Journal of Clinical and Experimental Hematopathology最新文献_第2页

Long-term remission in a patient with NK/T cell intravascular lymphoma with autologous hematopoietic cell transplantation. 自体造血细胞移植治疗NK/T细胞血管内淋巴瘤患者的长期缓解。

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Journal of Clinical and Experimental Hematopathology Pub Date : 2025-01-01 DOI: 10.3960/jslrt.24068

Hiroki Tsutsumi, Keisuke Tanaka, Atsushi Hamamura, Norihiko Nakamura, Shigeo Toyota

引用次数: 0

Utility of CSF IL-6 monitoring in managing ICANS associated with Epcoritamab treatment: a case report and literature review. 脑脊液IL-6监测在管理与依可瑞单抗治疗相关的ICANS中的应用：一个病例报告和文献综述

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Journal of Clinical and Experimental Hematopathology Pub Date : 2025-01-01 DOI: 10.3960/jslrt.24080

Atsushi Takahata, Kaori Akita, Tomohito Shimada, Kana Bando, Shigeo Toyota

{"title":"Utility of CSF IL-6 monitoring in managing ICANS associated with Epcoritamab treatment: a case report and literature review.","authors":"Atsushi Takahata, Kaori Akita, Tomohito Shimada, Kana Bando, Shigeo Toyota","doi":"10.3960/jslrt.24080","DOIUrl":"10.3960/jslrt.24080","url":null,"abstract":"Immune effector cell-associated neurotoxicity syndrome (ICANS) is a serious complication observed in patients receiving advanced immunotherapies such as bispecific antibodies and CAR-T cell therapies. Although the Immune Effector Cell-Associated Encephalopathy (ICE) score is commonly used to assess ICANS severity, its diagnostic accuracy can be compromised by factors such as concomitant medications, underlying comorbidities, and other external influences. This case report discusses a patient with diffuse large B-cell lymphoma who developed ICANS while receiving Epcoritamab. Notably, elevated interleukin-6 (IL-6) levels in the cerebrospinal fluid (CSF) correlated with the patient's clinical course of neurotoxicity. In contrast to conventional scoring systems, which can be affected by unrelated factors, CSF IL-6 levels appeared to more directly reflect the severity and progression of ICANS. These findings are consistent with similar reports from patients treated with CAR-T cells, suggesting that CSF IL-6 may serve as a reliable marker for ICANS progression. Further research that systematically measures CSF IL-6 in diverse clinical contexts could help validate its role as a biomarker, enhancing diagnostic precision and guiding optimal management strategies for ICANS.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"65 1","pages":"68-71"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An aggressive case of Fluid overload-associated large B-cell lymphoma (FO-LBCL) with CD20 down-regulation. CD20下调的侵袭性液体超载相关大b细胞淋巴瘤（FO-LBCL）病例

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Journal of Clinical and Experimental Hematopathology Pub Date : 2025-01-01 DOI: 10.3960/jslrt.24075

Seiichiro Nakabeppu, Hiroaki Miyoshi, Kenji Ishitsuka, Yoshihiro Komohara

引用次数: 0

ALK-negative anaplastic large cell lymphoma with TP53 mutation developing during the administration of baricitinib for atopic dermatitis - A case report. alk阴性间变性大细胞淋巴瘤伴TP53突变在巴西替尼治疗特应性皮炎期间发生- 1例报告。

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Journal of Clinical and Experimental Hematopathology Pub Date : 2025-01-01 DOI: 10.3960/jslrt.24048

Hidetsugu Kawai, Shino Iwata, Sawako Shiraiwa, Masashi Miyaoka, Daisuke Ogiya, Masako Toyosaki, Shinichiro Machida, Rikio Suzuki, Makoto Onizuka, Yoshiaki Ogawa, Naoya Nakamura, Hiroshi Kawada

引用次数: 0

Real-world use of BTK inhibitors for chronic lymphocytic leukemia in Japan: A retrospective observational database study. BTK抑制剂在日本慢性淋巴细胞白血病的实际应用：一项回顾性观察性数据库研究。

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Journal of Clinical and Experimental Hematopathology Pub Date : 2025-01-01 DOI: 10.3960/jslrt.24049

Momoko Nishikori, Kenji Nozaki, Yuko Hayashi, Yoshifumi Arita, Masakazu Fujiwara, Chikako Iwao, Hiroshi Kitagawa, Dai Maruyama

{"title":"Real-world use of BTK inhibitors for chronic lymphocytic leukemia in Japan: A retrospective observational database study.","authors":"Momoko Nishikori, Kenji Nozaki, Yuko Hayashi, Yoshifumi Arita, Masakazu Fujiwara, Chikako Iwao, Hiroshi Kitagawa, Dai Maruyama","doi":"10.3960/jslrt.24049","DOIUrl":"10.3960/jslrt.24049","url":null,"abstract":"Little is known about real-world treatment practices for chronic lymphocytic leukemia (CLL) in Japan. We aimed to assess the time to discontinuation/dose reduction of Bruton tyrosine kinase inhibitors (BTKis) in patients with CLL in a real-world clinical setting in Japan. This was a retrospective observational database study using data from the Medical Data Vision database (from 1 May 2016 to 30 September 2021). Among the 483 patients with CLL who were treated with BTKis, 182 (37.7%) started treatment with a reduced dose of BTKi (lower than the standard dose), 302 (62.5%) experienced at least one dose reduction during the study period, and 123 (25.5%) discontinued BTKi treatment early (for any reason) during the study period. The median time to BTKi discontinuation was 52.3 weeks in 286 patients who started treatment with a standard dose and 57.1 weeks in 182 patients who started treatment with a reduced dose. The use of prophylaxis with anti-infectives was similar during treatment with BTKis and non-BTKis. There was no major difference in the incidence rate of cardiovascular-related adverse events during treatment with BTKis and non-BTKis. This study provides valuable information for future research on the treatment of CLL patients in Japan.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"65 1","pages":"17-27"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poor outcome of older patients with diffuse large B-cell lymphoma after progression. 老年弥漫性大b细胞淋巴瘤进展后预后差。

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Journal of Clinical and Experimental Hematopathology Pub Date : 2025-01-01 DOI: 10.3960/jslrt.24064

Hiroyuki Takahashi, Rika Sakai, Natsuki Hirose, Yuto Hibino, Mayumi Tokunaga, Hideaki Nakajima

{"title":"Poor outcome of older patients with diffuse large B-cell lymphoma after progression.","authors":"Hiroyuki Takahashi, Rika Sakai, Natsuki Hirose, Yuto Hibino, Mayumi Tokunaga, Hideaki Nakajima","doi":"10.3960/jslrt.24064","DOIUrl":"10.3960/jslrt.24064","url":null,"abstract":"One-third of the patients with diffuse large B-cell lymphoma (DLBCL) experience relapse despite receiving standard R-CHOP chemotherapy. We aimed to elucidate the clinical course and prognosis in older patients with relapsed or refractory (R/R) DLBCL in a single-center experience in Japan. We conducted a retrospective survey of 52 older patients with R/R DLBCL (aged >65 years at diagnosis; 54% men) who received R-CHOP chemotherapy, to assess their clinical course and prognosis. The median progression-free survival was 8.5 months. Seventeen patients had central nervous system (CNS) relapse, with 11 receiving high-dose methotrexate or whole-brain irradiation. Briefly, 30 patients underwent salvage chemotherapy, whereas 11 received palliative care only. Overall survival (OS) from initial treatment and progression were 20.8 and 7.8 months, respectively. Patients with disease progression within 12 months from initial treatment had a significantly poorer OS than those with disease progression over 12 months, while CNS relapse did not affect OS. Among the 41 reported deaths, 40 were due to lymphoma. As the prognosis in older patients with R/R DLBCL is poor even after salvage chemotherapy, improved initial treatment strategies to reduce the risk of progression and more effective and feasible treatments after progression are warranted.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"65 1","pages":"40-48"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptome analysis of the cytokine storm-related genes among the subtypes of idiopathic multicentric Castleman disease. 特发性多中心卡斯特曼病各亚型细胞因子风暴相关基因的转录组分析。

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Journal of Clinical and Experimental Hematopathology Pub Date : 2024-12-25 Epub Date: 2024-10-28 DOI: 10.3960/jslrt.24061

Asami Nishikori, Midori Filiz Nishimura, Shuta Tomida, Ryota Chijimatsu, Himawari Ueta, You Cheng Lai, Yuri Kawahara, Yudai Takeda, Sayaka Ochi, Tomoka Haratake, Daisuke Ennishi, Naoya Nakamura, Shuji Momose, Yasuharu Sato

{"title":"Transcriptome analysis of the cytokine storm-related genes among the subtypes of idiopathic multicentric Castleman disease.","authors":"Asami Nishikori, Midori Filiz Nishimura, Shuta Tomida, Ryota Chijimatsu, Himawari Ueta, You Cheng Lai, Yuri Kawahara, Yudai Takeda, Sayaka Ochi, Tomoka Haratake, Daisuke Ennishi, Naoya Nakamura, Shuji Momose, Yasuharu Sato","doi":"10.3960/jslrt.24061","DOIUrl":"10.3960/jslrt.24061","url":null,"abstract":"Idiopathic multicentric Castleman disease (iMCD) is a type of Castleman disease unrelated to the Kaposi sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/HHV8) infection. Presently, iMCD is classified into iMCD-IPL (idiopathic plasmacytic lymphadenopathy), iMCD-TAFRO (thrombocytopenia, anasarca, fever, reticulin fibrosis/renal insufficiency, and organomegaly), and iMCD-NOS (not otherwise specified). The most common treatment for iMCD is using IL-6 inhibitors; however, some patients resist IL-6 inhibitors, especially for iMCD-TAFRO/NOS. Nevertheless, since serum IL-6 levels are not significantly different between the iMCD-IPL and iMCD-TAFRO/NOS cases, cytokines other than IL-6 may be responsible for the differences in pathogenesis. Herein, we performed a transcriptome analysis of cytokine storm-related genes and examined the differences between iMCD-IPL and iMCD-TAFRO/NOS. The results demonstrated that counts per million of STAT2, IL1R1, IL1RAP, IL33, TAFAIP1, and VEGFA (P < 0.001); STAT3, JAK2, MAPK8, IL17RA, IL18, TAFAIP2, TAFAIP3, PDGFA, VEGFC, CXCL10, CCL4, and CXCL13 (P < 0.01); and STAT1, STAT6, JAK1, MAPK1, MAPK3, MAPK6, MAPK7, MAPK9, MAPK10, MAPK11, MAPK12, MAPK14, NFKB1, NFKBIA, NFKBIB, NFKBIZ, MTOR, IL10RB, IL12RB2, IL18BP, TAFAIP6, TNFAIP8L1, TNFAIP8L3, CSF2RBP1, PDGFB, PDGFC, and CXCL9 (P < 0.05) were significantly increased in iMCD-TAFRO/NOS. Particularly, upregulated IL33 expression was demonstrated for the first time in iMCD-TAFRO/NOS. Thus, inflammatory signaling, such as JAK-STAT and MAPK, may be enhanced in iMCD-TAFRO/NOS and may be a cytokine storm.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":" ","pages":"297-306"},"PeriodicalIF":0.9,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep juvenile xanthogranuloma invading the left tensor fasciae latae muscle: a case report and a literature review. 侵犯左侧阔筋膜肌的深部幼年黄疽：病例报告和文献综述。

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Journal of Clinical and Experimental Hematopathology Pub Date : 2024-12-25 Epub Date: 2024-11-28 DOI: 10.3960/jslrt.24056

Atsushi Maejima, Keisuke Okuno, Masanori Miyaishi, Daisuke Kawaba, Sosuke Kakee, Kensaku Yamaga, Noriyuki Namba

{"title":"Deep juvenile xanthogranuloma invading the left tensor fasciae latae muscle: a case report and a literature review.","authors":"Atsushi Maejima, Keisuke Okuno, Masanori Miyaishi, Daisuke Kawaba, Sosuke Kakee, Kensaku Yamaga, Noriyuki Namba","doi":"10.3960/jslrt.24056","DOIUrl":"10.3960/jslrt.24056","url":null,"abstract":"Juvenile xanthogranuloma (JXG) is a rare benign non-Langerhans cell histiocytosis that usually occurs in cutaneous lesions on the head, neck, or upper trunk of neonates and young children. Intramuscular JXG, which invades muscle tissue, accounts for only 0.6% of all JXGs and mostly occurs in the skeletal muscles of the extremities or trunk. A 5-month-old girl was referred to our hospital. At the age of 3 months, she presented with a slow-growing lump on her left thigh. Magnetic resonance imaging (MRI) showed a 22 × 19 × 18 mm oval mass in her left thigh. First, needle biopsy results suggested deep JXG or myeloid sarcoma. Therefore, marginal resection was performed. Intraoperatively, the tumor adhered to the left tensor fasciae latae muscle and was resected together. Histopathological examination revealed a diffuse monotonous sheet-like proliferation of mononuclear histiocyte-like cells with pale, eosinophilic, foamy cytoplasm with a background of muscle and fatty tissue. Minimal mitotic figures and no nuclear atypia or multinucleated giant cells were observed. Immunohistochemical analysis was positive for CD68 (KP-1) and CD163; weakly positive for lysozyme; and negative for CD1a, S100, myeloperoxidase, and CD34. No blast proliferation was observed in the bone marrow. The patient was diagnosed with deep JXG and scheduled for periodic physical examination and MRI. Despite positive margins, the patient fared well without local recurrence 48 months after tumor removal. Understanding the unique pathology of deep JXG and detailed histological evaluation are important for decision-making.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":" ","pages":"323-327"},"PeriodicalIF":0.9,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment with epcoritamab in 10 patients in real-world clinical practice. 在实际临床实践中，对 10 名患者使用艾普科瑞他单抗进行治疗。

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Journal of Clinical and Experimental Hematopathology Pub Date : 2024-12-25 Epub Date: 2024-11-28 DOI: 10.3960/jslrt.24054

Yasunobu Sekiguchi, Hiroki Tsutsumi, Masahisa Kudo, Nobuo Maseki, Yoshie Iizaki, Machiko Kawamura, Kazuhiko Kobayashi, Yu Nishimura, Hiroaki Kanda, Daisuke Takei, Tomoya Abe, Makoto Hanai, Toshiaki Nakayama, Yasumasa Shimano, Hirofumi Kobayashi

引用次数: 0

Clinicopathological and genetic analyses of thyroid large B-cell lymphoma in a Japanese population. 日本人群中甲状腺大 B 细胞淋巴瘤的临床病理学和遗传学分析。

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Journal of Clinical and Experimental Hematopathology Pub Date : 2024-12-25 Epub Date: 2024-10-28 DOI: 10.3960/jslrt.24010

Ayumi Numata, Rika Sakai, Kae Kawachi, Yasufumi Ishiyama, Yukako Hattori, Hirotaka Takasaki, Tomoyuki Yokose, Naoya Nakamura, Hideaki Nakajima

{"title":"Clinicopathological and genetic analyses of thyroid large B-cell lymphoma in a Japanese population.","authors":"Ayumi Numata, Rika Sakai, Kae Kawachi, Yasufumi Ishiyama, Yukako Hattori, Hirotaka Takasaki, Tomoyuki Yokose, Naoya Nakamura, Hideaki Nakajima","doi":"10.3960/jslrt.24010","DOIUrl":"10.3960/jslrt.24010","url":null,"abstract":"Primary thyroid lymphoma is a rare type of cancer. Most cases involve large B-cell lymphomas (LBCLs), which largely show good prognoses. However, the reasons for this have not been understood. To identify the factors influencing the favorable clinical outcomes of thyroid LBCLs, clinicopathological and genetic analyses of 21 cases of thyroid LBCLs were performed, including immunohistochemistry, fluorescence in situ hybridization (FISH), and analysis for MYD88 mutations based on the World Health Organization Classification of Tumors, 5th Edition. The median age of the patients was 70 years (range, 54-80 years). Fifteen patients (71%) had limited-stage disease. The 5-year overall survival rate was 83% (95% confidence interval: 56%-94%). No instances of central nervous system (CNS) recurrence was observed. The series included 15 cases with diffuse LBCL not otherwise specified (DLBCLnos) and 6 cases with transformation of indolent BCLs (T-IBCLs). Immunohistochemistry subdivided DLBCLs into 12 germinal center B-cell (GCB) and 9 non-GCB subtypes. FISH analysis revealed split signals of MYC in 2/17 cases, MALT1 in 0/15 cases, and BCL6 in 3/15 cases. No MYD88 mutations were detected in any of the cases (0/21). The factors contributing to the favorable clinical course in thyroid LBCLs were a higher proportion of GCB phenotypes and the lack of MYD88 mutations in DLBCLnos and T-IBCLs. Even MYC-R cases showed better prognosis. Further studies involving a large series of LBCLs in extranodal organs are needed to expand on the findings of this study.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":" ","pages":"286-291"},"PeriodicalIF":0.9,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0