Current Hypertension Reviews最新文献

{"title":"Self-care practices among elderly hypertensive patients living in the Highlands of Vietnam: A cross-sectional study.","authors":"Yen Hoang Thi Bach, Tuyen Hoang Dinh, Dong Ho Van, Tien Hoang Anh","doi":"10.2174/0115734021399247251204192008","DOIUrl":"https://doi.org/10.2174/0115734021399247251204192008","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is a growing burden among the elderly, particularly in lowand middle-income countries. Self-care practices are critical for hypertension management but understudied, especially in the Highlands region of Vietnam.</p><p><strong>Aims: </strong>This study aims to assess self-care practices among elderly hypertensive patients in the Highlands region of Vietnam and to determine factors associated with non-adherence. By identifying sociodemographic and clinical predictors of poor self-care adherence, the study seeks to provide insights for targeted interventions to enhance hypertension management in this vulnerable population.</p><p><strong>Methods: </strong>A cross-sectional study was carried out involving 438 hypertensive patients aged 60 and older managed at six commune health centers. Self-care practices were assessed across six HSCALE domains. Data were collected via interviews, medical records, and blood pressure (BP) measurements, with adherence defined as meeting criteria in at least four domains. Multiple logistic regression was used to analyze factors associated with non-adherence.</p><p><strong>Results: </strong>Overall, 85.4% of participants adhered to self-care practices, with domain-specific adherence ranging from 39.5% (weight management) to 96.1% (low-sodium diet). Despite high adherence, only 12.8% achieved normotension. Non-adherence was associated with male sex [Adjusted Odds Ratio (AOR) = 4.73, 95% Confidence Interval (CI): 2.40 - 9.34], illiterate (AOR = 3.08, 95% CI: 1.18 - 8.03), currently working for income (AOR = 2.01, 95% CI: 1.10 - 3.67), isolated systolic hypertension (AOR = 2.34, 95% CI: 1.24 - 4.40), and poor hypertension knowledge (AOR = 4.57, 95% CI: 2.45 - 8.51).</p><p><strong>Conclusion: </strong>This study highlights the importance of comprehensive self-care strategies in hypertension control among the elderly. Despite high overall adherence, the persistence of inadequate BP control underscores the need for more effective weight management and tailored interventions. Findings emphasize the role of health literacy, socioeconomic factors, and clinical characteristics in shaping self-care behaviors, which could inform future policy and community-based hypertension management programs.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147491975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Medication Non-compliance among Hypertensive and Diabetic Patients in Jordan: A Prospective Cohort Study.","authors":"Mohammad Hassan Al-Thnaibat, Mohammad Hijab Alkubaisi, Aouf Alazzawi, Ja'far Saeed Alsheyyab, Seri Saed Sawaqed, Bayan Sami Al Srour, Marwa Mohammad Marahleh, Buthaina Yihea Altowara, Osama Wadah Rammaha, Mus'ab Theeb Mustafa","doi":"10.2174/0115734021421550260109060131","DOIUrl":"https://doi.org/10.2174/0115734021421550260109060131","url":null,"abstract":"<p><strong>Introduction: </strong>While medication non-compliance for hypertension (HTN) and type II diabetes mellitus (T2DM) patients drives poor outcomes globally, its specific clinical and financial impact in Jordan is poorly quantified. This study aimed to determine the prevalence of medication noncompliance, quantify its effect on hospitalization rates and costs, and assess the role of sociodemographic factors in a Jordanian patient cohort.</p><p><strong>Methods: </strong>A prospective cohort study was conducted at a major Jordanian hospital from 2022 to 2023. A final sample of 159 patients with HTN and/or T2DM was followed for one year. Participants were classified as compliant (n = 86) or non-compliant (n = 73) based on patient self-reports and pharmacy refill data. Hospitalization rates, intensive care unit admissions, and sociodemographic data were compared between groups.</p><p><strong>Results: </strong>The prevalence of poor compliance was 45.9% (n = 73). Poor compliance was strongly associated with hospitalization (p < 0.001). Non-compliant patients had significantly higher rates of floor admissions (82.6% vs. 16.4%) and intensive care unit admissions (37.2% vs. 0%) compared to the compliant group (n = 86). This resulted in substantially higher healthcare costs. After statistical adjustment, poor compliance was the most powerful independent predictor of hospital admission (Adjusted Odds Ratio 45.78), while baseline sociodemographic factors were not significantly associated with admission.</p><p><strong>Discussion: </strong>Our findings highlight that medication non-compliance is a major cause of hospitalizations and escalating healthcare costs in Jordan. The prevalence of non-adherence observed in our cohort (45.9%) aligns with trends reported in neighboring regional studies. Consequently, further research into the specific socio-behavioral barriers to adherence is essential.</p><p><strong>Conclusion: </strong>Medication non-compliance is a prevalent and critical driver of preventable hospital admissions and high healthcare costs among Jordanian patients with HTN and T2DM. These findings underscore an urgent need for targeted interventions to improve compliance and reduce the associated healthcare burden.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147491957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Serum ADMA with Endothelial Dysfunction in Chronic Periodontitis and Coronary Heart Disease Patients.","authors":"Afsheen Zehra, Hasan Ali, Farzeen Tanwir, Sadia Rehman, Areeb Arif Khan, Anila Bibi","doi":"10.2174/0115734021434691260120091010","DOIUrl":"https://doi.org/10.2174/0115734021434691260120091010","url":null,"abstract":"<p><strong>Introduction: </strong>Asymmetric Dimethylarginine (ADMA), a natural NO production inhibitor, is a key indicator of endothelial dysfunction. ADMA damages vessels and endothelial function by inhibiting NO-mediated vasodilation. Periodontal disease and cardiovascular diseases, especially CHD, share risk factors and inflammatory pathways, suggesting a mechanistic relationship. ADMA may be a molecular mediator between periodontitis and cardiovascular disease. This study examines serum ADMA levels as a biomarker of endothelial dysfunction in periodontitis and CHD patients. The study also examines lipid profile and periodontal factors to better understand the complex relationship between dental and cardiovascular health.</p><p><strong>Methods: </strong>In this case-control study, after the attainment of FRC and ERC approval, 22 subjects with Chronic Periodontitis (CP), 22 subjects with Coronary Heart Disease (CHD), 22 subjects with both periodontitis and Coronary Heart Disease (CHD), and 22 systemically healthy individuals aged between 30 and 60 years were recruited. All the male and female individuals were selected on the basis of inclusion criteria prior to taking written informed consent. The clinical and periodontal parameters (plaque index, probing depth, clinical attachment level, and bleeding on probing) were assessed in the participants of the study. The overnight fasting blood samples of patients were obtained for analysis of ADMA, C-reactive protein, and total cholesterol and triglycerides.</p><p><strong>Results: </strong>The results were analyzed with SPSS version 23.0. Adma was significant in all the groups (CP, CHD, CP+CHD, and controls). Subsequently, the levels of TC and hs-CRP were significantly different among the groups. The periodontal clinical parameters, which include the number of teeth, PD, CAL, BoP%, and PI, were also significant among all the groups (p<0.05). Multivariate regression analysis showed a significant positive association for the case groups (CP, CHD, and CP+CHD) for ADMA.</p><p><strong>Discussion: </strong>Chronic periodontitis patients, especially those with coronary heart disease, have raised ADMA levels and systemic inflammatory markers, according to the study. These data suggest that chronic periodontal inflammation may cause endothelial dysfunction, connecting oral and cardiovascular illness. The cumulative impact in the CP+CHD group shows that periodontal and vascular inflammation work together. Thus, elevated ADMA may identify cardiovascular-risk periodontitis patients.</p><p><strong>Conclusion: </strong>Our results specified that serum ADMA levels may be a valuable measure of endothelial dysfunction in individuals with periodontal disease and coronary heart disease.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Variability of Response to Amlodipine and Its Relation with the Angiotensinogen M235T Genotype among a Sample of Hypertensive Patients in Jordan.","authors":"Yazun Jarrar, Hussein Alhawari, Malek Zihlif, Ayman Wahbeh, Sameeha Alshelleh, Khaled Ojjoh, Dalia Abdelrazaq, Muhammad Feras Al-Hawari, Hussam Alhawari","doi":"10.2174/0115734021396078251121053232","DOIUrl":"https://doi.org/10.2174/0115734021396078251121053232","url":null,"abstract":"<p><p><p> Introduction: Amlodipine, a calcium channel blocker, is widely used to treat hypertension, but its effectiveness varies among individuals. Clinicians have observed this variability, and previous research suggests that the Angiotensinogen (AGT) M235T genotype influences response to antihypertensive drugs like valsartan. This study investigates the association between the AGT M235T genetic variant and non-genetic anthropometric factors, and the response to amlodipine in essential hypertensive patients at the University of Jordan Hospital. </p><p> Methods: A cohort of 46 unrelated Arabic Jordanian patients with essential hypertension was enrolled. Baseline systolic and diastolic blood pressure (BP) readings were recorded before initiating 5 mg amlodipine, with follow-up measurements taken after one month. AGT M235T genotyping was performed using PCR-RFLP, and non-genetic data were obtained from hospital records. </p><p> Results: It was found that 28.3% of the tested patients did not respond to amlodipine. The heterozygous AGT M235T genotype showed a significantly (p < 0.05, t-test) lower reduction in the BP compared to wild-type carriers, and its frequency was significantly higher (p < 0.05, ꭙ2 test) among the non-responders to amlodipine. In addition, the average age of the non-responders (41.5±10.3 years) was significantly (p < 0.05, t-test) lower than that of responders (47±10 years) to amlodipine. </p><p> Discussion: The heterozygous AGT M235T genotype partially explained inter-individual variation in response to amlodipine among hypertensive patients of Jordanian Arab origin. </p><p> Conclusion: It can be concluded that the AGT M235T heterozygous genotype is linked to reduced amlodipine response, while older age is associated with a higher efficacy. However, further multi-center studies with larger cohorts are needed to confirm these findings.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147460420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Strength Training on Blood Pressure in Older Hypertensive Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Diego Gama Linhares, Gustavo Gonçalves Cardozo, Bruno Gama Linhares, Claudio Joaquim Borba-Pinheiro, Rodrigo Gomes de Souza Vale","doi":"10.2174/0115734021411110251113064207","DOIUrl":"https://doi.org/10.2174/0115734021411110251113064207","url":null,"abstract":"<p><strong>Introduction: </strong>Controlling high blood pressure in older adults is essential for managing cardiovascular risk, as outlined in major guidelines around the world. This study aimed to investigate the effects of strength training on blood pressure in older individuals with hypertension.</p><p><strong>Methods: </strong>This meta-analysis followed the PRISMA guidelines and PICOS strategy. The databases used were MEDLINE (via PubMed), Web of Science, Scopus, and SciELO. The tools used for assessing risk of bias and methodological quality were Rob2 and TESTEX. In the meta-analysis, RevMan 5.4 software was employed.</p><p><strong>Results: </strong>After the search process, 8,760 publications were identified, and 6 RCTs were included in this systematic review and meta-analysis. The average age of the population was 69 years, and the total number of participants in the CG and EG was 134 and 191, respectively. The average training volume (VT) was 68 minutes per session, three times a week, over 11 weeks of intervention. In the SBP variable, the forest plot presented 6 studies and 8 analyses. The mean difference (MD) was -8.81 (-17.16 to -0.46) (I² = 95%, p < 0.00001), indicating an improvement in SBP (p= 0.04). In the DBP variable, n=6 studies and 8 analyses were included. The MD was -4.53 (-7.89 to -1.18) (I² = 88%, p< 0.001). Therefore, the mean result differed significantly from zero (p = 0.008), indicating improvement in the DBP variable.</p><p><strong>Conclusion: </strong>This meta-analysis concluded that strength training reduces systolic and diastolic blood pressure in older hypertensive individuals.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145935403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Drug for Resistant Hypertension: Aprocitentan.","authors":"Jaspreet Kaur Sidhu, Deepti Chopra, Abhinav Goyal, Yangshen Lhamo","doi":"10.2174/0115734021433257251128044458","DOIUrl":"https://doi.org/10.2174/0115734021433257251128044458","url":null,"abstract":"<p><p>Resistant hypertension (RH) is defined as uncontrolled blood pressure (BP) despite the use of three or more antihypertensive agents of different pharmacological classes. The treat-ment of resistant hypertension remains a challenge, as it is associated with a heightened risk of cardiovascular events. Many preclinical studies have demonstrated the importance of the endo-thelin pathway in resistant hypertension; however, the therapeutic application of endothelin an-tagonists in clinical practice has been limited due to various factors. Recently, in March 2024, the FDA approved aprocitentan, an orally active endothelin-1 (ET-1) receptor antagonist that inhibits the binding of ET-1 to ETA and ETB receptors. This is the first medication with a novel mechanism for the treatment of resistant hypertension. This review aims to summarise the avail-able evidence on the discovery, chemical nature, pharmacokinetics, pharmacodynamics, effi-cacy, and safety of the novel drug aprocitentan in the pharmacotherapy of resistant hyperten-sion. The landmark PRECISION trial demonstrated a significant BP-lowering effect with the use of the dual endothelin receptor antagonist aprocitentan in the treatment of resistant hyper-tension. Aprocitentan was shown to be particularly effective in patients over 75 years of age, those with a higher cardiovascular-risk profile, patients with diabetes, and individuals with ad-vanced chronic kidney disease (CKD). As a dual receptor antagonist, aprocitentan demonstrated a lower risk of fluid retention and vascular leakage, adverse effects previously observed with other endothelin receptor antagonists. Its mechanism of action, improved efficacy, and excellent tolerability make aprocitentan a promising therapeutic option for resistant hypertension. It may be particularly effective in the treatment of patients with comorbidities, such as diabetes and CKD.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Adherence in Moroccan Hypertensive Patients: Influence of Socioeconomic Status and Fixed-Dose Combination Therapy.","authors":"Yasmine Ouaddouh, Zakaria Bazid, Nabila Ismaili, Noha El Ouafi","doi":"10.2174/0115734021398378251014103137","DOIUrl":"10.2174/0115734021398378251014103137","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension represents a major public health challenge, contributing to the global health burden. Lifestyle modifications and pharmacotherapeutic interventions are the cornerstones in the management of hypertension. However, suboptimal adherence remains a critical impediment to achieving desired clinical outcomes, stemming from a complex interplay of socioeconomic factors, access to care, and affordability of medications. Therefore, the objective of this study was to assess adherence to lifestyle modifications and drug therapy and their associated factors.</p><p><strong>Methods: </strong>A monocentric cross-sectional study was conducted on 200 hypertensive patients from July 1st to October 30, 2022. Participants were selected using a consecutive sampling technique. Adherence to lifestyle modifications was assessed through questions filled in a data sheet, with consumption of salt and the DASH diet evaluated using a Food Frequency Questionnaire and the Hill-Bone Compliance to High Blood Pressure Therapy Scale, while medication adherence was assessed using the Morisky Medication Adherence Scale with 4 items (MMAS-4).</p><p><strong>Results: </strong>The overall adherence to lifestyle modifications was 39.8%, with good adherence to fruit and vegetable consumption at 59.5%, adherence to a low-salt diet at 43%, and physical activity at 24.5%. According to the MMAS-4, poor medication adherence was observed in 58.3% of our patients and was associated with advanced age (>60 years; p = 0.014), low socio-economic level (p = 0.012), and use of free-dose combination therapy (p = 0.001).</p><p><strong>Discussion: </strong>Our study demonstrates that poor adherence critically undermines hypertension control, while patient education and fixed-dose combination therapies improve outcomes. However, variability across populations and healthcare contexts limits generalizability and warrants further multicenter research.</p><p><strong>Conclusion: </strong>The findings of this study indicate that therapeutic adherence among individuals with hypertension remains suboptimal, highlighting the need for a comprehensive, multifactorial strategy to address the diverse and intersecting determinants of nonadherence.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"61-69"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145439528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Functions and Gene Polymorphism Associated with Cardiovascular Risk in Young Adults vs. Patients with Arterial Hypertension.","authors":"Anastasiya Yu Elkina, Yury G Shvarts, Anton R Kiselev, Natalya S Akimova","doi":"10.2174/0115734021428732251226052716","DOIUrl":"10.2174/0115734021428732251226052716","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to examine the relationship between cognitive functions and gene polymorphism associated with cardiovascular risk in young adults and patients with arterial hypertension (AH).</p><p><strong>Methods: </strong>The observational study involved 152 subjects, among whom there were 2 independent groups: a group of young healthy volunteers and a group of hypertensive patients. Cognitive functions were assessed using subtests 5 and 7 of the Wechsler Scale and the Bourdon test. Genetic testing was carried out for the following polymorphisms: APOC3 -482 C>T (rs2854117), PON1 L55M A>T (rs854560), and PON1 Q192R A>G (rs662). Identification of gene polymorphisms was performed via DNA pyrosequencing.</p><p><strong>Results: </strong>In both groups (young individuals and patients with AH), the presence of the Q192R A>G polymorphism of the PON1 gene was associated with worse results on cognitive tests. In young people, lower levels of concentration of attention, as well as the degree of mastery of visual-motor skills, were also associated with the -482 C>T polymorphism of the APOC3 gene and L55M A>T of the PON1 gene.</p><p><strong>Discussion: </strong>A relationship was identified between cognitive functions and polymorphism of genes associated with cardiovascular risk. The presence of the Q192R A>G polymorphism A allele of the PON1 gene accounted for the worst results of cognitive tests, both in young adults and patients with AH.</p><p><strong>Conclusion: </strong>It should be noted that polymorphic variants of genes involved in lipid metabolism and antioxidant defense-namely, the -482 C>T variant of the APOC3 gene and the L55M A>T variant of the PON1 gene-are significantly associated with lower cognitive test scores in young individuals. The genetic analysis, including the determination of the Q192R A>G polymorphism of the PON1 gene and the -482 C>T polymorphism of the APOC3 gene, may be included in the examination of patients with arterial hypertension to predict the development of cognitive dysfunction.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":"22 4","pages":"291-300"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension and Intracranial Hypertension Association: A Narrative Review.","authors":"Mikaelle Costa Correia, Sayuri Inuzuka, Matheus Martins da Costa, Priscila Valverde de Oliveira Vitorino, Polyana Vulcano de Toledo Piza, Gustavo Frigieri, Ana Luiza Lima Sousa, Antonio Coca, Weimar Kunz Sebba Barroso","doi":"10.2174/0115734021394152250922224959","DOIUrl":"10.2174/0115734021394152250922224959","url":null,"abstract":"<p><p>Hypertension and intracranial hypertension are associated with distinct clinical contexts, encompassing both neurological and cardiovascular implications. Hypertension induces significant structural and functional alterations in cerebral arteries, such as vascular wall thickening, increased arterial stiffness, reduced vascular compliance, and endothelial dysfunction, all of which can contribute to elevated intracranial pressure. These vascular changes may impair the integrity of the blood-brain barrier and disrupt cerebral autoregulation, thereby diminishing the brain's ability to effectively regulate cerebral blood flow in response to physiological demands. The persistence of these dysfunctions over time may increase the risk of neurological outcomes, including stroke, cerebral edema, and cognitive impairment. Intracranial hypertension in turn may remain subclinical in patients with chronic hypertension, particularly when there is a gradual loss of intracranial compliance. This potential link highlights the need for further studies on the topic. Emerging evidence points to advances in noninvasive techniques for intracranial hypertension assessment, which may enable the early identification of altered intracranial dynamics and promote broader clinical application. Although the association between hypertension and intracranial hypertension has not yet been fully elucidated, the literature suggests overlapping mechanisms that may be clinically relevant. Combined assessment of blood pressure and intracranial parameters could represent a complementary strategy for better understanding cerebrovascular risk in selected populations. In this narrative review, we discuss the potential association between hypertension and intracranial hypertension, emphasizing their pathophysiological connections, contributing risk factors, and potential consequences for brain structure and function. Further research is needed to clarify these associations and their implications in clinical practice.</p>","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":" ","pages":"73-81"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial Stiffness in Hypertension and Left Ventricular Dysfunction, PWV, Heart Failure.","authors":"Ramiro Sanchez","doi":"10.2174/0115734021474573260508035737","DOIUrl":"https://doi.org/10.2174/0115734021474573260508035737","url":null,"abstract":"","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":"22 2","pages":"71-72"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}