Current Hypertension Reviews最新文献

{"title":"Blood Pressure Management in Dialysis: A Comparative Review of Hemodialysis and Peritoneal Dialysis.","authors":"Jonny Jonny, Nada Putri Pranidya, Adrianus Jonathan Sugiharta","doi":"10.2174/0115734021408764250929235308","DOIUrl":"10.2174/0115734021408764250929235308","url":null,"abstract":"<p><p>Hypertension is a major challenge in patients with end-stage kidney disease (ESKD) undergoing dialysis, contributing to increased cardiovascular morbidity and mortality. Both hemodialysis (HD) and peritoneal dialysis (PD) serve as renal replacement therapies, yet their effectiveness in blood pressure (BP) control remains a subject of ongoing debate. Emerging evidence suggests that PD may offer better BP regulation than HD due to continuous ultrafiltration, superior sodium removal, and the preservation of residual kidney function. In contrast, HD is often associated with interdialytic fluid retention, leading to BP fluctuations and a higher risk of cardiovascular complications. However, BP control in PD patients is not without challenges, as ultrafiltration failure, peritoneal membrane dysfunction, and inflammation can contribute to resistant hypertension. Despite these limitations, PD may provide a more stable hemodynamic profile compared to HD, making it a promising option for patients with difficult-to-manage hypertension. Individualized dialysis selection remains crucial, as it balances the benefits of fluid control with the risks of PDrelated complications. Further research, particularly randomized controlled trials, is needed to determine the long-term impact of PD and HD on BP control and cardiovascular outcomes in dialysis patients.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"125-132"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13555753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145330402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambulatory Central Blood Pressure Allows the Confirmation of True Hypertension in the Young.","authors":"Maria J Sanchez, Agustin J Ramirez, Ramiro A Sanchez","doi":"10.2174/0115734021373638250811221313","DOIUrl":"10.2174/0115734021373638250811221313","url":null,"abstract":"<p><strong>Introduction: </strong>True isolated systolic hypertension (ISH) in youth must be evaluated by central blood pressure to avoid false or spurious hypertension. The purpose of this study was to perform a reliable assessment to confirm true hypertension and assess target organ damage.</p><p><strong>Methods: </strong>Fifty-eight early diagnosed, untreated systolic hypertensive patients with office BP and 24-h ABPM (25±4, 32 male) underwent central blood pressure evaluation with a non-invasive, validated Mobil-O-Graph device. In all of them, left ventricular mass (LVMi echocardiogram), pulse wave velocity (PWV), cardiac index, peripheral vascular resistance, and urinary albumin excretion were recorded at the beginning of the study.</p><p><strong>Results: </strong>All spurious systolic hypertensives had normal LVMi, cardiac output, peripheral vascular resistance, and urinary albumin excretion (UE), whereas true hypertensives showed a hyperkinetic behavior (high cardiac output) and early target organ damage (increased LVMi and higher urinary albumin excretion) at the time of observation.</p><p><strong>Discussion: </strong>In this study, young patients with elevated cBP had left ventricular mass index and urinary albumin excretion higher than those with normal cBP. This observation suggests that this group of subjects are true hypertensives, contrary to the claim of being spurious hypertensives. Spurious hypertension should not be underestimated because it could be a temporary condition, since other authors have found that ISH and normal cSBP in adolescents may progress to sustained hypertension and hypertensive organ damage, thus requiring close monitoring.</p><p><strong>Conclusion: </strong>In this study, central blood pressure was able to define true or spurious hypertension and confirm target organ damage in this youth cohort. A multicentric study will be of interest to confirm these preliminary findings.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"91-95"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence Integrated in Nutrition: A Mini Review on Artificial Intelligence in Estimating and Reducing Dietary Sodium Intake.","authors":"M A Aarthi, A Prithiviraj, N Venkateswaramurthy","doi":"10.2174/0115734021399236251210151840","DOIUrl":"10.2174/0115734021399236251210151840","url":null,"abstract":"<p><p>Excessive sodium intake remains a critical global health concern, significantly contributing to cardiovascular diseases and associated mortality. Traditional sodium intake reduction strategies have faced limitations in accuracy, compliance, and scalability. This review explores the transformative role of artificial intelligence (AI) in sodium intake estimation and reduction, marking a paradigm shift in dietary management. AI-driven innovations-ranging from image-based nutrient analysis to machine learning models-offer real-time, personalized dietary assessments that surpass conventional methods in precision and user engagement. This review uniquely consolidates emerging AI applications, including smartphone-based sodium tracking, predictive analytics, and AIenhanced behavioral modification tools, highlighting their potential to revolutionize dietary interventions. AI-powered solutions, such as image recognition for food composition and intelligent dietary coaching, have demonstrated enhanced accuracy in sodium monitoring and behavioral adaptation. However, variations in efficacy necessitate further refinement and integration into public health frameworks. By systematically evaluating AI's capabilities and limitations in sodium management, this review underscores its potential to bridge the gap between theoretical advancements and realworld implementation. The novelty of this work lies in its comprehensive synthesis of AI applications, presenting a future-oriented perspective on how AI-driven technologies can personalize and optimize sodium intake regulation. Future research should focus on improving AI model accuracy, user engagement, and clinical applicability for widespread adoption.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"241-250"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tirzepatide: A Breakthrough Therapy for Obstructive Sleep Apnea and Metabolic Dysfunction.","authors":"Gursimran Singh, Taresh Jaswal, Sourabh Kosey, Ranjeet Kumar, Amandeep Kaur","doi":"10.2174/0115734021398680251001102514","DOIUrl":"10.2174/0115734021398680251001102514","url":null,"abstract":"<p><p>Obstructive sleep apnea (OSA) is a breathing disorder characterized by repeated, complete, and partial upper airway blockage, which results in disturbances in sleep patterns, neurocognitive functions, and hypoxemia. It is strongly linked to obesity and metabolic dysfunction, contributing to cardiovascular and neurocognitive complications. Tirzepatide, a dual GIP/GLP-1 receptor agonist, has shown significant potential for weight loss with metabolic benefits, making it a potential therapeutic strategy for OSA by reducing fat deposition around the upper airway, improving insulin sensitivity, and lowering systemic inflammation. Emerging clinical studies have shown potential improvement in apnea-hypopnea index (AHI) and oxygenation. In this review, we have explored the role of tirzepatide in managing OSA by targeting obesity, metabolic dysfunction, and airway stability. Here, we have also examined tirzepatide mechanisms by highlighting clinical trials to find its efficacy in reducing OSA severity and improving patient outcomes.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"16-26"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145373165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Update on the Treatment of Arterial Stiffness.","authors":"Agustin Jose Ramirez","doi":"10.2174/0115734021400629251107114355","DOIUrl":"10.2174/0115734021400629251107114355","url":null,"abstract":"<p><p>Arterial stiffness, a hallmark of cardiovascular aging and disease, is characterized by the reduced elasticity of the arterial walls, which increases cardiovascular risk. Effective treatment aims not only to manage symptoms but also to address underlying causes and reduce associated risks. Thus, the present study aims to provide an understanding of lifestyle modifications and pharmacological treatments for arterial stiffness, as well as the associated cardiovascular risk. The cornerstone of arterial stiffness treatment involves lifestyle changes. Regular aerobic physical activity, combined with a healthy diet, can help reduce weight, lower blood pressure, and improve arterial function. Moreover, since tobacco use directly damages arterial walls and promotes stiffness, smoking cessation is necessary. Several classes of medication, such as renin-angiotensin-aldosterone system inhibitors and calcium channel blockers, not only help control blood pressure but also improve arterial compliance. New antidiabetic agents, such as SGLT2 inhibitors and GLP-1 receptor agonists, have been shown to have beneficial effects on arterial stiffness. Statins, which are commonly prescribed for cholesterol management, also have favorable effects on arterial health, beyond their lipid-lowering properties. In conclusion, treating arterial stiffness is a multifaceted process that involves lifestyle modifications, medication, and emerging therapies, all of which are best achieved through consistent monitoring. This holistic approach aims to enhance arterial elasticity, reduce cardiovascular risk, and improve overall quality of life.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"82-90"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Approach to Measure Heart-Carotid Pulse Wave Velocity by Using an Ultrasound-Based Method.","authors":"Franco Pessana, Ramiro Sanchez, Agustin Ramirez, Adrian Sebastián Miranda, Emiliano Ruisi B, Facundo Di Yelsi, Edmundo Cabrera Fischer","doi":"10.2174/0115734021415023251126112646","DOIUrl":"10.2174/0115734021415023251126112646","url":null,"abstract":"<p><strong>Introduction: </strong>Currently, regional or global assessments of vessel elasticity are performed by measuring pulse wave velocity (PWV) along a long arterial segment. However, this method of evaluating arterial stiffness is subject to bias due to several factors, including the difficulty of accurately measuring the arterial distance. The aim of this research was: (a) to develop a non-invasive method for calculating pulse wave velocity in the heart-carotid pathway (hc-PWV) using electrocardiographic and ultrasonic images; (b) to measure hc-PWV in an adult hypertensive population using this new method and compare the results with values reported in the specialized literature; and (c) to perform a correlation analysis between hc-PWV and heart- femoral pulse wave velocity (hf-PWV) in a population of adult hypertensive subjects.</p><p><strong>Methods: </strong>In this study, PWV was calculated using an image analysis technique developed in our laboratory. As an original technique, the theoretical background is first described, followed by its application in hypertensive volunteers. For each subject in the analysed population, the hc-PWV was calculated using the new technique, and the hc-PWV was measured using mechanotransducers.</p><p><strong>Results: </strong>in the analysed cohort of hypertensive patients, values of hc-PWV (8.57 ± 0.51 m/s) were similar to those obtained in the carotid-femoral pathway (8.57 ± 0.51 m/s versus 8.19 ± 1.27 m/s; PNS). Moreover, hc-PWV in our cohort of treated hypertensive patients (8.57 ± 0.51 m/s) was higher than that reported by other authors for healthy subjects in similar territories (4.9 ± 1.1 to 8.12 ± 3.54 m/s). Furthermore, the hc-PWV values in our cohort of treated hypertensive patients (8.57 ± 0.51 m/s) were lower than those reported in older subjects with systemic hypertension (11.56 ± 1.74 m/s). A significant correlation was observed between the hc-PWV and cf- PWV (r=0.73, p <0.05). A regression analysis was performed, yielding a slope of 0.2903.</p><p><strong>Discussion: </strong>This work showed a novel approach to measuring heart-carotid pulse wave velocity using ultrasound-based methods. In this initial exploration, our aim was not to evaluate or confirm a categorical result, but rather to highlight a trend toward a new methodology for calculating arterial stiffness, contrasted against previously validated standard methods.</p><p><strong>Conclusion: </strong>This study confirmed that hc-PWV can be calculated non-invasively using electrocardiographic and ultrasonic images. The calculated hc-PWV values were in the range of those reported in the literature.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"107-115"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146031331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial Stiffness Index as an Indicator of Coronary Artery Disease Presence and Severity.","authors":"Haihua Ye, Dingguo Zhang","doi":"10.2174/0115734021377631251001111712","DOIUrl":"10.2174/0115734021377631251001111712","url":null,"abstract":"<p><strong>Introduction: </strong>The arterial stiffness index (ASI) is a widely recognized metric used to assess arterial endothelial function and predict cardiovascular issues. This study has validated ASI as a non-invasive clinical assessment tool for atherosclerotic coronary artery disease (CAD).</p><p><strong>Methods: </strong>We conducted a retrospective, observational study involving 396 patients undergoing coronary angiography. ASI was measured using the CardioVision MS-2000 system, and the SYNTAX scores (SXscore) were computed to evaluate CAD severity. Patients were divided into two groups according to the SXscore: low SXscore (<22) and intermediate-high SXscore (≥ 22).</p><p><strong>Results: </strong>In total, 257 (64.9 %) patients had CAD, of whom 166 (64.6%) had low (<22), 75(29.2%) had intermediate (23-32), and 16 (6.2%) had high (≥ 33) SXscore. ASI was significantly higher in CAD patients (120.82 ± 76.26 mmHgx10) compared to non-CAD patients (56.60 ± 35.89 mmHgx10; p < 0.01). In the multivariate regression model, a significant association was observed between ASI and CAD, with an odds ratio (OR) of 1.031 [95% confidence interval (CI): 1.022-1.040; p < 0.0001]. Additionally, ASI demonstrated an independent association with both intermediate and high SXscore (adjusted OR: 1.027; 95% CI: 1.020-1.034; p < 0.0001). The levels of ASI differed significantly in groups of patients with control, low SXScore, and intermediate-high SXScore as follows: 56.60±35.89 mmHg×10, 92.67±51.79 mmHg×10, and 172.2±86.6 mmHg×10, respectively (p < 0.01). ASI exhibited 59% sensitivity and 90% specificity for recognizing CAD.</p><p><strong>Discussion: </strong>ASI serves as a non-invasive biomarker that independently predicts the risk of CAD and shows a positive correlation with coronary plaque burden and the severity of atherosclerosis. By assessing arterial elasticity and vascular endothelial function, this metric offers significant clinical value for the early detection of vascular dysfunction and subclinical atherosclerosis.</p><p><strong>Conclusion: </strong>Our findings suggested ASI to accurately evaluate arterial elastic function and provide information on CAD severity.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"96-106"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145379407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension-Mediated Organ Damages should be Divided into Acute and Chronic.","authors":"Goran Koracevic, Milovan Stojanovic, Marija Zdravkovic, Dragan Djordjevic, Miloje Tomasevic, Sonja Dakic, Tomislav Kostic, Dimitrije Pavlovic","doi":"10.2174/0115734021387631251016141754","DOIUrl":"10.2174/0115734021387631251016141754","url":null,"abstract":"<p><strong>Introduction: </strong>High blood pressure (BP) damages various structures. The damaged structures are named hypertension-mediated organ damages (HMODs). Some of HMODs are acute (i.e., intracranial haemorrhage), while the others are chronic (e.g., left ventricular hypertrophy (LVH)). The aim of the paper was to investigate how HMODs compare to each other, and to answer the question of whether HMODs are divided into acute and chronic forms in the major medical publications - guidelines.</p><p><strong>Methods: </strong>A search for 'acute hypertension-mediated organ damage' and 'acute target organ damage' was performed in the whole papers in SCOPUS. Moreover, the available guidelines on hypertension are analysed.</p><p><strong>Results: </strong>Our results show that the mentioned chronic HMODs differ a lot, both in number and qualitatively, i.e. which HMODs are specified. The difference regarding the number of HMODs listed reflects partially the different approach; some guidelines state organ damage in general, and the other guidelines provide extensive lists.</p><p><strong>Discussion: </strong>A substantial number of arterial hypertension (HTN) guidelines do not list both acute and chronic HMODs; several guidelines refer to acute HMODs, and some others to chronic HMODs. In a number of HTN guidelines, acute (e.g., intracranial haemorrhage) and chronic HMODs (such as LVH) were mixed. In the vast majority of guidelines, the acute and chronic HMODs are not directly divided.</p><p><strong>Conclusion: </strong>Consensus is clearly missing about the definition and classification of HMODs. Multiple reasons suggest that HMODs should be divided into acute and chronic subgroups. We presented some of the arguments and examples to start with.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"27-41"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145439463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Molecular Mechanisms of Diabetes mellitus, Hypertension, Cardiovascular Disease, and Chronic Kidney Disease: Clinical Insights and Future Perspectives.","authors":"Mallika Agrawal, Adarsh Kumar, Ankit Kumar Singh, Harshwardhan Singh, Praveen Kumar, Pradeep Kumar","doi":"10.2174/0115734021389208251113105243","DOIUrl":"10.2174/0115734021389208251113105243","url":null,"abstract":"<p><strong>Introduction: </strong>To decrypt the tangled interconnections that contribute to the concurrent worsening of hypertension, diabetes mellitus, cardiovascular diseases, and chronic kidney disease, this review focuses on how these interlinked health issues interact. The study aims to deepen our understanding of the complex relationships between diabetes, hypertension, CKD, and CVD, while identifying knowledge gaps that warrant further exploration.</p><p><strong>Methods: </strong>To gain insight into the shared pathophysiological mechanisms, this review investigates endothelial dysfunction, chronic inflammation, renin-angiotensin-aldosterone system activation, sympathetic nervous system hyperactivity, insulin resistance, and dyslipidemia. Data were extracted from reputable databases and search engines, including Medline, PubMed, Google Scholar, Scopus, Web of Science, Taylor and Francis, ScienceDirect/Elsevier, and Wiley Online Library.</p><p><strong>Results: </strong>This review emphasizes the necessity of comprehensive and integrative management strategies that account for multi-system interdependencies.</p><p><strong>Discussion: </strong>The rising prevalence of these conditions can be mitigated through preventive strategies such as lifestyle modification, physical activity, dietary interventions, stress management, and personalized clinical monitoring. Integrated lifestyle and medical interventions can significantly reduce the burden of interrelated chronic diseases.</p><p><strong>Conclusion: </strong>This comprehensive analysis serves as a vital resource for clinicians and researchers addressing these interconnected chronic health burdens. There is an urgent need for more targeted research into these synergistic disease mechanisms and their unified management.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"133-149"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145935427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Non-pharmacological Hypertension Management: DASH, Paleolithic, and Ketogenic Diet Comparisons: A Systematic Review.","authors":"Pranay Wal, Deepankar Rath, Neha Verma, Ankita Wal, Pallishree Bhukta, Arin Natania, Akash Ved, Prasanthi Samathoti, Amin Gasmi","doi":"10.2174/0115734021423628260212091911","DOIUrl":"10.2174/0115734021423628260212091911","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension impacts over one-third of the global population of adults and is a significant contributor to premature mortality, despite substantial progress in pharmaceutical interventions. Increasing evidence supports dietary strategies for the prevention and supplementary management of hypertension.</p><p><strong>Methods: </strong>This systematic review was conducted in accordance with PRISMA 2020 guidelines. Literature was retrieved from PubMed, MEDLINE, and Cochrane databases for studies published between 1995 and 2025, using the keywords: \"Hypertension,\" \"DASH Diet,\" \"Paleolithic Diet,\" \"Ketogenic Diet,\" \"Low-Carbohydrate Diet,\" \"Blood Pressure,\" and \"Cardiovascular Risk.\" Two investigators independently screened all titles and abstracts to determine eligibility for inclusion in the systematic analysis.</p><p><strong>Results: </strong>This review examined 13 studies involving approximately 87,597 individuals to evaluate the effects of four dietary strategies, DASH, Paleolithic, low-carbohydrate, and ketogenic diets, on hypertension. The DASH diet demonstrated persistent decreases in systolic blood pressure, particularly among adults. Low-carbohydrate and ketogenic diets enhanced both blood pressure and weight in overweight persons. The Paleolithic diet, supported by the most extensive sample, demonstrated significant advantages for blood pressure and metabolic health. All diets showed potential, with the Paleolithic and DASH diets emerging as the most effective approaches for hypertension management.</p><p><strong>Discussion: </strong>Non-pharmacological dietary interventions are increasingly recognized as high-impact and sustainable strategies for the management of hypertension. This review emphasizes that dietrelated strategies, most importantly the DASH and Paleolithic diets, are providing clinically significant reductions in blood pressure and cardiometabolic risk. Short-term outcomes are encouraging, but long-term safety and compliance are important concerns, especially for the ketogenic and lowcarb diets. Variation in study quality, sample size, and measures of adherence complicates direct comparisons. Personalization and integration with lifestyle are central to outcomes.</p><p><strong>Conclusion: </strong>Dietary interventions showed the highest potential for blood pressure prevention and control. The DASH and Paleolithic diets offer the strongest evidence to support their usage among all the therapies studied. However, further high-quality, long-term clinical studies would be needed to support these results and give evidence-based diet recommendations. Future efforts should focus on nutritional adequacy and sustained adherence to optimize outcomes in the hypertensive population.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"279-290"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}