{"title":"Immune-Related Encephalitis in a Patient With Pleural Mesothelioma: Case Report.","authors":"Fumie Onishi, Naofumi Hara, Moeko Ota, Kiriko Onishi, Yusuke Fujioka, Hisaaki Tanaka, Nobukazu Fujimoto","doi":"10.1002/rcr2.70748","DOIUrl":"10.1002/rcr2.70748","url":null,"abstract":"<p><p>A 69-year-old man who was a former plumber with a history of occupational asbestos exposure was diagnosed with unresectable pleural mesothelioma. Six months after initiation of combination therapy with ipilimumab and nivolumab, he presented with an altered level of consciousness and extrapyramidal symptoms and was diagnosed with immune-related encephalitis. Although high-dose corticosteroid therapy and intravenous immunoglobulin led to partial improvement in his level of consciousness, the response was limited. Immune-related encephalitis is rare, especially in association with pleural mesothelioma. Optimal management of the condition needs to be established.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 9","pages":"e70748"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saki Saijo, Mayu Noda, Yuta Arai, Konomi Moriwaki, Kota Miyoshi, Masaki Terazawa, Shotaro Otani, Kazuki Momota, Hiroki Sato, Takuya Takashima, Toshiyuki Nunomura, Manabu Ishihara, Taiga Itagaki, Tomonori Iwasaki, Jun Oto
{"title":"Computational Fluid Dynamics as an Adjunctive Functional Assessment of Airway Narrowing After Pulmonary Artery Banding: A Case Report.","authors":"Saki Saijo, Mayu Noda, Yuta Arai, Konomi Moriwaki, Kota Miyoshi, Masaki Terazawa, Shotaro Otani, Kazuki Momota, Hiroki Sato, Takuya Takashima, Toshiyuki Nunomura, Manabu Ishihara, Taiga Itagaki, Tomonori Iwasaki, Jun Oto","doi":"10.1002/rcr2.70749","DOIUrl":"10.1002/rcr2.70749","url":null,"abstract":"<p><p>Airway compression is a recognized complication after pulmonary artery banding (PAB) in infants with congenital heart disease; however, conventional imaging primarily provides anatomical information. We report an infant with respiratory instability after PAB who underwent computational fluid dynamics (CFD) as an adjunctive functional assessment. After extubation, recurrent intercostal retractions and oxygen desaturation occurred during crying. Contrast-enhanced CT and bronchoscopy revealed mild-to-moderate tracheobronchial narrowing caused by dilated pulmonary arteries without intrinsic obstruction. A patient-specific CFD model simulated inspiratory airflow at 100 mL/s, approximating crying. Total airway resistance was markedly elevated (15 Pa/mL/s vs. approximately 0.07 Pa/mL/s in healthy infants), with pronounced airflow asymmetry and reduced flow to the right main bronchus, suggesting functional impairment despite relatively preserved airway lumens. These findings were considered complementary to the overall clinical assessment, rather than an independent surgical indication. The patient's symptoms resolved after pulmonary artery plication and ventricular septal defect closure.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 9","pages":"e70749"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acute Respiratory Deterioration Following Parvovirus B19 Infection in a Patient With Interstitial Lung Disease: A Case Report.","authors":"Tomoki Kishaba, Satoshi Marumo, Yuya Nishida, Eri Nohara, Jukiya Higashi, Shohei Aoki, Chiaki Okura, Shiori Jinno, Noriyuki Tashima, Chie Morimoto, Takamasa Kitajima, Daiki Inoue","doi":"10.1002/rcr2.70751","DOIUrl":"10.1002/rcr2.70751","url":null,"abstract":"<p><p>Acute exacerbation of interstitial lung disease (AE-ILD) is often idiopathic, although viral infections are recognized precipitating factors. We report an adult patient with underlying ILD who developed acute respiratory deterioration in the setting of primary parvovirus B19 infection. A 70-year-old Japanese man was admitted to our department with a low-grade fever and a facial rash. Two years prior to admission, the patient had been diagnosed with ILD, which had been treated with systemic corticosteroids that were subsequently discontinued following clinical improvement. High-resolution computed tomography (HRCT) revealed newly developed bilateral ground-glass opacities. Infection with parvovirus B19 was confirmed by serological testing and bronchoalveolar lavage results. Although the precise contribution of parvovirus B19-associated lung injury, infection-triggered AE-ILD and acute exacerbation of the underlying ILD could not be definitively determined, steroid pulse therapy led to clinical and radiological improvement. This case highlights the importance of considering parvovirus B19 infection as a potential contributor to acute respiratory deterioration in patients with underlying ILD.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 9","pages":"e70751"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kani Shang, Ashleigh Witt, Neil Smith, Steven James Lindstrom
{"title":"Negative Pressure Pulmonary Oedema With Pulmonary Haemorrhage Following Brief Neck Compression in an Adolescent.","authors":"Kani Shang, Ashleigh Witt, Neil Smith, Steven James Lindstrom","doi":"10.1002/rcr2.70740","DOIUrl":"10.1002/rcr2.70740","url":null,"abstract":"<p><p>Negative pressure pulmonary oedema (NPPE) is well recognised in peri-operative settings but is infrequently reported following brief non-operative airway obstruction, particularly in adolescents. We report the case of an adolescent male who developed NPPE with features of concurrent negative pressure pulmonary haemorrhage (NPPH) following approximately 90 s of neck compression. He experienced transient loss of consciousness with hypoxic myoclonic activity, followed by haemoptysis and hypoxia requiring supplemental oxygen. Chest X-ray (CXR) revealed bilateral opacities, which was followed up by computed tomography (CT) of the chest demonstrating diffuse bilateral ground-glass and confluent opacities consistent with pulmonary oedema and probable superimposed haemorrhage. He recovered with supplemental oxygen alone within 48 h. This case shows that even brief neck compression can cause significant pulmonary injury, that chokeholds are an under-recognised precipitant, and that concurrent NPPH may mimic aspiration or infection, risking unnecessary intervention.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 9","pages":"e70740"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2026-08-28eCollection Date: 2026-09-01DOI: 10.1002/rcr2.70729
Ali Gohar, Aemin Tariq, Arham Saif, Asma Farooq, Esha Aziz, Muhammad Husnain Ahmad
{"title":"Atypical Fibrotic-Mimicking Pulmonary Sarcoidosis in a Young Female: The Basal Conundrum.","authors":"Ali Gohar, Aemin Tariq, Arham Saif, Asma Farooq, Esha Aziz, Muhammad Husnain Ahmad","doi":"10.1002/rcr2.70729","DOIUrl":"10.1002/rcr2.70729","url":null,"abstract":"<p><p>Pulmonary sarcoidosis is a systemic inflammatory disease characterized by the formation of non-caseating granulomas; it typically presents with bilateral hilar lymphadenopathy and upper-lobe predominant interstitial infiltrates. However, atypical radiological presentations can mimic fibrotic interstitial lung diseases, posing a significant diagnostic challenge. We present a case of pulmonary sarcoidosis in a young female who had a confounding basal-peripheral phenotype, eventually diagnosed through endobronchial biopsy showing non-necrotizing granulomas with asteroid bodies.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 9","pages":"e70729"},"PeriodicalIF":0.7,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2026-08-28eCollection Date: 2026-09-01DOI: 10.1002/rcr2.70743
Keisuke Shiraha, Yuki Takigawa, Mitsuki Furutaguchi, Ken Sato, Suzuka Matsuoka, Mayu Goda, Hiromi Watanabe, Jun Nishimura, Kenichiro Kudo, Keiichi Fujiwara
{"title":"Diagnosis of Synchronous Primary Lung Cancers Using EBUS-TBNA and BDBD-Assisted Transbronchial Biopsy During a Single Bronchoscopic Procedure: A Case Report.","authors":"Keisuke Shiraha, Yuki Takigawa, Mitsuki Furutaguchi, Ken Sato, Suzuka Matsuoka, Mayu Goda, Hiromi Watanabe, Jun Nishimura, Kenichiro Kudo, Keiichi Fujiwara","doi":"10.1002/rcr2.70743","DOIUrl":"10.1002/rcr2.70743","url":null,"abstract":"<p><p>Histopathological confirmation is essential to determine the optimal treatment strategy for patients with multiple pulmonary lesions. We report a case of synchronous small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) diagnosed during the same bronchoscopic session using endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and balloon dilation for bronchoscope delivery (BDBD) technique. A 70-year-old man with a history of gastric cancer presented with mediastinal lymphadenopathy and a nodule in the right upper lobe. EBUS-TBNA confirmed SCLC in the mediastinal lymph nodes. For the peripheral pulmonary lesion, BDBD enabled further advancement of the thin bronchoscope, allowing direct visualization and biopsy with standard forceps, which confirmed NSCLC. No procedure-related complications occurred. This case suggests that combining EBUS-TBNA with BDBD facilitates the accurate diagnosis of multiple pulmonary lesions during the same bronchoscopic session.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 9","pages":"e70743"},"PeriodicalIF":0.7,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2026-08-28eCollection Date: 2026-09-01DOI: 10.1002/rcr2.70744
Fabio Varon-Vega, Carlos Evelio Franco Parra, Doris Fabiola Adame Ochoa, Nancy Uricoechea, Eduardo Tuta-Quintero, María Camila Martinez Ayala
{"title":"Use of High-Flow Nasal Cannula in Amyotrophic Lateral Sclerosis Patients Intolerant to Non-Invasive Ventilation: A Case Series.","authors":"Fabio Varon-Vega, Carlos Evelio Franco Parra, Doris Fabiola Adame Ochoa, Nancy Uricoechea, Eduardo Tuta-Quintero, María Camila Martinez Ayala","doi":"10.1002/rcr2.70744","DOIUrl":"10.1002/rcr2.70744","url":null,"abstract":"<p><p>Non-invasive ventilation (NIV) is standard respiratory support for amyotrophic lateral sclerosis (ALS), but intolerance may limit its use. High-flow nasal cannula (HFNC) has emerged as a potential alternative in selected patients, but evidence regarding its use remains scarce. We describe 18 ALS patients' management with HFNC between 2014 and 2024 after documented intolerance to NIV. Mean age at HFNC initiation was 65.1 ± 12.5 years, and 66.7% of patients were female. Partial NIV intolerance occurred in 38.9% of cases, while 33.3% tolerated intermittent combined NIV and HFNC. During follow-up, 50.0% of patients required hospitalization, 33.3% experienced respiratory infections, and 27.8% died. Arterial blood gas parameters remained stable, including PaCO<sub>2</sub> (<i>p</i> = 0.314). Functional status declined significantly, with Barthel Index decreasing (35.0 ± 20.5 vs. 11.7 ± 11.3; <i>p</i> < 0.001), whereas respiratory muscle strength remained unchanged. HFNC was feasible as home-based support in ALS patients intolerant to NIV, warranting prospective comparative evaluation.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 9","pages":"e70744"},"PeriodicalIF":0.7,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-Term Recurrence-Free Outcome After Doxycycline Pleurodesis With Pulmonary Rehabilitation and Nutritional Support in an Underweight Patient With COPD: A Case Report.","authors":"Kemas Rakhmat Notariza, Prasenohadi Pradono, Siti Chandra Widjanantie, Elfina Rachmi, Agus Dwi Susanto","doi":"10.1002/rcr2.70675","DOIUrl":"10.1002/rcr2.70675","url":null,"abstract":"<p><p>Secondary spontaneous pneumothorax (SSP), a complication of chronic obstructive pulmonary disease (COPD), recurs more frequently in underweight patients. This case report describes a 63-year-old malnourished man with COPD presenting with recurrent left-sided SSP shortly after hospital discharge for a previous episode. Following chest tube reinsertion and complete lung re-expansion, chemical pleurodesis was performed using 1000 mg doxycycline in saline. Transient pleuritic pain was controlled with intravenous ketorolac and intrapleural lidocaine. No other immediate or delayed adverse events occurred. In parallel, pulmonary rehabilitation, including breathing exercises, posture correction, moderate-intensity endurance and inspiratory muscle training, was initiated alongside nutritional repletion with a respiratory-specific oral nutritional supplement. Over a 22-month follow-up, the patient remained free of SSP recurrence, with improved functional capacity and weight gain. This report describes a long-term recurrence-free outcome after doxycycline pleurodesis combined with pulmonary rehabilitation and nutritional support in an underweight patient with COPD.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 9","pages":"e70675"},"PeriodicalIF":0.7,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13523071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2026-08-28eCollection Date: 2026-09-01DOI: 10.1002/rcr2.70739
Noboru Morikawa, Satoshi Mikami, Daisuke Suzuki
{"title":"Gradually Enlarging Nodular Pulmonary Amyloidosis Associated With Sjögren's Syndrome.","authors":"Noboru Morikawa, Satoshi Mikami, Daisuke Suzuki","doi":"10.1002/rcr2.70739","DOIUrl":"10.1002/rcr2.70739","url":null,"abstract":"<p><p>A 65-year-old woman with primary Sjögren's syndrome without a history of immunosuppressive therapy presented with progressively enlarging pulmonary nodules showing calcification and cystic changes, mimicking malignancy. Histological examination confirmed AL λ-type nodular pulmonary amyloidosis. Recognition of this radiological pattern is important to avoid misdiagnosis and unnecessary invasive investigations.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 9","pages":"e70739"},"PeriodicalIF":0.7,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relapsing Polychondritis Presenting With Diffuse Tracheal Inflammation.","authors":"Daigo Imasato, Kazutoshi Toriyama, Hayato Kinoshita, Yukihisa Takeda, Yuko Iwata, Masayuki Kitahara, Hiroshi Kobayashi, Kenji Tsushima","doi":"10.1002/rcr2.70747","DOIUrl":"10.1002/rcr2.70747","url":null,"abstract":"<p><p>A 59-year-old man presented with sore throat and cough, and chest computed tomography and bronchoscopy revealed airway stenosis. Four McAdam's criteria supported the diagnosis of relapsing polychondritis. High-dose prednisolone and cyclophosphamide improved symptoms and airway lesions, highlighting the importance of early recognition and serial airway evaluation.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 9","pages":"e70747"},"PeriodicalIF":0.7,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13520779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}