可切除口腔癌手术等待期术前紫杉醇、卡铂和西妥昔单抗化疗的疗效

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2025-01-22 DOI:10.1016/j.ajoms.2025.01.008

Akinori Takeshita, Kazuhide Matsunaga, Yoshihiro Morita, Yuka Matsumiya, Takafumi Kashiwagi, Kana Kashima, Narikazu Uzawa

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引用次数: 0

摘要

背景：切除是可切除口腔癌的标准治疗方法；但是，如果不能立即进行手术，需要等待一段时间，则可以考虑术前化疗以防止肿瘤进展。尽管如此，口腔癌的术前化疗尚未建立。相比之下，多西紫杉醇/顺铂/5-氟尿嘧啶（TPF）被用作头颈癌的诱导化疗，紫杉醇/卡铂/西妥昔单抗（PCE）治疗被认为是一种替代方案。因此，我们研究了术前PCE治疗对可切除的口腔癌需要等待一段时间才能手术的疗效。材料与方法回顾性评价23例口腔癌患者术前等待手术期间采用PCE治疗的疗效及不良事件。结果总有效率55.6% %，疾病控制率100% %。原发肿瘤的组织学治疗反应，显著有效为13.0 %，中等有效为30.4 %。在主要不良事件方面，4.3 %的患者出现3级白细胞减少，13.0 %的患者出现3级中性粒细胞减少。未观察到4级不良事件。总体而言，在术后手术和术后处理过程中未观察到严重的不良事件和不良影响。在某些情况下，实现了功能保存和生活质量的维持。结论pce治疗可作为可切除口腔癌患者术前等待期化疗。

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Efficacy of preoperative chemotherapy with paclitaxel, carboplatin, and cetuximab during the surgery waiting period for resectable oral cancer

Background

Resection is the standard treatment for resectable oral cancer; however, if surgery cannot be performed immediately and a waiting period is necessary, preoperative chemotherapy may be considered to prevent tumor progression. Despite this, preoperative chemotherapy for oral cancer has not yet been established. In contrast, docetaxel/cisplatin/5-fluorouracil (TPF) is used as induction chemotherapy in head and neck cancer, with paclitaxel/carboplatin/cetuximab (PCE) therapy being considered as an alternative. Therefore, we investigated the efficacy of preoperative PCE therapy for resectable oral cancer requiring a waiting period for surgery.

Materials and methods

We retrospectively evaluated the efficacy and adverse events of PCE therapy in 23 patients with oral cancer treated with PCE therapy as preoperative chemotherapy during the waiting period for surgery.

Results

The overall response and disease control rates were 55.6 % and 100 %, respectively. The histological therapeutic response for the primary tumor was 13.0 % for markedly effective and 30.4 % for moderately effective. Regarding major adverse events, grade 3 leukopenia was observed in 4.3 % of patients, and grade 3 neutropenia was observed in 13.0 %. Grade 4 adverse events were not observed. Overall, no serious adverse events and no disturbing effects were observed during postoperative surgery and postoperative management. In some cases, functional preservation and maintenance of quality of life were achieved.