Cardio-Ankle Vascular Index as a Marker of Arterial Stiffness: Principles, Application, and Clinical Utility.

IF 1.5 Q3 PERIPHERAL VASCULAR DISEASE
Hamed Tavolinejad, Bianca Pourmussa, Julio A Chirinos
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引用次数: 0

Abstract

Large artery stiffness (LAS) is widely recognized as a highly clinically relevant deter-minant of cardiovascular health and an independent prognostic marker. However, routine assess-ment of LAS has not yet been integrated into clinical practice. Arterial wall stiffness is dependent on distending pressure (i.e., mean arterial pressure), which may confound the interpretation of in-dividual measurements. The cardio-ankle vascular index (CAVI) is an index of arterial stiffness designed to mitigate the dependence of pulse wave velocity on blood pressure. However, because CAVI incorporates pulse wave velocity measured between the heart and the ankle, it is influenced by both the stiffness of the aorta and medium-sized muscular arteries. Several observational, lon-gitudinal studies have demonstrated that higher CAVI is associated with cardiovascular events and mortality, although most available data are derived from Asian populations. Future studies of CAVI are needed to establish its prognostic value in addition to traditionally used cardiovascular risk factors in the setting of primary prevention. This review aims to provide a brief overview of the definition, theoretical principles, practical considerations, key strengths and limitations, and the clinical utility of CAVI.

心踝血管指数作为动脉僵硬度的标志:原理、应用和临床应用。
大动脉硬度(LAS)被广泛认为是心血管健康的一个高度临床相关的决定因素和一个独立的预后指标。然而,LAS的常规评估尚未纳入临床实践。动脉壁刚度取决于扩张压(即平均动脉压),这可能会混淆个人测量的解释。心踝血管指数(CAVI)是一种动脉硬度指数,旨在减轻脉搏波速度对血压的依赖。然而,由于CAVI包含了在心脏和脚踝之间测量的脉搏波速度,因此它受到主动脉和中等肌肉动脉硬度的影响。一些观察性的纵向研究表明,较高的CAVI与心血管事件和死亡率有关,尽管大多数现有数据来自亚洲人群。除了传统上用于一级预防的心血管危险因素外,还需要对CAVI进行进一步的研究,以确定其预后价值。本文旨在对CAVI的定义、理论原理、实践考虑、主要优势和局限性以及临床应用进行综述。
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来源期刊
Current Hypertension Reviews
Current Hypertension Reviews PERIPHERAL VASCULAR DISEASE-
CiteScore
4.80
自引率
0.00%
发文量
26
期刊介绍: Current Hypertension Reviews publishes frontier reviews/ mini-reviews, original research articles and guest edited thematic issues on all the latest advances on hypertension and its related areas e.g. nephrology, clinical care, and therapy. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all clinicians and researchers in the field of hypertension.
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