Pediatric Reports最新文献_第10页

Rate of Total Hip Replacement after Legg Calve Perthes Disease in a Canadian Province. 加拿大一省Legg-Calve-Perthes病后全髋关节置换率。

IF 1.1

Pediatric Reports Pub Date : 2023-10-07 DOI: 10.3390/pediatric15040053

Jonathan Tan, Anirudh Sharma, Rohit Bansal, Qier Tan, Heather J Prior, Sheila McRae, James R McCammon

{"title":"Rate of Total Hip Replacement after Legg Calve Perthes Disease in a Canadian Province.","authors":"Jonathan Tan, Anirudh Sharma, Rohit Bansal, Qier Tan, Heather J Prior, Sheila McRae, James R McCammon","doi":"10.3390/pediatric15040053","DOIUrl":"10.3390/pediatric15040053","url":null,"abstract":"Legg Calve Perthes disease is a pediatric hip condition that leads to early hip degeneration. The efficacy of operative and nonoperative treatment is not well defined in the literature. Using the rate of total hip arthroplasty as a surrogate measure for symptomatic hip degeneration, the rate of total hip arthroplasty was compared in Legg Calve Perthes disease patients with and without previous surgical intervention in the province of Manitoba, Canada. A retrospective review was conducted using de-identified, individual-level administrative records of health services for the entire population of Manitoba. Codes for Legg Calve Perthes disease, femoral osteotomies, pelvic osteotomies, adductor tenotomies, and total hip arthroplasty were searched from 1984 to 2018. The rate of total hip arthroplasty in patients with Legg Calve Perthes disease was determined for two groups: (1) patients with earlier surgical intervention and (2) patients with no previous surgical intervention. Of the 202 patients included in the study, 180 had no prior surgery and 22 had prior surgery. The rate of total hip arthroplasty between the previous operative and nonoperative groups was found to be 32% and 40%, respectively (p = 0.458). There was no significant difference in rates of total hip arthroplasty in the operative and nonoperative groups. Further prospective studies are required to elucidate the differences in outcomes between operative and nonoperative treatment groups in patients with Legg Calve Perthes disease.","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"15 4","pages":"582-590"},"PeriodicalIF":1.1,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49693023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Missed Nursing Care in the NICU: Perspectives of NICU Nurses in Saudi Arabia's Eastern Health Cluster. 探索新生儿重症监护室的漏诊护理：沙特阿拉伯东部卫生集群新生儿重症监护病房护士的观点。

IF 1.1

Pediatric Reports Pub Date : 2023-10-02 DOI: 10.3390/pediatric15040052

Nasreen Alsalem, Fatima Abu Rashid, Saleh Aljarudi, Mohammed I Al Bazroun, Roqayah Mirza Almatrouk, Fatimah M Alharbi, Lames Al Mansour, Nahid Baker Abuzaid

{"title":"Exploring Missed Nursing Care in the NICU: Perspectives of NICU Nurses in Saudi Arabia's Eastern Health Cluster.","authors":"Nasreen Alsalem, Fatima Abu Rashid, Saleh Aljarudi, Mohammed I Al Bazroun, Roqayah Mirza Almatrouk, Fatimah M Alharbi, Lames Al Mansour, Nahid Baker Abuzaid","doi":"10.3390/pediatric15040052","DOIUrl":"10.3390/pediatric15040052","url":null,"abstract":"(1) Background: Missed nursing care, an omission error characterized by delayed or omitted nursing interventions, poses significant risks to patients' safety and quality of car.; (2) Methods: This is a quantitative cross-sectional study on 151 nurses who work in NICUs in three main networks in the Eastern Health Province, Saudi Arabia: Dammam (n = 84), Qatif (n = 53), and Jubail (n = 14). The study uses a self-reported questionnaire (MISSCARE) and applies the 5-point Likert Scale. Statistical analysis data were analyzed using SPSS version 23.0. (3) Results: The primary reasons for missed care were shortage of nursing staff and unbalanced patient assignments. Missed nursing care negatively affects job satisfaction and was positively correlated with nurses' intentions to quit their jobs. Inadequate equipment, supplies, and breakdowns in communication between nurses and other healthcare professionals were also significant factors contributing to missed care. (4) Conclusions: Missed nursing care is associated with overwork, nursing shortages, and lower job satisfaction, impacting the quality of care provided in the NICU. Improving working conditions, nurse staffing, and patient assignment planning should be prioritized to address this issue effectively.","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"15 4","pages":"571-581"},"PeriodicalIF":1.1,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49693020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prechemotherapy Transperitoneal Robotic-Assisted Partial Nephrectomy (RAPN) for a Wilms Tumor: Surgical and Oncological Outcomes in a Four-Year-Old Patient. 肾母细胞瘤的化疗前经腹膜机器人辅助部分肾切除术（RAPN）：一名四岁患者的手术和肿瘤结果。

IF 1.1

Pediatric Reports Pub Date : 2023-09-21 DOI: 10.3390/pediatric15030051

Marcello Della Corte, Elisa Cerchia, Marco Oderda, Paola Quarello, Franca Fagioli, Paolo Gontero, Simona Gerocarni Nappo

{"title":"Prechemotherapy Transperitoneal Robotic-Assisted Partial Nephrectomy (RAPN) for a Wilms Tumor: Surgical and Oncological Outcomes in a Four-Year-Old Patient.","authors":"Marcello Della Corte, Elisa Cerchia, Marco Oderda, Paola Quarello, Franca Fagioli, Paolo Gontero, Simona Gerocarni Nappo","doi":"10.3390/pediatric15030051","DOIUrl":"https://doi.org/10.3390/pediatric15030051","url":null,"abstract":"Background: Wilms tumor (WT) is the most frequent renal tumor in children. The SIOP-UMBRELLA Guidelines allow for nephron-sparing surgery (NSS) in syndromic patients, as well as in cases of small (<300 mL) non-syndromic unilateral WTs, without lymph node involvement, and with a substantial expected remnant renal function, following neoadjuvant chemotherapy. We present a case of prechemotherapy transperitoneal robot-assisted partial nephrectomy (RAPN) for a unilateral, non-syndromic Wilms tumor.Methods: A four-year-old child presented with a solid mass measuring 3.6 cm in diameter involving the upper right renal pole, incidentally detected during an abdominal echotomography. CT scan and abdominal MRI revealed no local infiltration or lymph node involvement, suggesting that the exophytic mass could be easily resected via an NSS robotic approach. Preoperative imaging did not strongly suggest WT. A virtual 3D reconstruction of the tumor was performed.Results: After the oncologic board approval, a robot-assisted partial nephrectomy with an intraperitoneal approach was performed. Histopathological analysis confirmed the diagnosis of WT. The patient subsequently received 10 doses of vincristine as adjuvant chemotherapy. A 28-month follow-up showed no tumor recurrence.Conclusions: Intraperitoneal RAPN may be an option for selected WT and warrants consideration as a challenging but advantageous approach.","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"15 3","pages":"560-570"},"PeriodicalIF":1.1,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41147712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Diagnostic Markers of Late-Onset Neonatal Sepsis. 晚发新生儿败血症的早期诊断标志物。

IF 1.1

Pediatric Reports Pub Date : 2023-09-20 DOI: 10.3390/pediatric15030050

Preslava Gatseva, Alexander Blazhev, Zarko Yordanov, Victoria Atanasova

{"title":"Early Diagnostic Markers of Late-Onset Neonatal Sepsis.","authors":"Preslava Gatseva, Alexander Blazhev, Zarko Yordanov, Victoria Atanasova","doi":"10.3390/pediatric15030050","DOIUrl":"https://doi.org/10.3390/pediatric15030050","url":null,"abstract":"Objective: Early diagnosis of nosocomial infections in newborns is a great challenge, because in the initial phase of systemic infection, clinical symptoms are often non-specific, and routinely used hematological markers are not sufficiently informative. The aim of this study was to determine the potential of early inflammatory markers to diagnose late-onset neonatal sepsis-procalcitonin (PCT), interleukin 6 (IL-6), interleukin 8 (IL-8) and endocan (ESM-1).Material and methods: A prospective clinical-epidemiological study was conducted in a third-level NICU in Pleven, Bulgaria. Patients with suspected late-onset sepsis and healthy controls were tested. A sandwich ELISA method was used to measure the serum concentrations of biomarkers.Results: Sixty newborns were included, of which 35% symptomatic and infected, 33.3% symptomatic but uninfected and 31.7% asymptomatic controls. The mean values of PCT, IL-6, I/T index and PLT differ significantly in the three groups. For ESM-1, IL-8 and CRP, the difference was statistically insignificant. The best sensitivity (78%) and negative predictive value (84%) was found for IL-6. The combinations of PCT + IL-6 and PCT + IL-6+ I/T+ PLT showed very good diagnostic potential.Conclusion: The introduction into the routine practice of indicators such as PCT and IL-6 may provide an opportunity to promptly optimize the diagnostic and therapeutic approach to LOS.","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"15 3","pages":"548-559"},"PeriodicalIF":1.1,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41173658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Significance of Absence of Post-Feeding Contraction of the Gallbladder in Biliary Atresia: Two Case Reports. 两例胆道闭锁术后胆囊无进食后收缩的诊断意义。

IF 1.1

Pediatric Reports Pub Date : 2023-09-06 DOI: 10.3390/pediatric15030049

Masahiko Kosuga, Yoshimitsu Fujii, Takashi Doi, Kazunari Kaneko, Raoul Breugelmans

{"title":"Diagnostic Significance of Absence of Post-Feeding Contraction of the Gallbladder in Biliary Atresia: Two Case Reports.","authors":"Masahiko Kosuga, Yoshimitsu Fujii, Takashi Doi, Kazunari Kaneko, Raoul Breugelmans","doi":"10.3390/pediatric15030049","DOIUrl":"https://doi.org/10.3390/pediatric15030049","url":null,"abstract":"Ultrasonography is an essential part of the diagnostic process of biliary atresia (BA). The characteristic findings of BA include a hilar hyperechoic zone, the triangular cord sign (TCS), an absence of gallbladder contraction after feeding, and gallbladder atrophy. However, approximately 10% of patients with BA have a normal gallbladder. We herein present two cases of BA with normal morphology of the gallbladder as shown by ultrasonography. In the first case, the patient was positive for the TCS, negative for gallbladder atrophy, and positive for contraction of the gallbladder after feeding; the final diagnosis was hilar obstructive BA complicated by pancreaticobiliary maljunction. In the second case, the patient was positive for the TCS, negative for gallbladder atrophy, and negative for contraction of the gallbladder after feeding; the patient also had common bile duct obstruction and stenosis of the hepatic duct in the hilar region. Based on these two cases, we conclude that gallbladder findings are not diagnostic for BA because in some types, the gallbladder may be normal in morphology and even have the capacity for contraction after feeding.","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"15 3","pages":"541-547"},"PeriodicalIF":1.1,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41137418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2-Associated Multisystem Inflammatory Syndrome in Children (MIS-C): A Case Report from Iraq. 儿童严重急性呼吸系统综合征冠状病毒2型相关多系统炎症综合征（MIS-C）：一例来自伊拉克的病例报告。

IF 1.1

Pediatric Reports Pub Date : 2023-09-04 DOI: 10.3390/pediatric15030048

Ruwaid Behnam Y Al-Simaani, Lika'a Fasih Y Al-Kzayer, Kenan Hussien Ali, Mouroge H Al-Ani, Yozo Nakazawa

{"title":"SARS-CoV-2-Associated Multisystem Inflammatory Syndrome in Children (MIS-C): A Case Report from Iraq.","authors":"Ruwaid Behnam Y Al-Simaani, Lika'a Fasih Y Al-Kzayer, Kenan Hussien Ali, Mouroge H Al-Ani, Yozo Nakazawa","doi":"10.3390/pediatric15030048","DOIUrl":"https://doi.org/10.3390/pediatric15030048","url":null,"abstract":"The novel coronavirus disease (COVID-19) continues to evolve. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-associated multisystem inflammatory syndrome in children (MIS-C) is a rare post-COVID-19 complication that affects children with critical outcomes. Few MIS-C reports were available from Arab-Asian ethnicities. We here describe a presentation mimicking a head injury overlapping the manifestations of MIS-C in a child from Iraq. A 10-year-old boy presented with blunt trauma in a shock-like status, and a head injury was suspected. Since he was febrile two days before the trauma, another pathology was assumed. Imaging and laboratory evaluations were performed, and after excluding gross neurosurgical etiology, he was initially treated as a toxic shock syndrome. Meanwhile, he was deteriorating with continuous fever, impaired consciousness, and seizure on the following day. Although not considered initially, close monitoring with a multidisciplinary approach and serial investigations revealed that the child met the criteria of MIS-C. SARS-CoV-2 IgG was shown to be high, while the RT-PCR of COVID-19 was negative. Once he received immunoglobulin and methylprednisolone, he improved dramatically. In conclusion, this report aimed to increase awareness about MIS-C among health workers and emphasized the need for a multidisciplinary team approach in Iraq due to the importance of timely treatment.","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"15 3","pages":"532-540"},"PeriodicalIF":1.1,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41120007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BoDV-1 Infection in Children and Adolescents: A Systematic Review and Meta-Analysis. 儿童和青少年BoDV-1感染：系统综述和荟萃分析。

IF 1.4

Pediatric Reports Pub Date : 2023-09-01 DOI: 10.3390/pediatric15030047

Matteo Riccò, Ilaria Zanella, Elia Satta, Silvia Ranzieri, Silvia Corrado, Federico Marchesi, Simona Peruzzi

{"title":"BoDV-1 Infection in Children and Adolescents: A Systematic Review and Meta-Analysis.","authors":"Matteo Riccò, Ilaria Zanella, Elia Satta, Silvia Ranzieri, Silvia Corrado, Federico Marchesi, Simona Peruzzi","doi":"10.3390/pediatric15030047","DOIUrl":"10.3390/pediatric15030047","url":null,"abstract":"Borna disease virus 1 (BoDV-1) can cause a severe human syndrome characterized by meningo-myeloencephalitis. The actual epidemiology of BoDV-1 remains disputed, and our study summarized prevalence data among children and adolescents (<18-year-old). Through systematic research on three databases (PubMed, EMBASE, MedRxiv), all studies, including seroprevalence rates for BoDV-1 antigens and specific antibodies, were retrieved, and their results were summarized. We identified a total of six studies for a total of 2692 subjects aged less than 18 years (351 subjects sampled for BoDV-1 antibodies and 2557 for antigens). A pooled seroprevalence of 6.09% (95% Confidence Interval [95% CI] 2.14 to 16.17) was eventually calculated for BoDV-1 targeting antibodies and 0.76% (95% CI 0.26 to 2.19) for BoDV-1 antigens. Both estimates were affected by substantial heterogeneity. Seroprevalence rates for BoDV-1 in children and adolescents suggested that a substantial circulation of the pathogen does occur, and as infants and adolescents have relatively scarce opportunities for being exposed to hosts and animal reservoirs, the potential role of unknown vectors cannot be ruled out.","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"15 3","pages":"512-531"},"PeriodicalIF":1.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41137375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Learning Italian as a Second Language in a Sample of Ukrainian Children: A Game-Based Learning Approach. 以乌克兰儿童为样本学习意大利语作为第二语言：基于游戏的学习方法。

IF 1.4

Pediatric Reports Pub Date : 2023-08-18 DOI: 10.3390/pediatric15030046

Alessandro Frolli, Francesco Cerciello, Clara Esposito, Mariagrazia Russo, Fabio Bisogni

{"title":"Learning Italian as a Second Language in a Sample of Ukrainian Children: A Game-Based Learning Approach.","authors":"Alessandro Frolli, Francesco Cerciello, Clara Esposito, Mariagrazia Russo, Fabio Bisogni","doi":"10.3390/pediatric15030046","DOIUrl":"10.3390/pediatric15030046","url":null,"abstract":"Game-based learning is an educational approach aimed at acquiring knowledge through the use of play. There are various studies that note the effectiveness of playing as an educational tool and the use of digital platforms as a tool that can increase its effectiveness. We wanted to investigate whether a game-based learning approach may determine an improvement in Italian as a foreign language in terms of vocabulary expansion. The sample consists of 48 Ukrainian children between 6 and 7 years old. There were 24 female children and 24 male children in the sample, divided into two groups: the control group (Gr1) learnt Italian through frontal lessons (traditional approach), the experimental group (Gr2) learnt Italian through games and activities (game-based learning). The results have shown that the experimental group had a major increase in Italian vocabulary. However, both groups had an increase in this sense. Game-based learning remains an effective and promising educational approach, but other variables must be taken into account. Furthermore, the scarcity of literature on foreign language learning through game-based learning creates the need for more studies.","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"15 3","pages":"502-511"},"PeriodicalIF":1.4,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10057998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case Report of a 5-Year-Old Girl with Self-Limited Epilepsy with Autonomic Seizures. 5岁女童自限性癫痫伴自主神经发作1例报告。

IF 1.1

Pediatric Reports Pub Date : 2023-08-11 DOI: 10.3390/pediatric15030045

Georgios Katsaras, Petrina Samartzi, Pelagia Tsitsani

{"title":"A Case Report of a 5-Year-Old Girl with Self-Limited Epilepsy with Autonomic Seizures.","authors":"Georgios Katsaras, Petrina Samartzi, Pelagia Tsitsani","doi":"10.3390/pediatric15030045","DOIUrl":"https://doi.org/10.3390/pediatric15030045","url":null,"abstract":"Background: Self-limited epilepsy with autonomic seizures (SeLEAS), formerly known as Panayiotopoulos syndrome (PS), is a common multifocal autonomic childhood epileptic syndrome. SeLEAS affects 6% of children in between the ages of 1 and 15 years who have had one or more afebrile seizures in their lifetime.Case: A 5-year-old girl was admitted to the paediatric emergency room (ER) of our hospital due to a reported episode of vomiting during her sleep, followed by central cyanosis perorally of sort duration (<5'), a right turn of her head, and gaze fixation with right eye deviation. She was dismissed after a one-day hospitalization free of symptoms. A month later, the patient was admitted to the paediatric ER of a tertiary health unit due to a similar episode. The patient underwent EEG, which revealed pathologic paroxysmal abnormalities of high-amplitude sharp waves and spike-wave complexes in temporal-occipital areas of the left hemisphere, followed by enhancement of focal abnormalities in temporal-occipital areas of the left hemisphere during sleep. The patient was diagnosed with SeLEAS and started levetiracetam.Conclusions: SeLEAS can be easily misdiagnosed as many physicians may not be very familiar with this disease, and, on the other hand, the autonomic manifestations can be easily disregarded as seizures. The physician must always be alert and search beneath the symptoms to find the cause rather than only treat them.","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"15 3","pages":"494-501"},"PeriodicalIF":1.1,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10055248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory Biomarker Profiles in Very Preterm Infants within the Context of Preeclampsia, Chorioamnionitis, and Clinically Diagnosed Postnatal Infection. 在先兆子痫、绒毛膜羊膜炎和临床诊断的产后感染背景下的极早产儿炎症生物标志物谱。

IF 1.1

Pediatric Reports Pub Date : 2023-08-10 DOI: 10.3390/pediatric15030044

Jordan T Ewald, Baiba Steinbrekera, Jennifer R Bermick, Donna A Santillan, Tarah T Colaizy, Mark K Santillan, Robert D Roghair

{"title":"Inflammatory Biomarker Profiles in Very Preterm Infants within the Context of Preeclampsia, Chorioamnionitis, and Clinically Diagnosed Postnatal Infection.","authors":"Jordan T Ewald, Baiba Steinbrekera, Jennifer R Bermick, Donna A Santillan, Tarah T Colaizy, Mark K Santillan, Robert D Roghair","doi":"10.3390/pediatric15030044","DOIUrl":"10.3390/pediatric15030044","url":null,"abstract":"Preterm delivery can be precipitated by preeclampsia or infection, and preterm infants are at heightened risk of postnatal infection. Little is known about the ontogeny of inflammatory biomarkers in extremely preterm infants. We hypothesized that suspected prenatal infection (clinical chorioamnionitis or spontaneous preterm labor) and clinically diagnosed postnatal infection would be associated with unique biomarker signatures, and those patterns would be influenced by the degree of prematurity. Venous blood was collected daily for the first week and weekly for up to 14 additional weeks from 142 neonates born at 22-32 weeks gestation. A custom array was utilized to measure monocyte chemoattractant protein-1 (MCP-1) and interleukin-6 (IL-6). C-reactive protein (CRP) levels were obtained from the electronic medical record. Independent of gestational age, MCP-1 was significantly increased (p < 0.001) in association with maternal preeclampsia, but MCP-1 was decreased (p < 0.01), and CRP was increased (p < 0.01) in the presence of chorioamnionitis with funisitis. IL-6 and CRP were both increased in infants diagnosed with postnatal infection, with peak levels observed on days 2 and 3, respectively. In conclusion, suspected prenatal and postnatal infections and non-infectious complications of pregnancy are associated with unique biomarker profiles, independent of gestational age, including over a 2-fold increase in MCP-1 among newborns of mothers with preeclampsia. Further, in those clinically diagnosed with a postnatal infection in the absence of antenatal infection concerns, IL-6 increases before CRP, emphasizing a potential role for expanded biomarker screening if antibiotics are initially avoided in infants delivered for maternal indications.","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"15 3","pages":"483-493"},"PeriodicalIF":1.1,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10057996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0