Current Hypertension Reviews最新文献_第7页

Meet the Section Editor 会见剖面编辑器

IF 2.3

Current Hypertension Reviews Pub Date : 2021-08-01 DOI: 10.2174/157340211702211025095357

Hao-min Cheng

引用次数: 0

Meet Our Editorial Board Member 会见我们的编辑委员会成员

IF 2.3

Current Hypertension Reviews Pub Date : 2021-06-09 DOI: 10.2174/157340211701210527092713

G. Tse

{"title":"Meet Our Editorial Board Member","authors":"G. Tse","doi":"10.2174/157340211701210527092713","DOIUrl":"https://doi.org/10.2174/157340211701210527092713","url":null,"abstract":"Gary received his Ph.D. in physical/organic chemistry from Indiana University in 1982 under the direction of Dr. John E. Bartmess using Ion Cyclotron Resonance Spectrometry to study gas-phase ion chemistry. Following his Ph.D., he performed postdoctoral research with Dr. Paul Kebarle at the University of Alberta in Canada using High-Pressure Mass Spectrometry to study gas-phase ion chemistry. Gary joined Janssen Pharmaceutical Research and Development a subsidiary of Johnson & Johnson in 1985. During his 32-year career with Janssen Pharmaceutical R & D, Gary has managed a variety of functions within the drug discovery units. These functions include the NMR, GC/MS & LC/MS/MS spectroscopy group, the medicinal chemistry intermediates group, the large-scale separation group, the drug discovery in-vivo/in-vitro PK/ADME groups and the compound management group. His research interests primarily involve the use of advanced spectrometric and chromatographic techniques to chemically and biologically characterize new drug targets and drug entities. Presently, he is working on establishing targeted and untargeted metabolomic methods to understand “on” and “off” target effects to improve drug efficacy and reduce drug toxicity. He is the author of over 150 publications, two patents, over 50 poster presentations, and has given over 40 invited talks at universities, companies, and conferences. He is the co-editor of Frontier in Drug Design & Discovery (volumes 1-4), editor of Optimization in Drug Discovery: In-Vitro Methods (volumes 1-2).","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42172561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fungal infection in cystic fibrosis. 囊性纤维化中的真菌感染。

IF 2.3

Current Hypertension Reviews Pub Date : 2021-05-01 DOI: 10.2174/1573402117666210511012609

A. Sarvestani, M. Almasian, Amirhossein Nafari

{"title":"Fungal infection in cystic fibrosis.","authors":"A. Sarvestani, M. Almasian, Amirhossein Nafari","doi":"10.2174/1573402117666210511012609","DOIUrl":"https://doi.org/10.2174/1573402117666210511012609","url":null,"abstract":"BACKGROUND\u0000The prevalence of fungal infections has been increasing in recent years. Cystic fibrosis (CF) is a genetic disorder that affects organs such as the intestines, liver, pancreas, and especially the lungs.\u0000\u0000\u0000INTRODUCTION\u0000Fungal pathogens are becoming a challenge in CF. Advanced medical science is associated with longer life expectancy in some patient groups.\u0000\u0000\u0000METHOD\u0000A review was conducted on studies found on such online databases as Google Scholar, PubMed, and Scopus. Internet-based searches were performed on these databases for cystic fibrosis, respiratory infections, and fungal infection profiling to identify all relevant studies published between 2010 and 2020.\u0000\u0000\u0000RESULT\u0000Fungal pathogens most frequently isolated from the respiratory tract include the Aspergillus genus, the Candida genus, Scedosporium apiospermum, and the Rasamsonia genus. In cystic fibrosis, these organisms usually colonize the respiratory and intestinal tracts and cause hypersensitivity responses and invasive diseases.\u0000\u0000\u0000CONCLUSION\u0000Fungus-patient interactions are complicated and depend on various factors. Moreover, the emergence of drug-resistant species is a serious health issue, and the development of new treatments is crucial.","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49497176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meet Our Editorial Board Member 见见我们的编辑委员会成员

IF 2.3

Current Hypertension Reviews Pub Date : 2021-01-14 DOI: 10.2174/157340211603201127093819

A. Bagrov

引用次数: 0

GLP-1RA and SGLT2i: Cardiovascular Impact on Diabetic Patients. GLP-1RA和SGLT2i:对糖尿病患者心血管的影响。

IF 2.3

Current Hypertension Reviews Pub Date : 2021-01-01 DOI: 10.2174/1573402116999201124123549

Aschner Pablo, Blanc Evelyn, Folino Claudia, Morosán A Yanina

{"title":"GLP-1RA and SGLT2i: Cardiovascular Impact on Diabetic Patients.","authors":"Aschner Pablo, Blanc Evelyn, Folino Claudia, Morosán A Yanina","doi":"10.2174/1573402116999201124123549","DOIUrl":"https://doi.org/10.2174/1573402116999201124123549","url":null,"abstract":"Background: Diabetes is a chronic disease with high complexity that demands strategic medical care with a multifactorial risk-reduction approach. Over the past decade, the treatment of type 2 diabetes mellitus (T2DM) has entirely changed. One of the paradigm changes has been the arrival of new drugs that reduce cardiovascular risk beyond the reduction of A1C.Objective: Sodium-glucose cotransporter 2 (SGLT2i) and glucagon-like peptide-1 receptor agonist (GLP-1RA) are two groups of antidiabetics drugs, which have demonstrated superiority compared to placebo for major cardiovascular events (MACE).Methods: We update and discuss their impact on MACE expressed as relative risk (HR hazard ratio) and as the number needed to treat (NNT) to avoid one cardiovascular event in 5 years. We include the publications of the last 10 years.Results: Empagliflozin, Canagliflozin and Dapagliflozin present an HR for MACE of 0.86, 0.86, 0.86 and an NNT of 38, 44, and 33, respectively (Dapagliflozin in secondary prevention). Regarding HHF (Hospitalization for Heart Failure), the HR was 0.65, 0.67, 0.73 and NNT was 44, 62, and 98, respectively. Lixisenatide, Exenatide, Liragutide, Semaglutide, Albiglutide and Dulaglutide presented for MACE an HR of 1.02, 0.91, 0.87, 0.74, 0.78, 0.88, respectively. There was no increase in the risk of HHF, but there was no benefit either.Conclusion: Cardiovascular benefits of the GLP-1RA and the SGLT2i are clinically significant. A number needed to treat under 50 is required to avoid one MACE in five years. These benefits have led to important changes in the Clinical Practice Guidelines and in the care of our patients with T2DM.","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38643900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Diversity in Hypertension and Cardiovascular Disease Around the Globe. 全球高血压和心血管疾病的多样性

IF 2.3

Current Hypertension Reviews Pub Date : 2021-01-01 DOI: 10.2174/157340211701210527092629

Kazuomi Kario

引用次数: 0

Characteristics and Determinants of Pulse Pressure-Age Relationship in Healthy and Non-treated Hypertensive Subjects of Argentinean Population. 阿根廷健康和未治疗高血压患者脉搏压-年龄关系的特征和决定因素

IF 2.3

Current Hypertension Reviews Pub Date : 2021-01-01 DOI: 10.2174/1573402116999201210195123

Alejandro Díaz, Ariel F Pascaner, Sandra Wray, Edmundo C Fischer

{"title":"Characteristics and Determinants of Pulse Pressure-Age Relationship in Healthy and Non-treated Hypertensive Subjects of Argentinean Population.","authors":"Alejandro Díaz, Ariel F Pascaner, Sandra Wray, Edmundo C Fischer","doi":"10.2174/1573402116999201210195123","DOIUrl":"https://doi.org/10.2174/1573402116999201210195123","url":null,"abstract":"Background: The relationship between the increases in pulse pressure (PP) and arterial stiffness determined by aging or systemic hypertension has been widely reported. These findings are supported by large-cohort analyzes conducted in well-known populations, such as Framingham Study. However, there is evidence that an age-PP curvilinear relationship may exist in hypertensive subjects. This study aimed to evaluate the age-related change in pulse pressure and arterial stiffness in a population-based study.Methods: Carotid-femoral Pulse Wave Velocity (cfPWV) were obtained in 2075 subjects.Results: Age-related changes of PP showed a curvilinear relationship (R=0.39, p<0.0001) in normotensive subjects, with a nadir at around 50 years of age. On the other hand, the age-cfPWV relationship showed a linear and positive correlation (R=0.72, p<0.0001). PP also showed a curvilinear relationship with age (R=0.36, p<0.0001) in hypertensive subjects, with a nadir around 50 years of age. The age-cfPWV relationship showed a linear and positive correlation (R=0.55, p<0.0001). Similar results were observed in the adult population (age≥16 years). Multivariate analysis showed that age, sex, cfPWV, and mean arterial pressure are determinants of PP values in the entire population; however, this result was not uniform when different subgroups were analyzed.Conclusion: In conclusion, age-related changes in PP showed a curvilinear relationship and no parallelism with the age-cfPWV relationship for both normotensive and hypertensive subjects. The determinants of PP impact it differently depending on age and the pathological condition of the subject.","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38702604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Vascular Dysfunction in Hypertensive Disorders. 高血压疾病中的血管功能障碍。

IF 2.3

Current Hypertension Reviews Pub Date : 2021-01-01 DOI: 10.2174/157340211701210527092847

Gustavo H Oliveira-Paula

引用次数: 0

A Nested Case-Control Study of Serum Fasting Lipid Profiles in Pre- Eclamptic Primigravidas in Ile-Ife, Nigeria. 一项嵌套病例-对照研究在尼日利亚Ile-Ife的先期子痫患者的空腹血脂水平。

IF 2.3

Current Hypertension Reviews Pub Date : 2021-01-01 DOI: 10.2174/1573402116999200818101311

Oluwadare E Adepetu, Temitope O Okunola, Busola M Adepetu, Tewogbade A Adedeji, Olabisi M Loto, Ernest O Orji

{"title":"A Nested Case-Control Study of Serum Fasting Lipid Profiles in Pre- Eclamptic Primigravidas in Ile-Ife, Nigeria.","authors":"Oluwadare E Adepetu, Temitope O Okunola, Busola M Adepetu, Tewogbade A Adedeji, Olabisi M Loto, Ernest O Orji","doi":"10.2174/1573402116999200818101311","DOIUrl":"https://doi.org/10.2174/1573402116999200818101311","url":null,"abstract":"Background: Pre-eclampsia contributes significantly to both maternal and perinatal morbidities and mortalities. One of the identified pathophysiologies of pre-eclampsia is the deranged serum lipid profile of which some components have been found to be elevated early in pregnancy in women destined to develop pre-eclampsia.Objectives: To compare the serum fasting lipid profiles of pre-eclamptic primigravidas with normal primigravidas at week 20, 28, and 34.Methods: We conducted a nested case-control study at Obafemi Awolowo University, Ile-Ife between November 2016 and April 2018. A cohort of 290 primigravidas was recruited at week 20 and followed up until delivery. Serum fasting lipid profiles were quantified at weeks 20, 28 and 34 for all participants. Twenty four women that developed pre-eclampsia were compared with 48 women that had a normal pregnancy. Data were analyzed with SPSS version 22. We used a linear mixed-effect regression model with random intercept and slope. Significance was established using p<0.05.Results: Serum lipid profiles showed an average weekly increase in both groups. Primigravidas that developed pre-eclampsia had a weekly increase of 0.2(SE0.14) mmol/l in serum total cholesterol more than those with normal pregnancies. (p<0.001) Serum low-density lipoprotein also showed a differential weekly increase of 0.1(SE0.05)mmol/l in primigravidas that developed pre-eclampsia over primigravidas with normal pregnancies. (p<0.001).Conclusion: The average weekly increase in serum total cholesterol and low-density lipoprotein was significantly higher in primigravidas that developed pre-eclampsia when compared to the control group. These findings depicted an association between serum lipid profile and pre-eclampsia among the primigravidas.","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38285811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Hypertensive Potential and Epigenetics of Angiotensin II type 2 Receptor (AT2R). 血管紧张素II 2型受体(AT2R)的抗高血压潜能和表观遗传学。

IF 2.3

Current Hypertension Reviews Pub Date : 2021-01-01 DOI: 10.2174/1573402116999201209203015

Mayank Chaudhary

{"title":"Anti-Hypertensive Potential and Epigenetics of Angiotensin II type 2 Receptor (AT2R).","authors":"Mayank Chaudhary","doi":"10.2174/1573402116999201209203015","DOIUrl":"https://doi.org/10.2174/1573402116999201209203015","url":null,"abstract":"Background: Renin angiotensin system (RAS) is a critical pathway involved in blood pressure regulation. Octapeptide, angiotensin II (Ang II), is a biologically active compound of RAS pathway which mediates its action by binding to either angiotensin II type 1 receptor (AT1R) or angiotensin II type 2 receptor (AT2R). Binding of Ang II to AT1R facilitates blood pressure regulation, whereas AT2R is primarily involved in wound healing and tissue remodeling.Objectives: Recent studies have highlighted the additional role of AT2R to counterbalance the detrimental effects of AT1R. Activation of angiotensin II type 2 receptor using AT2R agonist has shown the effect on natriuresis and release of nitric oxide. Additionally, AT2R activation has been found to inhibit angiotensin converting enzyme (ACE) and enhance angiotensin receptor blocker (ARB) activity. These findings highlight the potential of AT2R as a novel therapeutic target against hypertension.Conclusion: The potential role of AT2R highlights the importance of exploring additional mechanisms that might be crucial for AT2R expression. Epigenetic mechanisms, including DNA methylation and histone modification, have been explored vastly with relation to cancer, but the role of such mechanisms in the expression of AT2R has recently gained interest.","PeriodicalId":45941,"journal":{"name":"Current Hypertension Reviews","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38697521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2