高内皮小静脉的定位对口腔鳞状细胞癌患者的预后很重要

IF 2.3 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Biosciences Pub Date : 2025-09-19 DOI:10.1016/j.job.2025.100695

Takashi Niiyama , Aya Matsuda , Nako Maishi , Yasuhiro Hida , Alam Mohammad Towfik , Saki Shinohara , Amane Mizuno , Ren Zixiao , Lihong Lin , Wataru Kakuguchi , Kenichiro Sakata , Yoichi Ohiro , Yoshimasa Kitagawa , Hiroaki Suzuki , Michihiro Ueda , Kyoko Hida

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引用次数: 0

摘要

目的目前恶性肿瘤的治疗方法主要有手术、化疗和放射治疗，而免疫治疗最近被确立为治疗癌症的第四大方法。因此，癌细胞及其周围微环境一直是人们关注的焦点。高内皮小静脉（HEVs）介导淋巴细胞外渗到淋巴器官已经报道在癌组织。然而，混合动力汽车的作用仍然存在争议。本研究旨在探讨口腔鳞状细胞癌（OSCC）患者体内hev的临床意义。方法对83例经手术治疗的舌鳞癌患者进行回顾性分析。免疫组织化学染色hev和淋巴细胞，评估其数量和定位。结果hev数量多的患者预后明显改善。此外，hev在肿瘤边缘的定位与良好的预后相关。肿瘤边缘有cd8阳性细胞局部浸润的患者预后明显较好，但hev周围cd8阳性细胞数量与预后无相关性。Cox比例风险模型显示，TNM分期、hev定位和cd8阳性细胞定位是影响OSCC患者无病生存的预后因素。结论hev和cd8阳性细胞的定位影响OSCC患者的预后，是有益的预后因素。

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Localization of high endothelial venules is important for the prognosis of patients with oral squamous cell carcinoma

Objectives

Surgery, chemotherapy, and radiation therapy are currently used for the treatment of malignant tumors, and immunotherapy has recently been established as the fourth method for treating cancer. Therefore, cancer cells and their surrounding microenvironments have been the focus of attention. High endothelial venules (HEVs) that mediate lymphocyte extravasation into lymphoid organs have been reported in cancerous tissues. However, the role of HEVs remains controversial. In this study, the clinical significance of HEVs in patients with oral squamous cell carcinoma (OSCC) was examined.

Methods

Eighty-three patients with OSCC of the tongue who had surgery as initial treatment were included. HEVs and lymphocytes were immunohistochemically stained, and their numbers and localization were evaluated.

Results

The prognosis significantly improved in patients with a high number of HEVs. Additionally, localization of HEVs to the tumor margins was associated with a good prognosis. Patients with localized infiltration of CD8-positive cells at the tumor margin had a significantly better prognosis, although no correlation was observed between the number of CD8-positive cells around the HEVs and the prognosis. Cox proportional hazards model revealed that TNM Stage, localization of HEVs, and localization of CD8-positive cells are prognostic factors affecting disease-free survival in patients with OSCC.