Fukushima Journal of Medical Science最新文献

Drug resistance of Pseudomonas aeruginosa based on the isolation sites and types of gastrointestinal diseases: An observational study.

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Fukushima Journal of Medical Science Pub Date : 2024-12-18 DOI: 10.5387/fms.24-00019

Hironori Tsujimoto, Yuji Fujikura, Taka-Aki Hamamoto, Hiroyuki Horiguchi, Risa Takahata, Yusuke Ishibashi, Takao Sugihara, Keita Kouzu, Yujiro Itazaki, Sei-Ichiro Fujishima, Koichi Okamoto, Yoshiki Kajiwara, Susumu Matsukuma, Hideki Ueno

{"title":"Drug resistance of Pseudomonas aeruginosa based on the isolation sites and types of gastrointestinal diseases: An observational study.","authors":"Hironori Tsujimoto, Yuji Fujikura, Taka-Aki Hamamoto, Hiroyuki Horiguchi, Risa Takahata, Yusuke Ishibashi, Takao Sugihara, Keita Kouzu, Yujiro Itazaki, Sei-Ichiro Fujishima, Koichi Okamoto, Yoshiki Kajiwara, Susumu Matsukuma, Hideki Ueno","doi":"10.5387/fms.24-00019","DOIUrl":"https://doi.org/10.5387/fms.24-00019","url":null,"abstract":"Introduction: We investigated the drug resistance status of Pseudomonas aeruginosa (P. aeruginosa) focusing on its isolation sites and types of diseases.　Materials and methods: A microbiological laboratory database was searched to identify all clinical cultures positive for P. aeruginosa.　Clinicopathologic features and susceptibility of P. aeruginosa to any antibiotics were evaluated in patients admitted to the division of upper (Upper-GI group) or lower gastrointestinal surgery (Lower-GI group).　In addition, we investigated the susceptibility of P. aeruginosa to any antibiotics based on the isolation site.　Results:P. aeruginosa was frequently detected in the sputum and urine of the Upper-GI and Lower-GI groups, respectively.　Among P. aeruginosa isolates from drain discharge, a significantly higher rate of resistance to imipenem, amikacin, and ciprofloxacin was observed; among P. aeruginosa isolates from wounds, a substantially higher proportion had resistance to imipenem and cefozopran in the Upper-GI group.　However, there was no difference between the two groups in the drug resistance of P. aeruginosa isolated from urine, sputum, blood, and ascites.　P. aeruginosa isolated from sputum showed more resistance to imipenem and ciprofloxacin than those isolated from other sites.　Conclusion: There were significant differences in the drug resistance of P. aeruginosa based on the isolation sites and types of diseases.　.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacologic background and clinical issue of anti-influenza drugs.

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Fukushima Journal of Medical Science Pub Date : 2024-12-18 DOI: 10.5387/fms.24-00029

Masatoki Sato

{"title":"Pharmacologic background and clinical issue of anti-influenza drugs.","authors":"Masatoki Sato","doi":"10.5387/fms.24-00029","DOIUrl":"https://doi.org/10.5387/fms.24-00029","url":null,"abstract":"Since 2000, rapid antigen detection kits and anti-influenza drugs have been used for the early diagnosis and treatment of influenza in Japan, respectively.　The main drugs available in clinical practice are the neuraminidase inhibitors oseltamivir, zanamivir, laninamivir, and peramivir, as well as the cap-dependent endonuclease inhibitor baloxavir marboxil.　Antiviral therapy with neuraminidase inhibitors has been practiced for many years, especially in Japan; it can shorten the febrile period and reduce complications.　Despite having similar structures, the pharmacologic background of neuraminidase inhibitors differs significantly, as reflected in their varying clinical efficacy.　Due to its inhibitory mechanism, baloxavir marboxil can rapidly reduce the viral load than neuraminidase inhibitors.　However, the duration of symptoms was similar after the administration of baloxavir marboxil and oseltamivir, and variants with reduced drug susceptibility have been detected in 20%-30% of pediatric patients treated with baloxavir marboxil.　Clinical trials of several novel anti-influenza drugs are currently underway.　When these drugs are first marketed, the characteristics of the influenza virus and the pharmacologic background of the drugs must be clarified before their administration to patients in clinical practice.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Final Report of Trends in Pregnancy and Birth Survey after the Great East Japan Earthquake and Fukushima Daiichi Nuclear Power Plant Accident: The Fukushima Health Management Survey.

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Fukushima Journal of Medical Science Pub Date : 2024-12-18 DOI: 10.5387/fms.24-00030

Keiya Fujimori, Kayoko Ishii, Hyo Kyozuka, Shun Yasuda, Tsuyoshi Murata, Aya Goto, Misao Ota, Kenichi Hata, Kohta Suzuki, Akihito Nakai, Tetsuya Ohira, Hitoshi Ohto, Kenji Kamiya, Seiji Yasumura

{"title":"Final Report of Trends in Pregnancy and Birth Survey after the Great East Japan Earthquake and Fukushima Daiichi Nuclear Power Plant Accident: The Fukushima Health Management Survey.","authors":"Keiya Fujimori, Kayoko Ishii, Hyo Kyozuka, Shun Yasuda, Tsuyoshi Murata, Aya Goto, Misao Ota, Kenichi Hata, Kohta Suzuki, Akihito Nakai, Tetsuya Ohira, Hitoshi Ohto, Kenji Kamiya, Seiji Yasumura","doi":"10.5387/fms.24-00030","DOIUrl":"https://doi.org/10.5387/fms.24-00030","url":null,"abstract":"This study aimed to assess long-term changes in pregnancy and birth outcomes after the Great East Japan Earthquake and the accident at the Tokyo Electric Power Company's Fukushima Daiichi Nuclear Power Plant in Fukushima Prefecture.　This is the final report on perinatal outcomes of the Prefectural Health Survey, which ended after a 10-year observation period.　Questionnaires based on a pregnancy and birth survey conducted by the Radiation Medical Science Center for the Fukushima Health Management Survey were sent to women who had received maternal and child health handbooks from municipal officers in Fukushima Prefecture.　Annual data from six geographic areas in Fukushima Prefecture were separately analyzed.　The number of eligible respondents, which was approximately 16,000 in 2011 when the earthquake occurred, declined temporarily the following year, recovered temporarily one year later, and has gradually declined since then.　However, the response rate remained at approximately 50% throughout the decade.　The incidence of preterm deliveries, low-birthweight infants, and congenital anomalies did not vary over the decade and showed a similar trend in national surveys and general reports.　Our analysis shows that the disaster had no significant adverse perinatal outcomes in Fukushima Prefecture and we recommend measures to ensure the safe delivery of babies in the region.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Agents and Patient Characteristics Affecting Metabolism ofThiopurines in Patients with Inflammatory Bowel Disease.

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Fukushima Journal of Medical Science Pub Date : 2024-12-12 DOI: 10.5387/fms.24-00009

Masato Aizawa, Kohei Suzuki, Yuki Nakajima Kenichi Utano, Kana Tamazawa, Kenta Ueda, Jun Wada, Kentaro Sato, Goro Shibukawa, Noriko Tanaka, Kazutomo Togashi

{"title":"Therapeutic Agents and Patient Characteristics Affecting Metabolism ofThiopurines in Patients with Inflammatory Bowel Disease.","authors":"Masato Aizawa, Kohei Suzuki, Yuki Nakajima Kenichi Utano, Kana Tamazawa, Kenta Ueda, Jun Wada, Kentaro Sato, Goro Shibukawa, Noriko Tanaka, Kazutomo Togashi","doi":"10.5387/fms.24-00009","DOIUrl":"https://doi.org/10.5387/fms.24-00009","url":null,"abstract":"Objectives: In inflammatory bowel disease therapy, thiopurines have been essential.　However, several reports have investigated factors affecting thiopurine metabolism to date.　This study investigated factors affecting intracellular concentrations of 6-thioguanine nucleotide (6-TGN) and 6-methylmercaptopurine (6-MMP) in a real-world setting.Methods: Between May 2013 and October 2021 in one institution, 44 patients (median age 44 years;male 35, female 9;ulcerative colitis 32, Crohn's disease 12) receiving thiopurines were reviewed.　Intracellular 6-TGN/6-MMP concentrations were measured by high-performance liquid chromatography, and the initial measurement in each patient was used for the study.Results: The 6-TGN level was significantly higher in females, with mild disease activity, absence of NUDT15 polymorphism, and allopurinol administration.　A higher trend was observed with high thiopurine dosage (>50 mg).　6-MMP levels were significantly lower with concomitant use of time-dependent 5-aminosalicylic acid (5-ASA) and allopurinol, and higher with high thiopurine dosage.　On multivariate analysis of variance, logarithmically transformed 6-TGN levels were significantly higher in females, with high thiopurine dosage, and allopurinol administration.　Similarly, logarithmically transformed 6-MMP levels were significantly higher with time-dependent 5-ASA administration and high thiopurine dosage.Conclusions: Patients who received allopurinol, a high dose of thiopurine, or were female showed higher 6-TGN levels.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Usefulness of Fecal Calprotectin Measurement in aPediatric Patient with Crohn's Disease.

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Fukushima Journal of Medical Science Pub Date : 2024-12-12 DOI: 10.5387/fms.23-00005

Shota Inoue, Kana Ito, Kiyotaka Zaha, Yusuke Yoshida, Yujin Sekinaka, Yoichi Kawamura

{"title":"Usefulness of Fecal Calprotectin Measurement in aPediatric Patient with Crohn's Disease.","authors":"Shota Inoue, Kana Ito, Kiyotaka Zaha, Yusuke Yoshida, Yujin Sekinaka, Yoichi Kawamura","doi":"10.5387/fms.23-00005","DOIUrl":"https://doi.org/10.5387/fms.23-00005","url":null,"abstract":"Acute pancreatitis in children in Japan is often caused by an anatomical abnormality of the pancreatic and bile duct, resulting in fever, abdominal pain, vomiting, diarrhea, and other symptoms.　Crohn's disease, however, is a chronic granulomatous inflammatory bowel disease with ulcerative lesions of the intestinal tract of unknown cause that occurs mainly in young people, with symptoms similar to those of acute pancreatitis.　We report a case of acute pancreatitis diagnosed in a patient not only with incomplete fusion of the pancreatic duct but also with Crohn's disease.　A 14-year-old girl, healthy by nature, presented to our hospital with complaints of abdominal pain and diarrhea.　She was initially diagnosed as having acute pancreatitis due to incomplete pancreas divisum.　However, a high level of fecal calprotectin led to endoscopic examination, which resulted in the diagnosis of Crohn's disease.　Fecal calprotectin can be useful in the diagnosis of inflammatory bowel disease associated with acute pancreatitis in children.　Although the relationship between inflammatory bowel disease and acute pancreatitis has not yet been clarified, we suggest that in the present case, acute pancreatitis may have manifested as a complication of Crohn's disease and an underlying case of incomplete pancreas divisum.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of increased fear of falling on falls in patients undergoing HD: A narrative review.

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Fukushima Journal of Medical Science Pub Date : 2024-12-12 DOI: 10.5387/fms.24-00014

Nobuyuki Shirai, Shinichiro Morishita, Yutaka Osawa, Suguru Yamamoto

{"title":"Effect of increased fear of falling on falls in patients undergoing HD: A narrative review.","authors":"Nobuyuki Shirai, Shinichiro Morishita, Yutaka Osawa, Suguru Yamamoto","doi":"10.5387/fms.24-00014","DOIUrl":"https://doi.org/10.5387/fms.24-00014","url":null,"abstract":"Increased fear of falling (FOF) increases the risk of falling and is an important issue for living an independent life.　Patients undergoing hemodialysis (HD) frequently fall, and this may be attributed to increased FOF due to common fall risk factors as well as severe chronic kidney disease and HD-related factors.　The purpose of this narrative review was to summarize the current knowledge on the mechanisms of increased FOF leading to falls in patients undergoing HD.　Patients undergoing HD have enhanced FOF compared to community elderly people.　Furthermore, an increase in FOF is correlated with a decrease in physical activity and physical function.　It has been reported that FOF in patients undergoing HD may be associated with past and future falls, and the risk of falling increases sharply when FOF exceeds a certain threshold.　Increased FOF may serve as a fundamental mechanism leading to increased fall risk by interacting with physical inactivity and physical frailty, affecting lower limb muscle activity during walking.　Further research is needed to clarify the relationship between increased FOF and falls in patients undergoing HD.　Regular clinical assessment of FOF is critical for identifying fall risk in patients undergoing HD.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2024 Fukushima Medical University International Symposium on the Fukushima Health Management Survey -3.11: Sharing Lessons of Fukushima with Japan and the World.

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Fukushima Journal of Medical Science Pub Date : 2024-12-07 DOI: 10.5387/fms.24-00058

Rie Mizuki, Seiji Yasumura

引用次数: 0

Successful treatment of anti-signal recognition particle antibody-positive myositis with intravenous cyclophosphamide: A case report.

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Fukushima Journal of Medical Science Pub Date : 2024-12-07 DOI: 10.5387/fms.24-00013

Jumpei Temmoku, Shuhei Yoshida, Kanae Tsuchihashi, Yuya Sumichika, Kenji Saito, Haruki Matsumoto, Yuya Fujita, Naoki Matsuoka, Tomoyuki Asano, Nozomu Matsuda, Shuzo Sato, Kiyoshi Migita

引用次数: 0

Histological outcome evaluation of selected brain preparation protocols for white fiber dissection. 对选定的白纤维解剖脑制备方案进行组织学结果评估。

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Fukushima Journal of Medical Science Pub Date : 2024-10-18 Epub Date: 2024-10-04 DOI: 10.5387/fms.23-00016

Masayuki Yamada, Kenichiro Iwami, Mudathir Bakhit, Masahiro Okamoto, Kiyoshi Saito, Masazumi Fujii

{"title":"Histological outcome evaluation of selected brain preparation protocols for white fiber dissection.","authors":"Masayuki Yamada, Kenichiro Iwami, Mudathir Bakhit, Masahiro Okamoto, Kiyoshi Saito, Masazumi Fujii","doi":"10.5387/fms.23-00016","DOIUrl":"10.5387/fms.23-00016","url":null,"abstract":"Background: White fiber dissection is essential for studying brain connections.　However, preparation protocols have not been validated.Methods: We microstructurally analyzed Klingler's brain preparation method and freezing process and assessed changes under two protocols:freeze-only and freeze-thaw.　The microstructure changes of these protocols were evaluated by measuring the ratio of the total gap area to the white matter area and determining the mean eccentricity value to assess the degree of anisotropy.Results: Sixty hemispheres were allocated to ten different freezing protocols.　In the freeze-only protocols, the total gap area ratio was significantly higher compared to that of specimens fixed with only formaldehyde, particularly after continuous freezing for 3-4 weeks;however, the difference in eccentricity was not significant.　In the freeze-thaw protocols, both the area ratio and eccentricity were significantly higher compared to the freeze-only.　The optimum degree of fiber separation in the freeze-thaw protocols reached its peak with four cycles of 1-week freezing periods interrupted by six hours of thawing.Conclusion: The Klingler method assists in the separation of the white fibers through the gaps formed by ice crystals, but an appropriate degree of anisotropy is reached when the freezing protocol is interrupted by at least four thawing cycles.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"203-209"},"PeriodicalIF":0.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The utility of MRI for the preoperative differential diagnosis of uterine sarcoma and leiomyoma: a single-center study. 核磁共振成像在子宫肉瘤和子宫肌瘤术前鉴别诊断中的应用：一项单中心研究。

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Fukushima Journal of Medical Science Pub Date : 2024-10-18 Epub Date: 2024-10-04 DOI: 10.5387/fms.23-00018

Hiroyuki Yazawa, Riho Yazawa, Kazuki Anjo, Akari Inazuki, Manabu Kikuta

{"title":"The utility of MRI for the preoperative differential diagnosis of uterine sarcoma and leiomyoma: a single-center study.","authors":"Hiroyuki Yazawa, Riho Yazawa, Kazuki Anjo, Akari Inazuki, Manabu Kikuta","doi":"10.5387/fms.23-00018","DOIUrl":"10.5387/fms.23-00018","url":null,"abstract":"Although uterine sarcoma is a rare disease, its prognosis is extremely poor;thus, it is important to differentiate it from uterine leiomyoma.　In this retrospective study, we examined the association between preoperative MRI findings and postoperative pathology results in 170 patients with uterine tumors who underwent preoperative MRI examination at Fukushima Red Cross Hospital.　In 4 cases of sarcoma / smooth muscle tumor of unknown malignant potential (STUMP), abnormal findings were found at a high frequency with T1-weighted imaging (T1WI) (75%), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and contrast enhancement (CE) (100%).　In cases of ordinary leiomyoma, on the other hand, abnormal findings were less frequent.　The rates of high DWI signal intensity for degenerated and cellular leiomyoma were 31% and 64%, respectively, and the CE-positive rates were 31% and 57%, respectively.　Apparent Diffusion Coefficient (ADC) values appeared to be useful in differentiating degenerated leiomyoma from sarcoma.　The relatively characteristic findings of uterine sarcoma on MRI images may overlap with those of degenerated leiomyoma and cellular leiomyoma, making it difficult to diagnose sarcoma on imaging alone.　However, findings that distinguish sarcoma from ordinary, degenerated, and cellular leiomyoma cases are worthy of attention, to avoid overlooking sarcoma.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"211-218"},"PeriodicalIF":0.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0