Current Hypertension Reviews最新文献_第10页

Perivascular Adipose Tissue Oxidative Stress on the Pathophysiology of Cardiometabolic Diseases 血管周围脂肪组织氧化应激对心脏代谢性疾病病理生理学的影响

IF 2.3

Current Hypertension Reviews Pub Date : 2020-12-01 DOI: 10.2174/15734021otc5koti1tcvy

Ana P. Davel

引用次数: 0

Endothelium: A Target for Harmful Actions of Metals 内皮：金属有害作用的靶点

IF 2.3

Current Hypertension Reviews Pub Date : 2020-12-01 DOI: 10.2174/15734021otu4emtmctcvy

D. Vassallo

引用次数: 6

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IF 2.3

Current Hypertension Reviews Pub Date : 2020-09-03 DOI: 10.2174/157340211202160525000755

M. Mogi

引用次数: 0

DASH Dietary Pattern: A Treatment for Non-communicable Diseases DASH饮食模式:非传染性疾病的治疗方法

IF 2.3

Current Hypertension Reviews Pub Date : 2020-08-01 DOI: 10.2174/1573402115666191007144608

Sheenam Suri, Prof Vikas Kumar, Satish Kumar, A. Goyal, Beenu Tanwar, J. Kaur, Jaspreet Kaur

引用次数: 13

Resistant Hypertension: Novel Insights. 顽固性高血压:新见解。

IF 2.3

Current Hypertension Reviews Pub Date : 2020-02-13 DOI: 10.2174/1573402115666191011111402

G. Lamirault, M. Artifoni, M. Daniel, N. Barber-Chamoux, Nantes University Hospital Working Group On Hypertension

{"title":"Resistant Hypertension: Novel Insights.","authors":"G. Lamirault, M. Artifoni, M. Daniel, N. Barber-Chamoux, Nantes University Hospital Working Group On Hypertension","doi":"10.2174/1573402115666191011111402","DOIUrl":"https://doi.org/10.2174/1573402115666191011111402","url":null,"abstract":"Hypertension is the most common chronic disease and the leading risk factor for disability and premature deaths in the world, accounting for more than 9 million deaths annually. Resistant hypertension is a particularly severe form of hypertension. It was described 50 years ago and since then has been a very active field of research. This review aims at summarizing the most recent findings on resistant hypertension. The recent concepts of apparent- and true-resistant hypertension have stimulated a more precise definition of resistant hypertension taking into account not only accuracy of blood pressure measurement and pharmacological class of prescribed drugs but also patient adherence to drugs and life-style recommendations. Recent epidemiological studies have reported a 10% prevalence of resistant hypertension among hypertensive subjects and demonstrated the high cardiovascular risk of these patients. In addition, these studies identified subgroups of patients with an even higher morbidity and mortality risk, probably requiring a more aggressive medical management. In the meantime, guidelines provided more standardized clinical work-up to identify potentially reversible causes for resistant hypertension such as secondary hypertension. Debate is however still ongoing on which would be the optimal method(s) to screen for non-adherence to hypertension therapy, recognized as the major cause for (pseudo)-resistance to treatment. Recent randomized clinical trials have demonstrated the strong benefit of anti-aldosterone drugs (mostly spironolocatone) as fourth line therapies in resistant hypertension whereas clinical trials with device-based therapies displayed contrasting results. New trials with improved devices and more carefully selected patients with resistant hypertension are ongoing.","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2020-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573402115666191011111402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44665958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

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IF 2.3

Current Hypertension Reviews Pub Date : 2020-02-13 DOI: 10.2174/157340211601191226162338

M. Kuwabara

引用次数: 0

Perivascular Adipose Tissue Oxidative Stress on the Pathophysiology of Cardiometabolic Diseases. 血管周围脂肪组织氧化应激对心脏代谢疾病病理生理的影响。

IF 2.3

Current Hypertension Reviews Pub Date : 2020-01-01 DOI: 10.2174/1573402115666190410153634

Jamaira A Victorio, Ana P Davel

引用次数: 14

Hypertension in Chronic Kidney Disease: Novel Insights. 高血压在慢性肾脏疾病:新见解。

IF 2.3

Current Hypertension Reviews Pub Date : 2020-01-01 DOI: 10.2174/1573402115666190415153554

Anila Duni, Evangelia Dounousi, Paraskevi Pavlakou, Theodoros Eleftheriadis, Vassilios Liakopoulos

{"title":"Hypertension in Chronic Kidney Disease: Novel Insights.","authors":"Anila Duni, Evangelia Dounousi, Paraskevi Pavlakou, Theodoros Eleftheriadis, Vassilios Liakopoulos","doi":"10.2174/1573402115666190415153554","DOIUrl":"https://doi.org/10.2174/1573402115666190415153554","url":null,"abstract":"Management of arterial hypertension in patients with chronic kidney disease (CKD) remains a major challenge due to its high prevalence and associations with cardiovascular disease (CVD) and CKD progression. Several clinical trials and meta-analyses have demonstrated that aggressive treatment of hypertension in patients with and without CKD lowers the risk of CVD and all-cause mortality, nevertheless the effects of blood pressure (BP) lowering in terms of renal protection or harm remain controversial. Both home and ambulatory BP estimation have shown that patients with CKD display abnormal BP patterns outside of the office and further investigation is required, so as to compare the association of ambulatory versus office BP measurements with hard outcomes and adjust treatment strategies accordingly. Although renin-angiotensin system blockade appears to be beneficial in patients with advanced CKD, especially in the setting of proteinuria, discontinuation of renin-angiotensin system inhibition should be considered in the setting of frequent episodes of acute kidney injury or hypotension while awaiting the results of ongoing trials. In light of the new evidence in favor of renal denervation in arterial hypertension, the indications and benefits of its application in individuals with CKD need to be clarified by future studies. Moreover, the clinical utility of the novel players in the pathophysiology of arterial hypertension and CKD, such as microRNAs and the gut microbiota, either as markers of disease or as therapeutic targets, remains a subject of intensive research.","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573402115666190415153554","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37156821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Effects of an Antihypertensive Combination in Japanese Hypertensive Outpatients Based on the Long-acting Calcium Channel Blocker Benidipine on Vascular and Renal Events: A Sub-analysis of the COPE Trial 基于长效钙通道阻滞剂贝尼地平的日本高血压门诊患者联合降压对血管和肾脏事件的影响:COPE试验的亚分析

IF 2.3

Current Hypertension Reviews Pub Date : 2020-01-01 DOI: 10.2174/1573402116666200129130151

Seiji Umemoto, Toshio Ogihara, Masunori Matsuzaki, Hiromi Rakugi, Kazuyuki Shimada, Koichi Hayashi, Hirofumi Makino, Yasuo Ohashi, Takao Saruta

{"title":"Effects of an Antihypertensive Combination in Japanese Hypertensive Outpatients Based on the Long-acting Calcium Channel Blocker Benidipine on Vascular and Renal Events: A Sub-analysis of the COPE Trial","authors":"Seiji Umemoto, Toshio Ogihara, Masunori Matsuzaki, Hiromi Rakugi, Kazuyuki Shimada, Koichi Hayashi, Hirofumi Makino, Yasuo Ohashi, Takao Saruta","doi":"10.2174/1573402116666200129130151","DOIUrl":"https://doi.org/10.2174/1573402116666200129130151","url":null,"abstract":"Background: In the trial known as COPE (Combination Therapy of Hypertension to Prevent Cardiovascular Events), three benidipine (a Calcium Channel Blocker; CCB) regimens were compared. Hypertensive Japanese outpatients aged 40-85 years (n=3,293) who did not achieve the target blood pressure of <140/90 mmHg with benidipine 4 mg/day were treated with the diuretic thiazide (n=1,094) or a β-blocker (n=1,089) or an additional Angiotensin Receptor Blocker (ARB; n=1,110). A significantly higher incidence of hard cardiovascular composite endpoints and of fatal or non-fatal strokes was observed in the benidipine-β-blocker group compared to the benidipine-thiazide group.Objective and methods: We further evaluated the treatment effects of the three benidipine-based regimens on vascular and renal events in a sub-analysis of the COPE patients.Results: A total of 10 vascular events (0.8 per 1,000 person-years) including one aortic dissection (0.1 per 1,000 person-years) and nine cases of peripheral artery disease (0.8 per 1,000 person-years) were documented, as was a total of seven renal events (0.6 per 1,000 person-years). No significant differences in vascular and renal events were revealed among the three treatment groups: vascular events, p=0.92; renal events, p=0.16, log-rank test.Conclusion: Blood pressure-lowering therapy with benidipine combined with an ARB, β-blocker, or thiazide was similarly effective in the prevention of vascular and renal events in hypertensive outpatients, although there are not enough events to compare the difference in the three treatment groups.","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37590558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sources and Effects of Oxidative Stress in Hypertension. 氧化应激在高血压中的来源和作用。

IF 2.3

Current Hypertension Reviews Pub Date : 2020-01-01 DOI: 10.2174/1573402115666190531071924

Lucas C Pinheiro, Gustavo H Oliveira-Paula

{"title":"Sources and Effects of Oxidative Stress in Hypertension.","authors":"Lucas C Pinheiro, Gustavo H Oliveira-Paula","doi":"10.2174/1573402115666190531071924","DOIUrl":"https://doi.org/10.2174/1573402115666190531071924","url":null,"abstract":"Background: Disruption of redox signaling is a common pathophysiological mechanism observed in several diseases. In hypertension, oxidative stress, resulted either from enhances in Reactive Oxygen Species (ROS) production or decreases in antioxidant defenses, is associated with increase in blood pressure, endothelial dysfunction and vascular remodeling. Although the role of oxidative stress in the development of hypertension is well known, it is still unclear if this process is a cause or a consequence of tissue changes in hypertension. Indeed, unbalanced ROS formation results in several detrimental effects that contribute to hypertension, including reduction in nitric oxide bioavailability and activation of metalloproteinases. Additionally, ROS may also directly react with lipids, proteins and DNA, thereby contributing to tissue damage associated with hypertension. Therefore, a deep understanding of the role of oxidative stress in hypertension is essential to comprehend its pathophysiology and to identify new therapeutic targets.Conclusion: This mini-review discusses the main enzymatic sources of oxidants and the major antioxidant defenses in the vasculature, followed by the effects of oxidative stress in hypertension, highlighting endothelial dysfunction, vascular remodeling and tissue damage.","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573402115666190531071924","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37287444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27