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Intraoperative Bleeding in Pediatric Otolaryngology: Trends and Future Perspectives. 儿科耳鼻喉科术中出血:趋势和未来展望。
IF 1.1
Pediatric Reports Pub Date : 2023-11-20 DOI: 10.3390/pediatric15040063
Antonino Maniaci, Salvatore Cocuzza, Ron B Mitchell, Ignazio La Mantia, Luigi La Via
{"title":"Intraoperative Bleeding in Pediatric Otolaryngology: Trends and Future Perspectives.","authors":"Antonino Maniaci, Salvatore Cocuzza, Ron B Mitchell, Ignazio La Mantia, Luigi La Via","doi":"10.3390/pediatric15040063","DOIUrl":"10.3390/pediatric15040063","url":null,"abstract":"<p><p>A significant challenge that ENT surgeons often encounter is managing intraoperative bleeding, a task that requires precision, adept judgment, and a thorough knowledge of the latest techniques and procedures [...].</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"15 4","pages":"707-709"},"PeriodicalIF":1.1,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Motor Skills and Executive Functions in Pediatric Patients with Down Syndrome: A Challenge for Tailoring Physical Activity Interventions 儿童唐氏综合症患者的运动技能和执行功能:调整身体活动干预的挑战
Pediatric Reports Pub Date : 2023-11-10 DOI: 10.3390/pediatric15040062
Matteo Vandoni, Matteo Giuriato, Agnese Pirazzi, Sara Zanelli, Francesca Gaboardi, Vittoria Carnevale Pellino, Alessandra Anna Gazzarri, Paola Baldassarre, Gianvincenzo Zuccotti, Valeria Calcaterra
{"title":"Motor Skills and Executive Functions in Pediatric Patients with Down Syndrome: A Challenge for Tailoring Physical Activity Interventions","authors":"Matteo Vandoni, Matteo Giuriato, Agnese Pirazzi, Sara Zanelli, Francesca Gaboardi, Vittoria Carnevale Pellino, Alessandra Anna Gazzarri, Paola Baldassarre, Gianvincenzo Zuccotti, Valeria Calcaterra","doi":"10.3390/pediatric15040062","DOIUrl":"https://doi.org/10.3390/pediatric15040062","url":null,"abstract":"Down syndrome (DS) is one of the most common chromosomal disorders. In addition to this variety of dysmorphic features. DS is also associated with a wide range of diseases and related comorbidities affecting different organs and systems. These comorbidities, together with societal and environmental influences, have a negative impact on physical activity in people with DS. Low levels of physical activity and energy expenditure have been identified as crucial players in worsening the acquisition of motor skills and executive functions. Executive functions are critical for the many skills (creativity, flexibility, self-control, and discipline) impacting our quality of life and make it possible to control impulses, mentally play with ideas, and stay focused. We proposed a broad overview of the available literature regarding motor skills and executive functions in pediatric patients with DS to understand the specific challenges for tailoring physical activity interventions. Motor skill interventions are effective in improving motor competence and performance on cognitive, emotional, and physical aspects in children with DS. Interventions based on executive functions in DS subjects are effective to contrast the cognitive decline and improve the everyday use of executive functions in youth and adults. Targeted interventions are mandatory for maximizing the benefits of physical activity, minimizing potential risks, and ultimately improving the overall health outcomes and quality of life for individuals with DS.","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"113 49","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135138250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Children’s Difficulties, Parent-Child Sleep, Parental Control, and Children’s Screen Time: A Cross-Sectional Study in Japan 儿童困难、亲子睡眠、父母控制和儿童屏幕时间之间的关系:日本的一项横断面研究
Pediatric Reports Pub Date : 2023-11-08 DOI: 10.3390/pediatric15040060
Yusuke Arai, Daimei Sasayama, Kazuhiro Suzuki, Toshinori Nakamura, Yuta Kuraishi, Shinsuke Washizuka
{"title":"Association between Children’s Difficulties, Parent-Child Sleep, Parental Control, and Children’s Screen Time: A Cross-Sectional Study in Japan","authors":"Yusuke Arai, Daimei Sasayama, Kazuhiro Suzuki, Toshinori Nakamura, Yuta Kuraishi, Shinsuke Washizuka","doi":"10.3390/pediatric15040060","DOIUrl":"https://doi.org/10.3390/pediatric15040060","url":null,"abstract":"Children’s screen time may affect their growth and development. However, differences in the impact of various psychiatric and psychological factors on children’s screen time is a research gap. This study aimed to explore the differences in the influence of related factors affecting children’s screen time based on their sleep, difficulties, and parental control among Japanese elementary and junior high school students. A cross-sectional survey was conducted among parents in Japan. Data on screen time duration, parent–child background, strengths and difficulties, sleep variables, and parental control types were collected from 225 households. A regression analysis revealed that high Strengths and Difficulties Questionnaire (SDQ) scores (β = 0.166, p = 0.008), sleep duration (β = −0.281, p < 0.001), and parental control (β = −0.204, p = 0.001) were significantly related to children’s screen time. Additionally, it was found that parents’ late bedtimes affect children’s screen time by mediating children’s sleep duration. This study, together with previous research, provides comprehensive insights into design interventions to decrease the screen time of children in the Japanese context.","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"37 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135430530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Retrospective Observational Study of the Impact of HIV Status on the Outcome of Paediatric Intensive Care Unit Admissions at a Tertiary Hospital in South Africa (2015–2019) 2015-2019年南非某三级医院儿童重症监护病房HIV感染状况对入院结果影响的回顾性观察研究
Pediatric Reports Pub Date : 2023-11-08 DOI: 10.3390/pediatric15040061
Kim Whitehead, Daynia E. Ballot
{"title":"A Retrospective Observational Study of the Impact of HIV Status on the Outcome of Paediatric Intensive Care Unit Admissions at a Tertiary Hospital in South Africa (2015–2019)","authors":"Kim Whitehead, Daynia E. Ballot","doi":"10.3390/pediatric15040061","DOIUrl":"https://doi.org/10.3390/pediatric15040061","url":null,"abstract":"HIV-infected and HIV-exposed but uninfected (HEU) children have unique health risks. Our study looked at how HIV exposure and infection impact presentation and outcomes in PICU in an era of improved ART. A retrospective analysis of children admitted to PICU was performed. The sample was divided into HIV negative, HEU and HIV infected, and presentation and outcomes were compared with a significance level set at α = 0.05. Our study showed that 16% (109/678) of children admitted to PICU were HEU and 5.2% (35/678) were HIV infected. HIV-infected children were admitted at a younger age (median two months) with an increased incidence of lower respiratory infections than HIV-negative children (p < 0.001); they also required longer ventilation and admission (p < 0.001). HIV-infected children had a higher mortality (40%) (p = 0.02) than HIV-negative (22.7%) children; this difference was not significant when comparing only children with a non-surgical diagnosis (p = 0.273). HEU children had no significant difference in duration of ICU stay (p = 0.163), ventilation (p = 0.443) or mortality (p = 0.292) compared to HIV-negative children. In conclusion, HIV-infected children presented with more severe disease requiring longer ventilation and admission. HEU had similar outcomes to HIV-negative children.","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"6 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135391789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adherence to Vitamin D Supplementation during Infancy—A Single Pediatric Primary Practice Retrospective Study 在婴儿期坚持补充维生素D -一项儿科初级实践回顾性研究
Pediatric Reports Pub Date : 2023-11-02 DOI: 10.3390/pediatric15040059
Jerko Vucak, Jeronim Matijevic, Ivan Pivac, Josko Markic
{"title":"Adherence to Vitamin D Supplementation during Infancy—A Single Pediatric Primary Practice Retrospective Study","authors":"Jerko Vucak, Jeronim Matijevic, Ivan Pivac, Josko Markic","doi":"10.3390/pediatric15040059","DOIUrl":"https://doi.org/10.3390/pediatric15040059","url":null,"abstract":"The risk of vitamin D deficiency is high in infants. Therefore, potential vitamin D deficiency should be prophylactically treated with vitamin D supplementation. Achieving good adherence to recommended prophylactic regimens is the goal of every primary pediatrician. The aim of this paper was to establish whether Croatian infants receive recommended prophylactic doses of vitamin D regularly. We analyzed the prescription rate of vitamin D preparation during the first year of life in one pediatric primary practice. Our research has shown, for the first time in Croatia, that there is low treatment adherence. Only 7.6% of infants received the recommended doses of vitamin D. The percentage of infants in the moderately irregular adherence group was 19.3%. There was no statistical difference regarding urban or rural place of living or parents’ educational level. Based on these findings, a comprehensive public health campaign is needed to improve adherence to vitamin D supplementation during infancy. Also, further studies on larger samples and on a national level are warranted.","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"12 22","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135973154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular Risk in Pediatrics: A Dynamic Process during the First 1000 Days of Life 儿科心血管风险:生命最初1000天的动态过程
Pediatric Reports Pub Date : 2023-11-01 DOI: 10.3390/pediatric15040058
Valeria Calcaterra, Savina Mannarino, Vittoria Garella, Virginia Rossi, Elia Mario Biganzoli, Gianvincenzo Zuccotti
{"title":"Cardiovascular Risk in Pediatrics: A Dynamic Process during the First 1000 Days of Life","authors":"Valeria Calcaterra, Savina Mannarino, Vittoria Garella, Virginia Rossi, Elia Mario Biganzoli, Gianvincenzo Zuccotti","doi":"10.3390/pediatric15040058","DOIUrl":"https://doi.org/10.3390/pediatric15040058","url":null,"abstract":"The early childhood period, encompassing prenatal and early stages, assumes a pivotal role in shaping cardiovascular risk factors. We conducted a narrative review, presenting a non-systematic summation and analysis of the available literature, focusing on cardiovascular risk from prenatal development to the first 1000 days of life. Elements such as maternal health, genetic predisposition, inadequate fetal nutrition, and rapid postnatal growth contribute to this risk. Specifically, maternal obesity and antibiotic use during pregnancy can influence transgenerational risk factors. Conditions at birth, such as fetal growth restriction and low birth weight, set the stage for potential cardiovascular challenges. To consider cardiovascular risk in early childhood as a dynamic process is useful when adopting a personalized prevention for future healthcare and providing recommendations for management throughout their journey from infancy to early adulthood. A comprehensive approach is paramount in addressing early childhood cardiovascular risks. By targeting critical periods and implementing preventive strategies, healthcare professionals and policymakers can pave the way for improved cardiovascular outcomes. Investing in children’s health during their early years holds the key to alleviating the burden of cardiovascular diseases for future generations.","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"77 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135271337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wolcott-Rallison Syndrome, a Rare Cause of Permanent Diabetes Mellitus in Infants-Case Report. 婴儿永久性糖尿病罕见病因Wolcott-Rallison综合征病例报告。
IF 1.1
Pediatric Reports Pub Date : 2023-10-16 DOI: 10.3390/pediatric15040056
Alexandru-Ștefan Niculae, Claudia Bolba, Alina Grama, Alexandra Mariş, Laura Bodea, Simona Căinap, Alexandra Mititelu, Otilia Fufezan, Tudor Lucian Pop
{"title":"Wolcott-Rallison Syndrome, a Rare Cause of Permanent Diabetes Mellitus in Infants-Case Report.","authors":"Alexandru-Ștefan Niculae,&nbsp;Claudia Bolba,&nbsp;Alina Grama,&nbsp;Alexandra Mariş,&nbsp;Laura Bodea,&nbsp;Simona Căinap,&nbsp;Alexandra Mititelu,&nbsp;Otilia Fufezan,&nbsp;Tudor Lucian Pop","doi":"10.3390/pediatric15040056","DOIUrl":"10.3390/pediatric15040056","url":null,"abstract":"<p><p>Wolcott-Rallison syndrome is a rare cause of permanent neonatal diabetes mellitus caused by mutations in the eukaryotic translation initiation factor 2 alpha kinase 3 gene (EIF2AK3). Individuals affected by this disorder have severe hyperglycemia, pancreatic failure, and bone abnormalities and are prone to severe and life-threatening episodes of liver failure. This report illustrates the case of a 2-month-old infant with extreme hyperglycemia and severe diabetic ketoacidosis. Acute management was focused on correcting severe acidosis. Further management aimed to obtain stable blood glucose levels, balancing the patient's need for comfort and lack of distress with the clinicians' need for adequate information regarding the patient's glycemic control. Genetic testing of the patient and his parents confirmed the diagnosis. The follow-up for 18 months after diagnosis is detailed, illustrating both the therapeutic success of subcutaneous insulin therapy and the ongoing complications that patients with Wolcott-Rallison syndrome are subject to.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"15 4","pages":"608-616"},"PeriodicalIF":1.1,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49693024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated Behavior Therapy for Exclusively Anxious Selective Mutism: A Nonconcurrent Multiple-Baseline Design across Five Participants. 排他性焦虑选择性缄默症的综合行为治疗:五名参与者的非并发多基线设计。
IF 1.1
Pediatric Reports Pub Date : 2023-10-16 DOI: 10.3390/pediatric15040057
Allison K Siroky, John S Carlson, Aimee Kotrba
{"title":"Integrated Behavior Therapy for Exclusively Anxious Selective Mutism: A Nonconcurrent Multiple-Baseline Design across Five Participants.","authors":"Allison K Siroky,&nbsp;John S Carlson,&nbsp;Aimee Kotrba","doi":"10.3390/pediatric15040057","DOIUrl":"10.3390/pediatric15040057","url":null,"abstract":"<p><p>Selective mutism (SM) is a rare childhood anxiety disorder which may be markedly detrimental to a child's academic and social functioning if left untreated. Cognitive-behavioral treatments for social anxiety disorders have been found to be effective for SM, yet a paucity of published studies have explored manualized treatment approaches carried out by novice clinicians. The purpose of the present study was to examine the adherence, effectiveness, and acceptability of a condensed, 16-session version of Integrated Behavior Therapy for Selective Mutism (IBTSM; Bergman, 2013), the first manualized treatment for SM. A nonconcurrent multiple-baseline single-case design was used across five children diagnosed with SM, exclusively anxious subtype. IBTSM was implemented with excellent adherence (M = 98%) over an average of 19 weeks (range = 16-22 weeks). Visual analyses of weekly caregiver ratings of social anxiety and speaking behaviors did not demonstrate a replicated intervention effect; however, Tau-U effect sizes and Reliable Change Index (RCI) calculations demonstrated significant individual improvements in social anxiety and speaking behaviors over time on several measures. Three children (60%) no longer met diagnostic criteria for SM following treatment. All caregivers rated IBTSM as acceptable, with specific endorsements of acceptability in the areas of time required and treatment quality.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"15 4","pages":"617-635"},"PeriodicalIF":1.1,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49693021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Nasal CPAP in the Pediatric Ward to Reduce PICU Admissions for Severe Bronchiolitis? 儿科病房应用鼻持续气道正压通气减少重症毛细支气管炎PICU的入院人数?
IF 1.1
Pediatric Reports Pub Date : 2023-10-13 DOI: 10.3390/pediatric15040055
Melodie O Aricò, Diana Wrona, Giovanni Lavezzo, Enrico Valletta
{"title":"Nasal CPAP in the Pediatric Ward to Reduce PICU Admissions for Severe Bronchiolitis?","authors":"Melodie O Aricò,&nbsp;Diana Wrona,&nbsp;Giovanni Lavezzo,&nbsp;Enrico Valletta","doi":"10.3390/pediatric15040055","DOIUrl":"10.3390/pediatric15040055","url":null,"abstract":"<p><p>In treating acute bronchiolitis in infants, the decision to use continuous positive airway pressure (CPAP) often involves infant referral from the pediatric ward to the pediatric intensive care unit (PICU). We present our experience of CPAP use in a general pediatric ward, aiming to reduce the pressure on the PICU in recent outbreaks of bronchiolitis. Clinical data of patients less than 12 months of age and admitted for bronchiolitis from 1 October 2021 to 31 March 2023 were retrospectively collected. Of 82 infants admitted for bronchiolitis, 16 (19%) were treated with nasal CPAP (nCPAP group); of the remaining 66, 21 (26%) were treated with a low-flow nasal cannula (LFNC) only, 1 (1%) was also treated a with high-flow nasal cannula (HFNC), 12 (15%) were treated with an HFNC only, and 41 (50%) were treated without oxygen support (no-nCPAP group). Overall, coinfection with RSV and SARS-CoV-2 was observed in three patients and SARS-CoV-2 infection was observed in two patients. None of them required any type of oxygen support. Only 3/16 (19%) infants in the nCPAP group were referred to the PICU due to worsening clinical conditions despite nCPAP support. In our experience of treating epidemic bronchiolitis, nCPAP can be safely managed in a general pediatric ward, thus reducing the burden of admissions to the PICU. Training and regular updating of the pediatric staff, careful monitoring of the patient, and close cooperation with the PICU were instrumental for our team.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"15 4","pages":"599-607"},"PeriodicalIF":1.1,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49693022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Outcome of Multisystem Inflammatory Syndrome in Neonates Diagnosed following Prenatal Maternal COVID-19 Infection: A Three-Case Series. 产前母亲新冠肺炎感染后诊断的新生儿多系统炎症综合征的早期结果:三个病例系列。
IF 1.1
Pediatric Reports Pub Date : 2023-10-10 DOI: 10.3390/pediatric15040054
Maria Terciu, Ioana Luca, Emilia Panait, Eugene Leibovitz, Maria Mitrica, Bianca Popovici, Anca Ilea, Oana Gabriela Falup-Pecurariu
{"title":"Early Outcome of Multisystem Inflammatory Syndrome in Neonates Diagnosed following Prenatal Maternal COVID-19 Infection: A Three-Case Series.","authors":"Maria Terciu,&nbsp;Ioana Luca,&nbsp;Emilia Panait,&nbsp;Eugene Leibovitz,&nbsp;Maria Mitrica,&nbsp;Bianca Popovici,&nbsp;Anca Ilea,&nbsp;Oana Gabriela Falup-Pecurariu","doi":"10.3390/pediatric15040054","DOIUrl":"10.3390/pediatric15040054","url":null,"abstract":"<p><strong>Background: </strong>The aim of this case series report is to evaluate the characteristics of multisystem inflammatory syndrome (MIS) in neonates following prenatal maternal COVID-19 infection.</p><p><strong>Methods: </strong>We present a case series of three newborns (≤28 days of age) diagnosed with MIS due to the vertical transmission of SARS-CoV2 infection and admitted from 1 January 2021 to 1 June 2023. The inclusion criteria were negative RT-PCR-SARS-CoV-2 test in infants, initial negative IgM-SARS-CoV-2 in infants followed by the emergence of positive IgG-SARS-CoV-2 antibodies in infants and maternal COVID-19 infection in the third trimester of pregnancy. Patients enrolled in this case series were admitted due to acute febrile illnesses.</p><p><strong>Results: </strong>All three cases occurred in patients born at a mean gestational age of 39 weeks and who were appropriate for gestational age. The mean age at admission was 18.3 days. Fibrinogen (>400 mg/dL) and ferritin (>120 mg/dL) were elevated above the upper normal limit. Elevated levels of myocardial biomarkers (D-dimers, N-terminal pro b-type natriuretic peptide troponin T and creatine phosphokinase myocardial band) were recorded, with normal heart function evaluated using echocardiography. All three patients were treated with antibiotics; one received intravenous immunoglobulin. A 4-week follow-up was completed in two patients when their myocardial biomarkers and ferritin were still elevated but lower compared with previous examinations. D-dimers levels were normalized in 2/3 patients.</p><p><strong>Conclusions: </strong>Subclinical myocarditis was diagnosed as an early outcome in infants with MIS diagnosed postnatally due to the vertical transmission of SARS-CoV2 infection and may represent a new challenge for pediatricians in the pandemic era.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"15 4","pages":"591-598"},"PeriodicalIF":1.1,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49693019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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