Taiwan Journal of Ophthalmology最新文献

Optical coherence tomography angiography characteristics of microvascular retinal alterations and the relationship with visual impairment in different patterns of retinitis pigmentosa. 不同类型色素性视网膜炎视网膜微血管病变的光学相干断层血管造影特征及其与视力损害的关系。

IF 1.2

Taiwan Journal of Ophthalmology Pub Date : 2025-09-15 eCollection Date: 2025-07-01 DOI: 10.4103/tjo.TJO-D-25-00088

Hsu-Hang Yeh, Chia-Yi Cheng, Ting-Chieh Ko, Chang-Hao Yang, Chung-May Yang, Pei-Lung Chen, Chao-Wen Lin, Teck Boon Tew, Ta-Ching Chen

{"title":"Optical coherence tomography angiography characteristics of microvascular retinal alterations and the relationship with visual impairment in different patterns of retinitis pigmentosa.","authors":"Hsu-Hang Yeh, Chia-Yi Cheng, Ting-Chieh Ko, Chang-Hao Yang, Chung-May Yang, Pei-Lung Chen, Chao-Wen Lin, Teck Boon Tew, Ta-Ching Chen","doi":"10.4103/tjo.TJO-D-25-00088","DOIUrl":"10.4103/tjo.TJO-D-25-00088","url":null,"abstract":"Purpose: The purpose of the study was to evaluate macular microvascular alterations using optical coherence tomography angiography (OCTA) in typical retinitis pigmentosa (RP) patients with and without isolated macular lesions, and to assess their relationship with best-corrected visual acuity (BCVA).Materials and methods: This retrospective study included 77 patients with typical RP from the Taiwan Inherited Retinal Degeneration Project, categorized into two groups: with isolated macular lesions (T+M, n = 44) and without (T, n = 33). Eighteen age-matched healthy individuals served as controls. All participants underwent comprehensive ophthalmic examinations and OCTA imaging. Quantitative parameters-vessel density in superficial and deep retinal plexuses, foveal avascular zone (FAZ) area, and outer retinal flow-were analyzed and correlated with BCVA.Results: Both RP groups showed compromised macular microcirculation compared to controls. FAZ area was significantly larger in the T+M group than in controls (P = 0.01) and showed a trend toward enlargement compared to the T group (P = 0.06). BCVA was significantly worse in the T+M group than in the T group and controls (P = 0.002). In the T+M group, decreased vessel density in the deep plexus, enlarged FAZ, and reduced outer retinal flow were significantly correlated with poorer vision; these correlations were not observed in the T group.Conclusion: Macular microvascular impairment is a common feature in typical RP, but its association with central visual loss is particularly pronounced in those with isolated macular lesions. OCTA parameters may serve as useful biomarkers for clinical monitoring and prognosis in this subgroup.","PeriodicalId":44978,"journal":{"name":"Taiwan Journal of Ophthalmology","volume":"15 3","pages":"450-456"},"PeriodicalIF":1.2,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in optical coherence tomography: Celebrating its transformative impact on eye care. 光学相干断层扫描的进展：庆祝其对眼科护理的变革性影响。

IF 1.2

Taiwan Journal of Ophthalmology Pub Date : 2025-09-15 eCollection Date: 2025-07-01 DOI: 10.4103/tjo.TJO-D-25-00118

Yali Jia

引用次数: 0

Advancing optical coherence tomography angiography to the clinic. 推进光学相干断层血管造影到临床。

IF 1.2

Taiwan Journal of Ophthalmology Pub Date : 2025-09-05 eCollection Date: 2025-07-01 DOI: 10.4103/tjo.TJO-D-25-00080

Tristan T Hormel, Yali Jia

{"title":"Advancing optical coherence tomography angiography to the clinic.","authors":"Tristan T Hormel, Yali Jia","doi":"10.4103/tjo.TJO-D-25-00080","DOIUrl":"10.4103/tjo.TJO-D-25-00080","url":null,"abstract":"Optical coherence tomography (OCT) angiography (OCTA) is a new clinical technology that advances the capabilities of OCT imaging by adding the ability to readily visualize vascular anatomy down to the capillary scale. With this level of detail, OCTA can be used to identify many important vascular pathologies such as capillary dropout, microaneurysms, or neovascularization. Because it offers high-resolution, high-contrast imaging of these and similar features, OCTA is useful not just for visualization but also for quantification. Quantification is a powerful feature that enables the potential for diagnostics, staging, evaluation of treatment response, and patient monitoring in a more rigorous way than simple observation. In this review, we will examine several OCTA measurements with either demonstrated clinical utility or clinical potential through the lens of three prevalent blinding diseases: diabetic retinopathy, age-related macular degeneration, and glaucoma. We will discuss the merits of these various measurements and care that should be taken in their interpretation and analyze their role in patient management.","PeriodicalId":44978,"journal":{"name":"Taiwan Journal of Ophthalmology","volume":"15 3","pages":"333-343"},"PeriodicalIF":1.2,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative optical coherence tomography in ophthalmology: Technologies and applications. 眼科学术中光学相干断层扫描：技术与应用。

IF 1.2

Taiwan Journal of Ophthalmology Pub Date : 2025-09-05 eCollection Date: 2025-07-01 DOI: 10.4103/tjo.TJO-D-25-00076

Yuankai K Tao

{"title":"Intraoperative optical coherence tomography in ophthalmology: Technologies and applications.","authors":"Yuankai K Tao","doi":"10.4103/tjo.TJO-D-25-00076","DOIUrl":"10.4103/tjo.TJO-D-25-00076","url":null,"abstract":"Intraoperative optical coherence tomography (iOCT) offers valuable real-time, depth-resolved visualization of ocular anatomy and during ophthalmic surgical maneuvers, which can be used to augment clinical decision-making, help verify surgical endpoints, enhance surgical precision, and facilitate the development of novel surgical techniques. Early iOCT demonstrations used perioperative devices, such as handheld and intraocular probes, which required pauses in surgery and disrupted clinical workflow. The advent of microscope-integrated systems addressed these limitations, allowing for iOCT imaging concurrent with surgical microscopy. iOCT image visualization has similarly progressed from external monitors, which require surgeons to divert their gaze, to heads-up displays integrated into microscope oculars, enabling direct overlays and improved ergonomics. Most recent advances have included increasing imaging speed to enable four-dimensional visualization of surgical dynamics and integration of automated surgical instrument tracking technologies. Clinical translation of iOCT has demonstrated utility across a range of procedures, including glaucoma surgery, corneal transplants, cataract extraction, vitrectomy, membrane peel, retinal detachment and macular hole repair, subretinal injection, and retinal prosthesis placement. As more advanced technologies are integrated into the conventional ophthalmic surgical workflow, iOCT has the potential to improve surgical performance and patient outcomes.","PeriodicalId":44978,"journal":{"name":"Taiwan Journal of Ophthalmology","volume":"15 3","pages":"378-388"},"PeriodicalIF":1.2,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations in the foveal avascular zone and surrounding capillary network as important indicators of visual prognosis for hereditary macular dystrophy. 中央凹无血管区及周围毛细血管网的改变是遗传性黄斑营养不良视觉预后的重要指标。

IF 1.2

Taiwan Journal of Ophthalmology Pub Date : 2025-09-05 eCollection Date: 2025-07-01 DOI: 10.4103/tjo.TJO-D-25-00089

Yen-Ching Lin, Ting-Chieh Ko, Chang-Hao Yang, Pei-Hsuan Chen, Chung-May Yang, Pei-Lung Chen, Bo-I Kuo, Ta-Ching Chen

{"title":"Alterations in the foveal avascular zone and surrounding capillary network as important indicators of visual prognosis for hereditary macular dystrophy.","authors":"Yen-Ching Lin, Ting-Chieh Ko, Chang-Hao Yang, Pei-Hsuan Chen, Chung-May Yang, Pei-Lung Chen, Bo-I Kuo, Ta-Ching Chen","doi":"10.4103/tjo.TJO-D-25-00089","DOIUrl":"10.4103/tjo.TJO-D-25-00089","url":null,"abstract":"Purpose: Hereditary macular dystrophy (MD) usually severely affects the central vision. This study aimed to explore macular microcirculation and its relationship with disease progression in different morphological patterns of MD.Materials and methods: Sixty-five patients with MD and 26 healthy participants were included. Panel-based next-generation sequencing (NGS), fundus autofluorescence (FAF), and optical coherence tomography angiography (OCTA) were used for genetic diagnosis, morphological classification, and evaluation of macular microcirculation, respectively. Patients were divided into two groups: the central lesion group (CLG) and the dispersed lesion group (DLG), based on FAF findings. The alterations in microcirculation between the groups and subgroups were analyzed and correlated with visual preservation.Results: A high diagnostic rate of disease-causing genes was achieved with a panel-based NGS test (72.3%). Compromised macular microcirculation was seen in MD of all genotypes. Enlargement of the foveal avascular zone and decreased foveal vessel density was significantly correlated with impaired vision (both P < 0.05). In Stargardt disease, the CLG had an earlier onset than the DLG, with more severely impaired central vision and compromised microcirculation.Conclusion: OCTA is a reliable, noninvasive tool for evaluating the microcirculation of MD. Our results demonstrate that compromised macular microcirculation occurs with MD, and foveal microcirculation is crucial for visual preservation.","PeriodicalId":44978,"journal":{"name":"Taiwan Journal of Ophthalmology","volume":"15 3","pages":"457-465"},"PeriodicalIF":1.2,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical coherence tomography and optical coherence tomography angiography in systemic disease. 光学相干断层扫描和光学相干断层扫描血管造影在全身性疾病中的应用。

IF 1.2

Taiwan Journal of Ophthalmology Pub Date : 2025-08-29 eCollection Date: 2025-07-01 DOI: 10.4103/tjo.TJO-D-25-00053

David J Merriott, Devayu Parikh, Michael J Najac, Luis Muncharaz Duran, Affan Haq, Richard B Rosen, Toco Y P Chui

{"title":"Optical coherence tomography and optical coherence tomography angiography in systemic disease.","authors":"David J Merriott, Devayu Parikh, Michael J Najac, Luis Muncharaz Duran, Affan Haq, Richard B Rosen, Toco Y P Chui","doi":"10.4103/tjo.TJO-D-25-00053","DOIUrl":"10.4103/tjo.TJO-D-25-00053","url":null,"abstract":"Optical coherence tomography (OCT) is an integral component of present-day ophthalmologic practice. As use of OCT has increased in popularity and frequency of use, a growing number of systemic diseases are now known to have associated findings on both OCT and OCT angiography (OCTA). This review was written to discuss how a multitude of cardiovascular, neurodegenerative, neoplastic, infectious, and autoimmune diseases manifest on OCT and OCTA. The findings thus far highlight the potential utility of OCT and OCTA for diagnosing and monitoring progression of these disease processes. Many current studies are limited by small sample sizes, varying image processing algorithms, image artifact, and differing machines used to acquire images, underscoring the need for further research with increased patient numbers and standardized image acquisition and image processing protocols. Despite these current limitations, the steadily increasing volume of data suggests that there will ultimately be a role for both OCT and OCTA to noninvasively monitor the progression of systemic disease over time.","PeriodicalId":44978,"journal":{"name":"Taiwan Journal of Ophthalmology","volume":"15 3","pages":"364-377"},"PeriodicalIF":1.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative optical coherence tomography angiography biomarkers of the choriocapillaris for objective detection of early diabetic retinopathy. 定量光学相干断层扫描血管造影生物标志物的绒毛膜毛细血管客观检测早期糖尿病视网膜病变。

IF 1.2

Taiwan Journal of Ophthalmology Pub Date : 2025-08-29 eCollection Date: 2025-07-01 DOI: 10.4103/tjo.TJO-D-25-00067

Zaara Haque, Albert Kofi Dadzie, Mansour Abtahi, Behrouz Ebrahimi, Tobiloba Adejumo, Taeyoon Son, Jennifer I Lim, Xincheng Yao

{"title":"Quantitative optical coherence tomography angiography biomarkers of the choriocapillaris for objective detection of early diabetic retinopathy.","authors":"Zaara Haque, Albert Kofi Dadzie, Mansour Abtahi, Behrouz Ebrahimi, Tobiloba Adejumo, Taeyoon Son, Jennifer I Lim, Xincheng Yao","doi":"10.4103/tjo.TJO-D-25-00067","DOIUrl":"10.4103/tjo.TJO-D-25-00067","url":null,"abstract":"Purpose: To evaluate quantitative optical coherence tomography (OCT) angiography (OCTA) biomarkers from the choriocapillaris (CC) for detecting early microvascular changes associated with diabetic retinopathy (DR).Materials and methods: In this retrospective study, 191 macular OCTA images were analyzed from 78 healthy eyes, 64 eyes from diabetic individuals without clinical signs of DR (NoDR), and 49 eyes with mild nonproliferative DR (NPDR). Five CC biomarkers were extracted from 6 mm × 6 mm enface OCTA images: flow deficit density (FDD), FD number (FDN), mean FD size (MFDS), perfusion intensity density (PID), and normalized blood flow index (NBFI). Flow maps were binarized using Phansalkar local thresholding, and statistical comparisons were performed using one-way analysis of variance and two-sample t-tests.Results: All five biomarkers demonstrated significant differences across study groups (P < 0.001). FDD and MFDS were significantly elevated in both NoDR and mild NPDR eyes compared to controls, indicating increased nonperfusion and enlargement of flow voids. FDN decreased with disease severity, indicating spatial consolidation of capillary loss. PID and NBFI, which reflect flow signal intensity, also declined in diabetic eyes, suggesting a reduction in overall CC perfusion consistent with early vascular compromise.Conclusion: Quantitative OCTA biomarkers of the CC reveal early microvascular changes in diabetic eyes. Among them, FDN and MFDS demonstrated the highest sensitivity to early disease progression. These findings support the use of CC-derived OCTA features as potential imaging biomarkers for detecting and monitoring early diabetic microvascular dysfunction.","PeriodicalId":44978,"journal":{"name":"Taiwan Journal of Ophthalmology","volume":"15 3","pages":"428-434"},"PeriodicalIF":1.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The path to clinical translation for visible light optical coherence tomography in retinal imaging. 视网膜成像中可见光光学相干断层扫描的临床翻译路径。

IF 1.2

Taiwan Journal of Ophthalmology Pub Date : 2025-08-29 eCollection Date: 2025-07-01 DOI: 10.4103/tjo.TJO-D-25-00078

Qingyu Chen, Stephanie Lauren Nolen, Sydni Adriana Spencer, Ji Yi

{"title":"The path to clinical translation for visible light optical coherence tomography in retinal imaging.","authors":"Qingyu Chen, Stephanie Lauren Nolen, Sydni Adriana Spencer, Ji Yi","doi":"10.4103/tjo.TJO-D-25-00078","DOIUrl":"10.4103/tjo.TJO-D-25-00078","url":null,"abstract":"Visible light optical coherence tomography (VIS-OCT) has made significant progress in the past decade from in vivo proof-of-concept retinal imaging in preclinical models to human clinical translation. The technical advances of VIS-OCT imaging devices include new light sources, optical fiber components, balanced detection methods, and an array of data processing methods. We summarize the unique features of using VIS-OCT in comparison with near-infrared OCT (NIR-OCT), including ultra-high resolution, retinal microvascular oximetry, and reflectance spectroscopy. The ultra-high resolution is granted by the shorter wavelengths in the visible light range ~500-650 nm, as compared with the conventional OCT wavelengths >800 nm. Detailed sub-bandings in the inner plexiform layer and outer segment of photoreceptors, as well as in the retinal pigment epithelium and Bruch's membrane, are consistently resolved in VIS-OCT. The three-dimensional resolving capacity of VIS-OCT allows better isolation of hemoglobin absorption features, allowing blood oxygen saturation (SO2) calculation in retinal microvasculature. Oximetry calculations were performed down to the capillary level in humans, albeit through massive averaging, which was unattainable by previous methods. Advancing VIS-OCT technology has a high potential to produce significant clinical impact in ophthalmology in the near future.","PeriodicalId":44978,"journal":{"name":"Taiwan Journal of Ophthalmology","volume":"15 3","pages":"389-398"},"PeriodicalIF":1.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shining light on photoreceptors: A minireview on the development and clinical applications of optoretinography. 光感受器上的照射：光视网膜造影术的发展和临床应用综述。

IF 1.2

Taiwan Journal of Ophthalmology Pub Date : 2025-08-29 eCollection Date: 2025-07-01 DOI: 10.4103/tjo.TJO-D-25-00066

Alexander Matteson, Anna Andrews, David Huang, Siyu Chen

{"title":"Shining light on photoreceptors: A minireview on the development and clinical applications of optoretinography.","authors":"Alexander Matteson, Anna Andrews, David Huang, Siyu Chen","doi":"10.4103/tjo.TJO-D-25-00066","DOIUrl":"10.4103/tjo.TJO-D-25-00066","url":null,"abstract":"Retinal diseases often result in photoreceptor dysfunction and cell death, leading to progressive vision impairment and eventual blindness. Clinical management can benefit from assessing photoreceptor mediated visual function, such as for progression monitoring. Meanwhile, therapeutic development requires accurate and reliable vision end points. The emerging optoretinography (ORG) technologies promise noninvasive, objective, and highly sensitive markers of photoreceptor function. ORG is an umbrella term that covers several imaging modalities that use intrinsic optical signal, i.e., without dyes or labeling agents, to quantify photoreceptor responses to light. Early studies showed stimulus-evoked light scattering and morphological changes in isolated photoreceptor and retina, which provided the experimental foundation for subsequent inquires in vivo. Technology advancements allowed for optically quantifying photoreceptor light responses in live human subjects using two-dimensional (2D) fundus photography and 3D optical coherence tomography (OCT). The integration of adaptive optics (AO) with OCT enabled direct measurements of outer segment length changes of individual human photoreceptors, revealing essential steps of the phototransduction cascades. In an effort to enlarge measurement field of view, ease imaging workflow, and improve accessibility, more recent studies investigated ORG techniques without the need to resolve or track individual cells. Clinical ORG imaging culminated in demonstrating highly sensitive and reliable detection of photoreceptor dysfunction in patients with degenerative retinal diseases. Ongoing development of both AO and non-AO ORG approaches promises to advance our understanding of phototransduction and the visual processing pathway, while establishing a powerful clinical tool for assessing vision.","PeriodicalId":44978,"journal":{"name":"Taiwan Journal of Ophthalmology","volume":"15 3","pages":"399-410"},"PeriodicalIF":1.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proton beam radiotherapy as an alternative to enucleation in adult intraocular medulloepithelioma. 质子束放疗作为成人眼内髓样上皮瘤去核治疗的替代方法。

IF 1.2

Taiwan Journal of Ophthalmology Pub Date : 2025-08-19 eCollection Date: 2025-07-01 DOI: 10.4103/tjo.TJO-D-25-00013

Wei-Hsiang Lin, Yueh-Ju Tsai, Shih-Ming Jung, An-Ning Chao

引用次数: 0