Fukushima Journal of Medical Science最新文献_第6页

Cellular carcinogenesis in preleukemic conditions:drivers and defenses. 白血病前期的细胞癌变:驱动因素和防御因素。

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Fukushima Journal of Medical Science Pub Date : 2024-01-27 Epub Date: 2023-11-11 DOI: 10.5387/fms.2023-17

Koki Ueda, Kazuhiko Ikeda

{"title":"Cellular carcinogenesis in preleukemic conditions:drivers and defenses.","authors":"Koki Ueda, Kazuhiko Ikeda","doi":"10.5387/fms.2023-17","DOIUrl":"10.5387/fms.2023-17","url":null,"abstract":"Acute myeloid leukemia (AML) arises from preleukemic conditions. We have investigated the pathogenesis of typical preleukemia, myeloproliferative neoplasms, and clonal hematopoiesis. Hematopoietic stem cells in both preleukemic conditions harbor recurrent driver mutations; additional mutation provokes further malignant transformation, leading to AML onset. Although genetic alterations are defined as the main cause of malignant transformation, non-genetic factors are also involved in disease progression. In this review, we focus on a non-histone chromatin protein, high mobility group AT-hook2 (HMGA2), and a physiological p53 inhibitor, murine double minute X (MDMX). HMGA2 is mainly overexpressed by dysregulation of microRNAs or mutations in polycomb components, and provokes expansion of preleukemic clones through stem cell signature disruption. MDMX is overexpressed by altered splicing balance in myeloid malignancies. MDMX induces leukemic transformation from preleukemia via suppression of p53 and p53-independent activation of WNT/β-catenin signaling. We also discuss how these non-genetic factors can be targeted for leukemia prevention therapy.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"11-24"},"PeriodicalIF":0.8,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10867434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89719926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation and treatment of constipation in pregnancy:Examination using the Japanese version of the constipation evaluation scale. 孕期便秘的评估和治疗：使用日文版便秘评估量表进行检查。

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Fukushima Journal of Medical Science Pub Date : 2024-01-27 Epub Date: 2024-01-25 DOI: 10.5387/fms.2023-25

Makiho Ishibashi, Fumie Hashimoto, Yoshihiro Kouchi, Karin Imaizumi, Fumihiro Ito, Shun Yasuda

{"title":"Evaluation and treatment of constipation in pregnancy:Examination using the Japanese version of the constipation evaluation scale.","authors":"Makiho Ishibashi, Fumie Hashimoto, Yoshihiro Kouchi, Karin Imaizumi, Fumihiro Ito, Shun Yasuda","doi":"10.5387/fms.2023-25","DOIUrl":"10.5387/fms.2023-25","url":null,"abstract":"Objectives: No study has examined the effects of new constipation treatment drugs released in recent years in pregnant women. This prospective cohort study aimed to examine and compare the perinatal prognosis, efficacy rate, and safety of drugs frequently used to treat constipation.Methods: The study included 211 perinatally managed individuals who answered a self-administered questionnaire during the second trimester and after delivery. The Japanese version of the constipation evaluation scale (Constipation Assessment Scale [CAS] long-term [LT] version) was used for the subjective evaluation of defecation status.Results: Participants aware of constipation had significantly higher CAS scores than those who were unaware. Some participants with a CAS score of 5 points (treatment range) had no subjective symptoms of constipation, whereas some participants with a CAS score of ≤ 5 points were aware of constipation. Regarding the time of onset, 60% of those who had constipation before pregnancy had a high rate of constipation during pregnancy and after delivery. No significant difference was noted in conventional magnesium oxide and polyethylene glycol, a relatively new daily treatment drug, in perinatal prognosis or side effects.Conclusions: Polyethylene glycol preparations alleviate constipation without inducing diarrhea, making them an appropriate therapeutic option for pregnant women.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"35-47"},"PeriodicalIF":0.8,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10867430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139547467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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RETRACTED ARTICLE. 被撤回的文章。

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Fukushima Journal of Medical Science Pub Date : 2024-01-27 Epub Date: 2024-01-25 DOI: 10.5387/fms.retraction

引用次数: 0

2023 Fukushima Medical University International Symposium on the Fukushima Health Management Survey, "Thinking Together about Health, Life, and our Future in Fukushima". 2023 年福岛医科大学福岛健康管理调查国际研讨会，"共同思考福岛的健康、生活和我们的未来"。

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Fukushima Journal of Medical Science Pub Date : 2024-01-01 DOI: 10.5387/fms.24-00007

Michio Shimabukuro, Kenji Kamiya

引用次数: 0

Cytokine profiles in an extremely preterm infant with congenital syphilis. 患有先天性梅毒的极早产儿的细胞因子谱。

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Fukushima Journal of Medical Science Pub Date : 2023-11-15 Epub Date: 2023-09-28 DOI: 10.5387/fms.2023-06

Eisuke Fukama, Tomoaki Nomura, Daisuke Hatanaka, Michiko Kusakari, Hidehiro Takahashi, Toshihiko Nakamura, Naoto Takahashi

引用次数: 0

A case of delayed postoperative bleeding after excision of endometrial polyp using resectoscope in an infertile woman with von Willebrand disease:a case report and literature review. 一例患有von Willebrand病的不孕妇女在子宫内膜息肉切除术后延迟出血的病例报告和文献复习。

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Fukushima Journal of Medical Science Pub Date : 2023-11-15 Epub Date: 2023-10-17 DOI: 10.5387/fms.2023-04

Chihiro Okoshi, Toshifumi Takahashi, Masahiko Fukatsu, Ryota Suganuma, Takayuki Ikezoe, Keiya Fujimori

{"title":"A case of delayed postoperative bleeding after excision of endometrial polyp using resectoscope in an infertile woman with von Willebrand disease:a case report and literature review.","authors":"Chihiro Okoshi, Toshifumi Takahashi, Masahiko Fukatsu, Ryota Suganuma, Takayuki Ikezoe, Keiya Fujimori","doi":"10.5387/fms.2023-04","DOIUrl":"10.5387/fms.2023-04","url":null,"abstract":"Von Willebrand disease (VWD) is a bleeding disorder caused by a congenital quantitative reduction, deficiency, or qualitative abnormality of the von Willebrand factor (VWF). Here, we report a case of delayed postoperative bleeding in an infertile woman with endometrial polyps complicated by VWD. The patient was a 39-year-old infertile woman with type 2A VWD. At 38 years of age, she was referred to our hospital for infertility and heavy menstrual bleeding. Hysteroscopy revealed a 15-mm polyp lesion in the uterus. The patient was scheduled for transcervical resection (TCR) of the endometrial polyp. Gonadotropin-releasing hormone agonists were preoperatively administered to prevent menstruation. The VWF-containing concentrate was administered for 3 days according to guidelines. The patient was discharged on postoperative day 3 after confirming the absence of uterine bleeding. Uterine bleeding began on postoperative day 6. The patient was readmitted on postoperative day 7 and treated with VWF-containing concentrate for 5 days, after which hemostasis was confirmed. TCR surgery for endometrial lesions is classified as a minor surgery, and guidelines recommend short-term VWF-containing concentrate replacement. However, it should be kept in mind that only short-term VWF-containing concentrate replacement may cause rebleeding postoperatively.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"197-204"},"PeriodicalIF":0.8,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension:its history and development, and regional medical cooperation in Fukushima. 球囊肺血管成形术治疗慢性血栓栓塞性肺动脉高压：其历史和发展，以及福岛地区的医疗合作。

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Fukushima Journal of Medical Science Pub Date : 2023-11-15 Epub Date: 2023-09-28 DOI: 10.5387/fms.2023-09

Kazuhiko Nakazato, Koichi Sugimoto, Masayoshi Oikawa, Yasuchika Takeishi

{"title":"Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension:its history and development, and regional medical cooperation in Fukushima.","authors":"Kazuhiko Nakazato, Koichi Sugimoto, Masayoshi Oikawa, Yasuchika Takeishi","doi":"10.5387/fms.2023-09","DOIUrl":"10.5387/fms.2023-09","url":null,"abstract":"Chronic thromboembolic pulmonary hypertension (CTEPH) is designated as an intractable disease by the Ministry of Health, Labour and Welfare of Japan, and has an extremely poor prognosis if untreated. Surgical pulmonary endarterectomy is the curative treatment for cases in which the organized thrombi are located in the central part of the pulmonary artery, but there had been no effective treatment for cases in which the thrombi are located in the peripheral part of the pulmonary artery. Recently, balloon pulmonary angioplasty (BPA), a transcatheter procedure to dilate stenotic or occluded lesions in the peripheral pulmonary artery, has been rapidly developed. Although BPA was once a globally abandoned procedure due to hemorrhagic complications, Japanese experts have improved the technique, and its safety and efficacy have been enhanced. As a result, BPA is now being reevaluated worldwide. This review describes the history and development of BPA in the treatment of CTEPH, as well as the status of this treatment in Fukushima Prefecture.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"167-176"},"PeriodicalIF":0.8,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41137171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of the prognosis of somatoform disorders using the Minnesota Multiphasic Personality Inventory. 使用明尼苏达多相人格量表预测躯体形式障碍的预后。

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Fukushima Journal of Medical Science Pub Date : 2023-08-10 DOI: 10.5387/fms.2022-04

Akiko Sato, Shuntaro Itagaki, Takatomo Matsumto, Yoko Ise, Shunya Yokokura, Tomohiro Wada, Kaoru Hayashi, Takeyasu Kakamu, Tetsuhito Fukushima, Takuya Nikaido, Shinichi Konno, Hirooki Yabe

{"title":"Prediction of the prognosis of somatoform disorders using the Minnesota Multiphasic Personality Inventory.","authors":"Akiko Sato, Shuntaro Itagaki, Takatomo Matsumto, Yoko Ise, Shunya Yokokura, Tomohiro Wada, Kaoru Hayashi, Takeyasu Kakamu, Tetsuhito Fukushima, Takuya Nikaido, Shinichi Konno, Hirooki Yabe","doi":"10.5387/fms.2022-04","DOIUrl":"https://doi.org/10.5387/fms.2022-04","url":null,"abstract":"Background: Somatoform disorders are frequently resistant to treatment. This study aimed to determine the utility of the Minnesota Multifaceted Personality Inventory (MMPI) in predicting the prognosis of somatoform disorders.Methods: Overall, 125 patients diagnosed with somatoform disorders between January 1, 2013 and December 31, 2017 in the psychiatric department of Fukushima Medical University Hospital were included. Patients with positive outcomes were identified based on a subjective estimation regarding (1) pain and (2) social functions, including activities of daily living. They were divided into the improved group (IG) and the non-improved group (NIG). Each factor was then descriptively compared between the two groups, and the sensitivity and specificity were determined.Results: The NIG had significantly higher scores but only on the Hy scale. Thus, the optimal Hy scale cutoff score was calculated. The cutoff point was 73.5, with a sensitivity of 55.7% and a specificity of 71.7%.Conclusion: An MMPI Hy scale score higher than a cutoff value of 73.5 predicts a poor response to conventional supportive psychotherapy or drug therapy in patients with somatoform disorders. This cutoff point may be used as an important index for selecting treatment for somatoform disorders.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"69 2","pages":"105-113"},"PeriodicalIF":0.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a4/8c/2185-4610-69-105.PMC10480515.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10175576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A muscle-preserving, spinous process-splitting approach for ossification of the ligamentum flavum in the thoracic spine in professional athletes: a report of three cases. 保留肌肉，棘突分离入路治疗专业运动员胸椎黄韧带骨化:三例报告。

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Fukushima Journal of Medical Science Pub Date : 2023-08-10 DOI: 10.5387/fms.2022-32

Kinshi Kato, Shoji Yabuki, Koji Otani, Takuya Nikaido, Kenichi Otoshi, Kazuyuki Watanabe, Hiroshi Kobayashi, Shin-Ichi Konno

{"title":"A muscle-preserving, spinous process-splitting approach for ossification of the ligamentum flavum in the thoracic spine in professional athletes: a report of three cases.","authors":"Kinshi Kato, Shoji Yabuki, Koji Otani, Takuya Nikaido, Kenichi Otoshi, Kazuyuki Watanabe, Hiroshi Kobayashi, Shin-Ichi Konno","doi":"10.5387/fms.2022-32","DOIUrl":"https://doi.org/10.5387/fms.2022-32","url":null,"abstract":"A muscle-preserving, spinous process-splitting approach may be a less invasive approach to conventional laminectomy in patients with thoracic ossification of the ligamentum flavum. Few reports have discussed the usefulness of this procedure for thoracic lesions in professional athletes who need highly active thoracic spinal function after surgery. The treatment of thoracic ossification of the ligamentum flavum using a spinous process-splitting approach in 3 professional athletes is presented. In all three cases the patients could return to play within 3 months after surgery without complications, and in two of the cases, there was no spinal deformity or local recurrence of ossification of the ligamentum flavum at the final follow-up at least 8 years after surgery. The spinous process-splitting approach could be a safe procedure for multi-level and all other forms of ossification of the ligamentum flavum and is less invasive to the paraspinal muscles, relieves back symptoms, and restores function for athletes.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"69 2","pages":"143-150"},"PeriodicalIF":0.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/05/56/2185-4610-69-143.PMC10480514.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10232372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of rehabilitation in patients undergoing hematopoietic stem cell transplantation. 康复对造血干细胞移植患者的影响。

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Fukushima Journal of Medical Science Pub Date : 2023-08-10 DOI: 10.5387/fms.2022-33

Takahiro Takekiyo, Shinichiro Morishita

引用次数: 0