Journal of Clinical and Experimental Hematopathology最新文献

Merkel cell polyomavirus DNA sequences in tissue from a patient with Histiocytosis. 组织细胞增多症患者组织中的默克尔细胞多瘤病毒DNA序列。

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Journal of Clinical and Experimental Hematopathology Pub Date : 2025-06-28 Epub Date: 2025-04-30 DOI: 10.3960/jslrt.24066

Ichiro Murakami, Kenji Yorita, Yumiko Hashida, Masanori Daibata, Tadashi Yoshino

引用次数: 0

Non-germinal center diffuse large B-cell lymphoma arising from a common origin of duodenal-type follicular lymphoma. 非生发中心弥漫性大b细胞淋巴瘤，起源于十二指肠型滤泡性淋巴瘤。

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Journal of Clinical and Experimental Hematopathology Pub Date : 2025-06-28 Epub Date: 2025-04-30 DOI: 10.3960/jslrt.25009

Tomoyo Kubo, Yuya Nagai, Yoshimitsu Shimomura, Kimimori Kamijo, Yumi Shiroishi, Hayato Maruoka, Daisuke Yamashita, Takayuki Ishikawa

{"title":"Non-germinal center diffuse large B-cell lymphoma arising from a common origin of duodenal-type follicular lymphoma.","authors":"Tomoyo Kubo, Yuya Nagai, Yoshimitsu Shimomura, Kimimori Kamijo, Yumi Shiroishi, Hayato Maruoka, Daisuke Yamashita, Takayuki Ishikawa","doi":"10.3960/jslrt.25009","DOIUrl":"10.3960/jslrt.25009","url":null,"abstract":"Duodenal-type follicular lymphoma (DFL) is a rare subtype of follicular lymphoma (FL) characterized by a remarkably indolent clinical course. However, histological transformation to diffuse large B-cell lymphoma (DLBCL) has been sporadically reported, and its clinicopathological features remain poorly understood. We describe a rare case of DFL that transformed to non-germinal center DLBCL, including the specific biological characteristics based on immunohistochemical, cytogenetic, and molecular analyses. A 62-year-old woman was diagnosed with DFL and followed without treatment. Six years later, she presented with progressive anemia and an ulcerative lesion in the ileocecum. Biopsy confirmed the diagnosis of DLBCL with the non-GCB immunophenotype according to Hans' algorithm, which is an uncommon immunophenotype of transformed FL. Fluorescence in situ hybridization analysis revealed BCL6 translocation in both DFL and DLBCL samples. In addition, polymerase chain reaction and sequencing analyses of immunoglobulin heavy and light chain rearrangements clearly demonstrated that the DFL and DLBCL share a common origin. After surgical resection of the ileocecal lesion and six cycles of R-CHOP chemotherapy, the patient has remained in complete remission for 3 years. This case highlights the importance of long-term follow-up of DFL and provides insights into the pathophysiology underlying the transformation of DFL.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":" ","pages":"135-139"},"PeriodicalIF":0.9,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kimura disease of the tongue base: a rare case diagnosed through cytological examination of Warthin-Finkeldey-type multinucleated cells. 舌底木村病：一例罕见的通过warthin - finkeldey型多核细胞细胞学检查诊断的病例。

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Journal of Clinical and Experimental Hematopathology Pub Date : 2025-06-28 Epub Date: 2025-03-12 DOI: 10.3960/jslrt.25007

Hidetoshi Satomi, Ayumi Ryu, Azusa Shingetsu, Sei Murayama, Yuki Morimoto, Yoshinori Kodama, Satoshi Tanada, Keiichiro Honma

{"title":"Kimura disease of the tongue base: a rare case diagnosed through cytological examination of Warthin-Finkeldey-type multinucleated cells.","authors":"Hidetoshi Satomi, Ayumi Ryu, Azusa Shingetsu, Sei Murayama, Yuki Morimoto, Yoshinori Kodama, Satoshi Tanada, Keiichiro Honma","doi":"10.3960/jslrt.25007","DOIUrl":"10.3960/jslrt.25007","url":null,"abstract":"Kimura disease (KD) is a rare chronic inflammatory condition that primarily affects Asian males and typically presents in the head and neck region. We describe an exceptionally rare case of KD involving the lingual tonsil of Waldeyer's ring in a 39-year-old Japanese man, marking only the second reported instance of lingual involvement and the first specifically affecting the tongue base. The patient presented with a well-circumscribed, 3.5-cm mass extending from the lingual tonsil to the epiglottis. Laboratory findings revealed significant peripheral eosinophilia (13.5%) and elevated serum IgE levels (2,750 IU/mL). Because of the challenging location for conventional biopsy, fine-needle aspiration cytology was performed on associated cervical lymph nodes. Cytological examination identified Warthin-Finkeldey-type multinucleated cells, eosinophilic infiltration, and vascular proliferation, leading to a presumptive KD diagnosis based on cytomorphology. The diagnosis was confirmed through surgical excision and histopathological analysis. This case is noteworthy for two reasons: it documents an extremely rare presentation of KD in the tongue base and underscores the diagnostic value of cytological examination in anatomically difficult locations where surgical biopsy may be unfeasible. The presence of Warthin-Finkeldey-type multinucleated cells in cytological specimens provided a key diagnostic clue, particularly when integrated with clinical and laboratory findings. At six months post-surgery, the patient showed no recurrence. This case highlights the importance of considering KD in the differential diagnosis of head and neck masses, even in atypical locations, and demonstrates the potential utility of cytological examination in diagnosing KD.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":" ","pages":"129-134"},"PeriodicalIF":0.9,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Composite mantle cell lymphoma and T-cell prolymphocytic leukemia: a case report. 复合套细胞淋巴瘤合并t细胞前淋巴细胞白血病1例。

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Journal of Clinical and Experimental Hematopathology Pub Date : 2025-06-28 Epub Date: 2025-04-30 DOI: 10.3960/jslrt.24065

Emi Kemmoku, Shigeru Kusumoto, Seiichi Kato, Yuka Kawaguchi, Shinya Hagiwara, Toko Saito, Fukumi Tokumasu, Ayako Nonaka, Masamitsu Yanada, Tomohiro Kinoshita, Waki Hosoda, Kazuhito Yamamoto

{"title":"Composite mantle cell lymphoma and T-cell prolymphocytic leukemia: a case report.","authors":"Emi Kemmoku, Shigeru Kusumoto, Seiichi Kato, Yuka Kawaguchi, Shinya Hagiwara, Toko Saito, Fukumi Tokumasu, Ayako Nonaka, Masamitsu Yanada, Tomohiro Kinoshita, Waki Hosoda, Kazuhito Yamamoto","doi":"10.3960/jslrt.24065","DOIUrl":"10.3960/jslrt.24065","url":null,"abstract":"We encountered a patient with composite mantle cell lymphoma (MCL) and T-cell prolymphocytic leukemia (T-PLL) who presented with inactive disease to active T-PLL over 8 years. A 71-year-old man was diagnosed with MCL with an atypical T-cell population showing CD2+, CD3-, CD4+, CD7+, CD8-, and CD25+; however, the cause of the T-cell population could not be determined at the first MCL diagnosis. When MCL relapsed approximately 8 years after the initial treatment, T-PLL was definitively diagnosed using the T-PLL International Study Group criteria. MCL and T-PLL were determined to coexist in the lymph nodes and bone marrow by histological or flowcytometry analysis. Retrospective flow cytometry and T-cell receptor-polymerase chain reaction analysis of the stored samples suggested that the T-cell population noted at the time of initial MCL diagnosis eight years earlier was the same clone of T-PLL and the progression from inactive disease to active disease of his T-PLL. To the best of our knowledge, this is the first report of a composite MCL and T-PLL.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":" ","pages":"107-114"},"PeriodicalIF":0.9,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic resonance imaging findings of intravascular large B-cell lymphoma mimicking fasciitis of the thigh: A case report. 模拟大腿筋膜炎的血管内大b细胞淋巴瘤1例。

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Journal of Clinical and Experimental Hematopathology Pub Date : 2025-06-28 Epub Date: 2025-04-30 DOI: 10.3960/jslrt.24072

Michiko Suzuki, Akiko Yashima-Abo, Shigeru Ehara, Shigeki Ito, Takashi Satoh

引用次数: 0

Prognostic predictors of newly diagnosed Diffuse large B-cell lymphoma treated with R-THP-COP regimen. R-THP-COP方案治疗新诊断弥漫性大b细胞淋巴瘤的预后预测因素

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Journal of Clinical and Experimental Hematopathology Pub Date : 2025-03-28 DOI: 10.3960/jslrt.24073

Yoshiaki Okano, Tatsuo Oyake, Sawako Kitamura, Kazuya Asano, Tsuyoshi Sato, Takahiro Maeta, Shinri Miyajima, Akihiro Otsu, Maki Nishiya, Ryousei Sasaki, Shugo Kowata, Yoji Ishida, Shigeki Ito

{"title":"Prognostic predictors of newly diagnosed Diffuse large B-cell lymphoma treated with R-THP-COP regimen.","authors":"Yoshiaki Okano, Tatsuo Oyake, Sawako Kitamura, Kazuya Asano, Tsuyoshi Sato, Takahiro Maeta, Shinri Miyajima, Akihiro Otsu, Maki Nishiya, Ryousei Sasaki, Shugo Kowata, Yoji Ishida, Shigeki Ito","doi":"10.3960/jslrt.24073","DOIUrl":"10.3960/jslrt.24073","url":null,"abstract":"The prognostic value of models such as the international prognostic index (IPI) in patients with malignant lymphomas treated with a combination of rituximab, doxorubicin, cyclophosphamide, vincristine, and prednisolone is well established. However, whether these prognostic models apply to patients treated with a combination of tetrahydropyranyl adriamycin, rituximab, cyclophosphamide, vincristine, and prednisolone (R-THP-COP) is unclear. This retrospective analysis included 101 patients with Diffuse large B-cell lymphoma (DLBCL) treated with R-THP-COP. The primary endpoint was overall survival (OS). The secondary endpoints were progression-free survival (PFS), complete response rate (CRR), and effectiveness of risk prediction in the IPI, revised international prognostic index (R-IPI), and National Comprehensive Cancer Network (NCCN)-IPI groups. OS and PFS at 5 years were 67% and 58.9%. CRR was 63.5%. The IPI, R-IPI, and NCCN-IPI predicted the outcomes of patients treated with R-THP-COP. According to the NCCN-IPI, OS and PFS could distinguish four risk groups. In conclusion, the NCCN-IPI is the most effective prognostic tool for identifying patients with poor prognosis, even those treated with R-THP-COP.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":" ","pages":"49-54"},"PeriodicalIF":0.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hans's algorithm and MYD88^L265P mutation may affect prognosis of primary central nervous system B-cell lymphoma. Hans算法和MYD88L265P突变可能影响原发性中枢神经系统b细胞淋巴瘤的预后。

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Journal of Clinical and Experimental Hematopathology Pub Date : 2025-03-28 Epub Date: 2025-01-30 DOI: 10.3960/jslrt.24057

Yuka Oka, Shoki Yamada, Moe Takeda, Yuko Hashimoto

{"title":"Hans's algorithm and MYD88L265P mutation may affect prognosis of primary central nervous system B-cell lymphoma.","authors":"Yuka Oka, Shoki Yamada, Moe Takeda, Yuko Hashimoto","doi":"10.3960/jslrt.24057","DOIUrl":"10.3960/jslrt.24057","url":null,"abstract":"Primary central nervous system (CNS) lymphomas account for 1.9-3% of all brain tumors, with the majority being histologically classified as primary large B-cell lymphoma of the CNS (PCNS-LBCL). PCNS-LBCL is characterized by mature germinal center-exit B cells, and most cases of this phenotype are classified as activated B-cell-like phenotype according to gene expression profiling, or as non-germinal center B-cell-like phenotype (non-GCB type) according to Hans's algorithm. Genetically, PCNS-LBCL often shows mutations in MYD88L265P and CD79BY196, and is similar to MCD or C5 in genetic subtypes. Therefore, we here investigated the clinicopathological and molecular characteristics of primary CNS B-cell lymphomas (PCNSBLs), focusing on the differences in the frequency of MYD88L265P and CD79BY196 mutations, as well as the prognosis between GCB and non-GCB types. Forty-two patients with PCNSBLs were included in this study, with 12 (28.6%) classified as GCB type and 30 (71.4%) as non-GCB type. There were no significant differences between the two types in gender, tumor location, or frequency of MYD88L265P and CD79BY196 mutations. Even after consideration of the confounding of age and the presence of R-MPV therapy, the GCB type PCNSBLs tended to exhibit better prognosis. Overall survival tended to be better in those with the GCB/MYD88L265P mutation (-) group, followed by the GCB/MYD88L265P mutation (+) group, and the non-GCB type. We speculate that Hans's algorithm and MYD88L265P mutation may have potential prognostic value for PCNSBLs.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":" ","pages":"28-39"},"PeriodicalIF":0.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extranodal marginal zone B-cell lymphoma with LP-like cells: indication of the link between MALT and nodular lymphocyte predominant Hodgkin lymphoma. 结外边缘区b细胞淋巴瘤伴lp样细胞：MALT与结节性淋巴细胞为主的霍奇金淋巴瘤之间的联系。

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Journal of Clinical and Experimental Hematopathology Pub Date : 2025-01-01 DOI: 10.3960/jslrt.24079

Kennosuke Karube, Megumi Tsuzuki, Akari Iwakoshi, Yoshiko Murakami, Rieko Nishimura

引用次数: 0

Impact of NRAS mutation on efficacy of triplet induction therapy in newly diagnosed multiple myeloma. NRAS突变对新诊断多发性骨髓瘤三胞胎诱导治疗疗效的影响。

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Journal of Clinical and Experimental Hematopathology Pub Date : 2025-01-01 DOI: 10.3960/jslrt.24077

Yuko Mishima, Yuko Shirouchi, Tomoko Takayama, Sayuri Minowa, Yuko Ishihara, Kei Hirano, Mitsuhito Hirano, Kikuaki Yoshida, Yukako Teramoto, Nobuhiko Yamauchi, Siew-Kee Low, Dai Maruyama

引用次数: 0

Utility of CSF IL-6 monitoring in managing ICANS associated with Epcoritamab treatment: a case report and literature review. 脑脊液IL-6监测在管理与依可瑞单抗治疗相关的ICANS中的应用：一个病例报告和文献综述

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Journal of Clinical and Experimental Hematopathology Pub Date : 2025-01-01 DOI: 10.3960/jslrt.24080

Atsushi Takahata, Kaori Akita, Tomohito Shimada, Kana Bando, Shigeo Toyota

{"title":"Utility of CSF IL-6 monitoring in managing ICANS associated with Epcoritamab treatment: a case report and literature review.","authors":"Atsushi Takahata, Kaori Akita, Tomohito Shimada, Kana Bando, Shigeo Toyota","doi":"10.3960/jslrt.24080","DOIUrl":"10.3960/jslrt.24080","url":null,"abstract":"Immune effector cell-associated neurotoxicity syndrome (ICANS) is a serious complication observed in patients receiving advanced immunotherapies such as bispecific antibodies and CAR-T cell therapies. Although the Immune Effector Cell-Associated Encephalopathy (ICE) score is commonly used to assess ICANS severity, its diagnostic accuracy can be compromised by factors such as concomitant medications, underlying comorbidities, and other external influences. This case report discusses a patient with diffuse large B-cell lymphoma who developed ICANS while receiving Epcoritamab. Notably, elevated interleukin-6 (IL-6) levels in the cerebrospinal fluid (CSF) correlated with the patient's clinical course of neurotoxicity. In contrast to conventional scoring systems, which can be affected by unrelated factors, CSF IL-6 levels appeared to more directly reflect the severity and progression of ICANS. These findings are consistent with similar reports from patients treated with CAR-T cells, suggesting that CSF IL-6 may serve as a reliable marker for ICANS progression. Further research that systematically measures CSF IL-6 in diverse clinical contexts could help validate its role as a biomarker, enhancing diagnostic precision and guiding optimal management strategies for ICANS.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"65 1","pages":"68-71"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0