. This review examines the scope of these issues in Latin America, their socioeconomic impacts, and potential interventions to mitigate their effects. To better manage hypertension, comprehensive strategies are recommended, including patient-centered interventions, education directed at providers, essential healthcare reforms, and team-based care strategies that involve non-physician providers.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"116-124"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Contemporary Review of Myocardial Infarction with Emphasis on Clinical Trials and Therapeutic Approaches.","authors":"Anuj Kumar Sharma, Yogesh Murti, Akash Ved, Karuna Shanker Shukla, Sabeena Anjum, Mayank Kulshreshtha","doi":"10.2174/0115734021414104251206092002","DOIUrl":"https://doi.org/10.2174/0115734021414104251206092002","url":null,"abstract":"<p><p>Myocardial infarction (MI), a major manifestation of coronary artery disease, remains a global health challenge despite significant advances in research and therapy. This review highlights current developments in diagnostic criteria, pathophysiology, treatment strategies, and emerging therapeutic targets. Type 1 MI, driven by atherosclerotic plaque rupture and thrombosis, continues to dominate, but growing recognition of type 2 MI and MINOCA (myocardial infarction with nonobstructive coronary arteries) underscores the need for refined diagnostic and therapeutic approaches. High-sensitivity cardiac troponins and advanced imaging have improved early detection, classification, and risk stratification. The management now emphasizes personalized, evidence-based care, including percutaneous coronary intervention or thrombosis, dual antiplatelet therapy, lipid-lowering agents, and cardioprotective drugs. Despite improved outcomes, challenges, such as late presentation, treatment disparities, recurrent events, and progression to heart failure, persist. A comprehensive literature search was conducted using electronic databases, such as Web of Science, Google Scholar, PubMed, SciFinder, Reaxys, and the Cochrane Library. By identifying persistent gaps, this work aimed to inform clinicians, researchers, and policymakers on innovative strategies for prevention, early detection, and optimal MI management.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":"22 4","pages":"251-265"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension and Related Factors in the Ba Na Ethnic Group Aged 25 and Over in Kon Tum City, Vietnam: Cross-sectional Study.","authors":"Quang La, Mai To","doi":"10.2174/0115734021395711251115063603","DOIUrl":"10.2174/0115734021395711251115063603","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension has become a salient public health issue on a global scale, affecting more than one billion people worldwide. In Vietnam, and specifically in Kon Tum province, many studies on hypertension have been conducted, mainly focusing on Kinh people, the majority ethnic group in Vietnam. Very few hypertension studies have focused on ethnic minority groups. This study aims to determine the prevalence of hypertension and identify related factors in members of the Ba Na ethnic group, aged 25 years and older, in Kon Tum City, Kon Tum province, Vietnam, in 2019.</p><p><strong>Methods: </strong>A descriptive cross-sectional analysis design was carried out among 450 Ba Na ethnic people aged 25 years and older living in Kon Tum province.</p><p><strong>Results: </strong>The study results indicated that the rate of hypertension in the study population was 30.89%. Increasing age was associated with increasing hypertension, with the highest rate found in the ≥ 65 age group at 66.67%. The lowest rate of hypertension in the group was found among participants aged 25-34 years at 9.66%. In addition to age (>65 years), factors associated with hypertension included BMI (obesity), a family history of hypertension, smoking cigarettes, number of cigarettes smoked per day (>10 cigarettes/day), and having diabetes.</p><p><strong>Discussion: </strong>The prevalence of hypertension in the Ba Na ethnic group in this study is quite high compared to the average prevalence rate of hypertension across Kon Tum province. The factors related to hypertension in Ba Na ethnic group were age, BMI, family history, smoking, and having diabetes, as found in other studies.</p><p><strong>Conclusion: </strong>This is one of the very few studies conducted to measure the prevalence of hypertension in ethnic minority populations in Vietnam. It is necessary to implement community interventions to reduce the exposure to the risk factors of hypertension for the Ba Na ethnic people in Kon Tum, Vietnam.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"309-315"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145655599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mixed-Methods Investigation of Sleep Quality and Hypertension Among Adults Attending an Outpatient Department in Thailand.","authors":"Cherdpong Wongwaipanich, Kasidid Lawongsa","doi":"10.2174/0115734021409893250924122230","DOIUrl":"10.2174/0115734021409893250924122230","url":null,"abstract":"<p><strong>Introduction: </strong>Sleep problems are increasingly recognized as a factor that may contribute to high blood pressure. Evidence in Asian populations, however, remains limited. This study explored the link between sleep quality and hypertension in middle-aged adults through a mixedmethods design.</p><p><strong>Methods: </strong>A sequential approach was used, beginning with a cross-sectional survey of 492 adults aged 35-60 years who attended the outpatient clinic at Phramongkutklao Hospital. Sleep quality was assessed with the Pittsburgh Sleep Quality Index, while blood pressure was measured by standard procedures. Logistic regression identified predictors of hypertension. In the second phase, 15 participants with poor sleep and/or hypertension were interviewed, and transcripts were analyzed thematically.</p><p><strong>Results: </strong>Poor sleep quality (PSQI >5) was strongly associated with hypertension (adjusted OR 7.54; 95% CI: 3.33-17.06; p < 0.001). Older age, alcohol use, and a family history of hypertension also emerged as independent risk factors. The qualitative findings highlighted three recurring issues: lifestyle and psychological obstacles to adequate sleep, low awareness of the connection between sleep and blood pressure, and limited counseling on sleep health in routine care.</p><p><strong>Discussion: </strong>These results emphasize the importance of sleep as a modifiable risk factor for hypertension. The lack of awareness among patients and insufficient advice from healthcare providers point to gaps in current practice.</p><p><strong>Conclusion: </strong>Poor sleep quality is a strong predictor of hypertension among middle-aged adults. Incorporating sleep assessment and education into outpatient services may help improve the prevention and management of hypertension.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"51-60"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rosuvastatin Reduces Allostatic Overload due to Mechanical Strain: A New Finding on Vascular Remodeling Linked to Hypertension in Spontaneously Hypertensive Rats.","authors":"Virna Margarita Martin Gimenez, Federico García, Alejandro Gutierrez, Felipe Inserra, León Ferder, Demetrios A Spandidos, Walter Manucha","doi":"10.2174/0115734021400864251020044405","DOIUrl":"10.2174/0115734021400864251020044405","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic hemodynamic overload due to hypertension produces cardiovascular remodeling, where mechanical stretch (MS) deformation, neurohumoral factors, and/or chronic interaction promote a harmful allostatic overload. Previously, our laboratory demonstrated that rosuvastatin modulates the NO-Hsp70-WT1 pathway during MS at the renal level, and other authors have reported that some statins inhibit the proliferation of rat vascular smooth muscle cells (VSMC) induced by MS. Therefore, this study aims to evaluate, in VSMC culture, the possible modulation of rosuvastatin on NO-Hsp70-WT1 signaling linked to MS and its impact on vascular remodeling due to hypertension.</p><p><strong>Methods: </strong>After 10 weeks of age, mesenteric vascular smooth muscle cells (VSMCs) were cultured from spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. Prior to cell culture, systolic blood pressure (SBP) was measured: SHR exhibited SBP of 180 ± 10 mmHg, while WKY rats had SBP of 125 ± 8 mmHg. Eight experimental groups were established: SHR and WKY, each with or without mechanical stretch (MS) for 48 hours (Flexcell® system), and with or without treatment with rosuvastatin (10⁻⁵ mol/L). Apoptosis was assessed by flow cytometry, while fibrosis was evaluated via TGF-&946; levels. Nitric oxide (NO) levels, as well as WT1 and Hsp70 expression, were also analyzed.</p><p><strong>Results: </strong>SHR cultures without MS vs WKY without MS showed higher apoptosis/fibrosis and low NO, WT1, and Hsp70 (p &60; 0.01). Notably, WKY with MS was similar to SHR without MS. Furthermore, when comparing SHR with MS vs SHR without MS, we verified more significant apoptosis/fibrosis with lower NO, WT1, and Hsp70 (p &60; 0.01). However, rosuvastatin reduced these differences, promoting the restoration of the altered parameters.</p><p><strong>Discussion: </strong>Mechanical Stretch (MS) induces apoptosis and fibrosis in vascular smooth muscle cells (VSMCs) from hypertensive rats, correlating with impaired nitric oxide (NO) production. Rosuvastatin treatment significantly attenuated MS-induced damage and restored NO bioavailability. Critically, MS downregulated the expression of WT1 and Hsp70, and rosuvastatin restored these levels, suggesting that its protective effects are mediated through the modulation of the NO-Hsp70-WT1 signaling pathway. This study proposes a novel mechanistic framework for statin-mediated vascular protection, highlighting the potential of rosuvastatin to mitigate mechanical stress-induced cardiovascular remodeling in hypertension and related pathologies.</p><p><strong>Conclusion: </strong>Rosuvastatin can reduce vascular remodeling and allostatic overload during hypertension by decreasing MS-associated apoptosis/fibrosis in mesenteric VSMC and regulating the NO-Hsp70-WT1 axis, which highlights its potential clinical use in treating hypertensioninduced vascular remodeling.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"150-161"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}