{"title":"Multiple cavitary pulmonary metastases from pancreatic cancer diagnosed using transbronchial lung cryobiopsy.","authors":"Takashi Funasaka, Yasushi Makino, Tomofumi Shibata, Hirotoshi Yasui, Yasutaka Fukui, Mitsuru Odate, Takayasu Ito","doi":"10.1002/rcr2.70031","DOIUrl":"https://doi.org/10.1002/rcr2.70031","url":null,"abstract":"<p><p>Multiple cavitary pulmonary metastases are rare, and cavitary lung lesions have various aetiologies and differential diagnoses. Therefore, radiological diagnosis of lung cavities is extremely difficult. Herein, we report a case of pancreatic cancer with multiple cavitary pulmonary metastases diagnosed using transbronchial lung cryobiopsy (TBLC), that required differentiation from pulmonary lesions of Sjögren's syndrome whose pulmonary manifestation may present as bronchiectasis and cystic change. TBLC may be useful for the diagnosis of multiple lesions because sufficiently large specimens can be obtained to allow pathological evaluation of the lung parenchyma and bronchiolar lesions.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 9","pages":"e70031"},"PeriodicalIF":0.8,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11423189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2024-09-24eCollection Date: 2024-09-01DOI: 10.1002/rcr2.70030
Jean-Benoit Martinot, Lorent Hostaux, Atul Malhotra, Dennis Hwang, Jean-Louis Pépin
{"title":"Air leak phenotyping by mandibular jaw movement analysis in CPAP therapy: Key insights for practitioners.","authors":"Jean-Benoit Martinot, Lorent Hostaux, Atul Malhotra, Dennis Hwang, Jean-Louis Pépin","doi":"10.1002/rcr2.70030","DOIUrl":"https://doi.org/10.1002/rcr2.70030","url":null,"abstract":"<p><p>Monitoring unintentional air leaks in continuous positive airway pressure (CPAP) treatment for obstructive sleep apnea (OSA) is essential for therapy success. While leaks are often attributed to improperly sealed masks, mouth openings may also cause them, requiring interventions. Recent studies demonstrated distinctive mandibular jaw movement (MJM) signal patterns during sleep related to respiratory events and sleep stages. Analysing MJM during CPAP treatment reveals air leak peaks coinciding with maximal MJM amplitude during obstructive events, and air leak decreases corresponding to arousals. Examining leaks with MJM offers valuable insights into their origins and might open new avenues for CPAP management.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 9","pages":"e70030"},"PeriodicalIF":0.8,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11421881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Re-expansion pulmonary edema and atelectasis due to mucus plug following chest tube placement for pneumothorax.","authors":"Nghi Nguyen-Dang, Quoc-Khanh Tran-Le, Lam Nguyen-Ho","doi":"10.1002/rcr2.70032","DOIUrl":"https://doi.org/10.1002/rcr2.70032","url":null,"abstract":"<p><p>Re-expansion pulmonary edema (REPE) and mucus plug-induced atelectasis are potential complications that clinicians should be aware of following chest tube placement for pneumothorax.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 9","pages":"e70032"},"PeriodicalIF":0.8,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11421880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2024-09-24eCollection Date: 2024-09-01DOI: 10.1002/rcr2.70033
Anjali Murali, Anju Farsana A, Sobha Subramaniam, Malini Eapen, Indu R Nair, Keechilat Pavithran
{"title":"Exceptional long term response to crizotinib in ROS 1-postive advanced non small cell lung cancer.","authors":"Anjali Murali, Anju Farsana A, Sobha Subramaniam, Malini Eapen, Indu R Nair, Keechilat Pavithran","doi":"10.1002/rcr2.70033","DOIUrl":"https://doi.org/10.1002/rcr2.70033","url":null,"abstract":"<p><p>Non-small-cell lung cancer (NSCLC) accounts for the majority of lung cancer cases worldwide, with a significant proportion of patients harbouring actionable oncogenic alterations. Among these alterations, the ROS1 rearrangement represents a distinct subset with therapeutic implications. Here, we present the case of a 52-year-old man diagnosed with advanced NSCLC harbouring the ROS1 fusion gene. Despite the initial poor response to conventional chemotherapy, the patient exhibited an exceptional and sustained response to crizotinib, with a progression-free survival of 94 months and complete metabolic response on PET scan. This case underscores the importance of molecular profiling in guiding treatment decisions and highlights the efficacy of targeted therapies for ROS1-positive NSCLC.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 9","pages":"e70033"},"PeriodicalIF":0.8,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11421889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful treatment of tracheal stenosis due to a broken uncovered metallic stent placed over 20 years ago in a patient with recurrent polychondritis using argon plasma coagulation and airway ballooning.","authors":"Yuki Takigawa, Ken Sato, Kenichiro Kudo, Takeru Ichikawa, Yuto Sasano, Shoichiro Matsumoto, Tomoyoshi Inoue, Miho Fujiwara, Suzuka Matsuoka, Hiromi Watanabe, Akiko Sato, Keiichi Fujiwara, Takuo Shibayama","doi":"10.1002/rcr2.70034","DOIUrl":"https://doi.org/10.1002/rcr2.70034","url":null,"abstract":"<p><p>A woman in her mid-60s with recurrent polychondritis was admitted to our hospital due to airway stenosis secondary to an uncovered metallic stent. She underwent a bronchoscopic intervention under general anaesthesia. During the procedure, the stent fracture was cauterized using Argon Plasma Coagulation (APC) cauterisation, performed with argon flow at 1 L/min and power set at 70 W. APC cauterisation caused the stent wire to flex circularly, gradually improving the stenosis. Tracheal dilatation was then performed using an airway balloon. Following the ballooning, a thin bronchoscope was easily passed through the lower trachea, and the left and right main bronchi were observed; therefore, the procedure was completed without any complications. APC coagulation and airway ballooning are viable choices for the temporary treatment of airway stenosis due to broken metallic stents.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 9","pages":"e70034"},"PeriodicalIF":0.8,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11421887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2024-09-19eCollection Date: 2024-09-01DOI: 10.1002/rcr2.70027
Raul Leguizamon, Ian McLaren, Tara John, Rasha Khan, Alexander Prendergast, Phuuwadith Wattanachayakul, Andrew Geller, John Malin, Simone A Jarret, Kevin Bryan Lo, Jose Manuel Martinez Manzano, Christian Witzke
{"title":"Pulmonary vasodilators in patients with advanced chronic kidney disease and pre-capillary pulmonary hypertension-A case series.","authors":"Raul Leguizamon, Ian McLaren, Tara John, Rasha Khan, Alexander Prendergast, Phuuwadith Wattanachayakul, Andrew Geller, John Malin, Simone A Jarret, Kevin Bryan Lo, Jose Manuel Martinez Manzano, Christian Witzke","doi":"10.1002/rcr2.70027","DOIUrl":"https://doi.org/10.1002/rcr2.70027","url":null,"abstract":"<p><p>Pulmonary hypertension (PH) is a prevalent complication among patients with chronic kidney disease (CKD). In these patients, pulmonary vasodilators may be useful but are underused. We describe a group of patients with precapillary PH and advanced CKD treated with pulmonary vasodilators. This was a case series of patients with CKD stage 4 and 5 and precapillary PH (isolated or combined) based on right heart catheterization (RHC) treated with pulmonary vasodilators from 2018 to 2023. Of 263 patients with isolated precapillary or combined PH and advanced CKD, only 17 (6%) were treated with pulmonary vasodilators; 53% (<i>n</i> = 9) with precapillary PH and 47% (<i>n</i> = 8) with combined PH. Most patients (94%, <i>n</i> = 16) received phosphodiesterase-5 antagonists, while 12% (<i>n</i> = 2) received endothelin receptor antagonists. Adverse clinical outcomes were seen in 35% of patients within a year. The use of pulmonary vasodilator did not prevent adverse outcomes in patients with precapillary PH and advanced CKD.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 9","pages":"e70027"},"PeriodicalIF":0.8,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chest wall subcutaneous mass leading to the diagnosis of pericostal tuberculosis.","authors":"Shimpei Kajie, Kentaro Nakamura, Tomohiro Moriya, Tomoyuki Ogata, Takaaki Yamashita","doi":"10.1002/rcr2.70029","DOIUrl":"https://doi.org/10.1002/rcr2.70029","url":null,"abstract":"<p><p>When diagnosing a chest wall mass, even in the absence of pulmonary lesions, it is crucial to consider pericostal tuberculosis as a differential diagnosis. Attention must be paid to the characteristic findings on contrast-enhanced computed tomography, such as central low attenuation, peripheral rim enhancement of soft tissue, and pleural involvement.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 9","pages":"e70029"},"PeriodicalIF":0.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11410871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2024-09-18eCollection Date: 2024-09-01DOI: 10.1002/rcr2.70028
Minoru Sugihara, Sawako Okamoto, Tetsuo Taniguchi
{"title":"Pulmonary Langerhans cell histiocytosis with multiple cavitary nodules after lung cancer surgery.","authors":"Minoru Sugihara, Sawako Okamoto, Tetsuo Taniguchi","doi":"10.1002/rcr2.70028","DOIUrl":"https://doi.org/10.1002/rcr2.70028","url":null,"abstract":"<p><p>Pulmonary Langerhans cell histiocytosis (PLCH) is a subtype of Langerhans cell histiocytosis, a rare neoplastic disease characterized by lung involvement. Here, we present a case involving a patient with multiple cavitary nodules who was diagnosed with PLCH during surveillance after lung cancer surgery. A 74-year-old woman underwent right upper lobe resection surgery for right upper lobe lung adenocarcinoma, pStage IIA, 5 years ago. The patient underwent surveillance without adjuvant chemotherapy. During the fifth year of follow-up, multiple nodules with cavitation were observed on computed tomography in both lung fields. Chemotherapy was considered to address the suspected recurrence of lung cancer; however, video-assisted thoracoscopic surgery was performed due to the need for biomarker testing. Pathological examination led to the diagnosis of PLCH. This case emphasizes the importance of a proactive histological diagnosis to determine the appropriate treatment strategy, even in situations where lung cancer recurrence is clinically suspected.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 9","pages":"e70028"},"PeriodicalIF":0.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11410873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Combination effect of Mepolizumab and Endobronchial Watanabe Spigot (EWS) in drug-induced eosinophilic pneumonia complicated by refractory pneumothorax.","authors":"Nana Ayame, Yuki Tanabe, Mai Motojima, Ryosuke Tachi, Fumihiko Makino, Shiaki Oh, Shinichi Sasaki, Kazuhisa Takahashi","doi":"10.1002/rcr2.70021","DOIUrl":"https://doi.org/10.1002/rcr2.70021","url":null,"abstract":"<p><p>Few reports have described the treatment of eosinophilic pneumonia (EP) complicated by refractory pneumothorax. A 62-year-old man with a medical history of ulcerative colitis who was undergoing maintenance treatment presented with fever, cough, and diffuse bilateral consolidation on chest radiography. Laboratory findings showed peripheral eosinophilia, and he was hospitalized with a diagnosis of drug-induced EP and started on corticosteroid therapy. During the course, he developed refractory pneumothorax, and it was difficult to control the air leakage. As it was necessary to control the eosinophilic inflammation and air leakage, mepolizumab, a humanized anti-interleukin-5 monoclonal antibody, and an endobronchial Watanabe spigot (EWS), were introduced. After EWS insertion, the leakage of the refractory pneumothorax disappeared. The patient continued to have no recurrence of EP or pneumothorax after the removal of the EWS. The combination of mepolizumab and an EWS may be effective in cases of EP complicated by refractory pneumothorax.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 9","pages":"e70021"},"PeriodicalIF":0.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11408264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A rare case of tracheal squamous cell carcinoma presented with critical airway obstruction.","authors":"Chen-Yu Ho, Yu-Wei Liu, Wei-An Lai, Chia-Min Chen, Kuan-Li Wu","doi":"10.1002/rcr2.70024","DOIUrl":"https://doi.org/10.1002/rcr2.70024","url":null,"abstract":"<p><p>Tracheal squamous cell carcinoma is a rare and potentially fatal thoracic cancer mimicking common airway disorders. Accurate diagnosis requires a detailed history, thorough physical examination, and high clinical suspicion.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 9","pages":"e70024"},"PeriodicalIF":0.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11408120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}