Current Hypertension Reviews最新文献

{"title":"Current Hypertension Reviews.","authors":"Guido Grassi","doi":"10.2174/0115734021411011250501112641","DOIUrl":"https://doi.org/10.2174/0115734021411011250501112641","url":null,"abstract":"<p><p>The second 2025 issue of Current Hypertension Reviews includes six papers covering various aspects of hypertension research.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium Antagonists in Hypertension Treatment: When Heterogeneity is Important.","authors":"Ramiro Sanchez, Guido Grassi","doi":"10.2174/0115734021388726250429102020","DOIUrl":"https://doi.org/10.2174/0115734021388726250429102020","url":null,"abstract":"","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology-Enhanced Transdermal Patches for Hypertension: A Review.","authors":"Nishant Yadav, Parveen Kumar, Thakur Gurjeet Singh, Sushma Devi","doi":"10.2174/0115734021373953250416105243","DOIUrl":"https://doi.org/10.2174/0115734021373953250416105243","url":null,"abstract":"<p><p>Transdermal Drug Delivery System (TDDS) is one of the controlled drug delivery sys-tems whose purpose is to deliver medication through the skin at a predetermined and regulated rate. Nanotechnology has enhanced the skin's absorption of lipophilic, low-molecular-weight med-icines with low-dose efficacy, making transdermal drug delivery systems a viable technique for treating various conditions. TDDS permits greater skin permeation of hydrophilic drugs, and sci-entists are studying macromolecules to improve disease treatment and vaccine development. While additional study is needed to determine nanocarrier safety, this approach could increase the usage of transdermal routes for administering hypertension medicines. As hypertension remains the most prevalent form of cardiovascular illness, we focus on how nanoparticles as skin delivery methods might be used to better treat this global problem. In addition, patients may not be willing to comply with traditional doses due to the greater frequency of drug administration necessary for long-term care of hypertension conditions. Transdermal drug delivery has provided numerous benefits to the medical community since its inception. These benefits include the drug's non-invasive nature, ex-tended therapeutic effect, reduced adverse effects, greater bioavailability, improved patient com-pliance, and simple termination. This review aims to explore the potential of several antihyperten-sive drugs for transdermal delivery.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactions between Hypertension and Breastfeeding: What Do We Know?","authors":"Aline do Carmo França-Botelho, Eduardo Luzia França, Adenilda Cristina Honório-França","doi":"10.2174/0115734021377669250418104703","DOIUrl":"https://doi.org/10.2174/0115734021377669250418104703","url":null,"abstract":"<p><p>Substantial evidence indicates that breastfeeding reduces mortality and morbidity in in-fants. However, social changes in the 20th century resulted in a considerable decline in breastfeed-ing rates in many countries. Breast milk is crucial because of its nutritional, immunological, and emotional benefits and economic value. Approximately 10% of pregnancies are complicated by hypertensive syndromes, which are the most commonly diagnosed conditions during pregnancy. This review aims to explore how hypertension may interfere with the quality of human breast milk. While numerous studies have investigated the composition of breast milk and its numerous benefits for both infants and mothers, limited research examines the relationship between colostrum, breast milk, and hypertension. Given the diverse nutritional and immunological components of breast milk, many questions remain about this complex interaction.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Efficacy of Integrating Yoga and Ayurveda for Hypertension Treatment.","authors":"Acharya Balkrishna, Ankita Kukreti, Deepika Srivastava, Ashwani Kumar, Vedpriya Arya","doi":"10.2174/0115734021350052250406161932","DOIUrl":"https://doi.org/10.2174/0115734021350052250406161932","url":null,"abstract":"<p><p>Hypertension, a condition affecting 1.28 billion adults globally, poses significant health risks, including damage to the heart, kidneys, and brain. Factors such as unhealthy lifestyles, poor dietary habits, obesity, and diabetes contribute to its prevalence. While pharmaceutical interven-tions are effective in controlling blood pressure, their adverse effects have led to growing interest in alternative therapies such as Ayurveda and Yoga. This review explores the potential of these traditional practices, individually and in combination, for managing hypertension. A thorough lit-erature review was conducted using databases like PubMed and Google Scholar to analyze peer-reviewed studies up to 2024. Ayurvedic treatments, including therapies like Basti and Shirodhara and herbal formulations such as Raktadabashamak Ghana Vati and Sarpagandha Vati, have shown promise in reducing blood pressure. Similarly, Yoga practices, including OM chanting and Yoga Nidra, have demonstrated stress-reducing and blood pressure-lowering effects. Despite evidence supporting their efficacy, research on their integrated use remains limited. This review underscores the importance of combining Ayurveda and Yoga for holistic hypertension management. Further scientific studies are necessary to validate this integrative approach, which has the potential to offer a safer, non-pharmacological alternative for managing hypertension and improving overall well-being.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Effect of Intermittent Fasting with Mediterranean Diet on Glycemic, Lipid, and Anthropometric Indices in Type 2 Diabetes: A Review of Randomized Controlled Trials.","authors":"Shakila Dehghani, Parisa Karimi, Narges Naimi Tarei, Mohammad Masoumvand, Mohammad Amin Nazari Manesh, Elmira Ramezani, Vahid Reza Askari","doi":"10.2174/0115734021351456250326051146","DOIUrl":"https://doi.org/10.2174/0115734021351456250326051146","url":null,"abstract":"<p><strong>Introduction: </strong>Type 2 diabetes is a metabolic disorder that is becoming more prevalent over time. Research has shown that the Mediterranean diet (MD) and intermittent fasting (IF) can improve the metabolic parameters of patients with type 2 diabetes. However, there has yet to be a study comparing the effectiveness of these two diets in diabetic patients. This review aims to com-pare the impact of the Mediterranean diet and intermittent fasting on glycemic, lipid, and anthro-pometric indices in patients with type 2 diabetes.</p><p><strong>Methods: </strong>We selected clinical trial studies published between 2013 and 2023 that examined the impact of the MD and the IF diet on glycemic, lipid, and anthropometric indices in patients with type 2 diabetes, in the PubMed and Scopus databases on November 23, 2023, and were included in our study following the PRISMA guidelines.</p><p><strong>Results: </strong>A total of 22 clinical trials meeting the inclusion criteria were chosen. Out of these, 13 clinical trials focused on the impact of the Mediterranean diet, while the remaining trials examined the effects of the IF diet on type 2 diabetes. The age range of participants in all studies was above 18 years, with the number of individuals investigated ranging from 9 to 557. The duration of the interventions varied from 1 week to 8 years. The MD and IF have both have been shown to effec-tively improve glycemic control, lipid profiles, and anthropometric measurements in patients with type 2 diabetes. However, the MD tends to offer more consistent and sustainable long-term bene-fits. This can be attributed to its rich composition of antioxidants, healthy fats, and dietary fiber. IF has demonstrated potential benefits for improving blood sugar levels and lipid profiles over short periods. However, its effectiveness may be compromised by the risk of hypoglycemia and the inconsistent commitment of patients.</p><p><strong>Conclusion: </strong>These findings suggest that the MD is preferable for long-term, while IF may serve as a complementary short-term strategy. Further research in this area is necessary to provide a definitive opinion.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Risk Factors and Clinical Complications of Chronic Kidney Disease (CKD) on Renal Arterial Resistive Index (RRI)","authors":"Zobin Souri, Alireza Ramezanzadeh, Elham Ramezanzadeh, Ehsan Kazemnezhad Leyli, Fatemeh Jalali-Zefrei","doi":"10.2174/0115734021346088241228184539","DOIUrl":"10.2174/0115734021346088241228184539","url":null,"abstract":"<p><strong>Background: </strong>Chronic Kidney Disease (CKD) is a known risk factor for End-Stage Renal Disease (ESRD) and Cardiovascular Diseases (CVD). Renal Doppler Ultrasound (RDU) can detect early renal involvement in CKD using the Renal Resistive Index (RRI).</p><p><strong>Aims: </strong>This study aimed to investigate the effects of risk factors and clinical complications associated with CKD on RRI among patients with different stages of CKD.</p><p><strong>Methods: </strong>In this analytical cross-sectional study, 186 patients referred to Poursina Hospital for RDU were categorized into six groups (normal and five stages of CKD). We analyzed the impact of demographic factors and clinical complications on RRI across all groups.</p><p><strong>Results: </strong>Our findings indicated that CKD prevalence was particularly high among older patients and those with CVD, type 2 diabetes mellitus (DM), and hypertension (HTN). Elevated RRI in CKD patients was significantly associated with age, CKD stage, CVD, and HTN (p < 0.05). Furthermore, RRI was higher in CKD patients with elevated serum phosphorus (P) levels, higher low-density lipoproteins (LDL), and lower calcium (Ca) and hemoglobin (Hb) levels. Based on a multivariate regression model, CVD, lower Ca, high LDL, and proteinuria were identified as independent predictors of elevated RRI (p < 0.05).</p><p><strong>Conclusion: </strong>This study concludes that elevated RRI is associated with the severity of CKD and its clinical complications, suggesting that RRI can serve as a reliable indicator for assessing CKD patients, managing treatment, and preventing early death complications.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WITHDRAWN: Hypertension and High-Density Lipoprotein Cholesterol: A Narrative Review","authors":"Rufei Liu, Wenli Cheng","doi":"10.2174/0115734021345634241115115253","DOIUrl":"10.2174/0115734021345634241115115253","url":null,"abstract":"<p><p>Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn.</p><p><p>Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.</p><p><p>The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php</p><p><strong>Bentham science disclaimer: </strong>It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of Hypertension: Pathophysiology, Risk Factors, and Modern Management.","authors":"Deepshikha, Pooja Mathur, Monika, Vikas Jhawat, Saurabh Shekhar, Rohit Dutt, Vandana Garg, Saahil Arora, Sonali, Rahul Pratap Singh","doi":"10.2174/0115734021349254250224074832","DOIUrl":"https://doi.org/10.2174/0115734021349254250224074832","url":null,"abstract":"<p><p>Hypertension, commonly known as high blood pressure, is a chronic condition charac-terized by elevated arterial pressure. It occupies a unique position in population health. It is the leading cause of cardiovascular disease and the most common non-communicable condition af-fecting millions worldwide and is a major public health challenge. The etiology of hypertension involves a complex interplay of environmental and pathophysiolog-ical factors alongside genetics, diet, lifestyle, and other coexisting medical conditions. Treatment typically involves medication and lifestyle adjustments such as dietary changes, regular exercise, weight management, and stress reduction to pharmacological interventions involving drugs like diuretics, beta-blockers & ACE inhibitors to lower blood pressure. The pathogenesis of hyperten-sion is linked to endothelial dysfunction, vascular remodelling, sympathetic nervous system acti-vation, and the renin-angiotensin-aldosterone system (RAAS). Diagnosis is made by measuring blood pressure using a sphygmomanometer, with stages including prehypertension, stage 1 hyper-tension, and stage 2 hypertension. Effective management of hypertension requires lifestyle modi-fications such as dietary changes, regular exercise, weight control, and reduced alcohol consump-tion, alongside pharmacological interventions. As hypertension continues to be a leading cause of death and disability globally, understanding and addressing these factors are crucial for mitigating the widespread impact of hypertension on public health.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of primary Hypertension in Primary Health Care Settings in Coastal Karnataka Using Artificial Neural Network.","authors":"Achal Shetty, Ruban S, Mohammed Jabeer, Deeksha Deepak, Shalya N E, Sudhir Prabhu","doi":"10.2174/0115734021329874250222053144","DOIUrl":"https://doi.org/10.2174/0115734021329874250222053144","url":null,"abstract":"<p><strong>Background: </strong>Hypertension, characterized by chronically elevated blood pressure, poses a significant global health burden. Its prevalence, a critical public health concern, necessitates ac-curate prediction models for timely intervention and management.</p><p><strong>Aim: </strong>The proposed approach leverages the capability of an Artificial Neural Network to capture complex patterns and non-linear relationships within the time series data, allowing for the devel-opment of a robust forecasting model to predict Hypertension. The study population consisted of known hypertensives. In this study, historical time series data related to Hypertension, including patient demographics, lifestyle factors, and medical records, were collected from a Rural primary health center associated with the medical college in coastal Karnataka, India, which is employed to train and validate the model.</p><p><strong>Methods: </strong>The performance of the Artificial Neural Network (ANN) is evaluated using metrics such as MAE (Mean Absolute Error) and RMSE (Root Mean Squared Error) on a separate test dataset. This research explores the potential of ANN in time series forecasting of Hypertension.</p><p><strong>Result: </strong>ANN performs well for this data and has been chosen as the best algorithm for this data set, as it has the lowest MAP (0.20) and MAE (0.45) and the highest R-Square (0.89), making it the most accurate and reliable model for the given data. If these algorithms prove beneficial, they can be used in the primary prevention of Hypertension. Individuals, institutions, and even govern-ment bodies can use it to save treatment costs and lives.</p><p><strong>Conclusion: </strong>The ANN model demonstrated reasonably accurate predictions despite the lower overall fit. It has shown the potential to be used as a primary healthcare tool by helping physicians predict and warn about the dangers of elevated blood pressure to patients. These algorithms, de-ployed using a web application, will enable people to evaluate themselves in the comfort of their homes. This would make us inch closer to the WHO's broader goal of making health a universal right, irrespective of a person's place of residence.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}