Supplementation of Olive Oil and Flaxseed Oil on Blood Pressure and Inflammation in Healthy and At-Risk Adults: A Systematic Literature Review and Meta-Analysis.

IF 1.5 Q3 PERIPHERAL VASCULAR DISEASE

Current Hypertension Reviews Pub Date : 2024-11-15 DOI:10.2174/0115734021337760241104063418

Tara B McNabb, Ian Young, Rachel G Newman, R Chris Skinner, Vagner A Benedito, Janet C Tou

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引用次数: 0

Abstract

Background: Adding olive oil (OO) and flaxseed oil (FLO) to the diet has been reported to improve endothelial function and reduce inflammation. However, the efficacy of supplementing OO and FLO on blood pressure (BP) in normo-, pre-, and hypertensive stage 1 adults is uncertain.

Objective: This study aimed to systematically review the literature on OO and FLO supplementation on BP and select inflammatory markers in healthy adults and adults at risk of hypertension.

Methods: Four databases, PubMed, CINHAL, Web of Science, and Medline (Ovid), were searched from inception until October 2023 for randomized control trials (RCTs) comparing OO and FLO supplementation in normotensive or adults at risk of hypertension. The outcomes included were systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) and at least one inflammatory marker, C-reactive protein (CRP), interleukin6 (IL6), or tumor necrosis factor alpha (TNFα). The risk of bias was assessed using version 2 of the Cochrane risk of bias tool for RCTs, publication bias visualization was performed using funnel plots, and meta-analysis was completed to generate average estimates of effects in 2024.

Results: Seventeen RCTs, comprising 14 studies on OO and 3 on FLO, met the inclusion criteria. Meta-analysis using a random-effects model reported no significant effect on SBP n=17 mean difference (MD) -0.48; 95% CI: -1.76, 0.80; p=0.65, I2=0%) and DBP (n=16, MD -0.47; 95% CI: -1.33, 0.39; p=0.65, I2=0%) or inflammatory markers, CRP (n=8, MD 0.11; 95% CI: -1.18, 0.40; p=0.98, I2=0%), IL6 (n=3, MD -0.15; 95% CI: -0.57, 0.27; p=0.87, I2=0%), and TNFα (n=3, MD-0.08; 95% CI: -0.12, -0.03; p=0.98, I2=0%).

Conclusion: Longer-duration, higher-dose, and larger-scale RCTs are needed to better understand the efficacy of OO and FLO supplementation on BP. Further insight will better inform dietary supplement use for preventing hypertension.

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补充橄榄油和亚麻籽油对健康和高危成人血压和炎症的影响：系统文献综述与元分析》。

背景：据报道，在饮食中添加橄榄油（OO）和亚麻籽油（FLO）可改善内皮功能并减少炎症。然而，补充橄榄油和亚麻籽油对正常、前期和一期高血压成人血压（BP）的疗效尚不确定：本研究旨在系统回顾有关补充 OO 和 FLO 对健康成人和高血压风险成人的血压和特定炎症指标影响的文献：方法：在 PubMed、CINHAL、Web of Science 和 Medline (Ovid) 四个数据库中检索了从开始到 2023 年 10 月的随机对照试验 (RCT)，这些试验对正常血压或有高血压风险的成年人补充 OO 和 FLO 进行了比较。研究结果包括收缩压（SBP）和/或舒张压（DBP），以及至少一种炎症指标：C反应蛋白（CRP）、白细胞介素6（IL6）或肿瘤坏死因子α（TNFα）。使用针对 RCT 的 Cochrane 偏倚风险工具第 2 版对偏倚风险进行了评估，使用漏斗图对发表偏倚进行了可视化，并完成了荟萃分析，以生成 2024 年效应的平均估计值：17项研究性试验符合纳入标准，其中包括14项关于OO的研究和3项关于FLO的研究。使用随机效应模型进行的 Meta 分析表明，对 SBP（n=17，平均差（MD）-0.48；95% CI：-1.76，0.80；P=0.65，I2=0%）和 DBP（n=16，MD -0.47；95% CI：-1.33，0.39；P=0.65，I2=0%）或炎症指标CRP（n=8，MD 0.11；95% CI：-1.18，0.40；p=0.98，I2=0%）、IL6（n=3，MD -0.15；95% CI：-0.57，0.27；p=0.87，I2=0%）和TNFα（n=3，MD-0.08；95% CI：-0.12，-0.03；p=0.98，I2=0%）：为了更好地了解补充 OO 和 FLO 对血压的疗效，需要进行持续时间更长、剂量更大、规模更广的 RCT 研究。进一步的了解将更好地为使用膳食补充剂预防高血压提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Hypertension Reviews PERIPHERAL VASCULAR DISEASE-

CiteScore

4.80

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0.00%

发文量

期刊介绍： Current Hypertension Reviews publishes frontier reviews/ mini-reviews, original research articles and guest edited thematic issues on all the latest advances on hypertension and its related areas e.g. nephrology, clinical care, and therapy. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all clinicians and researchers in the field of hypertension.