Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献

{"title":"Nasopalatine duct cyst following Le Fort I osteotomy: A case report","authors":"Hikaru Takasu ,&nbsp;Yuichiro Hayashi ,&nbsp;Haruka Yoshii ,&nbsp;Hiroki Miyagishima ,&nbsp;Yoshiaki Inayama ,&nbsp;Makoto Hirota ,&nbsp;Kenji Mitsudo","doi":"10.1016/j.ajoms.2025.01.013","DOIUrl":"10.1016/j.ajoms.2025.01.013","url":null,"abstract":"<div><div>Nasopalatine duct cyst (NPDC) is the most common non-odontogenic developmental cyst arising from proliferation of embryonic epithelial remnants in the nasopalatine duct. Notably, cyst formation can occur as a result of trauma or infection in rare cases. Herein, we report a 30-year-old Japanese woman who had undergone a Le Fort I osteotomy 10 years prior and was referred to our hospital 10 years after surgery for concerns about a growing mass in the palate. Computed tomography revealed a 25 × 25 × 20 mm cystic lesion in the midline region of the anterior maxilla, continuous with the incisive canal. Under general anesthesia, the cyst was removed together with the plates and screws used during the former surgery; histopathological examination showed a squamous epithelium lining the cyst wall. Based on the clinical and histological findings, the cyst was diagnosed as NPDC following Le Fort I osteotomy. Therefore, NPDC should be suspected in patients undergoing Le Fort I osteotomy who present with symptoms such as hard palate, nasolabial, anterior maxillary alveolus swelling, and nasal obstruction. Additionally, patients undergoing maxillary orthognathic surgery should be informed about the possibility of postoperative NPDC occurrence.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 4","pages":"Pages 729-732"},"PeriodicalIF":0.4,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pleomorphic adenoma gene 1 (PLAG1) protects p53-/- myoepithelial cells from mitochondria-related apoptosis caused by hypoxia","authors":"Nodoka Kindaichi,&nbsp;Yoshiki Mukudai,&nbsp;Yuzo Abe,&nbsp;Masataka Watanabe,&nbsp;Maki Nara,&nbsp;Konomi Yamada,&nbsp;Asami Houri,&nbsp;Toshikazu Shimane,&nbsp;Tatsuo Shirota","doi":"10.1016/j.ajoms.2025.01.005","DOIUrl":"10.1016/j.ajoms.2025.01.005","url":null,"abstract":"<div><h3>Objective</h3><div>Pleomorphic adenoma (PA) is one of the most frequent benign tumors of the salivary glands. Although pleomorphic adenoma gene 1 (PLAG1) is considered to be responsible for the oncogenesis of a PA, its role in myoepithelial cells remains poorly understood. This study investigated the intrinsic involvement of PLAG1 in the apoptosis pathway at hypoxia in the absence of p53.</div></div><div><h3>Methods</h3><div>Mouse myoepithelial (ME) cells were derived from p53^-/- mice. The cells were grown in serum-free medium in an atmosphere of 5 % CO₂ and 100 % humidity. Hypoxic conditions were set at 37°C, 2 % O₂, and 5 % CO₂. Cell viability and cell proliferation were measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and cell cycle assay, respectively. Apoptosis was assessed by caspase-3/7 and mitochondrial membrane potential (MMP) assays and western blotting for apoptosis-related proteins. In gene knockdown experiments, small interference RNAs (siRNA) were transfected into cells using the lipofection method.</div></div><div><h3>Results</h3><div>PLAG1 is regulated downstream of HIF-1α and shows potential to inhibit and/or resist apoptosis via the modulation of the Bcl-2 pathway under hypoxic conditions, which is often observed at the center of PAs.</div></div><div><h3>Conclusions</h3><div>Exposure to hypoxia in myoepithelial cells increases PLAG1 expression, whereby Bcl-2-relataed pathway and MMP is activated.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 4","pages":"Pages 654-661"},"PeriodicalIF":0.4,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of preoperative chemotherapy with paclitaxel, carboplatin, and cetuximab during the surgery waiting period for resectable oral cancer","authors":"Akinori Takeshita,&nbsp;Kazuhide Matsunaga,&nbsp;Yoshihiro Morita,&nbsp;Yuka Matsumiya,&nbsp;Takafumi Kashiwagi,&nbsp;Kana Kashima,&nbsp;Narikazu Uzawa","doi":"10.1016/j.ajoms.2025.01.008","DOIUrl":"10.1016/j.ajoms.2025.01.008","url":null,"abstract":"<div><h3>Background</h3><div>Resection is the standard treatment for resectable oral cancer; however, if surgery cannot be performed immediately and a waiting period is necessary, preoperative chemotherapy may be considered to prevent tumor progression. Despite this, preoperative chemotherapy for oral cancer has not yet been established. In contrast, docetaxel/cisplatin/5-fluorouracil (TPF) is used as induction chemotherapy in head and neck cancer, with paclitaxel/carboplatin/cetuximab (PCE) therapy being considered as an alternative. Therefore, we investigated the efficacy of preoperative PCE therapy for resectable oral cancer requiring a waiting period for surgery.</div></div><div><h3>Materials and methods</h3><div>We retrospectively evaluated the efficacy and adverse events of PCE therapy in 23 patients with oral cancer treated with PCE therapy as preoperative chemotherapy during the waiting period for surgery.</div></div><div><h3>Results</h3><div>The overall response and disease control rates were 55.6 % and 100 %, respectively. The histological therapeutic response for the primary tumor was 13.0 % for markedly effective and 30.4 % for moderately effective. Regarding major adverse events, grade 3 leukopenia was observed in 4.3 % of patients, and grade 3 neutropenia was observed in 13.0 %. Grade 4 adverse events were not observed. Overall, no serious adverse events and no disturbing effects were observed during postoperative surgery and postoperative management. In some cases, functional preservation and maintenance of quality of life were achieved.</div></div><div><h3>Conclusion</h3><div>PCE therapy may be useful as preoperative chemotherapy during the waiting period for resectable oral cancer.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 4","pages":"Pages 669-676"},"PeriodicalIF":0.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evaluation of the usefulness of dual-energy computed tomography in the preoperative diagnosis of cervical lymph node metastases in oral squamous cell carcinoma","authors":"Erina Kitamoto ,&nbsp;Toru Chikui ,&nbsp;Kazutoshi Okamura ,&nbsp;Kazuhito Hioki ,&nbsp;Shintaro Kawano ,&nbsp;Wataru Kumamaru ,&nbsp;Tamotsu Kiyoshima ,&nbsp;Osamu Togao ,&nbsp;Kazunori Yoshiura","doi":"10.1016/j.ajoms.2025.01.012","DOIUrl":"10.1016/j.ajoms.2025.01.012","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate useful parameters for differentiating metastatic lymph nodes in oral squamous cell carcinoma using dual-energy computed tomography (DECT) in the venous phase.</div></div><div><h3>Methods</h3><div>A total of 117 lymph nodes without visually obvious necrosis (83 non-metastatic and 34 metastatic) from 40 patients were retrospectively analyzed. The region of interest was defined at the area with the maximum short diameter. Nine parameters were calculated and correlated with the pathology images: CT values of virtual monochromatic X-ray images at 40, 70, and 100 keV (HU_40 keV, HU_70 keV, HU_100 keV), iodine concentration (IC), CT value variation at 40–70 keV (λ_40–70 _HU), 40–100 keV (λ_40–100 _HU), lymph node long diameter, short diameter, and long-short diameter ratio.</div></div><div><h3>Results</h3><div>Metastatic lymph nodes had lower CT and IC values than non-metastatic nodes. However, the short diameter had the highest the area under the receiver operating characteristic curve (AUC) with 0.846 (95 % confidence interval: 0.741–0.914), and the respective sensitivity and specificity were 82.4 % and 84.3 % at a cutoff of 7.54 mm. For parameters using CT values and IC, HU_100 keV had the highest AUC (0.737), followed by HU_70 keV (0.717), HU_40 keV (0.686), IC (0.660), λ_40–100 _HU (0.659), and λ_40–70 _HU (0.659). Six DECT-derived parameters showed the significant negative correlation to the short axis length.</div></div><div><h3>Conclusion</h3><div>In the venous phase, although the significant differences were found in the DECT-derived parameters, the maximal short diameter was found to be the most useful parameter for the differentiation of metastatic lymph nodes.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 4","pages":"Pages 662-668"},"PeriodicalIF":0.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological analysis of tumor microenvironmental changes after near-infrared photoimmunotherapy","authors":"Takehiro Chida ,&nbsp;Aya Matsuda ,&nbsp;Nako Maishi ,&nbsp;Kohei Nakajima ,&nbsp;Mineyoshi Sato ,&nbsp;Zi Jia ,&nbsp;Yoichi Ohiro ,&nbsp;Mikako Ogawa ,&nbsp;Yasuhiro Hida ,&nbsp;Kyoko Hida","doi":"10.1016/j.ajoms.2025.01.006","DOIUrl":"10.1016/j.ajoms.2025.01.006","url":null,"abstract":"<div><h3>Objective</h3><div>Although NIR-PIT has been approved in Japan for recurrent and previously treated head and neck cancer, detailed analysis of tumor microenvironment remains lacking. This study aimed to evaluate the effects of near-infrared photoimmunotherapy (NIR-PIT) on the tumor microenvironment, focusing on tumor blood vessels delivering antibodies and immune cells to tumor tissue and macrophages migrating through tumor blood vessels into tumor tissue after NIR-PIT, in a mouse model of human tongue carcinoma.</div></div><div><h3>Methods</h3><div>A mouse tumor model using SAS human tongue carcinoma cell lines was utilized to investigate changes in necrosis, blood vessels, and macrophage infiltration 24 hours after NIR-PIT. The NIR-PIT treatment involved the photoactivation of IRDye®700DX (IR700)-conjugated antibodies with near-infrared light. Histological analysis assessed necrotic tissue, the number and distribution of open vessels, and macrophage recruitment.</div></div><div><h3>Results</h3><div>At 24 hours post-NIR-PIT, necrotic tumor areas were three times larger, while the number of open blood vessels and macrophage recruitment increased by two to three times compared to controls. These findings suggest that NIR-PIT enhances the tumor immune response by expanding the tumor vascular lumen and facilitating macrophage infiltration.</div></div><div><h3>Conclusions</h3><div>NIR-PIT promotes vascular changes and enhances macrophage recruitment, which could improve drug delivery and enhance the antitumor immune response. The combination of NIR-PIT with chemotherapy may further increase therapeutic efficacy. While the lack of cellular immunity in nude mice limited conclusions on immune activation, this study provides the first histological evidence of innate immune involvement in short-term tissue changes after NIR-PIT, supporting its potential as an effective cancer treatment.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 4","pages":"Pages 807-817"},"PeriodicalIF":0.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The tongue microbiome: A gateway to systemic health and disease","authors":"Marwan Mansoor Ali Mohammed ,&nbsp;Sausan Al Kawas ,&nbsp;Gamilah Al-Qadhi","doi":"10.1016/j.ajoms.2025.01.009","DOIUrl":"10.1016/j.ajoms.2025.01.009","url":null,"abstract":"<div><h3>Objective</h3><div>In this review, we summarize the current state of the art of the tongue microbiome research and its potential as a diagnostic tool for different oral and systemic diseases. We discuss the methods used to characterize the tongue microbiome, the factors that influence its composition, and the potential mechanisms by which it may be linked to systemic diseases.</div></div><div><h3>Methods</h3><div>A comprehensive literature search of articles on tongue microbiome from Jan 2010 to Jan 2024.</div></div><div><h3>Results</h3><div>The majority of the studies reviewed demonstrated significant alterations in the tongue microbiome across various diseases and conditions. including chronic insomnia, rheumatoid arthritis, Sjogren syndrome, chronic hepatitis B, pneumonia, geographic tongue, post-menopausal osteoporosis, human immunodeficiency virus (HIV), diabetes mellitus, and pediatric inflammatory bowel disease. There are some conditions that show no significant changes in the tongue microbiome of patients compared to the healthy control like in children with autism and the young patients with chronic kidney disease and their healthy mothers.</div></div><div><h3>Conclusions</h3><div>The microbiome of the tongue has been shown to be connected to the development and progression of different types of systemic diseases and conditions.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 4","pages":"Pages 733-742"},"PeriodicalIF":0.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of multicentric reticulohistiocytosis with multiple nodules in the oral cavity","authors":"Sho Akashi ,&nbsp;Tatsushi Matsumura ,&nbsp;Yohsuke Yoshioka ,&nbsp;Koichi Sawaki ,&nbsp;Makoto Nakano ,&nbsp;Seiji Iida","doi":"10.1016/j.ajoms.2025.01.007","DOIUrl":"10.1016/j.ajoms.2025.01.007","url":null,"abstract":"<div><div>Multicentric reticulohistiocytosis (MRH) is a rare systemic disease categorized under non-Langerhans cell histiocytosis. It is clinically characterized by papulonodular skin lesions and multiple destructive arthritis and is often associated with malignant tumors. We report a rare case of MRH involving multiple nodules in the oral cavity. A 77-year-old woman was referred to our department with multiple nodules on her lower lip, buccal mucosa, and tongue, which caused difficulties with mastication. She had a history of knee osteoarthritis and heart failure, for which she was under treatment by her primary physician. Initially diagnosed with multiple benign tumors, she underwent a biopsy, which suggested a granular cell tumor. Consequently, the tumors were excised under general anesthesia. Three days prior to the operation, the patient was referred to the Department of Dermatology for a nodule on the occipital skin, and a biopsy was performed. Histopathological examination of both the skin lesion and the orally excised tumors revealed histiocytes with ground-glass eosinophilic cytoplasm. Immunohistochemical analysis showed that the histiocytes were positive for CD68 and negative for AE1/AE3, S-100, and CD1a. These findings confirmed the diagnosis of MRH. Systemic screening subsequently identified thyroid and breast cancers. Due to her deteriorating condition, no active treatment could be administered, and she passed away 11 months post-operation from heart failure. During this period, new oral tumors emerged, but no recurrence was detected in the previously excised areas.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 4","pages":"Pages 718-723"},"PeriodicalIF":0.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Nutritional Index for Oral Cancer: A predictive parameter of surgical site infection and prognosis in oral cancer patients undergoing extensive resection with reconstruction-a single-centre retrospective study","authors":"Keisuke Suzuki,&nbsp;Masaru Ogawa,&nbsp;Takahiro Yamaguchi,&nbsp;Takaya Makiguchi,&nbsp;Satoshi Yokoo","doi":"10.1016/j.ajoms.2025.01.003","DOIUrl":"10.1016/j.ajoms.2025.01.003","url":null,"abstract":"<div><h3>Objective</h3><div>The incidence of surgical site infection (SSI) after extensive oral cancer surgery has now fallen to about 20 % but remains a challenge perioperative management. In this study, we investigated potential factors predictive of SSI, with a particular focus on nutrition, in patients undergoing extensive oral cancer surgery, and created an assessment tool specifically designed for predicting the onset of SSI in patients with oral cancer.</div></div><div><h3>Methods</h3><div>117 Patients treated at Gunma University Hospital between April 2009 and March 2018 were assessed for inclusion in the study. We investigated the relationship between tumour characteristics, nutritional factors, and SSI onset during post-operative hospitalisation. Based on the SSI predictors extracted by logistic regression analysis, the Prognostic Nutrition Index for Oral Cancer (PNI-OC) score was devised.</div></div><div><h3>Results</h3><div>A total of 29 patients (24.8 %) developed SSIs. In the logistic analysis, body mass index (BMI) (p &lt; 0.05), total lymphocyte count (TLC) (p &lt; 0.05), and total cholesterol level (T-cho) (p &lt; 0.05) were identified as independent factors for SSI onset. The PNI-OC score as a predictive tool for SSI had an AUC was 0.84, a sensivitivity of 82.3 %, and a negative predictive value of 92.3 %. The PNI-OC (high risk score 4) was significantly associated with overall survival (OS) (log-rank test: p = 0.032).</div></div><div><h3>Conclusion</h3><div>In the setting of low SSI incidence, BMI, TLC, and T-cho were independent predictors. The PNI-OC score calculated using these three factors represented a useful nutrutional assessment tool for ruling out the perioperative SSI risk. Furthermore, the PNI-OC was determined to be an oncological predictive factor of OS.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 4","pages":"Pages 756-764"},"PeriodicalIF":0.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral metastatic tumor (renal cell carcinoma) in maxillary gingiva: A case report and systematic review","authors":"Yusuke Nakako ,&nbsp;Tatsufumi Fujimoto ,&nbsp;Hiroko Wada ,&nbsp;Naoya Yoshihama ,&nbsp;Yukiko Kami ,&nbsp;Shinsuke Fujii ,&nbsp;Kenichi Kohashi ,&nbsp;Wataru Kumamaru ,&nbsp;Toru Chikui ,&nbsp;Masafumi Moriyama ,&nbsp;Tamotsu Kiyoshima","doi":"10.1016/j.ajoms.2025.01.004","DOIUrl":"10.1016/j.ajoms.2025.01.004","url":null,"abstract":"<div><h3>Background and objective</h3><div>Oral metastases are rare. We experienced a case of oral metastasis of renal cell carcinoma (RCC) and discussed its characteristics with a systematic review to survey the literature for useful features for the diagnosis of oral metastatic RCC.</div></div><div><h3>Methods</h3><div>A systematic review was conducted according to the PRISMA 2020 statement. An electronic search was performed using three databases and the literature of cases of renal cancer metastasis to the jawbone and gingiva.</div></div><div><h3>Results</h3><div>Thirty studies were identified (male-to-female ratio, 2.75:1). The site of metastasis was the jawbone in 66.7 % (mandible, 60 %; maxilla, 6.7 %) and the gingiva in 30 %. Clinical symptoms were a mass in 86.7 % and hypoesthesia in 23.3 %. A total of 76.7 % of oral metastases were clear cell type. In our case, the male patient showed a mass in the maxillary gingiva without hypoesthesia. Metastatic clear cell RCC was suspected by an oral biopsy, which was confirmed on clinical examinations, including a renal biopsy.</div></div><div><h3>Conclusion</h3><div>Oral metastases are rare, and the clinical and imaging findings for oral metastases of RCC are wide-ranged with low specificity, depending on the metastatic site. It is necessary to fully understand the key points in histopathological differentiation. Because the clinician plays a fundamental role in the early diagnosis of oral cancer and the identification of metastatic lesions, awareness of the possibility of rare tumors as in this study can facilitate an accurate preoperative diagnosis and the planning of appropriate treatment.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 4","pages":"Pages 839-848"},"PeriodicalIF":0.4,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated osteochondroma in the temporomandibular joint: A rare case report","authors":"Seung-eun Shin ,&nbsp;Jung-woo Nam","doi":"10.1016/j.ajoms.2025.01.001","DOIUrl":"10.1016/j.ajoms.2025.01.001","url":null,"abstract":"<div><div>Osteochondroma is a common benign tumor typically found at the distal ends of long bones, characterized by a bony outgrowth capped by cartilage. While it is uncommon in the craniomaxillofacial region, it most frequently occurs within the mandibular condyle within this area. This report presents an exceptionally rare case of an intraarticular osteochondroma of the mandibular condyle, exhibiting a unique detachment from the host bone. We review this unusual presentation along with relevant literature and discuss potential etiological factors.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 4","pages":"Pages 835-838"},"PeriodicalIF":0.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}