Pediatric Reports最新文献

{"title":"Childhood Mediterranean Diet Compliance Is Associated with Lower Incidence of Childhood Obesity, Specific Sociodemographic, and Lifestyle Factors: A Cross-Sectional Study in Children Aged 6-9 Years.","authors":"Constantina Jacovides, Agathi Pritsa, Maria Chrysafi, Sousana K Papadopoulou, Maria G Kapetanou, Eleftherios Lechouritis, Martin Mato, Vasiliki G Papadopoulou, Gerasimos Tsourouflis, Athanasios Migdanis, Anastasia Sampani, Rena I Kosti, Evmorfia Psara, Constantinos Giaginis","doi":"10.3390/pediatric16040102","DOIUrl":"10.3390/pediatric16040102","url":null,"abstract":"<p><strong>Background: </strong>Mediterranean diet (MD) constitutes a commonly examined dietary model. It includes a plethora of bioactive ingredients with strong antioxidant, anti-inflammatory, antithrombotic and anticancer properties. Several substantial studies support strong evidence that MD can exert preventing actions against human morbidity and mortality, promoting human well-being and quality of life. The present study aims to evaluate whether childhood MD compliance may be associated with socio-demographic, anthropometric, and lifestyle factors in children at the age of 6-9 years.</p><p><strong>Methods: </strong>This is a cross-sectional survey on 3875 children aged 6-9 years old with their matched mothers. Qualified questionnaires were used to evaluate and collect by one-to-one interviews with trained professionals the above data.</p><p><strong>Results: </strong>Elevated MD adherence was observed only in 22.2% of the enrolled children, while 37.5% of children maintained intermediate MD adherence and 40.3% of children adopted lower MD levels. Children MD compliance was related at an independent manner with maternal education level, childhood anthropometric factors such as Body Mass Index (BMI), Waist circumference to Height ratio (WtHR), quality of life, and exclusively breastfeeding behaviors after adjusting for several possible confounders (<i>p</i> ˂ 0.05).</p><p><strong>Conclusions: </strong>Elevated MD adherence of children aged 6-9 years old showed a lower obesity of overweight/obesity, including abdominal obesity. A higher maternal educational status and adopting exclusively breastfeeding practices were associated with greater levels of children's MD adherence, promoting their quality of life and well-being. Based on the present results, future prospective surveys need to be performed to evaluate if there is a causality relation concerning this topic.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"16 4","pages":"1207-1222"},"PeriodicalIF":1.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>PPP2R5D</i>-Related Neurodevelopmental Disorder and Multiple Haemangiomas: A Novel Phenotypic Trait?","authors":"Francesco Comisi, Consolata Soddu, Francesco Lai, Monica Marica, Michela Lorrai, Giancarlo Mancuso, Sabrina Giglio, Salvatore Savasta","doi":"10.3390/pediatric16040101","DOIUrl":"10.3390/pediatric16040101","url":null,"abstract":"<p><strong>Background: </strong>Houge-Janssens syndrome 1 is a condition with onset in early childhood caused by heterozygous pathogenic variants in the <i>PPP2R5D</i> gene, which encodes a B56 regulatory subunit of the serine/threonine protein phosphatase 2A (PP2A). There is evidence that the PP2A-PPP2R5D complex is involved in regulating the phosphatidylinositol 3-kinase (PI3K)/AKT signalling pathway, which is crucial for several cellular processes, including the pathogenesis and progression of haemangiomas.</p><p><strong>Case presentation: </strong>We report the first <i>PPP2R5D</i>-related neurodevelopmental disorder case from Sardinia, a child with transient hypoglycaemia, facial dysmorphisms, and multiple haemangiomas. Whole Exome Sequencing analysis confirmed the clinical suspicion, detecting the presence of the de novo missense variant c.592G>A in the <i>PPP2R5D</i> gene.</p><p><strong>Conclusions: </strong>Haemangiomas have never been linked to the syndromic phenotype of the <i>PPP2R5D</i>-associated disorder. The close correlation between the PP2A enzyme and the PI3K/AKT signalling pathway suggests the possible correlation between its dysfunction and activation of haemangiogenesis. Our report highlights a possible link between the PPP2R5D-related disorder and altered angiogenesis, characterizing diffuse haemangiomas as a possible novel phenotypic trait of this condition.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"16 4","pages":"1200-1206"},"PeriodicalIF":1.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Metabolic Control in a Pediatric Population with Type 1 Diabetes Mellitus Using Hybrid Closed-Loop and Predictive Low-Glucose Suspend Insulin Pump Treatments.","authors":"Irina Bojoga, Sorin Ioacara, Elisabeta Malinici, Victor Chiper, Olivia Georgescu, Anca Elena Sirbu, Simona Fica","doi":"10.3390/pediatric16040100","DOIUrl":"10.3390/pediatric16040100","url":null,"abstract":"<p><strong>Background: </strong>Insulin pumps coupled with continuous glucose monitoring sensors use algorithms to analyze real-time blood glucose levels. This allows for the suspension of insulin administration before hypoglycemic thresholds are reached or for adaptive tuning in hybrid closed-loop systems. This longitudinal retrospective study aims to analyze real-world glycemic outcomes in a pediatric population transitioning to such devices.</p><p><strong>Methods: </strong>We evaluated children with type 1 diabetes mellitus (T1D) admitted to the Pediatric Diabetes Department from a major University Hospital in Bucharest, Romania, who transitioned to hybrid closed-loop or predictive low-glucose suspend system from either non-automated insulin pumps or multiple daily injections. The primary outcome was assessing the change in glycated hemoglobin (HbA1c) after initiating these devices. Secondary outcomes analyzed changes in glucose metrics from the 90 days prior to the baseline and follow-up visit.</p><p><strong>Results: </strong>51 children were included (58.8% girls), the mean age was 10.3 ± 3.7 years, and the mean follow-up duration was 13.2 ± 4.5 months. The analyzed parameters, such as HbA1c (6.9 ± 0.7% vs. 6.7 ± 0.6%, <i>p</i> = 0.023), time in range (69.3 ± 11.2% vs. 76 ± 9.9%, <i>p</i> < 0.001), time in tight range (47.4 ± 10.9% vs. 53.7 ± 10.7%, <i>p</i> < 0.001), time below range (5.6 ± 2.9% vs. 3.5 ± 1.9%, <i>p</i> < 0.001), time above range (25 ± 11.2% vs. 20.4 ± 9.4%, <i>p</i> = 0.001), and coefficient of variation (37.9 ± 4.8% vs. 35.6 ± 4.6%, <i>p</i> = 0.001), showed significant improvements.</p><p><strong>Conclusions: </strong>The application of these sensor-integrated insulin pumps can significantly enhance metabolic control in pediatric populations, minimizing glycemic variations to mitigate complications and enrich the quality of life.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"16 4","pages":"1188-1199"},"PeriodicalIF":1.4,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Evaluation of Whether Routine QTc Interval Screening Is Necessary Prior to Starting ADHD Medications: Experience from a Large Retrospective Study.","authors":"Hamza A Alsayouf, Lima M Dyab, Redab Al-Ghawanmeh, Luay S Alhawawsha, Osama Alsarhan, Hadeel Al-Smadi, Ghaith M Al-Taani, Azhar Daoud, Haitham E Elsadek, Wael H Khreisat","doi":"10.3390/pediatric16040098","DOIUrl":"10.3390/pediatric16040098","url":null,"abstract":"<p><strong>Background/objectives: </strong>Routine screening electrocardiograms (ECGs) prior to starting medications for attention-deficit/hyperactivity disorder (ADHD) remain controversial. This real-world study assessed corrected QT (QTc) interval data from pediatric patients who had a baseline ECG performed prior to initiating treatment with ADHD medications and ≥6 months of clinical follow-up.</p><p><strong>Methods: </strong>A retrospective chart review of children aged 2-18 years diagnosed with ADHD with/without autism spectrum disorder (ASD) at child neurology clinics in Jordan (June 2019 and June 2021) was performed, and children were prescribed with ADHD medications to manage symptoms. Patients had ≥6 months of follow-up and no known cardiac disease/family history. A baseline ECG and regular clinical exams were performed for each child.</p><p><strong>Results: </strong>Of 458 patients with baseline ECGs, 362 met the study inclusion criteria. Overall, 286 (79.0%) patients were diagnosed with ASD/comorbid ADHD and 76 (21.0%) with ADHD alone; 61 (16.9%) were prescribed atomoxetine, 38 (10.5%) methylphenidate, 134 (37.0%) risperidone, and 129 (35.6%) aripiprazole. The patients' mean ± SD age was 6.4 ± 3.5 years, and most were male (n = 268, 74.0%). The mean baseline QTc interval was 400 ± 22 ms (median, 400 ms); one patient had a QTc interval >460 ms and was excluded from initiating treatment with any ADHD medications. During the ≥6-month follow-up, none of the patients had any signs or symptoms of adverse cardiac effects.</p><p><strong>Conclusions: </strong>Routine screening ECGs prior to treatment with ADHD medications may not be necessary in healthy children with no family history of cardiac disease. However, further studies are needed to evaluate the long-term effects of ADHD medications in low-risk pediatric patients.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"16 4","pages":"1161-1168"},"PeriodicalIF":1.4,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric Analysis of Anxiety and Physical Education in Web of Science-A Performance and Co-Word Study.","authors":"Josué González-Ruiz, Antonio Granero-Gallegos, José-Antonio Marín-Marín, Antonio José Moreno-Guerrero","doi":"10.3390/pediatric16040099","DOIUrl":"10.3390/pediatric16040099","url":null,"abstract":"<p><p>This study conducts a comprehensive bibliometric analysis of the concepts 'physical edu- cation' and 'anxiety' (PHYEDU_ANX) in the Web of Science (WoS) database. <b>Background/Objectives:</b> No previous biblio- metric studies were found that addressed this intersection, so this research is a pioneering exploration of this knowledge gap. The aim of the study is to examine the presence of both concepts in the scientific literature, identifying their trends, approaches, and future prospects. <b>Methods:</b> For this purpose, the methodology of co-word analysis was used. <b>Results</b>: The results of the study show that research on PHYEDU and ANX has traditionally focused on three main areas: motivation, exercise, and depression. In this first period, the focus was on the problem (ANX, depression…), <b>Conclusions</b>: whereas nowadays, research focuses on the subjects who suffer from it, mainly adolescents and students. The study suggests that future research in this field will focus on the areas of satisfaction, intervention, and association. This research also answers questions relevant to the field, such as which institutions or countries are the most prolific publishers of PHYEDU_ANX, as well as the most cited authors in this area of study.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"16 4","pages":"1169-1187"},"PeriodicalIF":1.4,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attributional Styles and Their Impact on Depressive and Anxious Symptoms in Italian Children: Insights from the Italian Children's Attributional Style Questionnaire-Revised (CASQ-R).","authors":"Simona Scaini, Silvia Grazioli, Ludovica Giani, Barbara Forresi, Stefano De Francesco, Marcella Caputi","doi":"10.3390/pediatric16040096","DOIUrl":"10.3390/pediatric16040096","url":null,"abstract":"<p><strong>Background: </strong>There is evidence that the tendency to adopt a peculiar pattern of causal inference, known as attributional style, is likely related to specific patterns of psychopathology among youth.</p><p><strong>Objective: </strong>This study aims to assess preliminary psychometric properties of the Italian Children's Attributional Style Questionnaire-Revised (CASQ-R) and to explore the presence of any subgroups of children and early adolescents from the general population who might exhibit internally homogeneous and externally heterogeneous attributional styles through latent class analysis, delving into the potential sociodemographic, namely age and gender, and clinical differences among the identified classes of attributional styles.</p><p><strong>Method: </strong>A sample of 337 children (11.29 ± 1.76 years old, 169 females, and 168 males) was recruited and their attributional styles and depressive and anxious symptoms were analyzed.</p><p><strong>Results: </strong>Two distinct classes were defined using the CASQ-R items in a latent class analysis (LCA). In particular, high levels of depressive (Kruskal-Wallis chi-squared = 9.37, df = 1, Bonferroni-adjusted <i>p</i> = 0.002) and school phobia (Kruskal-Wallis chi-squared = 7.17 df = 1, Bonferroni-adjusted <i>p</i> = 0.037) symptoms were reported by children showing an internal, global and stable attributional style for negative events and an external, specific and unstable attributional style for positive events. Conversely, low levels of depressive and school phobia symptoms were reported by children showing the opposite attributional style.</p><p><strong>Conclusions: </strong>The identified classes shed light on distinct patterns associated with depressive and anxious symptoms, offering potential insights for targeted interventions.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"16 4","pages":"1134-1148"},"PeriodicalIF":1.4,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Symmetry of Positional Anomalies in Second Permanent Molars: Study of Romanian Patients.","authors":"Rahela Tabita Moca, Abel Emanuel Moca, Mihai Juncar","doi":"10.3390/pediatric16040097","DOIUrl":"10.3390/pediatric16040097","url":null,"abstract":"<p><strong>Background/objectives: </strong>This study aimed to investigate the prevalence and characteristics of positional anomalies in second permanent molars among Romanian patients. These molars play a crucial role in occlusion but can exhibit positional issues such as tilting, rotation, infraocclusion, and impaction.</p><p><strong>Methods: </strong>This retrospective study examined the digital models of 103 patients aged 12-40, which were obtained by using the Medit i500 intraoral scanner. Positional anomalies were categorized by tilting, rotation, infraocclusion, and impaction.</p><p><strong>Results: </strong>The results showed a high prevalence of anomalies, particularly infraocclusion and buccal tilting in upper molars and oral tilting and mesio-buccal rotations in lower molars. The significant symmetry of anomalies within the same dental arch was noted. Gender and malocclusion type did not significantly influence anomaly frequency.</p><p><strong>Conclusions: </strong>The findings emphasize the need for the vigilant monitoring of second permanent molars to maintain functional occlusion and suggest potential common etiological factors within dental arches. Despite this study's limitations, including sample size and retrospective design, this study underscores the clinical importance of the early detection and management of molar anomalies. Future research should expand on these findings, considering genetic and environmental influences on dental development.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"16 4","pages":"1149-1160"},"PeriodicalIF":1.4,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incremental Validity of ADHD Dimensions in the Predictions of Emotional Symptoms, Conduct Problems, and Peer Problems in Adolescents Based on Parent, Teacher, and Self-Ratings.","authors":"Rapson Gomez, Taylor Brown","doi":"10.3390/pediatric16040095","DOIUrl":"10.3390/pediatric16040095","url":null,"abstract":"<p><p><b>Background:</b> The present study investigated the incremental validity of the ADHD dimensions of inattention (IA), hyperactivity (HY), and impulsivity (IM) in the predictions of emotion symptoms (ESs), conduct problems (CPs), and peer problems (PPs) in adolescents based on parent, teacher, and self- ratings. <b>Method:</b> A total of 214 ratings were collected from adolescents, their parents, and teachers in Australia. A structural equation modeling approach was employed to evaluated incremental validity. <b>Results:</b> The findings revealed that, controlling for gender, IM contributed moderate, low, and low levels of variance in predicting ESs based on parent, teacher, and self-ratings, respectively. Additionally, IM contributed moderate, substantial, and moderate levels of variance to CP predictions based on parent, teacher, and self-ratings, respectively. Furthermore, after controlling for gender, IM, and HY, parent-rated IA contributed a low level of variance to the prediction of ESs, while teacher and self-rated IA did not contribute significantly to the prediction of ESs, CPs, or PPs. <b>Conclusions:</b> The findings underscore the differential predictive validity of ADHD dimensions across informants and outcomes, highlighting impulsivity's stronger association with conduct problems and emotional symptoms. These results have theoretical and practical implications for understanding ADHD-related risks in adolescence and tailoring interventions accordingly.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"16 4","pages":"1115-1133"},"PeriodicalIF":1.4,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Re-Evaluation of the Utility of Symptom Checklist-90-Revised for Measuring the Spectra in the Hierarchical Taxonomy of Psychopathology.","authors":"Rapson Gomez, Daniel Zarate, Taylor Brown, Vasileios Stavropoulos","doi":"10.3390/pediatric16040093","DOIUrl":"10.3390/pediatric16040093","url":null,"abstract":"<p><p>The present study examines the potential of the Symptom Checklist-90-Revised (SCL-90-R) as a measure for the Hierarchical Taxonomy of Psychopathology (HiTop) model. Two structural models were evaluated. In Model 1, the SCL-90-R dimensions were allocated to somatoform (comprising somatization), internalizing (comprising obsessive-compulsive, interpersonal sensitivity, depression, anxiety, and phobic anxiety), and antagonistic disinhibited (comprising hostility) spectra. Model 2 included an additional detachment spectrum (comprising paranoid ideation and psychoticism).</p><p><strong>Method: </strong>A total of 1594 adolescents [52.2% boys; age ranged from 14 to 17 years; mean age (<i>SD</i>) = 16.04 years (0.737 years)] from the general community in Athens completed the SCL-90-R and the Funf-Faktoren-Fragebogen fur Kinder (FFFK). Confirmatory factor analysis (CFA) was conducted to validate the proposed models.</p><p><strong>Results: </strong>The findings supported Model 1, demonstrating adequate global fit, salient and significant factor loadings, discriminant validity, reliability, and external validity of the factors.</p><p><strong>Conclusions: </strong>These results indicate that the SCL-90-R scales of somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, and phobic anxiety are appropriate measures for the corresponding HiTop dimensions. However, the scales for paranoid ideation and psychoticism were not suitable for this purpose. The theoretical contributions and conclusions are discussed, highlighting the implications of these findings for the clinical and theoretical application of the SCL-90-R in psychopathological assessment and research.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"16 4","pages":"1089-1098"},"PeriodicalIF":1.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Neutrophil Gelatinase-Associated Lipocalin in Pediatric CKD: Correlations with Renal Function and Mineral Metabolism.","authors":"Ruxandra Maria Steflea, Emil Robert Stoicescu, Oana Aburel, Florin George Horhat, Silviu Valentin Vlad, Felix Bratosin, Andreea-Mihaela Banta, Gabriela Doros","doi":"10.3390/pediatric16040094","DOIUrl":"10.3390/pediatric16040094","url":null,"abstract":"<p><strong>Background: </strong>Pediatric chronic kidney disease (CKD) requires reliable biomarkers for early detection and monitoring. Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a potential marker due to its responsiveness to renal impairment and involvement in mineral metabolism.</p><p><strong>Objectives: </strong>To evaluate serum NGAL levels in pediatric CKD patients and explore correlations with estimated glomerular filtration rate (eGFR), ferritin, calcium-phosphorus (Ca*P) product, and total serum protein.</p><p><strong>Methods: </strong>A cross-sectional study included 54 pediatric CKD patients and 29 healthy controls. Laboratory assessments encompassed serum NGAL, creatinine, ferritin, calcium, phosphorus, and total serum protein. eGFR was calculated using the Schwartz formula. Pearson correlation and linear regression analyses determined associations between NGAL and other parameters.</p><p><strong>Results: </strong>NGAL levels were significantly higher in CKD patients compared to controls (median 453 ng/mL vs. 78 ng/mL, <i>p</i> < 0.001). A strong negative correlation existed between NGAL and eGFR (r = -0.81, <i>p</i> < 0.001). NGAL showed moderate positive correlations with ferritin (r = 0.56, <i>p</i> = 0.009) and CaP product (r = 0.57, <i>p</i> = 0.006) and a moderate negative correlation with total serum protein (r = -0.36, <i>p</i> = 0.225). Regression analysis confirmed NGAL as a significant predictor of eGFR, ferritin, and CaP product.</p><p><strong>Conclusions: </strong>Elevated serum NGAL levels are associated with decreased renal function and alterations in mineral metabolism in pediatric CKD patients. NGAL may serve as a valuable biomarker for assessing disease progression and guiding clinical management in this population.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"16 4","pages":"1099-1114"},"PeriodicalIF":1.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}