Respirology Case Reports最新文献

{"title":"Metastatic Mediastinal Germ Cell Tumour: A Florid and Fulminant Presentation.","authors":"Zhong Xhen Khor","doi":"10.1002/rcr2.70348","DOIUrl":"10.1002/rcr2.70348","url":null,"abstract":"<p><p>A previously healthy teenager presented with acute respiratory distress and constitutional symptoms. Imaging revealed a mediastinal mass with multiple pulmonary nodules, and markedly elevated β-HCG confirmed metastatic choriocarcinoma. Despite urgent chemotherapy, he succumbed within a week. This case underscores its rarity, diagnostic challenge, and dismal prognosis in tuberculosis-endemic regions.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 9","pages":"e70348"},"PeriodicalIF":0.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transformation of Thoracic SMARCA4-Deficient Undifferentiated Tumour to Squamous Cell Carcinoma: A Case Report.","authors":"Heng You, Yuanyue Yi, Ran Wang, Jiayu Li, Zhi Xu","doi":"10.1002/rcr2.70338","DOIUrl":"10.1002/rcr2.70338","url":null,"abstract":"<p><p>Thoracic SMARCA4-deficient undifferentiated tumour (SMARCA4-dUT) is a rare and highly aggressive malignant tumour with poor response to conventional chemotherapy and a poor prognosis, for which there is currently no standard treatment. This article details a case of SMARCA4-dUT in which next-generation sequencing (NGS) revealed a frameshift mutation in SMARCA4 (N259Tfs44), along with high PD-L1 expression (tumour proportion score, TPS 90%) and a high tumour mutational burden (TMB, 24.58 mutations/Mb). The patient achieved a progression-free survival (PFS) of over 32 months following treatment with pembrolizumab combined with conventional chemotherapy. However, the tumour eventually recurred and transformed into SMARCA4-deficient squamous cell carcinoma (SMARCA4-dSCC). To our knowledge, this is the first reported case of histological transformation in SMARCA4-dUT. Immunotherapy may represent a potential treatment option for SMARCA4-dUT, particularly in patients with high TMB and PD-L1 expression.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 9","pages":"e70338"},"PeriodicalIF":0.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Bronchial Foreign Body Aspiration Caused by Inhaling a Mukago (Edible Yam Bulbil) Presenting With Persistent Cough.","authors":"Takayuki Yamamoto, Yukihiro Sugimoto, Yu Tsukasa, Ririko Shinozaki, Daiki Hasama, Ryota Aoki, Hirofumi Nakano, Sosei Abe, Masanori Takayama","doi":"10.1002/rcr2.70346","DOIUrl":"10.1002/rcr2.70346","url":null,"abstract":"<p><p>An 85-year-old man presented with a persistent cough accompanied by sputum production. He was initially treated with antibiotics and expectorants but showed no improvement. Chest computed tomography revealed a dense nodule in the right bronchus intermedius. On detailed history-taking, he recalled eating mukago-a small edible bulbil of <i>Dioscorea japonica</i> that is occasionally consumed in Japan-shortly before symptom onset. Flexible bronchoscopy identified an oval, hard foreign body lodged in the bronchus, which was successfully removed using biopsy forceps. The extracted object was confirmed to be a mukago. His cough disappeared after removal. Our case highlights the importance of considering foreign body aspiration in elderly patients presenting with unexplained chronic cough, even in the absence of overt choking episodes. Thorough dietary history-taking, appropriate imaging, and bronchoscopy are essential for timely diagnosis and effective management of foreign body aspiration.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 9","pages":"e70346"},"PeriodicalIF":0.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiotherapy-Induced Pleural Mesothelioma in a Childhood Leukaemia Survivor: A Case Report.","authors":"Sho Saeki, Rin Kurosawa, Akihiro Yamada, Minori Shimamura, Megumi Inaba, Takahiro Tashiro, Akiko Sakagami, Naomi Hirata, Yasumiko Jodai, Shinji Iyama, Yusuke Tomita, Takuro Sakagami","doi":"10.1002/rcr2.70342","DOIUrl":"10.1002/rcr2.70342","url":null,"abstract":"<p><p>We report the case of a 41-year-old woman who developed an epithelioid-type pleural mesothelioma (PM) decades after treatment for childhood acute myeloid leukaemia (AML), who was treated with chemotherapy and total body irradiation (TBI). The diagnosis was confirmed by thoracoscopic pleural biopsy and immunohistochemical staining. Although PM is classically associated with asbestos exposure, the patient had no known history of exposure. This case report highlights the fact that PM can occur as a late-onset secondary malignancy following radiation therapy in childhood cancer survivors. Although radiation-induced PM has been reported primarily in survivors of Hodgkin lymphoma or breast cancer, incidences following treatment for leukaemia are exceptionally rare. This case report highlights the importance of considering prior therapeutic irradiation, including total-body irradiation, as a potential etiological factor for non-asbestos-related PM. It also emphasises the need for the long-term surveillance and monitoring of childhood cancer survivors, particularly those who have received radiation therapy.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 9","pages":"e70342"},"PeriodicalIF":0.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bronchoscopic Excision of Endobronchial Leiomyoma: Evidence for Successful Long-Term Outcome.","authors":"Elaine Yap","doi":"10.1002/rcr2.70344","DOIUrl":"10.1002/rcr2.70344","url":null,"abstract":"<p><p>Pulmonary leiomyomas are rare benign tumours of bronchial smooth muscle origin. They can present either in the lung parenchyma or tracheobronchial tree, with 45% being located endobronchially. Endobronchial leiomyomas typically present with airways symptoms such as dyspnoea, cough, and obstructive pneumonia. Traditionally, endobronchial leiomyomas were managed surgically with lobectomy or pneumonectomy but, increasingly, management has shifted to bronchoscopic resection with different endoscopic techniques described in the case report literature. Most reports include outcomes ranging from 3 to 6 months following bronchoscopic resection. We present a case of a 40-year-old female with a left upper lobe (LUL) leiomyoma who presented with complete LUL collapse consolidation. Bronchoscopic resection was performed using a combination of diathermy snare, cryo-recanalisation, and argon plasma coagulation (APC) which resulted in excellent restoration of the LUL patency. Annual bronchoscopy surveillance over 7 years confirmed durability of the procedure with no recurrence detected.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 9","pages":"e70344"},"PeriodicalIF":0.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Cement Embolism After Vertebroplasty.","authors":"Randeep Singh, Kawleen Kour, Harkirat Singh Panaych","doi":"10.1002/rcr2.70343","DOIUrl":"10.1002/rcr2.70343","url":null,"abstract":"<p><p>Pulmonary cement embolism is a rare complication of vertebroplasty. We report an 81-year-old man with idiopathic pulmonary fibrosis presenting with respiratory failure, 18 months post-vertebroplasty. CT revealed a hyperdense pulmonary artery embolus, underscoring the importance of vigilance for delayed vertebroplasty complications.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 9","pages":"e70343"},"PeriodicalIF":0.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Supportive Care Trial to Enhance Physical Activity in Malignant Pleural Effusion-Protocol for the ISC-TEAM/AMPLE-5 Randomised Controlled Trial.","authors":"Bianca M Iacopetta, Chloe Charlesworth, Emily Jeffery, Lauren J Breen, Ai Ling Tan, Joanne McVeigh, Kevin Murray, Rob U Newton, Y C Gary Lee, Carolyn J Peddle-Mcintyre","doi":"10.1002/rcr2.70328","DOIUrl":"10.1002/rcr2.70328","url":null,"abstract":"<p><strong>Background: </strong>Malignant pleural effusion (MPE) heralds advanced cancer with poor patient outcomes. High symptom burden of weight loss, fatigue, breathlessness, distress, and anxiety leaves many patients unable to participate in desired activities of daily life and is associated with poor outcomes. Freedom from symptoms and maintaining daily activities are the key wishes of patients and carers. For the best outcome, accessible services aimed at prevention and management of malnutrition, care of psychological well-being, and support for increasing physical activity are required.</p><p><strong>Methods: </strong>The Integrative Supportive Care Trial to Enhance physical Activity in Malignant pleural effusion (ISC-TEAM) study is a two-armed, parallel group randomised controlled trial. Participants (<i>n</i> = 100) diagnosed with MPE will be randomly assigned to receive standard clinical care or integrative supportive care. Integrative supportive care will entail an individualised multidisciplinary program of dietetics, exercise physiology, and psychological input over 12 weeks. Participants will receive telehealth consultations with each discipline at week 1, week 4, and week 8. The primary outcome is device-assessed daily physical activity (steps/day). Secondary outcomes include quality of life, malnutrition risk, psychopathology, symptoms, physical activity profile, and program acceptability and compliance.</p><p><strong>Discussion: </strong>This randomised trial will evaluate the effects of a multidisciplinary supportive care program in MPE aimed at improving participants ability to engage in physical activities.</p><p><strong>Trial registration: </strong>Australian New Zealand Clinical Trials Registry: ACTRN12624000038594; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=386529&isReview=true.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 9","pages":"e70328"},"PeriodicalIF":0.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct Intranodal Visualization During EBUS-TBNA Using the Iriscope: A Novel Case Series.","authors":"Sammy Onyancha, Nesrin Tekeli, Emilia Nitsch, Birol Dedeoglu, Amel Havkic, Kati Kiil, Gernot Rohde","doi":"10.1002/rcr2.70330","DOIUrl":"10.1002/rcr2.70330","url":null,"abstract":"<p><p>Endobronchial ultrasound (EBUS)-guided biopsy remains the gold standard in the diagnosis of mediastinal pathologies. However, visualisation of intranodal architecture has yet to be achieved. With the implementation of miniature video probes in interventional pulmonology, these tools may help bring an added dimension to EBUS-guided diagnostics by allowing visualisation of intranodal architecture. We report a four-patient case series demonstrating the clinical use of the Iriscope, a miniature videoprobe, for direct visualisation of mediastinal lymph nodes during EBUS-guided biopsy. In each case, the Iriscope was deployed over a guide-sheath through the working channel of the EBUS bronchoscope following transbronchial needle aspiration (TBNA) and inserted through the biopsy tract into the lymph node under continuous ultrasound guidance. Real-time video imaging allowed inspection of nodal architecture and tissue consistency. The procedure was well tolerated in all cases, and no immediate complications were observed. This novel application introduces a new diagnostic dimension, potentially enhancing interpretation beyond cytologic or histologic sampling. All procedures were technically successful and complication-free, supporting the feasibility and safety of this approach. These findings lay the groundwork for broader clinical validation and integration of direct intranodal endoscopy in interventional pulmonology.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 9","pages":"e70330"},"PeriodicalIF":0.8,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Surgical Resection for Rare Cases of Lung Cancer in Teenagers\".","authors":"","doi":"10.1002/rcr2.70340","DOIUrl":"10.1002/rcr2.70340","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1002/rcr2.70281.].</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 9","pages":"e70340"},"PeriodicalIF":0.8,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Paradox of Metachronous Lipoid Pneumonia.","authors":"Haruki Kobayashi","doi":"10.1002/rcr2.70325","DOIUrl":"10.1002/rcr2.70325","url":null,"abstract":"<p><p>A 70-year-old female patient diagnosed with stage IV EGFR-mutant non-small-cell lung cancer experienced three distinct instances of exogenous lipoid pneumonia while undergoing chemotherapy. Chest CT consistently revealed ground-glass opacities with a crazy-paving pattern, and bronchoscopy confirmed the presence of lipid-laden, CD163-positive foamy macrophages. It is noteworthy that each episode was associated with a distinct exogenous exposure: intranasal administration of petroleum jelly, prolonged utilisation of a kerosene heater, and subsequently, intranasal application of Junma Moisturising Oil. The localisation of all episodes to the right middle lobe was noted, and resolution was attained with the cessation of the offending agent. This is the first reported case of recurrent exogenous lipoid pneumonia in a single patient caused by multiple unrelated substances. This case underscores the diagnostic value of radiologic patterns, the significance of meticulous exposure history, and the necessity of contemplating alternative aetiologies in patients with new infiltrates during cancer therapy.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 9","pages":"e70325"},"PeriodicalIF":0.8,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}