Journal of Clinical and Experimental Hematopathology最新文献_第3页

Follicular lymphoma with Epstein-Barr virus-associated transformation: A case report and review of the literature. 伴有 Epstein-Barr 病毒相关转化的滤泡性淋巴瘤：病例报告和文献综述。

IF 0.9

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-06-27 Epub Date: 2024-05-30 DOI: 10.3960/jslrt.23060

Yuta Tsuyuki, Kennosuke Karube

{"title":"Follicular lymphoma with Epstein-Barr virus-associated transformation: A case report and review of the literature.","authors":"Yuta Tsuyuki, Kennosuke Karube","doi":"10.3960/jslrt.23060","DOIUrl":"10.3960/jslrt.23060","url":null,"abstract":"Follicular lymphoma (FL) is a common type of B-cell lymphoma, accounting for about 20% of all lymphomas. Although FL is primarily characterized by an indolent clinical course, histological transformation (HT) remains one of the significant challenges in managing patients with FL. Here, we present a case of FL with partial large-cell transformation due to Epstein-Barr Virus (EBV) arising in a 50-year-old Japanese woman with no known immunodeficiency. Immunohistochemical studies revealed that medium-sized FL cells expressed CD20, CD10, BCL2, and BCL6, whereas large cells were positive for CD20, and MUM1. In situ hybridization (ISH) revealed large cells to be positive for EBV-encoded small RNA (EBER) and further immunohistochemical investigation demonstrated EBER+ cells to express latent membrane protein 1 (LMP1). The Ki-67 index was about 30% in FL cells, and over 70% in large cells. Fluorescence in situ hybridization for BCL2 combined with EBER-ISH identified BCL2 rearrangement in both EBV-infected large cells and EBV-uninfected FL cells, suggesting these two components were clonally related. These findings indicate that EBV contributes to the transformation of FL. As far as the authors could find, only four previous cases of FL development to EBV-positive aggressive lymphoma have been reported. Further studies are needed to clarify the role of EBV in the HT of FL.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":" ","pages":"144-148"},"PeriodicalIF":0.9,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of peripheral T-cell lymphoma in which therapy-related myelodysplastic syndrome developed and a second autologous transplantation was performed. 一例外周 T 细胞淋巴瘤患者出现了与治疗相关的骨髓增生异常综合征，并进行了第二次自体移植。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-03-28 Epub Date: 2024-02-28 DOI: 10.3960/jslrt.23054

Shun-Ichiro Nakagawa, Yuki Nukii, Kanako Mochizuki, Akio Uchiyama, Yoshinobu Maeda, Toshiro Kurokawa

{"title":"A case of peripheral T-cell lymphoma in which therapy-related myelodysplastic syndrome developed and a second autologous transplantation was performed.","authors":"Shun-Ichiro Nakagawa, Yuki Nukii, Kanako Mochizuki, Akio Uchiyama, Yoshinobu Maeda, Toshiro Kurokawa","doi":"10.3960/jslrt.23054","DOIUrl":"10.3960/jslrt.23054","url":null,"abstract":"We report a case of therapy-related myelodysplastic syndrome (MDS), which developed 9 years after autologous peripheral blood stem cell transplantation (PBSCT) for peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). A 65-year-old male was diagnosed with PTCL-NOS. After 6 cycles of the CHOP (cyclophosphamide [CPA], doxorubicin, vincristine, and prednisone) regimen, he achieved a first complete response (CR). He relapsed 33 months later and received salvage chemotherapy, which consisted of the CHASE regimen (CPA, high-dose cytarabine, dexamethasone, and etoposide). During the recovery phase of the first cycle of CHASE, his peripheral blood stem cells (PBSCs) were harvested and frozen in 2 bags. After 2 courses of CHASE, he underwent autologous PBSCT, which involved the use of the LEED preconditioning regimen (melphalan, CPA, etoposide, and dexamethasone) and one of the frozen bags. This resulted in a second CR. At 39 months after PBSCT, he relapsed with a tumor in his right arm. After it was resected, he received eight cycles of brentuximab vedotin and 45 Gy of involved-field irradiation concurrently and achieved a third CR. Nine years after autologous PBSCT, he was diagnosed with MDS with excess blasts 2 (MDS-EB-2). His disease progressed to acute myeloid leukemia after 2 courses of azacitidine therapy. He successfully underwent a second autologous PBSCT involving the busulfan and melphalan preconditioning regimen and the other frozen bag, which had been stored for 9 years. He has been in complete cytogenetic remission for 1 year since the second autologous PBSCT.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":" ","pages":"59-64"},"PeriodicalIF":1.5,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-grade B-cell lymphoma, not otherwise specified, presenting as primary peritoneal lymphomatosis and successfully treated with dose-adjusted EPOCH-R. 表现为原发性腹膜淋巴瘤的高级别B细胞淋巴瘤（未另作说明），使用剂量调整后的EPOCH-R治疗成功。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-03-28 Epub Date: 2024-01-28 DOI: 10.3960/jslrt.23044

Akihito Fujimi, Yasuhiro Nagamachi, Naofumi Yamauchi, Naoki Onoyama, Naotaka Hayasaka, Teppei Matsuno, Kazuhiko Koike, Yoshiro Goto, Kohji Ihara, Junji Kato, Takuji Nishisato, Hiroshi Kawase, Tomoyuki Yano, Takayuki Kanaseki, Shintaro Sugita, Masayoshi Kobune

{"title":"High-grade B-cell lymphoma, not otherwise specified, presenting as primary peritoneal lymphomatosis and successfully treated with dose-adjusted EPOCH-R.","authors":"Akihito Fujimi, Yasuhiro Nagamachi, Naofumi Yamauchi, Naoki Onoyama, Naotaka Hayasaka, Teppei Matsuno, Kazuhiko Koike, Yoshiro Goto, Kohji Ihara, Junji Kato, Takuji Nishisato, Hiroshi Kawase, Tomoyuki Yano, Takayuki Kanaseki, Shintaro Sugita, Masayoshi Kobune","doi":"10.3960/jslrt.23044","DOIUrl":"10.3960/jslrt.23044","url":null,"abstract":"Peritoneal lymphomatosis (PL) is a rare lymphoma-associated condition defined as the dissemination of lymphoma cells in the peritoneum. An 82-year-old man presented with abdominal pain, heartburn, and high fever. Radiological findings, including positron emission tomography-computed tomography (PET-CT), and gastrointestinal fiberscopy, showed diffuse thickening of the peritoneum, omentum, and mesentery; however, no lymphadenopathy, hepatosplenomegaly, or gastrointestinal lesions were observed. Under suspicion of peritonitis carcinomatosa of unknown origin, exploratory laparoscopy was performed that revealed multiple white nodules and masses on the surfaces of the peritoneum, mesentery, and intestinal serosa. The histopathological and cytogenetic findings of the peritoneum revealed high-grade B-cell lymphoma, not otherwise specified, and a gain of MYC by fluorescence in-situ hybridization. The patient was treated with two cycles of R-CHOP therapy, followed by six cycles of dose-adjusted EPOCH-R therapy, and a complete metabolic response was confirmed by PET-CT. Since there are no specific radiological findings to confirm the diagnosis of PL, a histopathological diagnosis is usually required. Most PL exhibit an aggressive lymphoma phenotype and can be cured by appropriate chemotherapy. Therefore, early diagnosis and treatment are desirable.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":" ","pages":"37-44"},"PeriodicalIF":1.5,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Notch1 protein expression in methotrexate-associated lymphoproliferative disorders. 甲氨蝶呤相关淋巴组织增生性疾病中Notch1蛋白表达分析

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-03-28 Epub Date: 2024-01-28 DOI: 10.3960/jslrt.23038

Takeshi Okatani, Midori Filiz Nishimura, Yuria Egusa, Sayako Yoshida, Yoshito Nishimura, Asami Nishikori, Tadashi Yoshino, Hidetaka Yamamoto, Yasuharu Sato

{"title":"Analysis of Notch1 protein expression in methotrexate-associated lymphoproliferative disorders.","authors":"Takeshi Okatani, Midori Filiz Nishimura, Yuria Egusa, Sayako Yoshida, Yoshito Nishimura, Asami Nishikori, Tadashi Yoshino, Hidetaka Yamamoto, Yasuharu Sato","doi":"10.3960/jslrt.23038","DOIUrl":"10.3960/jslrt.23038","url":null,"abstract":"Methotrexate (MTX)-associated lymphoproliferative disorder (MTX-LPD) is a lymphoproliferative disorder in patients treated with MTX. The mechanism of pathogenesis is still elusive, but it is thought to be a complex interplay of factors, such as underlying autoimmune disease activity, MTX use, Epstein-Barr virus infection, and aging. The NOTCH genes encode receptors for a signaling pathway that regulates various fundamental cellular processes, such as proliferation and differentiation during embryonic development. Mutations of NOTCH1 have been reported in B-cell tumors, including chronic lymphocytic leukemia/lymphoma, mantle cell lymphoma, and diffuse large B-cell lymphoma (DLBCL). Recently, it has also been reported that NOTCH1 mutations are found in post-transplant lymphoproliferative disorders, and in CD20-positive cells in angioimmunoblastic T-cell lymphoma, which might be associated with lymphomagenesis in immunodeficiency. In this study, to investigate the association of NOTCH1 in the pathogenesis of MTX-LPD, we evaluated protein expression of Notch1 in nuclei immunohistochemically in MTX-LPD cases [histologically DLBCL-type (n = 24) and classical Hodgkin lymphoma (CHL)-type (n = 24)] and de novo lymphoma cases [DLBCL (n = 19) and CHL (n = 15)]. The results showed that among MTX-LPD cases, the expression of Notch1 protein was significantly higher in the DLBCL type than in the CHL type (P < 0.001). In addition, among DLBCL morphology cases, expression of Notch1 tended to be higher in MTX-LPD than in the de novo group; however this difference was not significant (P = 0.0605). The results showed that NOTCH1 may be involved in the proliferation and tumorigenesis of B cells under the use of MTX. Further research, including genetic studies, is necessary.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":" ","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful treatment of isolated central nervous system recurrence of primary testicular lymphoma by autologous stem cell transplantation using a conditioning regimen of thiotepa and busulfan. 使用噻替派和丁胺磺胺治疗方案进行自体干细胞移植，成功治疗原发性睾丸淋巴瘤孤立性中枢神经系统复发。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-03-28 Epub Date: 2024-02-28 DOI: 10.3960/jslrt.23039

Yasuhiro Tanaka, Tomomi Sakai, Hiroko Tsunemine, Tomoo Ito, Nobuyoshi Arima

{"title":"Successful treatment of isolated central nervous system recurrence of primary testicular lymphoma by autologous stem cell transplantation using a conditioning regimen of thiotepa and busulfan.","authors":"Yasuhiro Tanaka, Tomomi Sakai, Hiroko Tsunemine, Tomoo Ito, Nobuyoshi Arima","doi":"10.3960/jslrt.23039","DOIUrl":"10.3960/jslrt.23039","url":null,"abstract":"Primary testicular lymphoma (PTL) frequently relapses in the central nervous system (CNS) despite prophylactic intrathecal chemotherapy, and the outcome for CNS recurrence of PTL is very poor. We report a case of isolated CNS recurrence of bilateral PTL. Our patient achieved complete response (CR) after rituximab-combination chemotherapy for PTL. Approximately five years later, isolated CNS recurrence of PTL occurred. Our patient achieved CR again after high-dose methotrexate therapy and autologous stem cell transplantation (ASCT) with a conditioning regimen of thiotepa and busulfan as a consolidation therapy. The secondary failure of platelet recovery, probably caused by busulfan, occurred after the platelet engraftment. Our patient has remained in CR for over three years. The treatment strategy for CNS recurrence of PTL is mainly whole-brain radiotherapy or high-dose methotrexate-based chemotherapy; however, CNS recurrence of PTL may occur again even after achieving CR. ASCT with a conditioning regimen of thiotepa and busulfan is the optimal consolidation therapy for secondary CNS lymphoma. To the best of our knowledge, this is the second reported case of a patient with isolated CNS recurrence of PTL successfully treated by ASCT with a conditioning regimen of thiotepa and busulfan as a consolidation therapy.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":" ","pages":"32-36"},"PeriodicalIF":1.5,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diverse B-cell tumors associated with t(14;19)(q32;q13)/IGH::BCL3 identified by G-banding and fluorescence in situ hybridization. 通过G-带和荧光原位杂交鉴定与t(14;19)(q32;q13)/IGH::BCL3相关的多种B细胞肿瘤。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-01-01 DOI: 10.3960/jslrt.23053

Hitoshi Ohno, Fumiyo Maekawa, Masahiko Hayashida, Miho Nakagawa, Katsuhiro Fukutsuka, Mitsuko Matsumura, Kayo Takeoka, Wataru Maruyama, Naoya Ukyo, Shinji Sumiyoshi, Yasuhiro Tanaka, Hironori Haga

{"title":"Diverse B-cell tumors associated with t(14;19)(q32;q13)/IGH::BCL3 identified by G-banding and fluorescence in situ hybridization.","authors":"Hitoshi Ohno, Fumiyo Maekawa, Masahiko Hayashida, Miho Nakagawa, Katsuhiro Fukutsuka, Mitsuko Matsumura, Kayo Takeoka, Wataru Maruyama, Naoya Ukyo, Shinji Sumiyoshi, Yasuhiro Tanaka, Hironori Haga","doi":"10.3960/jslrt.23053","DOIUrl":"10.3960/jslrt.23053","url":null,"abstract":"We characterized 5 B-cell tumors carrying t(14;19)(q32;q13) that creates the IGH::BCL3 fusion gene. The patients' ages ranged between 55 and 88 years. Two patients presented with progression or recurrence of B-cell chronic lymphocytic leukemia (B-CLL)/small lymphocytic lymphoma (SLL), two with diffuse large B-cell lymphoma (DLBCL) of non-germinal center B-like phenotype, and the remaining one with composite angioimmunoblastic T-cell lymphoma and Epstein-Barr virus-positive DLBCL. The presence of t(14;19)(q32;q13) was confirmed by fluorescence in situ hybridization (FISH), showing colocalization of 3' IGH and 3' BCL3 probes on der(14)t(14;19) and 5' BCL3 and 5' IGH probes on der(19)t(14;19). One B-CLL case had t(2;14)(p13;q32)/IGH::BCL11A, and 2 DLBCL cases had t(8;14)(q24;q32) or t(8;11;14)(q24;q11;q32), both of which generated IGH::MYC by FISH, and showed nuclear expression of MYC and BCL3 by immunohistochemistry. The IGH::BCL3 fusion gene was amplified by long-distance polymerase chain reaction in 2 B-CLL/SLL cases and the breakpoints occurred immediately 5' of BCL3 exon 1 and within the switch region associated with IGHA1. The 5 cases shared IGHV preferentially used in B-CLL cells, but the genes were unmutated in 2 B-CLL/SLL cases and significantly mutated in the remaining 3. B-cell tumors with t(14;19)(q32;q13) can be divided into B-CLL/SLL and DLBCL groups, and the anatomy of IGH::BCL3 in the latter may be different from that of the former.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"64 1","pages":"21-31"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extranodal natural killer/T-cell lymphoma coexisting with peripheral T-cell lymphoma, not otherwise specified. 结节外自然杀伤/T 细胞淋巴瘤与外周 T 细胞淋巴瘤并存，未作其他说明。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-01-01 DOI: 10.3960/jslrt.23049

Kenta Hayashino, Chikamasa Yoshida, Yoshiyuki Ayata, Ryouya Yukawa, Aya Komura, Makoto Nakamura, Yusuke Meguri, Kazuhiko Yamamoto, Wakako Oda, Kenji Imajo

{"title":"Extranodal natural killer/T-cell lymphoma coexisting with peripheral T-cell lymphoma, not otherwise specified.","authors":"Kenta Hayashino, Chikamasa Yoshida, Yoshiyuki Ayata, Ryouya Yukawa, Aya Komura, Makoto Nakamura, Yusuke Meguri, Kazuhiko Yamamoto, Wakako Oda, Kenji Imajo","doi":"10.3960/jslrt.23049","DOIUrl":"10.3960/jslrt.23049","url":null,"abstract":"We report the case of a 52-year-old male who presented to our hospital with cervical lymphadenopathy. Lymph node biopsy revealed small atypical lymphoid cells positive for CD3 and CD5 and negative for CD56 and Epstein-Barr virus (EBV)-encoded small RNA (EBER) by in situ hybridization. CD4-positive cells and CD8-positive cells were mixed in almost equal numbers. He was diagnosed with peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). The patient received one cycle of chemotherapy, resulting in severe sepsis. While undergoing treatment in the intensive care unit with an antimicrobial agent and prednisone, ascitic fluid appeared. Abdominal aspiration revealed neutrophil-predominant ascites and microbiological studies revealed Candida albicans. However, ascites did not improve when treated with micafungin for Candida peritonitis. Abdominal aspiration was re-performed, and atypical lymphoid cells that were positive for CD3 and CD56 were detected. EBV-DNA levels in whole blood were significantly elevated. Atypical lymphoid cells were positive for EBER by in situ hybridization and Southern blot analysis showed EBV terminal repeat monoclonal patterns. Bone marrow examination revealed the same atypical lymphoid cells. Therefore, the patient was diagnosed with extranodal natural killer/T-cell lymphoma (ENKTL) with bone marrow involvement 3 months after the diagnosis of PTCL-NOS. Complications associated with PTCL-NOS and ENKTL are rare. PTCL-NOS, chemotherapy, sepsis, and prednisone might have led to immunodeficiency and reactivation of EBV, which might be one of the pathophysiologies for developing ENKTL. Our case indicates that measuring EBV-DNA in the blood is a simple and prompt examination to detect complications of EBV-associated lymphoma.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"64 1","pages":"52-58"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation of fibroblasts by plasma cells via PDGF/PDGFR signaling in IgG4-related sialadenitis. 在 IgG4 相关性唾液腺炎中，浆细胞通过 PDGF/PDGFR 信号激活成纤维细胞。

IF 0.9

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-01-01 DOI: 10.3960/jslrt.24040

Takumi Kitaoka, Rintaro Ohe, Takanobu Kabasawa, Masayuki Kaneko, Nobuyuki Sasahara, Michihisa Kono, Kazushi Suzuki, Naoya Uchiyama, Rinako Ogawa, Mitsuru Futakuchi

{"title":"Activation of fibroblasts by plasma cells via PDGF/PDGFR signaling in IgG4-related sialadenitis.","authors":"Takumi Kitaoka, Rintaro Ohe, Takanobu Kabasawa, Masayuki Kaneko, Nobuyuki Sasahara, Michihisa Kono, Kazushi Suzuki, Naoya Uchiyama, Rinako Ogawa, Mitsuru Futakuchi","doi":"10.3960/jslrt.24040","DOIUrl":"10.3960/jslrt.24040","url":null,"abstract":"IgG4-related sialadenitis (IgG4-SA) is one of the IgG4-related disease. The histological features of IgG4-SA include dense lymphoplasmacytic infiltrates and fibrosis. This study aimed to reveal the involvement of plasma cells in the development of fibrosis and the mechanism underlying fibrosis in IgG4-SA. Hematoxylin-eosin staining, Azan staining, silver staining, and immunohistochemistry (IHC) were performed on IgG4-SA and chronic sialadenitis specimens, and theses samples were analyzed by image analysis software. Histological spatial analysis was used to analyze the localization of IHC-positive cells and the distances between these cells. In the IgG4-SA group, many secondary lymphoid follicles with germinal centers were found, and many collagen fibers developed around these germinal centers. Collagen fibers composed mainly of type I collagen was abundant at sites away from secondary lymphoid follicles, and reticular fibers composed of type III collagen was abundant near secondary lymphoid follicles. Many FAP+ fibroblasts and MUM1+ plasma cells were localized near secondary lymphoid follicles. Histological spatial analysis demonstrated that 90.4% of MUM1+ plasma cells accumulated within 20 µm of FAP+ fibroblasts. Multiple immunofluorescence assays revealed that MUM1+ plasma cells expressed platelet-derived growth factor (PDGF) β, and FAP+ fibroblasts expressed PDGF receptor (PDGFR) β and pSTAT3 in IgG4-SA. We have shown that fibrosis is localized around secondary lymphoid follicles and that fibroblasts are activated by plasma cells via PDGF/PDGFR signaling in IgG4-SA.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"64 3","pages":"223-231"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrence of solitary plasmacytoma in the liver 10 years after the onset of multiple bone lesions. 多发性骨病10年后肝脏单发浆细胞瘤复发。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-01-01 DOI: 10.3960/jslrt.23056

Jun Numata, Hiroko Tsunemine, Asuka Imai, Naokazu Nakamura, Tomomi Sakai, Tomoo Itoh, Nobuyoshi Arima

引用次数: 0

Extranodal NK/T-cell lymphoma with localized relapse in bone marrow of lower leg detected using PET-CT. PET-CT 发现小腿骨髓局部复发的结节外 NK/T 细胞淋巴瘤。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-01-01 DOI: 10.3960/jslrt.23046

Takahisa Nakamura, Hiro Tatetsu, Yusuke Higuchi, Shinya Endo, Shinya Shiraishi, Koichi Kawanaka, Daisuke Imakane, Miyu Sonoda, Rie Furuta, Takafumi Shichijo, Yumi Honda, Kennosuke Karube, Yoshiki Mikami, Kisato Nosaka, Masao Matsuoka, Jun-Ichirou Yasunaga

{"title":"Extranodal NK/T-cell lymphoma with localized relapse in bone marrow of lower leg detected using PET-CT.","authors":"Takahisa Nakamura, Hiro Tatetsu, Yusuke Higuchi, Shinya Endo, Shinya Shiraishi, Koichi Kawanaka, Daisuke Imakane, Miyu Sonoda, Rie Furuta, Takafumi Shichijo, Yumi Honda, Kennosuke Karube, Yoshiki Mikami, Kisato Nosaka, Masao Matsuoka, Jun-Ichirou Yasunaga","doi":"10.3960/jslrt.23046","DOIUrl":"10.3960/jslrt.23046","url":null,"abstract":"Extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is a rare subtype of non-Hodgkin lymphoma (NHL) with poor prognosis, particularly in relapsed or refractory patients. Thus, timely detection of relapse and appropriate disease management are crucial. We present two patients with ENKTL, wherein positron emission tomography-computed tomography (PET-CT) with total-body coverage after induction therapy, detected newly relapsed regions in the bone marrow of the lower leg prior to progression. Case 1: A 47-year-old woman with nasal obstruction, showing 18F-fluoro-deoxyglucose (FDG) uptake in the nasal cavity (Lugano stage IE). After induction therapy (RT-2/3 DeVIC), PET-CT revealed abnormal uptake only in the right fibula. Case 2: A 68-year-old man with a skin nodule/ulcer and an enlarged right inguinal lymph node was diagnosed with advanced ENKTL. A PET-CT scan revealed abnormal uptake in the subcutaneous mass of the right medial thigh, lymph nodes, and descending colon (Lugano stage IV). After induction therapy, PET-CT revealed new abnormal uptake only in the left tibia. In both patients, CT-guided biopsy confirmed ENKTL recurrence. Moreover, PET-CT with whole-body coverage was useful for the timely assessment of relapse and detection of asymptomatic bone involvement. This approach allowed for modifications to treatment strategies in certain patients.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"64 1","pages":"45-51"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0