Salivary IL-1 Beta Level Associated with Poor Sleep Quality in Children/Adolescents with Autism Spectrum Disorder.

IF 1.4 Q3 PEDIATRICS
Milagros Fuentes-Albero, Mayra Alejandra Mafla-España, José Martínez-Raga, Omar Cauli
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引用次数: 0

Abstract

Background: Sleep disorders are common in youths with autism spectrum disorders. Inflammatory cytokines such as Il-1 beta and Il-6 in saliva have been associated with alterations in sleep quality in various conditions. We assessed whether there were associations between the salivary concentration of IL-1 beta and IL-6 and sleep quality in youths with ASD versus typically developing (TD) age- and gender-matched youths.

Method: Forty children and adolescents with ASD or TD participated in this study (20% females). Their parents answered the items of a validated questionnaire on sleep quality (Pittsburgh Sleep Quality Index).

Results: The mean Pittsburgh score was significantly higher (i.e., the quality of sleep was poorer) in the ASD group (8.68 ± 0.35 (SEM), ranging from 7 to 12 points), compared to the TD group (7.35 ± 0.54 (SEM), ranging from 2 to 12 points) (p = 0.02, Mann-Whitney U test). There were no significant differences in the salivary concentration of Il-1 beta and IL-6 receptor between the two groups, but salivary IL-1 beta concentration was inversely associated with poor sleep quality in the ASD group. No associations between the salivary Il-6 concentration and sleep quality were found in either group. Linear regression analysis by separate groups revealed significant associations between the sleep quality score and the concentration of IL-1 beta in the ASD group (p = 0.01, OR = -0.53, 95% CI -0.008-0.001). In contrast, no significant associations were observed in the TD group, or for IL-6 in either group. No significant effects of sex, age, or use of psychotropic medications were found.

Conclusions: Children and adolescents with ASD showed significantly poorer sleep quality based on their parents' reports compared to the TD group, and the salivary IL-1 beta concentration was inversely associated with sleep quality only in the ASD group. Further studies on the associations between inflammatory cytokines and sleep in ASD are needed.

唾液 IL-1 Beta 水平与自闭症谱系障碍儿童/青少年睡眠质量差有关。
背景:睡眠障碍在患有自闭症谱系障碍的青少年中很常见。唾液中的炎性细胞因子(如 Il-1 beta 和 Il-6)与各种情况下睡眠质量的改变有关。我们评估了自闭症谱系障碍青少年唾液中IL-1 beta和IL-6的浓度与睡眠质量之间是否存在关联:40 名患有 ASD 或 TD 的儿童和青少年(女性占 20%)参加了这项研究。他们的父母回答了睡眠质量有效问卷(匹兹堡睡眠质量指数)的各个项目:ASD组的匹兹堡平均得分(8.68 ± 0.35 (SEM),从7分到12分不等)明显高于TD组(7.35 ± 0.54 (SEM),从2分到12分不等)(P = 0.02,曼-惠特尼U检验)。两组患者唾液中Il-1 beta和IL-6受体的浓度无明显差异,但ASD组患者唾液中IL-1 beta的浓度与睡眠质量差呈反比。两组的唾液Il-6浓度均与睡眠质量无关。按不同组别进行的线性回归分析显示,ASD 组的睡眠质量评分与 IL-1 beta 浓度之间存在显著关联(p = 0.01,OR = -0.53,95% CI -0.008-0.001)。相比之下,在TD组和IL-6组均未观察到明显的相关性。性别、年龄或服用精神药物均无明显影响:结论:根据父母的报告,患有 ASD 的儿童和青少年的睡眠质量明显低于 TD 组,而且只有 ASD 组的唾液 IL-1 beta 浓度与睡眠质量成反比。我们需要进一步研究 ASD 患者的炎症细胞因子与睡眠之间的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pediatric Reports
Pediatric Reports PEDIATRICS-
CiteScore
2.10
自引率
0.00%
发文量
55
审稿时长
11 weeks
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