Current Hypertension Reviews最新文献_第6页

Atrial Fibrillation and Hypertension: "Quo Vadis". 心房颤动和高血压:“Quo Vadis”。

IF 2.3

Current Hypertension Reviews Pub Date : 2022-01-01 DOI: 10.2174/1573402118666220112122403

McCall Walker, Paras Patel, Osung Kwon, Ryan J Koene, Daniel A Duprez, Younghoon Kwon

{"title":"Atrial Fibrillation and Hypertension: \"Quo Vadis\".","authors":"McCall Walker, Paras Patel, Osung Kwon, Ryan J Koene, Daniel A Duprez, Younghoon Kwon","doi":"10.2174/1573402118666220112122403","DOIUrl":"https://doi.org/10.2174/1573402118666220112122403","url":null,"abstract":"Hypertension is one of the most well-established risk factors for atrial fibrillation. Longstanding untreated hypertension leads to structural remodeling and electrophysiologic alterations, causing an atrial myopathy that forms a vulnerable substrate for the development and maintenance of atrial fibrillation. Hypertension-induced hemodynamic, inflammatory, hormonal, and autonomic changes all appear to be important contributing factors. Furthermore, hypertension is also associated with several atrial fibrillation-related comorbidities. As such, hypertension may represent an important target for therapy in atrial fibrillation. Clinicians should be aware of the pitfalls of blood pressure measurement in atrial fibrillation. While the auscultatory method is preferred, the use of automated devices appears to be an acceptable method in the ambulatory setting. There are pathophysiologic basis and emerging clinical evidence suggesting the benefit of renin-angiotensin system inhibition in risk reduction of atrial fibrillation development, particularly in patients with left ventricular hypertrophy or left ventricular dysfunction. A better understanding of hypertension's pathophysiologic link to atrial fibrillation may lead to the development of novel therapies for the primary prevention of atrial fibrillation. Finally, future studies are needed to address the strategies of optimal blood pressure to minimize the risk of atrial fibrillation-related complications.","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":"18 1","pages":"39-53"},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39678017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Predictive Factors for the Care and Control of Hypertension Based on the Health Belief Model Among Hypertensive Patients During the COVID-19 Epidemic in Sirjan, Iran. 基于健康信念模型的伊朗锡尔扬地区新冠肺炎疫情期间高血压患者高血压护理与控制的预测因素

IF 2.3

Current Hypertension Reviews Pub Date : 2022-01-01 DOI: 10.2174/1573402117666210603115309

Reza Sadeghi, Mahmood Reza Masoudi, Athina Patelarou, Narges Khanjani

{"title":"Predictive Factors for the Care and Control of Hypertension Based on the Health Belief Model Among Hypertensive Patients During the COVID-19 Epidemic in Sirjan, Iran.","authors":"Reza Sadeghi, Mahmood Reza Masoudi, Athina Patelarou, Narges Khanjani","doi":"10.2174/1573402117666210603115309","DOIUrl":"https://doi.org/10.2174/1573402117666210603115309","url":null,"abstract":"Background: Hypertension is a leading risk factor for morbidity and mortality around the world. Preventing this health problem is considered an important priority. The aim of this study was to investigate the predictive factors for care and control of hypertension (CCH) according to the health belief model (HBM), in patients with hypertension during the COVID-19 epidemic in Sirjan, Iran.Methods: In this cross-sectional study, participants were chosen by simple random sampling. Data were collected by a valid and reliable researcher-made questionnaire from 200 patients with high blood pressure aged 30-60 years. Data were analyzed by SPSS21 and analysis based on descriptive statistics, Pearson correlation coefficients, and linear regression was conducted.Results: The results of Pearson correlation coefficients showed that there was a significant correlation among almost all constructs of the Health Belief Model (HBM), but the strongest correlations were between self-efficacy and perceived susceptibility (r = 0.940, P ≤ 0.001), and between perceived barriers with perceived benefits (r = -0.615, P ≤ 0.001). According to linear regression, perceived barriers (β = -0.291), cues to action (β = -0.590), and knowledge (β = 0.973) predicted more than 26% of CCH variability. Knowledge had a stronger role than other variables.Conclusion: The results of this study show that the constructs of the Health Belief Model can predict CCH in hypertensive patients. This model can be used as a tool for designing and implementing educational interventions to increase CCH among hypertensive patients.","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":"18 1","pages":"78-84"},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38977895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

(Pro)renin Receptor and Blood Pressure Regulation: A Focus on the Central Nervous System. 肾素受体与血压调节:以中枢神经系统为中心。

IF 2.3

Current Hypertension Reviews Pub Date : 2022-01-01 DOI: 10.2174/1570162X20666220127105655

Lucas A C Souza, Yumei Feng Earley

{"title":"(Pro)renin Receptor and Blood Pressure Regulation: A Focus on the Central Nervous System.","authors":"Lucas A C Souza, Yumei Feng Earley","doi":"10.2174/1570162X20666220127105655","DOIUrl":"https://doi.org/10.2174/1570162X20666220127105655","url":null,"abstract":"The renin-angiotensin system (RAS) is classically described as a hormonal system in which angiotensin II (Ang II) is one of the main active peptides. The action of circulating Ang II on its cognate Ang II type-1 receptor (AT1R) in circumventricular organs has important roles in regulating the autonomic nervous system, blood pressure (BP) and body fluid homeostasis, and has more recently been implicated in cardiovascular metabolism. The presence of a local or tissue RAS in various tissues, including the central nervous system (CNS), is well established. However, because the level of renin, the rate-limiting enzyme in the systemic RAS, is very low in the brain, how endogenous angiotensin peptides are generated in the CNS-the focus of this review-has been the subject of considerable debate. Notable in this context is the identification of the (pro)renin receptor (PRR) as a key component of the brain RAS in the production of Ang II in the CNS. In this review, we highlight cellular and anatomical locations of the PRR in the CNS. We also summarize studies using gain- and loss-of function approaches to elucidate the functional importance of brain PRR-mediated Ang II formation and brain RAS activation, as well as PRR-mediated Ang II-independent signaling pathways, in regulating BP. We further discuss recent developments in PRR involvement in cardiovascular and metabolic diseases and present perspectives for future directions.","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":"18 2","pages":"101-116"},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10605864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Blood Pressure Responses in Firefighters: A Review. 消防员的血压反应:综述。

IF 2.3

Current Hypertension Reviews Pub Date : 2022-01-01 DOI: 10.2174/1573402118666220103094201

Carly McMorrow, Deborah L Feairheller

{"title":"Blood Pressure Responses in Firefighters: A Review.","authors":"Carly McMorrow, Deborah L Feairheller","doi":"10.2174/1573402118666220103094201","DOIUrl":"https://doi.org/10.2174/1573402118666220103094201","url":null,"abstract":"Blood pressure (BP) responses are controlled by various factors and understanding how BP changes is important to occupational health. This paper presents a review of the literature that reports BP responses in the firefighter population. Hypertension is one of the main risk factors underlying the pathophysiology of cardiovascular disease (CVD), and cardiac incidents remain the leading cause of line-of-duty deaths in firefighters. Risk factors for line-of-duty deaths include obesity, previous or underlying heart disease, and hypertension. The occupation of firefighting is one of the most hazardous and dangerous jobs, yet over 50 % of firefighters are volunteers. Tactical operations and the hazardous nature of firefighting are exposures that influence stress responses and, therefore, affect BP. In fact, hypertension in firefighters often remains undocumented or undiagnosed. CVD risk and elevated BP in tactical populations, like firefighters, maybe a combination of physical and emotional stress due to the nature of the job. Cross-sectional studies have reported that firefighters have higher levels of BP and higher rates of hypertension compared to civilians. Interestingly, there is a limited amount of research that reports BP values before and after firefighting- related activities, and very few studies on interventional changes in BP. Here, we synthesize the literature on firefighting and provide a summary of the studies that report pre- and post- BP levels that relate to CVD risk factors, occupational factors, firefighting activities, and the data on exercise training and BP. More studies are needed that examine BP in firefighters and report on the changes in BP with occupational activities.","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":"18 2","pages":"145-152"},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10616120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Target Blood Pressure and Combination Therapy: Focus on Angiotensin Receptor Blockers Combination with Either Calcium Channel Blockers or Beta Blockers. 目标血压和联合治疗:关注血管紧张素受体阻滞剂联合钙通道阻滞剂或受体阻滞剂。

IF 2.3

Current Hypertension Reviews Pub Date : 2022-01-01 DOI: 10.2174/1573402118666220627120254

Selvia M Farag, Hoda M Rabea, Mohamed Ea Abdelrahim, Hesham B Mahmoud

{"title":"Target Blood Pressure and Combination Therapy: Focus on Angiotensin Receptor Blockers Combination with Either Calcium Channel Blockers or Beta Blockers.","authors":"Selvia M Farag, Hoda M Rabea, Mohamed Ea Abdelrahim, Hesham B Mahmoud","doi":"10.2174/1573402118666220627120254","DOIUrl":"https://doi.org/10.2174/1573402118666220627120254","url":null,"abstract":"Background: The target blood pressure has changed many times in the guidelines in past years. However, there is always a question; is it good to lower blood pressure below 120/80 or not? Control of blood pressure in hypertension is very important in reducing hypertension-modified organ damage. So, the guidelines recommend combining more than one antihypertensive drug to reach the target blood pressure goal.Results: Combination therapy is recommended by guidelines to reach the blood pressure goal. The guidelines recommend many combinations, such as the combination of angiotensin receptor blockers with either calcium channel blockers (CCB) or beta-blocker (BB). Angiotensin receptor blocker (ARB) combination with CCB has gained superiority over other antihypertension drug combinations because it reduces blood pressure and decreases the incidence of CV events and organ damage. BB combinations are recommended by guidelines in patients with ischemic events but not all hypertensive patients. Unfortunately, the new generation BB, for example, nebivolol, has a vasodilator effect, making it new hope for BB.Conclusion: Combination therapy is a must in treating the hypertensive patient. The new generation BBs may change the recommendations of guidelines because they have an effect that is similar to CCBs.","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":"18 2","pages":"138-144"},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10617389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Genetic Polymorphisms as an Epidemiological Factor of Arterial Hypertension in Patients with Hyposodical Diet. 新的遗传多态性作为低钠饮食患者动脉高血压的流行病学因素。

IF 2.3

Current Hypertension Reviews Pub Date : 2022-01-01 DOI: 10.2174/1573402117666210204205447

Sabina López-Toledo, Sergio A Ramírez-García, Carlos E Cabrera-Pivaral, Luis Javier Flores-Alvarado, Dalia Madrigal Ruiz, María E Aguilar Aldrete, Felipe Parada-Luna

引用次数: 0

Shedding Light on the Pathophysiology of Preeclampsia-Syndrome in the Era of Cardio-Obstetrics: Role of Inflammation and Endothelial Dysfunction. 揭示子痫前期综合征在心产时代的病理生理:炎症和内皮功能障碍的作用。

IF 2.3

Current Hypertension Reviews Pub Date : 2022-01-01 DOI: 10.2174/1573402117666210218105951

María M Pereira, Juan Torrado, Claudio Sosa, Yanina Zócalo, Daniel Bia

{"title":"Shedding Light on the Pathophysiology of Preeclampsia-Syndrome in the Era of Cardio-Obstetrics: Role of Inflammation and Endothelial Dysfunction.","authors":"María M Pereira, Juan Torrado, Claudio Sosa, Yanina Zócalo, Daniel Bia","doi":"10.2174/1573402117666210218105951","DOIUrl":"https://doi.org/10.2174/1573402117666210218105951","url":null,"abstract":"Background: Preeclampsia (PE) is a pregnancy complication with serious maternal and neonatal consequences worldwide. Our understanding of PE pathophysiology has significantly evolved over the last decades by recognizing that endothelial dysfunction and systemic inflammation, with an associated angiogenic imbalance, are key pieces of this incomplete puzzle. In the present era, where no single treatment to cure or treat this obstetric condition has been developed so far, PE prevention and early prediction are the most useful clinical approach to reduce the PE burden.Introduction: Although most PE episodes occur in healthy nulliparous women, the identification of specific clinical conditions that increase the risk of PE dramatically provides a critical opportunity to improve outcomes by acting on potentially reversible factors, and also contributes to better understand this pathophysiologic enigma.Methods: Pertinent studies were searched in PubMed/Medline and Google Scholar (updated August 2020) using common keywords applied in the field of preeclampsia, inflammation and endothelial dysfunction. Given the design of this work as a narrative review, no formal criteria for study selection or appraisal were utilized.Conclusion: In this review, we highlight major clinical contributors of PE and shed light on their potential link with endothelial dysfunction and inflammation.","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":"18 1","pages":"17-33"},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25381853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hormone-Dependent Regulation of Renin and Effects on Prorenin Receptor Signaling in the Collecting Duct. 肾素的激素依赖性调控及其对肾素收集管中原肾素受体信号传导的影响。

IF 2.3

Current Hypertension Reviews Pub Date : 2022-01-01 DOI: 10.2174/1573402118666220216105357

Lucienne S. Lara, Alexis A. Gonzalez, Matthew T. Hennrikus, Minolfa C. Prieto

{"title":"Hormone-Dependent Regulation of Renin and Effects on Prorenin Receptor Signaling in the Collecting Duct.","authors":"Lucienne S. Lara, Alexis A. Gonzalez, Matthew T. Hennrikus, Minolfa C. Prieto","doi":"10.2174/1573402118666220216105357","DOIUrl":"https://doi.org/10.2174/1573402118666220216105357","url":null,"abstract":"The production of renin by the principal cells of the collecting duct has widened our understanding of the regulation of intrarenal angiotensin II (Ang II) generation and blood pressure. In the collecting duct, Ang II increases the synthesis and secretion of renin by mechanisms involving the activation of Ang II type 1 receptor (AT1R) via stimulation of the PKCα, Ca2+, and cAMP/PKA/CREB pathways. Additionally, paracrine mediators, including vasopressin (AVP), prostaglandins, bradykinin (BK), and atrial natriuretic peptide (ANP), regulate renin in principal cells. During Ang II-dependent hypertension, despite plasma renin activity suppression, renin and prorenin receptor (RPR) are upregulated in the collecting duct and promote de novo formation of intratubular Ang II. Furthermore, activation of PRR by its natural agonists, prorenin and renin, may contribute to the stimulation of profibrotic factors independent of Ang II. Thus, the interactions of RAS components with paracrine hormones within the collecting duct enable tubular compartmentalization of the RAS to orchestrate complex mechanisms that increase intrarenal Ang II, Na+ reabsorption, and blood pressure.","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":"18 2","pages":"91-100"},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132771/pdf/nihms-1888356.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9349397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences Among Sexes in Blood Pressure: A Combinatorial Consequence of the Differences between RAAS Components, Sex Hormones, and Time Course. 血压的性别差异:RAAS成分、性激素和时间进程差异的组合结果。

IF 2.3

Current Hypertension Reviews Pub Date : 2022-01-01 DOI: 10.2174/1573402117666210511011444

Xiaomei Yang, Shien Liu, Zhongming Zhang

引用次数: 2

The High Potency of Polymeric Nanoparticles in the Drug Delivery System for Hypertension Treatment: A Systematic Review. 高效聚合物纳米颗粒在高血压治疗药物传递系统中的应用:系统综述。

IF 2.3

Current Hypertension Reviews Pub Date : 2022-01-01 DOI: 10.2174/1573402117666210921121622

Fatemeh Mohammadipour, Aliasghar Kiani, Arash Amin

{"title":"The High Potency of Polymeric Nanoparticles in the Drug Delivery System for Hypertension Treatment: A Systematic Review.","authors":"Fatemeh Mohammadipour, Aliasghar Kiani, Arash Amin","doi":"10.2174/1573402117666210921121622","DOIUrl":"https://doi.org/10.2174/1573402117666210921121622","url":null,"abstract":"Background: Polymeric nanomaterials with sizes ranging from 10 to 1000 nm are one of the most widely used types of nanoparticles with ideal properties in the drug delivery systems. Here, we decided to systematically review the antihypertensive effects of polymeric nanomaterials in vitro, in vivo, and clinical trials.Methods: The present review was conducted based on the 06- PRISMA guideline; whereas five English databases, including Scopus, PubMed, Web of Science, EMBASE, and Google Scholar without time limitation were used for searching the publications related to antihypertensive effects of natural and synthetic polymeric nanoparticles.Results: The results demonstrated that among 1701 papers, 25 papers including 11 in vitro (44%), 6 in vivo (24%), 7 in vitro / in vivo (28%), and 1 in vitro / ex vivo (4%) up to 2020, met the inclusion criteria for discussion in this systematic review. The most used nanoparticles were poly-(lactic- co-glycolic) acid nanoparticle (PLGANPs) (7, 29.2%), chitosan based nanoparticles (6, 25%), followed by polylactide acid nanoparticles (5, 20.8%).Conclusion: We concluded that the high potency of polymeric nanoparticles in the drug delivery system was for hypertension treatment. Although the accurate mechanisms are not fully understood; however, some mechanisms, such as sustained release forms with increased bioavailability, increasing oral bioavailability and improving the oral and non-oral absorption, counteracting excessive superoxide and decreasing blood pressure, etc. can be related to these nanoparticles.","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":"18 1","pages":"54-63"},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39436661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2