Taiwan Journal of Ophthalmology最新文献_第2页

Innovations in brachytherapy. 近距离治疗的创新。

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Taiwan Journal of Ophthalmology Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.4103/tjo.TJO-D-24-00108

Joshua Lim, Alvin Wei Jun Teo, Tian Rui Siow, Kwang Ping Chan, Gavin Siew Wei Tan

引用次数: 0

Growing choroidal osteoma: Treated by proton beam radiation. 生长中的脉络膜骨瘤：质子束放射治疗。

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Taiwan Journal of Ophthalmology Pub Date : 2025-02-17 eCollection Date: 2025-01-01 DOI: 10.4103/tjo.TJO-D-24-00124

Ahad Sedaghat, Mary E Aronow, Arun D Singh

引用次数: 0

Surgical treatment of uveal melanoma: Exoresection versus endoresection. 葡萄膜黑色素瘤的手术治疗：外切与内切。

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Taiwan Journal of Ophthalmology Pub Date : 2025-02-06 eCollection Date: 2025-01-01 DOI: 10.4103/tjo.TJO-D-24-00131

Seung Min Lee, Min Kim

{"title":"Surgical treatment of uveal melanoma: Exoresection versus endoresection.","authors":"Seung Min Lee, Min Kim","doi":"10.4103/tjo.TJO-D-24-00131","DOIUrl":"https://doi.org/10.4103/tjo.TJO-D-24-00131","url":null,"abstract":"Uveal melanoma, the most common primary intraocular malignancy in adults, presents significant therapeutic challenges. With the advancement of surgical instruments and techniques, exoresection (ab-externo) and endoresection (ab-interno) have emerged as viable treatment methods. These surgical interventions can be implemented particularly for tumors exceeding traditional size criteria for plaque brachytherapy and for tumors that are too large, which pose an elevated risk of radiation-related complications. Moreover, surgical interventions not only enhance the potential for functional vision preservation and globe retention but also provide effective control of intraocular tumors and metastatic disease when combined with adjunctive radiation therapy. Exoresection, an external approach, involves dissection and removal of the tumor through a scleral flap, while endoresection utilizes vitreoretinal surgical techniques for internal tumor excision. Both surgical techniques for uveal melanoma removal are highly challenging, carry significant risks of complications, and should be performed by experienced vitreoretinal surgeons specializing in ocular oncology at specialized centers. They aim to preserve the eye and potentially maintain useful vision while saving patients' lives, a crucial consideration in ocular oncology. These surgical modalities have become increasingly relevant as the field progresses towards more conservative, function-preserving approaches in cancer treatment. The aim of this article is to conduct a comparative analysis of exoresection and endoresection in the context of uveal melanoma management. By critically evaluating these surgical modalities, this review seeks to provide clinicians with valuable insights to guide treatment decisions for patients with large uveal melanomas.","PeriodicalId":44978,"journal":{"name":"Taiwan Journal of Ophthalmology","volume":"15 1","pages":"34-44"},"PeriodicalIF":1.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Growth of indeterminate choroidal melanocytic tumors: Time to malignant transformation. 不确定脉络膜黑色素细胞肿瘤的生长：到恶性转化的时间。

IF 1

Taiwan Journal of Ophthalmology Pub Date : 2025-02-06 eCollection Date: 2025-01-01 DOI: 10.4103/tjo.TJO-D-24-00138

Zackery Oakey, Yağmur Seda Yeşiltaş, Emily C Zabor, Arun D Singh

{"title":"Growth of indeterminate choroidal melanocytic tumors: Time to malignant transformation.","authors":"Zackery Oakey, Yağmur Seda Yeşiltaş, Emily C Zabor, Arun D Singh","doi":"10.4103/tjo.TJO-D-24-00138","DOIUrl":"https://doi.org/10.4103/tjo.TJO-D-24-00138","url":null,"abstract":"Indeterminate choroidal melanocytic tumors may exhibit growth under observation, but the clinical significance of early versus late growth remains unclear. In this review we aim to explore the temporal profile of growth to detect benign and malignant subsets. There was no specific set of tumor dimensions or characteristics applied for exclusion or inclusion except that all included tumors had to be described as indeterminate or suspicious nevus and observed for growth by the authors. Nine published studies (1977-2021) that included 8766 patients were reviewed. The primary outcomes were time to event (growth) and its correlation with the growth rate of small choroidal melanoma. The studies were largely retrospective and had differing inclusion criteria: largest basal diameter of 7.5-24 mm (mean, 14.83 mm) and maximum height of 2-6.7 mm (mean, 4.19 mm). Most defined growth by a change in height of >0.3 mm or base of >0.5. Among 8606 tumors followed, 478 (5.6%) showed growth over 5 years, with growth rates in individual studies ranging from 2% to 55% (mean: 19.0%). The highest event rate occurred in the 1st year (range: 0.7%-15%; mean: 6.5%), stabilizing to 0%-5% (mean: 1.5%) by year 5. The majority (range: 52%-83%; mean: 67%) were observed to grow in the initial 2 years (early growth). Over subsequent years (late growth), the proportion of growing tumors reduced and stabilized by years 4 and 5 to a mean of 6.1% and 8.3%, respectively. Time-to-event analysis indicates the heterogeneity of IMTs. Tumors growing in the first 2 years (early growth) may be melanoma in the evolution and their characteristics previously identified as the risk factors for growth may be interpreted as the factors predictive or diagnostic of small choroidal melanoma. In contrast, tumors demonstrating growth in subsequent years (late growth), after documented stability, may represent malignant transformation of a choroidal nevus.","PeriodicalId":44978,"journal":{"name":"Taiwan Journal of Ophthalmology","volume":"15 1","pages":"73-78"},"PeriodicalIF":1.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Necrotic iris melanocytoma with secondary glaucoma. 坏死性虹膜黑色素细胞瘤伴继发性青光眼。

IF 1

Taiwan Journal of Ophthalmology Pub Date : 2025-01-17 eCollection Date: 2025-01-01 DOI: 10.4103/tjo.TJO-D-24-00126

Yağmur Seda Yeşiltaş, Zackery Oakey, Jennifer Brainard, Gabrielle Yeaney, Arun D Singh

{"title":"Necrotic iris melanocytoma with secondary glaucoma.","authors":"Yağmur Seda Yeşiltaş, Zackery Oakey, Jennifer Brainard, Gabrielle Yeaney, Arun D Singh","doi":"10.4103/tjo.TJO-D-24-00126","DOIUrl":"https://doi.org/10.4103/tjo.TJO-D-24-00126","url":null,"abstract":"A 54-year-old female was referred because of a pigmented iris lesion with uncontrolled glaucoma in the left eye. The intraocular pressure (IOP) was 54 mm Hg despite anti-glaucoma medications. Her visual acuity (VA) was 20/100. A slit-lamp examination showed corneal edema and a darkly pigmented small iridociliary lesion (Ultrasound biomicroscopy: 5 mm × 3 mm × 2 mm) with diffuse pigment shedding onto the anterior iris surface and diffuse circumferential pigmentation of the trabecular meshwork with wide-open angle (gonioscopy). Diagnostic fine needle aspiration biopsy of the main tumor and anterior chamber lavage were performed. Cytology revealed polygonal cells with dense intracytoplasmic pigment obscuring nuclear details diagnostic of a melanocytoma. During follow-up, as the tumor continued to cause new pigment shedding with high IOP, therefore, excision of the primary tumor via iridocyclectomy was performed. At postoperative 1 month, the IOP was 13 mm Hg with maximal medical therapy for glaucoma requiring glaucoma shunt surgery. At 6 months, the IOP remained below 13 mm Hg and the VA was 20/50 without recurrence of pigment shedding. Necrotic iris melanocytoma, though rare, can lead to pigment dispersion glaucoma. Surgical excision of the primary tumor, coupled with glaucoma surgery, proved effective in controlling intraocular pressure and preserving vision in this case.","PeriodicalId":44978,"journal":{"name":"Taiwan Journal of Ophthalmology","volume":"15 1","pages":"135-137"},"PeriodicalIF":1.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wide field imaging biomarkers: A different perspective. 宽视场成像生物标志物：不同的视角。

IF 1

Taiwan Journal of Ophthalmology Pub Date : 2024-12-20 eCollection Date: 2024-10-01 DOI: 10.4103/tjo.TJO-D-24-00125

Sakshi Shiromani, Niveditha Pattathil, Elham Sadeghi, Netan Choudhry, Jay Chhablani

{"title":"Wide field imaging biomarkers: A different perspective.","authors":"Sakshi Shiromani, Niveditha Pattathil, Elham Sadeghi, Netan Choudhry, Jay Chhablani","doi":"10.4103/tjo.TJO-D-24-00125","DOIUrl":"10.4103/tjo.TJO-D-24-00125","url":null,"abstract":"Wide field retinal imaging has emerged as a transformative technology over the last few decades, revolutionizing our ability to visualize the intricate landscape of the retina. By capturing expansive retinal areas, these techniques offer a panoramic view going beyond traditional imaging methods. In this review, we explore the significance of retinal imaging-based biomarkers to help diagnose ocular and systemic conditions. We discuss quantitative biomarkers, including ischemic index, nonperfusion area and more, and their application in diabetic retinopathy, central retinal vein occlusion, neurodegenerative diseases, and more. In addition, we outline qualitative biomarkers such as choroidal venous hyperpermeability and intervortex anastomoses. The role of wide field fundus autofluorescence in assessing hereditary retinal diseases is also emphasized. Standardized imaging procedures, professional collaboration, and validation across a range of clinical circumstances are necessary for the effective use of these biomarkers. They have the potential to transform disease identification, risk assessment, and customize therapy.","PeriodicalId":44978,"journal":{"name":"Taiwan Journal of Ophthalmology","volume":"14 4","pages":"510-518"},"PeriodicalIF":1.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To see with new eyes. 用新的眼光看世界。

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Taiwan Journal of Ophthalmology Pub Date : 2024-12-20 eCollection Date: 2024-10-01 DOI: 10.4103/tjo.TJO-D-24-00123

Chui Ming Gemmy Cheung

引用次数: 0

Advances in intraoperative imaging in retinal diseases: A narrative review. 视网膜疾病术中影像学研究进展综述。

IF 1

Taiwan Journal of Ophthalmology Pub Date : 2024-12-20 eCollection Date: 2024-10-01 DOI: 10.4103/tjo.TJO-D-24-00078

Jorge Rocha, Raphaela M Fuganti, Antonio M Casella

引用次数: 0

Reshaping vitreoretinal surgery: Intraoperative optical coherence tomography as a tool for enhancing surgical decision-making in complex cases. 玻璃体视网膜整形手术：术中光学相干断层扫描作为复杂病例中提高手术决策的工具。

IF 1

Taiwan Journal of Ophthalmology Pub Date : 2024-12-05 eCollection Date: 2024-10-01 DOI: 10.4103/tjo.TJO-D-24-00060

Yin-Hsi Chang, Gavin S W Tan, Hung-Da Chou, Andrew S H Tsai

引用次数: 0

Utility of multimodal imaging in the clinical diagnosis of inherited retinal degenerations. 多模态成像在遗传性视网膜变性临床诊断中的应用。

IF 1

Taiwan Journal of Ophthalmology Pub Date : 2024-12-03 eCollection Date: 2024-10-01 DOI: 10.4103/tjo.TJO-D-24-00066

Brian J H Lee, Christopher Z Y Sun, Charles J T Ong, Kanika Jain, Tien-En Tan, Choi Mun Chan, Ranjana S Mathur, Rachael W C Tang, Yasmin Bylstra, Sylvia P R Kam, Weng Khong Lim, Beau J Fenner

{"title":"Utility of multimodal imaging in the clinical diagnosis of inherited retinal degenerations.","authors":"Brian J H Lee, Christopher Z Y Sun, Charles J T Ong, Kanika Jain, Tien-En Tan, Choi Mun Chan, Ranjana S Mathur, Rachael W C Tang, Yasmin Bylstra, Sylvia P R Kam, Weng Khong Lim, Beau J Fenner","doi":"10.4103/tjo.TJO-D-24-00066","DOIUrl":"10.4103/tjo.TJO-D-24-00066","url":null,"abstract":"Inherited retinal degeneration (IRD) is a heterogeneous group of genetic disorders of variable onset and severity, with vision loss being a common endpoint in most cases. More than 50 distinct IRD phenotypes and over 280 causative genes have been described. Establishing a clinical phenotype for patients with IRD is particularly challenging due to clinical variability even among patients with similar genotypes. Clinical phenotyping provides a foundation for understanding disease progression and informing subsequent genetic investigations. Establishing a clear clinical phenotype for IRD cases is required to corroborate the data obtained from exome and genome sequencing, which often yields numerous variants in genes associated with IRD. In the current work, we review the use of contemporary retinal imaging modalities, including ultra-widefield and autofluorescence imaging, optical coherence tomography, and multispectral imaging, in the diagnosis of IRD.","PeriodicalId":44978,"journal":{"name":"Taiwan Journal of Ophthalmology","volume":"14 4","pages":"486-496"},"PeriodicalIF":1.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0