细胞疗法在日本牙科推广的挑战与前景

IF 2.3 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Morikuni Tobita, Anna Arita
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引用次数: 0

摘要

在日本,再生医学在牙科中得到了积极的应用,间充质间质细胞(MSC)治疗显示出良好的潜力。尽管越来越多的兴趣和一些临床和私人实践应用,采用msc为基础的疗法仍然有限。在本研究中,我们报告了日本牙科细胞治疗的现状,并讨论了普及细胞治疗的挑战和牙科再生医学的未来方向。截至2025年5月,MSCs已被用于口腔组织再生的临床研究和私人实践。牙髓是骨髓间充质干细胞的主要来源,其次是脂肪组织和骨髓。日本大约有50家私人牙科诊所提供基于msc的治疗,大多数外包细胞处理。目前在确保牙科细胞治疗的安全性和有效性方面面临的挑战是:1)在提供私人诊所之前,对特定疾病的安全性和有效性的验证有限;2)缺乏适当收集的临床数据来支持循证实践。结论要安全推广牙科再生医学,必须加强对牙科诊所的支持。这包括与学术机构进行更密切的合作,并系统地收集临床数据,以确保安全性和有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Challenges and prospects for popularizing cell therapy in the dentistry in Japan

Background

Regenerative medicine is actively used in dentistry in Japan and mesenchymal stromal cell (MSC) therapy shows promising potential. Despite the growing interest and some clinical and private practice applications, the adoption of MSC-based therapies remains limited. In this study, we report the current status of cell therapy in dentistry in Japan and discuss the challenges in popularizing cell therapy and the future direction of dental regenerative medicine.

Highlights

As of May 2025, MSCs were being used for oral tissue regeneration in clinical research and private practice. Dental pulp is the primary source of MSCs, followed by adipose tissue and bone marrow. Approximately 50 private practice dental clinics in Japan offer MSC-based therapies, with most outsourcing cell processing. Current challenges in ensuring the safety and validity of cell therapy in dentistry are: 1) limited verification of safety and efficacy for specific diseases before offering private practice and 2) lack of appropriately collected clinical data to support evidence-based practice.

Conclusion

To safely expand regenerative medicine in dentistry, stronger support for dental clinics is essential. This includes closer collaboration with academic institutions and the systematic collection of clinical data to ensure safety and efficacy.
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来源期刊
Journal of Oral Biosciences
Journal of Oral Biosciences DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
4.40
自引率
12.50%
发文量
57
审稿时长
37 days
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