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Very Late Age-Onset Asthma: Mimic of Other Respiratory Diseases and Important Diagnosis Not to Be Missed.
IF 0.8
Respirology Case Reports Pub Date : 2025-03-17 eCollection Date: 2025-03-01 DOI: 10.1002/rcr2.70148
Hanson Siu, Allison Michaud, Philip G Bardin
{"title":"Very Late Age-Onset Asthma: Mimic of Other Respiratory Diseases and Important Diagnosis Not to Be Missed.","authors":"Hanson Siu, Allison Michaud, Philip G Bardin","doi":"10.1002/rcr2.70148","DOIUrl":"10.1002/rcr2.70148","url":null,"abstract":"<p><p>Asthma is often not recognised and is frequently not diagnosed and treated in older people. This may reflect the belief that the disease is unlikely to manifest late in this group. We report a patient who presented with a respiratory infection and persistent breathlessness after the age of 80. Asthma was not initially suspected, and other diagnoses were pursued. However, subsequent spirometry suggested late age-onset asthma that responded dramatically to appropriate treatment. This case provides a timely reminder for physicians to consider this diagnosis in older patients.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70148"},"PeriodicalIF":0.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Potential of Pulmonary Vasodilators as a Bridging Therapy for Lung Transplantation: Two Cases of Interstitial Pneumonia With Pulmonary Hypertension During the Waiting Period for Lung Transplantation.
IF 0.8
Respirology Case Reports Pub Date : 2025-03-17 eCollection Date: 2025-03-01 DOI: 10.1002/rcr2.70136
Yuichi Nagata, Tetsutaro Nagaoka, Yuriko Terayama, Yoshifumi Suzuki, Takashi Yoshida, Sachiko Kuriyama, Satomi Shiota, Masaaki Sato, Kazuhisa Takahashi
{"title":"The Potential of Pulmonary Vasodilators as a Bridging Therapy for Lung Transplantation: Two Cases of Interstitial Pneumonia With Pulmonary Hypertension During the Waiting Period for Lung Transplantation.","authors":"Yuichi Nagata, Tetsutaro Nagaoka, Yuriko Terayama, Yoshifumi Suzuki, Takashi Yoshida, Sachiko Kuriyama, Satomi Shiota, Masaaki Sato, Kazuhisa Takahashi","doi":"10.1002/rcr2.70136","DOIUrl":"10.1002/rcr2.70136","url":null,"abstract":"<p><p>Pulmonary hypertension (PH) associated with interstitial pneumonia (IP) has a poor prognosis, and lung transplantation (LT) is the only effective treatment option for severe cases. However, the waiting period for LT often exceeds the median survival time in these patients, and the effectiveness of pulmonary vasodilators during this period is not well established. In Case 1, a patient with scleroderma-related IP and PH was treated with sildenafil, which resulted in improved PH and successful single-lung transplantation. In Case 2, a patient with rheumatoid arthritis-related IP and PH was treated with tadalafil and macitentan, leading to successful single-lung transplantation. These cases suggest that pulmonary vasodilators may be valuable bridging therapies for patients with PH associated with IP who are awaiting LT.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70136"},"PeriodicalIF":0.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to "Rapid On-Site Digital Histopatholocal Evaluation (RODE) on Endobronchial Ultrasound (EBUS) Mediastinal Lymph Node Cryobiopsy Sampling Using Confocal Laser Microscopy-A Proof-Of-Concept Study".
IF 0.8
Respirology Case Reports Pub Date : 2025-03-17 eCollection Date: 2025-03-01 DOI: 10.1002/rcr2.70159
{"title":"Correction to \"Rapid On-Site Digital Histopatholocal Evaluation (RODE) on Endobronchial Ultrasound (EBUS) Mediastinal Lymph Node Cryobiopsy Sampling Using Confocal Laser Microscopy-A Proof-Of-Concept Study\".","authors":"","doi":"10.1002/rcr2.70159","DOIUrl":"https://doi.org/10.1002/rcr2.70159","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1002/rcr2.70103.].</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70159"},"PeriodicalIF":0.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dramatic Metabolic Response to Dual ICI With Chemotherapy in Low PD-L1 NSCLC Case.
IF 0.8
Respirology Case Reports Pub Date : 2025-03-16 eCollection Date: 2025-03-01 DOI: 10.1002/rcr2.70150
Toshikazu Kumasa, Akina Nigi, Keisuke Iwamoto, Hidetoshi Itani, Shigeto Kondou
{"title":"Dramatic Metabolic Response to Dual ICI With Chemotherapy in Low PD-L1 NSCLC Case.","authors":"Toshikazu Kumasa, Akina Nigi, Keisuke Iwamoto, Hidetoshi Itani, Shigeto Kondou","doi":"10.1002/rcr2.70150","DOIUrl":"10.1002/rcr2.70150","url":null,"abstract":"<p><p>Despite low PD-L1 (Programmed Death-ligand 1) expression, this patient exhibited a dramatic positron emission tomography-computed tomography response to dual immune checkpoint inhibitors with chemotherapy. This case highlights the potential benefits of combination therapy beyond traditional PD-L1-based treatment selection.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70150"},"PeriodicalIF":0.8,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging of a Case for Primary Pulmonary Dedifferentiated Liposarcoma.
IF 0.8
Respirology Case Reports Pub Date : 2025-03-14 eCollection Date: 2025-03-01 DOI: 10.1002/rcr2.70151
Tongxin Yang, Minlong Zhang
{"title":"Imaging of a Case for Primary Pulmonary Dedifferentiated Liposarcoma.","authors":"Tongxin Yang, Minlong Zhang","doi":"10.1002/rcr2.70151","DOIUrl":"https://doi.org/10.1002/rcr2.70151","url":null,"abstract":"<p><p>This clinical image highlights a rare instance of primary pulmonary dedifferentiated liposarcoma, detailing its diagnosis through comprehensive imaging, pathological, and immunohistochemical analyses, followed by successful surgical resection and favourable patient recovery, thereby providing valuable insights for the management of this uncommon tumour.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70151"},"PeriodicalIF":0.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Out of Breath, out of Options: Benralizumab as a Last Hope in ICU-Treated Near-Fatal Eosinophilic Asthma: A Case Series.
IF 0.8
Respirology Case Reports Pub Date : 2025-03-12 eCollection Date: 2025-03-01 DOI: 10.1002/rcr2.70117
Lennart Conemans, Emel Demir, Martijn Bischoff, Frits Franssen, Sami Simons
{"title":"Out of Breath, out of Options: Benralizumab as a Last Hope in ICU-Treated Near-Fatal Eosinophilic Asthma: A Case Series.","authors":"Lennart Conemans, Emel Demir, Martijn Bischoff, Frits Franssen, Sami Simons","doi":"10.1002/rcr2.70117","DOIUrl":"10.1002/rcr2.70117","url":null,"abstract":"<p><p>Asthma exacerbations remain life-threatening events despite advancements in biologic therapies. This case series reports on four patients with near-fatal eosinophilic asthma exacerbations who had been admitted to intensive care and were treated with benralizumab as a last resort after failing maximal standard therapies. All patients exhibited marked blood or airway eosinophilia and required intensive care ventilatory support. Following the administration of benralizumab, significant clinical improvements were observed. This series highlights the potential role of benralizumab in treating life-threatening asthma exacerbations driven by eosinophilic airway inflammation and underlines the need for phenotyping and timely intervention in managing such patients with near-fatal asthma while also stressing the need for continued adherence to asthma guidelines to prevent these extreme situations.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70117"},"PeriodicalIF":0.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatitis B Antigenaemia, Nephrotic Syndrome and Pulmonary Embolism A Series of Unfortunate Events: A Case Report.
IF 0.8
Respirology Case Reports Pub Date : 2025-03-10 eCollection Date: 2025-03-01 DOI: 10.1002/rcr2.70145
Muhammad Hassaan Malik, Muhammad Shaheer Bin Faheem, Khawaja Shaheryar, Javed Iqbal, Syed Aun Bin Nasar
{"title":"Hepatitis B Antigenaemia, Nephrotic Syndrome and Pulmonary Embolism A Series of Unfortunate Events: A Case Report.","authors":"Muhammad Hassaan Malik, Muhammad Shaheer Bin Faheem, Khawaja Shaheryar, Javed Iqbal, Syed Aun Bin Nasar","doi":"10.1002/rcr2.70145","DOIUrl":"10.1002/rcr2.70145","url":null,"abstract":"<p><p>Hepatitis B is a major health concern. It primarily affects the liver, but it can also cause systemic complications like antigenaemia and nephrotic syndrome. Nephrotic syndrome causes proteinuria, hypoalbuminaemia, oedema, hyperlipidaemia and hypercoagulability. This hypercoagulable state may lead to a life-threatening complication of nephrotic syndrome: thromboembolism. This case report presents a rare medical case where a patient with chronic HBV develops nephrotic syndrome and subsequent pulmonary embolism. The co-occurrence of these diseases in a single patient highlights the importance of their intricate pathology. By examining this unique case, we aim to highlight the diagnostic and therapeutic challenges in such clinical presentations, providing valuable insight for professionals dealing with similar cases.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70145"},"PeriodicalIF":0.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Miliary Mesothelioma.
IF 0.8
Respirology Case Reports Pub Date : 2025-03-10 eCollection Date: 2025-03-01 DOI: 10.1002/rcr2.70141
Dujinthan Jayabalan, Michaela Donaghy, Chloe Charlesworth, Edward Fysh, Y C Gary Lee
{"title":"Miliary Mesothelioma.","authors":"Dujinthan Jayabalan, Michaela Donaghy, Chloe Charlesworth, Edward Fysh, Y C Gary Lee","doi":"10.1002/rcr2.70141","DOIUrl":"10.1002/rcr2.70141","url":null,"abstract":"<p><p>Miliary spread of mesothelioma is a rare but important manifestation of late-stage disease, likely due to hematogenous dissemination. This case highlights characteristic CT imaging findings, emphasizing the need for awareness among clinicians and radiologists. Recognizing this pattern can aid in diagnosis, prognostication, and appropriate referral for palliative management.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70141"},"PeriodicalIF":0.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dasatinib-Induced Pulmonary Arterial Hypertension in Chronic Myeloid Leukaemia: A Case Report and Literature Review.
IF 0.8
Respirology Case Reports Pub Date : 2025-03-10 eCollection Date: 2025-03-01 DOI: 10.1002/rcr2.70147
Sathish Krishnan, Sashi Adigopula
{"title":"Dasatinib-Induced Pulmonary Arterial Hypertension in Chronic Myeloid Leukaemia: A Case Report and Literature Review.","authors":"Sathish Krishnan, Sashi Adigopula","doi":"10.1002/rcr2.70147","DOIUrl":"10.1002/rcr2.70147","url":null,"abstract":"<p><p>Dasatinib, a second-generation tyrosine kinase inhibitor used for treating chronic myeloid leukaemia (CML), is associated with rare but significant adverse effects, including pulmonary arterial hypertension. This condition is thought to result from endothelial dysfunction and vascular remodelling linked to Src kinase inhibition. Symptoms such as progressive dyspnoea and fatigue may appear months or years after starting therapy, emphasising the need for long-term vigilance. We present the case of a 55-year-old female with CML who developed severe pre-capillary pulmonary hypertension after prolonged dasatinib use. Diagnosis was confirmed via echocardiography and right heart catheterisation, with other causes excluded. Following dasatinib discontinuation, initiation of targeted PAH therapy, and replacement with imatinib, the patient showed significant clinical and haemodynamic improvement.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70147"},"PeriodicalIF":0.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple Myeloma Complicated With Bronchiolitis Obliterans Syndrome After Allogeneic Haematopoietic Stem Cell Transplantation and Subsequently Underwent Lung Transplantation Successfully: A Case Report.
IF 0.8
Respirology Case Reports Pub Date : 2025-03-10 eCollection Date: 2025-03-01 DOI: 10.1002/rcr2.70120
Shih-Wei Huang, Ko-Wei Chang, Wei-Hsun Chen, Pin-Li Chou, Chien-Hung Chiu, Yun-Hen Liu, Chih-Wei Wang, Hsiao-Wen Kao, Tung-Liang Lin, Shaw-Woei Leu, Han-Chung Hu, Kuo-Chin Kao
{"title":"Multiple Myeloma Complicated With Bronchiolitis Obliterans Syndrome After Allogeneic Haematopoietic Stem Cell Transplantation and Subsequently Underwent Lung Transplantation Successfully: A Case Report.","authors":"Shih-Wei Huang, Ko-Wei Chang, Wei-Hsun Chen, Pin-Li Chou, Chien-Hung Chiu, Yun-Hen Liu, Chih-Wei Wang, Hsiao-Wen Kao, Tung-Liang Lin, Shaw-Woei Leu, Han-Chung Hu, Kuo-Chin Kao","doi":"10.1002/rcr2.70120","DOIUrl":"10.1002/rcr2.70120","url":null,"abstract":"<p><p>Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for multiple myeloma; however, the development of chronic graft-versus-host disease remains a significant challenge. Bronchiolitis obliterans syndrome (BOS) is one of the complications. Even with available medications for treatment, the prognosis of BOS remains poor. We present a 32-year-old female with multiple myeloma experienced BOS 6 months after allo-HSCT. Even with medical treatment, her clinical condition and pulmonary function was deteriorating. Based on the indication of a BODE (Body-mass index, Obstruction, Dyspnoea and Exercise) index of 7, she underwent bilateral lung transplantation 33 months after allo-HSCT. Three months post-operation, there was a significant improvement in pulmonary function. After approximately 5 years of follow-up, her lung function remains stable, and she is able to work and live a normal life. Lung transplantation may be an effective therapeutic strategy for BOS developed after allo-HSCT.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70120"},"PeriodicalIF":0.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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