Journal of Oral Biosciences最新文献

Impact of organic, conventional, and stingless bee honeys on the antibacterial activity of gummy candies against oral bacteria. 有机蜂蜜、传统蜂蜜和无刺蜂蜂蜜对口腔细菌软糖抗菌活性的影响。

IF 2.6

Journal of Oral Biosciences Pub Date : 2024-11-19 DOI: 10.1016/j.job.2024.100589

José Renato Silva, Jerônimo Kahn Villas-Bôas, Guilherme Biz, Ricardo Sergio Couto Almeida, Wilma Spinosa, Sandra Helena Prudencio

{"title":"Impact of organic, conventional, and stingless bee honeys on the antibacterial activity of gummy candies against oral bacteria.","authors":"José Renato Silva, Jerônimo Kahn Villas-Bôas, Guilherme Biz, Ricardo Sergio Couto Almeida, Wilma Spinosa, Sandra Helena Prudencio","doi":"10.1016/j.job.2024.100589","DOIUrl":"https://doi.org/10.1016/j.job.2024.100589","url":null,"abstract":"Objectives: This study aimed to investigate the impact of organic, conventional, and stingless honey on gummy candies, focusing on the effect of the cariogenic bacterium, Streptococcus mutans UA159, and total bacterial count in saliva from adolescents.Methods: Antimicrobial compounds in three honey samples were identified, and the minimum inhibitory concentration against S. mutans UA159 was determined. The antibacterial activities of the three honey candy formulations were determined against S. mutans UA159 in artificial saliva and total bacteria in saliva collected from adolescents. The sensory acceptance of the candy formulations by children, adolescents, and adults was investigated.Results: Candies prepared using conventional honey showed the highest antibacterial activity against S. mutans UA159 in vitro and total bacteria in human saliva. This effect was attributed to the higher levels of quercetin, myricetin, caffeine, and hydrogen peroxide in conventional honey.Conclusions: Nicotinic, ferulic, and p-coumaric acids found in honey had low antibacterial activity against oral bacteria. Quercetin, myricetin, caffeine, and hydrogen peroxide are the main anticariogenic compounds in honey and exert antibacterial effects on adolescent saliva, despite added to candies. However, organic production does not necessarily improve the biological properties of honey. All candies were equally liked by sensory assessors (acceptance > 70%), facilitating the selection of honey with higher biological activities to formulate functional candies.","PeriodicalId":45851,"journal":{"name":"Journal of Oral Biosciences","volume":" ","pages":"100589"},"PeriodicalIF":2.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Mechanism of tiRNA-Val-CAC-002 in the Pathogenesis of Oral Submucous Fibrosis. 探索 tiRNA-Val-CAC-002 在口腔黏膜下纤维化发病机制中的作用机制

IF 2.6

Journal of Oral Biosciences Pub Date : 2024-11-19 DOI: 10.1016/j.job.2024.100588

Liujun Zeng, Hui Peng, Leiye Sun, Huiqiao Yu, Yingfang Wu

{"title":"Exploring the Mechanism of tiRNA-Val-CAC-002 in the Pathogenesis of Oral Submucous Fibrosis.","authors":"Liujun Zeng, Hui Peng, Leiye Sun, Huiqiao Yu, Yingfang Wu","doi":"10.1016/j.job.2024.100588","DOIUrl":"https://doi.org/10.1016/j.job.2024.100588","url":null,"abstract":"Objectives: Oral submucous fibrosis (OSF) is a chronic, progressive, and potentially malignant disease of the oral cavity. A previous study by our team found that the aberrant expression of tRNA-derived small RNA (tsRNA) was involved in the development of OSF, with tiRNA-Val-CAC-002 showing the most significant difference. This study aimed to investigate the effect of tiRNA-Val-CAC-002 on fibroblast activation and its underlying mechanisms, elucidate the pathogenesis of OSF, and explore new effective targets for OSF prevention and treatment.Methods: RT-PCR was used to detect tiRNA-Val-CAC-002 expression in OSF and arecoline-treated fibroblasts. Western blotting, MDC staining, and transmission electron microscopy validated the effects of arecoline and 002 on fibroblast autophagy. Western blotting was used to explore the signaling pathways related to tiRNA-Val-CAC-002 in OSF.Results: Arecoline promotes fibroblast (FB) activation by upregulating tiRNA-Val-CAC-002. Arecoline stimulation and tiRNA-Val-CAC-002 overexpression activated fibroblasts by promoting autophagy. tiRNA-Val-CAC-002 regulates PI3K/AKT by mediating ITGB3 expression.Conclusions: Arecoline upregulates tiRNA-Val-CAC-002 expression in fibroblasts. Moreover, tiRNA-Val-CAC-002 may activate the autophagy of fibroblasts in OSF by ITGB3/PI3K/AKT pathway regulation, promoting the expression of collagen fibers.","PeriodicalId":45851,"journal":{"name":"Journal of Oral Biosciences","volume":" ","pages":"100588"},"PeriodicalIF":2.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CCN2: a potential contributor to gingival overgrowth. CCN2：牙龈过度生长的潜在因素。

IF 2.6

Journal of Oral Biosciences Pub Date : 2024-11-07 DOI: 10.1016/j.job.2024.100587

Asmaa Fadl, Andrew Leask

引用次数: 0

Anti-fungal effects of slightly acidic electrolyzed water on Candida species. 微酸性电解水对念珠菌的抗真菌作用

IF 2.6

Journal of Oral Biosciences Pub Date : 2024-11-06 DOI: 10.1016/j.job.2024.10.005

Chia-Hsin Wu, Yoshino Kaneyasu, Kanako Yano, Hideo Shigeishi, Honami Kitasaki, Tomoko Maehara, Yoshie Niitani, Toshinobu Takemoto, Yuichi Mine, Mi Nguyen-Tra Le, Miki Kawada-Matsuo, Hitoshi Komatsuzawa, Kouji Ohta

{"title":"Anti-fungal effects of slightly acidic electrolyzed water on Candida species.","authors":"Chia-Hsin Wu, Yoshino Kaneyasu, Kanako Yano, Hideo Shigeishi, Honami Kitasaki, Tomoko Maehara, Yoshie Niitani, Toshinobu Takemoto, Yuichi Mine, Mi Nguyen-Tra Le, Miki Kawada-Matsuo, Hitoshi Komatsuzawa, Kouji Ohta","doi":"10.1016/j.job.2024.10.005","DOIUrl":"https://doi.org/10.1016/j.job.2024.10.005","url":null,"abstract":"Objectives: Slightly acidic electrolyzed water (SAEW) is produced by electrolyzing 2-6% diluted hydrochloric acid in a membrane-less chamber, resulting in 5.0-6.5 pH, and can be applied to various foods as a disinfectant. Although SAEW has shown to have bactericidal activity, the details of its anti-fungal effects towards Candida species remain unknown. Therefore, we examined the fungicidal effects of SAEW on Candida spp. and biofilms on acrylic resins.Methods: The fungicidal effects of SAEW on Candida spp. at different reaction times and total numbers of colonies in culture plates were examined. Subsequently, SAEW was added to Candida spp. biofilms formed on polystyrene plates, and adenosine triphosphate (ATP) in SAEW was measured to examine its fungicidal effects towards Candida spp. biofilms. The fungicidal effect of SAEW on Candida spp. biofilms was determined by counting the number of colonies on the acrylic resin after adding SAEW.Results: SAEW completely killing activity within 1 min with the tested Candida spp.. C. albicans and C. glabrata ATP were increased 5 min after adding SAEW compared with the controls, suggesting the removal of biofilm. Of the C. albicans on acrylic resin, > 99.9%were killed by SAEW compared to their levels in deionized distilled water (DW) (76.2x102/mL and 43.3x102/mL, respectively). Similarly, 93.1% of C. glabrata were killed by SAEW compared to DW (159.3x102/mL).Conclusions: SAEW may be useful in preventing oral candidiasis as part of oral care.","PeriodicalId":45851,"journal":{"name":"Journal of Oral Biosciences","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maxillary sinus floor augmentation using sponge- and cotton-like graft materials in a rabbit model. 在兔子模型中使用海绵和棉花状移植材料进行上颌窦底隆起。

IF 2.6

Journal of Oral Biosciences Pub Date : 2024-11-04 DOI: 10.1016/j.job.2024.100586

Seigo Ohba, Rena Shido, Hideyuki Yamamoto, Masahito Hara, Yasutoshi Nishikawa, Toshihiro Kasuga, Tomohiro Yamada, Yoshinori Sumita, Tatsuo Shirota

{"title":"Maxillary sinus floor augmentation using sponge- and cotton-like graft materials in a rabbit model.","authors":"Seigo Ohba, Rena Shido, Hideyuki Yamamoto, Masahito Hara, Yasutoshi Nishikawa, Toshihiro Kasuga, Tomohiro Yamada, Yoshinori Sumita, Tatsuo Shirota","doi":"10.1016/j.job.2024.100586","DOIUrl":"https://doi.org/10.1016/j.job.2024.100586","url":null,"abstract":"Objectives: Bone graft materials commonly used for maxillary sinus floor augmentation (MSFA), including hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP), are mostly granular and have poor handleability. HAp/collagen composite material (HAp/Col) and β-tricalcium phosphate (β-TCP)/poly(L-lactide-co-glycolide) (PLGA) have shown promise but their application in MSFA as bone graft materials remains unclear. Here, we investigated the bone-forming behavior of HAp/Col and β-TCP/PLGA in an MSFA rabbit model.Methods: Male Japanese white rabbits were used. HAP/Col or β-TCP/PLGA was randomly applied to the MSFA model. The specimens were harvested at 4 weeks (W), 8W, 16W, and 24W after surgery, and the augmented regions were evaluated using micro-computed tomography and histological analyses.Results: The graft materials were retained up to 16W in the HAp/Col group and 24W in the β-TCP/PLGA group. The augmented volume detected in the HAp/Col group at 4W was substantially reduced at subsequent time points. However, in the β-TCP/PLGA group, the volume observed at 4W was maintained up to 24W. In the HAp/Col group, the bone mineral content (BMC) at 4W was significantly lower than that at 8W (p=0.03716), and this elevated BMC was significantly decreased at 16W (p=0.00185) and 24W (p=0.00236). In the β-TCP/PLGA group, the BMC tended to increase from 4W to 16W and then decreased.Conclusions: Both HAp/Col and β-TCP/PLGA are useful for MSFA because of their ability to form new bone and good handleability. The appropriate graft material should be selected depending on the application needs while understanding the properties of the newly formed bone.","PeriodicalId":45851,"journal":{"name":"Journal of Oral Biosciences","volume":" ","pages":"100586"},"PeriodicalIF":2.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decline in stimulus responsiveness of secretory granules in salivary glands with age. 唾液腺分泌颗粒对刺激的反应能力随年龄增长而下降。

IF 2.6

Journal of Oral Biosciences Pub Date : 2024-11-02 DOI: 10.1016/j.job.2024.100583

Miyuki Toda, Megumi Yokoyama, Osamu Katsumata-Kato, Junko Fujita-Yoshigaki

{"title":"Decline in stimulus responsiveness of secretory granules in salivary glands with age.","authors":"Miyuki Toda, Megumi Yokoyama, Osamu Katsumata-Kato, Junko Fujita-Yoshigaki","doi":"10.1016/j.job.2024.100583","DOIUrl":"https://doi.org/10.1016/j.job.2024.100583","url":null,"abstract":"Objectives: Secretory granules produced by salivary acinar cells accumulate if secretory stimulation is suppressed. Aged and deteriorated secretory granules can cause tissue damage because of abnormal secretion and/or intracellular leakage. To elucidate the deterioration process, we characterized the changes in the stimulus responsiveness of secretory granules using HaloTag technology.Methods: We established a system in which HaloTag-fused cystatin D, a salivary protein, was transported to the secretory granules of rat parotid acinar cells in primary culture. HaloTags can be labeled with cell-permeable ligands conjugated to fluorescent dyes in living cells. To observe the new and old secretory granules, the cells were labeled with two HaloTag ligands conjugated to different fluorescent dyes at different times. We measured the secretion rates of newly synthesized and old HaloTag-fused proteins in the absence and presence of isoproterenol, a β-adrenergic agonist, at 3 and 6 h after initial labeling.Results: Sequential labeling of HaloTag-fused proteins with two different dyes enabled the discrimination between new and old secretory granules. The secretory responsiveness of the proteins synthesized within 3 h to isoproterenol was higher than that of proteins synthesized earlier. However, there was no significant difference in the responsiveness between the new and old proteins at 6 h after initial labeling.Conclusion: New secretory granules have a higher sensitivity to stimulants than older ones and that their response declines over time.","PeriodicalId":45851,"journal":{"name":"Journal of Oral Biosciences","volume":" ","pages":"100583"},"PeriodicalIF":2.6,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apoptotic cell death during regressive changes in salivary glands: a morphological perspective. 唾液腺退行性变化过程中的细胞凋亡：形态学视角。

IF 2.6

Journal of Oral Biosciences Pub Date : 2024-11-01 DOI: 10.1016/j.job.2024.100585

Shigeru Takahashi, Akihiro Nezu, Akihiko Tanimura, Chikage Tamura, Kenji Imamachi, Tadasu Sato

{"title":"Apoptotic cell death during regressive changes in salivary glands: a morphological perspective.","authors":"Shigeru Takahashi, Akihiro Nezu, Akihiko Tanimura, Chikage Tamura, Kenji Imamachi, Tadasu Sato","doi":"10.1016/j.job.2024.100585","DOIUrl":"https://doi.org/10.1016/j.job.2024.100585","url":null,"abstract":"Background: Apoptosis was initially identified through transmission electron microscopy. Subsequent advances in morphological techniques for apoptosis detection have revealed its involvement in multiple pathological conditions in various tissues. This review summarizes previous experimental studies on apoptotic cell death during regressive changes in the salivary glands, with a focus on morphological observations.Highlight: Obstructive sialadenitis is histologically characterized by acinar cell loss and increased number of duct cells. Although acinar cells were previously believed to dedifferentiate into duct cells, there is evidence that they are eliminated by apoptosis. Animals fed a soft diet exhibited parotid gland atrophy, in which acinar cells decreased in size and disappeared because of apoptosis. Age-related changes in the salivary glands involved a reduced number of acinar cell through apoptosis. Additionally, apoptotic acinar cell death occurs in other pathological conditions, including the regression of hypertrophic and irradiated salivary glands.Conclusion: Apoptosis often eliminates acinar cells during atrophic alterations in the salivary glands. Unlike necrosis, apoptosis is an active form of cell death, thereby helping prevent the complete destruction of the salivary glands. However, the contribution of apoptosis to regressive changes in the salivary glands remains unclear and warrants further investigation.","PeriodicalId":45851,"journal":{"name":"Journal of Oral Biosciences","volume":" ","pages":"100585"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MANDI-Code: A Coding System for the human mandible. MANDI-Code：人类下颌骨编码系统。

IF 2.6

Journal of Oral Biosciences Pub Date : 2024-10-30 DOI: 10.1016/j.job.2024.100584

Doha Abualhija, Julieta Gómez García-Donas, Simon Shepherd, Ranya Al Ghazi, Scheila Manica

引用次数: 0

Conditional heterozygous loss of Kit receptor tyrosine kinase in neural crest cell lineage is associated with midline cleft lip and bifid nose deformity. 神经嵴细胞系中Kit受体酪氨酸激酶的条件性杂合性缺失与中线唇裂和双劈鼻畸形有关。

IF 2.6

Journal of Oral Biosciences Pub Date : 2024-10-17 DOI: 10.1016/j.job.2024.10.004

Hitomi Aoki, Hiroyuki Tomita, Akira Hara, Takahiro Kunisada

{"title":"Conditional heterozygous loss of Kit receptor tyrosine kinase in neural crest cell lineage is associated with midline cleft lip and bifid nose deformity.","authors":"Hitomi Aoki, Hiroyuki Tomita, Akira Hara, Takahiro Kunisada","doi":"10.1016/j.job.2024.10.004","DOIUrl":"https://doi.org/10.1016/j.job.2024.10.004","url":null,"abstract":"Objectives: The receptor tyrosine kinase Kit is expressed in cells derived from the trunk neural crest (NC), such as melanocytes; however, its role in cranial NC cell development is not fully understood.Methods: We investigated the effects of the heterozygous loss of Kit in NC cells during embryonic development by mating Kit2lox/+ mice with Wnt1-Cre mice to produce Wnt1-Cre; Kit2lox/+ embryos. In addition, Wnt1-Cre mice were mated with Rosa26R-yellow fluorescent protein (YFP) mice to visualize the tissue regions expressing Cre recombinase. Histological studies of the craniofacial regions of these mice were performed using samples from embryonic day (E) 12.5 and postnatal day (P) 1. Cellular apoptosis and proliferation were both analyzed through the immunostaining of tissue sections collected on E13.5 and E14.5 using anti-cleaved caspase 3 (CC3) to detect apoptosis and anti-Ki67 to detect proliferation. Cells from YFP-positive tissue regions of the facial areas of Wnt1-Cre; Kit+/+; Rosa26R-YFP embryos and Wnt1-Cre; Kit2lox/+; Rosa26R-YFP embryos collected on E12.5 and E15.5 were cultured and evaluated for cell proliferation.Results: Compared with control littermates, Wnt1-Cre; Kit2lox/+ embryos exhibited midline cleft lip and bifid nose deformities. Substantial early (P1) postnatal lethality was observed in Wnt1-Cre; Kit2lox/+ mice, with none surviving to 3 weeks of age. YFP-positive cells from the maxillary regions of Wnt1-Cre; Kit2lox/+; Rosa26R-YFP embryos exhibited defective cell growth and self-renewal in vitro.Conclusion: Conditional heterozygous loss of Kit in Wnt1-Cre; Kit2lox/+ embryos is associated with craniofacial dysplasia and exhibit defective NC development in vitro and in vivo.","PeriodicalId":45851,"journal":{"name":"Journal of Oral Biosciences","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142477311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remineralizing capacity of zinc oxide eugenol sealer following the addition of nanohydroxyapatite-tyrosine amino acid: An in vivo animal study. 添加纳米羟基磷灰石-酪氨酸氨基酸后氧化锌丁香酚封闭剂的再矿化能力：活体动物研究。

IF 2.6

Journal of Oral Biosciences Pub Date : 2024-10-15 DOI: 10.1016/j.job.2024.09.006

Rasha M Al-Shamaa, Raghad A Al-Askary

{"title":"Remineralizing capacity of zinc oxide eugenol sealer following the addition of nanohydroxyapatite-tyrosine amino acid: An in vivo animal study.","authors":"Rasha M Al-Shamaa, Raghad A Al-Askary","doi":"10.1016/j.job.2024.09.006","DOIUrl":"https://doi.org/10.1016/j.job.2024.09.006","url":null,"abstract":"Objective: Although several sealers have been developed, the zinc oxide eugenol (ZOE) sealer is still used in many private dental clinics. This study aimed to compare the biocompatibility and remineralizing capacity οf ZOE sealer with the addition of nanohydroxyapatite-tyrosine amino acid.Methods: This study was conducted on Twenty rabbits. The rabbits were divided into four groups based on the test observation period (3, 7, 21, and 28 days) following surgical implantation. General anesthesia was administered to each rabbit, and a subcutaneous incision of approximately 1±0.5 cm was made along the symphyseal area of the mandible of each rabbit. Four bone cavities were generated in the interdental space of the lower jaw between the central and molar teeth of each rabbit, with one longitudinal subcutaneous incision. The ZOE sealers were mixed according to the manufacturer's guidelines and directly inserted within the cavities generated at the end of each test period. The animals were sacrificed, and bone biopsy was carried out at the site of testing. The biopsy samples were obtained and subjected to histological analysis using a low-power light microscope (Olympus C ⅹ 21, Japan) and immunohistochemistry using Ki67 antibody.Results: The collected information was examined by parametric statistical tests using SPSS software version ''22.\" One-way ANOVA and post-hoc Duncan's tests were used to measure the significance among various groups, with statistical significance set, when \"P≤0.01\".Conclusion: The 20% mixed endodontic sealer displayed excellent outcomes compared to other experimental groups, as identified by higher new bone formation at every evaluation period.","PeriodicalId":45851,"journal":{"name":"Journal of Oral Biosciences","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142477314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0