Fukushima Journal of Medical Science最新文献

Changes in peripheral blood test results among adults in the six years following the Great East Japan Earthquake: the Fukushima Health Management Survey. 日本东部大地震后6年成人外周血检测结果的变化：福岛健康管理调查

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Fukushima Journal of Medical Science Pub Date : 2025-10-01 Epub Date: 2025-04-11 DOI: 10.5387/fms.24-00041

Akira Sakai, Hironori Nakano, Koichi Hashimoto, Kanako Okazaki, Masanori Nagao, Michio Shimabukuro, Tetsuya Ohira, Tetsuo Ishikawa, Masaharu Tsubokura, Mitsuaki Hosoya, Atsushi Takahashi, Junichiro J Kazama, Shigeatsu Hashimoto, Kazuyuki Watanabe, Gen Kobashi, Hiroaki Satoh, Hideto Takahashi, Fumikazu Hayashi, Shiho Sato, Hitoshi Ohto, Seiji Yasumura

{"title":"Changes in peripheral blood test results among adults in the six years following the Great East Japan Earthquake: the Fukushima Health Management Survey.","authors":"Akira Sakai, Hironori Nakano, Koichi Hashimoto, Kanako Okazaki, Masanori Nagao, Michio Shimabukuro, Tetsuya Ohira, Tetsuo Ishikawa, Masaharu Tsubokura, Mitsuaki Hosoya, Atsushi Takahashi, Junichiro J Kazama, Shigeatsu Hashimoto, Kazuyuki Watanabe, Gen Kobashi, Hiroaki Satoh, Hideto Takahashi, Fumikazu Hayashi, Shiho Sato, Hitoshi Ohto, Seiji Yasumura","doi":"10.5387/fms.24-00041","DOIUrl":"10.5387/fms.24-00041","url":null,"abstract":"The Fukushima Health Management Survey, conducted by Fukushima Prefecture since the 2011 Great East Japan Earthquake (GEJE), has not identified any health effects from radiation exposure.　Complete blood counts (CBC), which are sensitive to radiation exposure, have not shown lymphocytopenia, neutropenia, anemia, or thrombocytopenia, but the white blood cell fractions have not yet been analyzed since 2011.　We classified 25,885 residents (11,383 male, 14,502 female;age range, 16-84 years) in evacuation areas with external exposure dose estimates based on behavioral surveys conducted 4 months after the GEJE into two groups (0-1 [≥0 and <1] and ≥1 mSv) and analyzed changes in CBC and leukocyte fractions from fiscal year (FY) 2011 to FY2017 and their influencing factors.　Compared with FY2011, no significant increase in the number of residents with leukopenia was seen, but the rate of male residents with anemia increased through 2017, regardless of the radiation exposure dose, but factors contributing to the development of anemia were more critical in males.　No links were found between the development of anemia and smoking, evacuation, or heavy alcohol drinking, whereas significant associations were found with thinness and older age.　These findings suggest that malnutrition is a cause of anemia, especially in males.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"213-226"},"PeriodicalIF":0.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zinner syndrome, a rare congenital urogenital tract malformation: the first reported case in Indonesia. 津纳综合征，一种罕见的先天性泌尿生殖道畸形：印度尼西亚首例报告病例。

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Fukushima Journal of Medical Science Pub Date : 2025-10-01 Epub Date: 2025-04-11 DOI: 10.5387/fms.24-00059

Cecilia N Salim, Novelia P Widyanto, Adsel Kartadinata, Richardo R Handoko, Budiawan Atmadja

{"title":"Zinner syndrome, a rare congenital urogenital tract malformation: the first reported case in Indonesia.","authors":"Cecilia N Salim, Novelia P Widyanto, Adsel Kartadinata, Richardo R Handoko, Budiawan Atmadja","doi":"10.5387/fms.24-00059","DOIUrl":"10.5387/fms.24-00059","url":null,"abstract":"Zinner syndrome (ZS) is a rare urogenital anomaly characterized by cystic seminal vesicles, obstructed ejaculatory duct, and ipsilateral renal agenesis, complicating diagnosis and management due to its rarity and nonspecific symptoms.　ZS incidence is 0.0021%, with symptoms typically appearing in the 2nd and 3rd decades of life, including dysuria, urinary frequency, perianal pain, and infertility.　MRI is the gold standard for diagnosis, while surgery is reserved for symptomatic patients.　Mildly symptomatic patients receive conservative management, including antibiotics and regular monitoring.　We report the first case of ZS in Indonesia, involving a 36-year-old male presenting with perineal pain similar to an episode a decade earlier.　MRI revealed right kidney agenesis, ejaculatory duct obstruction, a 4.95 cm cyst on the right seminal vesicle, and a right ectopic ureter.　Semen analysis was unremarkable.　Diagnosis of ZS was confirmed, and the patient opted for conservative management.This case highlights the importance of diagnosing ZS in underrepresented regions, where limited awareness and access to advanced tools delay identification.　The conservative approach reflected the patient's preference to avoid surgical risks while achieving effective symptom relief through tailored, patient-centered care.　Clinicians should consider ZS in cases of unilateral renal agenesis with cystic pelvic masses.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"265-269"},"PeriodicalIF":0.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two cases of low-grade appendiceal mucinous neoplasm (LAMN) mimicking ovarian tumors successfully treated with laparoscopic surgery. 腹腔镜手术成功治疗低级别阑尾黏液性肿瘤2例。

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Fukushima Journal of Medical Science Pub Date : 2025-10-01 Epub Date: 2025-05-17 DOI: 10.5387/fms.24-00051

Kazuki Anjo, Hiroyuki Yazawa, Tsukasa Sanpei Ojima, Riho Yazawa, Akari Inazuki

{"title":"Two cases of low-grade appendiceal mucinous neoplasm (LAMN) mimicking ovarian tumors successfully treated with laparoscopic surgery.","authors":"Kazuki Anjo, Hiroyuki Yazawa, Tsukasa Sanpei Ojima, Riho Yazawa, Akari Inazuki","doi":"10.5387/fms.24-00051","DOIUrl":"10.5387/fms.24-00051","url":null,"abstract":"We report two cases of low-grade appendiceal mucinous neoplasm (LAMN) mimicking ovarian tumors that were treated with laparoscopic surgery. Case 1: A 57-year-old woman was referred to our hospital because of a pelvic mass noted during physical examination. Imaging revealed an oval, cystic, 81×39-mm mass diagnosed as a right ovarian tumor, and surgery was performed. Intraoperative findings revealed an appendiceal tumor, and laparoscopic appendectomy was conducted. The pathological diagnosis was LAMN.Case 2: A 76-year-old woman was referred to our hospital because of a pelvic mass noted during physical examination. Imaging revealed an oval, cystic, 36×23-mm mass in the pelvic cavity, which was suspected to be a right ovarian tumor. Since it was slightly displaced to the cephalic side, surgery was performed with the possibility of a gastrointestinal tumor in mind. Intraoperative findings revealed an appendiceal tumor, and a laparoscopic appendectomy was conducted. The pathological diagnosis was LAMN.LAMN is a rare lesion with a risk of serious complications if the appendiceal wall ruptures and the tumor extends beyond the appendix. Although its preoperative diagnosis is challenging, it is important that gynecologists differentiate it from adnexal tumors.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"271-276"},"PeriodicalIF":0.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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Fukushima Journal of Medical Science Pub Date : 2025-10-01 Epub Date: 2025-05-17 DOI: 10.5387/fms.25-00003

Kengo Suzuki, Daisuke Koyama, Yasuhito Suzuki, Kiyohito Hayashi, Yasuhiro Uchida, Yuki Sato, Koichiro Fukuchi, Masahiko Fukatsu, Yoko Shibata, Takayuki Ikezoe

{"title":"Dasatinib-related diffuse alveolar hemorrhage in de novo blast phase chronic myeloid leukemia: a case report.","authors":"Kengo Suzuki, Daisuke Koyama, Yasuhito Suzuki, Kiyohito Hayashi, Yasuhiro Uchida, Yuki Sato, Koichiro Fukuchi, Masahiko Fukatsu, Yoko Shibata, Takayuki Ikezoe","doi":"10.5387/fms.25-00003","DOIUrl":"10.5387/fms.25-00003","url":null,"abstract":"Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm driven by the BCR::ABL tyrosine kinase. Tyrosine kinase inhibitors (TKIs) have significantly improved the outcome of CML patients. Dasatinib, a second-generation TKI, is highly effective but associated with off-target effects, including pulmonary toxicities. While pleural effusion induced by dasatinib has been linked to therapeutic efficacy, its role remains controversial. Severe pulmonary complications, such as diffuse alveolar hemorrhage (DAH), can lead to treatment failure and increased mortality. We report a 72-year-old man with de novo blast-phase CML on clopidogrel who developed respiratory failure due to DAH 16 days after initiating dasatinib and prednisolone as induction therapy. Immediate steroid pulse therapy with methylprednisolone (1,000 mg/day for three days) was administered, and both dasatinib and clopidogrel were discontinued. Maintenance prednisolone (1 mg/kg/day) was then tapered by 10 mg per week. The patient's symptoms and radiographic findings improved without recurrence during tapering. This case highlights the importance of early recognition and management of severe complications like DAH in patients receiving dasatinib. Careful monitoring is essential to mitigate the risk of life-threatening respiratory failure and optimize CML treatment outcomes.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"277-282"},"PeriodicalIF":0.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge of genetic effects of radiation exposure in Fukushima after the nuclear accident in relation to health literacy. 福岛核事故后辐射暴露对遗传影响的知识与健康素养的关系。

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Fukushima Journal of Medical Science Pub Date : 2025-10-01 Epub Date: 2025-05-17 DOI: 10.5387/fms.2023-15

Natsuki Tsuchiya, Chihiro Nakayama, Seiji Yasumura

{"title":"Knowledge of genetic effects of radiation exposure in Fukushima after the nuclear accident in relation to health literacy.","authors":"Natsuki Tsuchiya, Chihiro Nakayama, Seiji Yasumura","doi":"10.5387/fms.2023-15","DOIUrl":"10.5387/fms.2023-15","url":null,"abstract":"Purpose: Since the nuclear power plant accident in Fukushima, there has been anxiety about the effects of radiation exposure on future generations, specifically that the effects of radiation exposure may be inherited by descendants. We explored the relationship between health literacy and knowledge of the genetic effects of radiation exposure on this anxiety in both men and women.Methods: In August 2016, a mail survey was conducted among 2,000 Fukushima residents aged 20-79 years. The objective variable was a true/false question, \"No genetic effects have been observed among second- and third-generation atomic bomb survivors of Hiroshima and Nagasaki.\" The explanatory variable was the Critical and Communicative Health Literacy (CCHL) scale score. We also asked about variables including attributes of age, sex, affiliation with an organization or group, and media used for information about radiation.Results: There were 861 valid responses (43.4%). Logistic regression analysis revealed that both men and women with higher CCHL scores were more knowledgeable about genetic effects. Men who were older and women who used government publications were knowledgeable about genetic effects, but men who belonged to community groups and women in evacuation areas who used private national broadcast TV or word-of-mouth were not knowledgeable about genetic effects.Conclusions: CCHL was significantly associated with knowledge about genetic effects of radiation exposure. For men and women in Fukushima, the results suggest that improvement in health literacy is necessary to select media that disseminate accurate information. For men, recommendations regarding suitable sources of information cannot be ascertained through this study, because the source of information for men was not significantly associated with KOGEORE by multivariate logistic regression analysis.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"243-255"},"PeriodicalIF":0.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of prolonged severe urinary incontinence after robot-assisted radical prostatectomy: a prospective study. 机器人辅助根治性前列腺切除术后长期严重尿失禁的预测因素：一项前瞻性研究。

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Fukushima Journal of Medical Science Pub Date : 2025-10-01 Epub Date: 2025-04-24 DOI: 10.5387/fms.24-00031

Ryo Tanji, Nobuhiro Haga, Akari Hiraguri, Takahiro Tsumori, Tomoyuki Kumekawa, Shunsuke Yoshioka, Hiroki Natsuya, Yusuke Kirihana, Yusuke Hakozaki, Yu Endo, Kei Yaginuma, Syunta Makabe, Akihisa Hasegawa, Yuki Harigane, Hitomi Imai, Satoru Meguro, Akifumi Onagi, Ruriko Takinami, Kanako Matsuoka, Seiji Hoshi, Emina Kayama, Tomoyuki Koguchi, Junya Hata, Yuichi Sato, Hidenori Akaihata, Masao Kataoka, Soichiro Ogawa, Yoshiyuki Kojima

{"title":"Predictors of prolonged severe urinary incontinence after robot-assisted radical prostatectomy: a prospective study.","authors":"Ryo Tanji, Nobuhiro Haga, Akari Hiraguri, Takahiro Tsumori, Tomoyuki Kumekawa, Shunsuke Yoshioka, Hiroki Natsuya, Yusuke Kirihana, Yusuke Hakozaki, Yu Endo, Kei Yaginuma, Syunta Makabe, Akihisa Hasegawa, Yuki Harigane, Hitomi Imai, Satoru Meguro, Akifumi Onagi, Ruriko Takinami, Kanako Matsuoka, Seiji Hoshi, Emina Kayama, Tomoyuki Koguchi, Junya Hata, Yuichi Sato, Hidenori Akaihata, Masao Kataoka, Soichiro Ogawa, Yoshiyuki Kojima","doi":"10.5387/fms.24-00031","DOIUrl":"10.5387/fms.24-00031","url":null,"abstract":"Objectives: To identify predictors of prolonged severe urinary incontinence after robot-assisted radical prostatectomy (RARP), perioperative clinical parameters were investigated.Methods: Participants were 299 patients who underwent RARP at our institute.　Prolonged severe urinary incontinence was defined as a 1-h (one-hour) pad test >50 g/h and/or use of >3 pads/day at 12 months after RARP.　The cohort was divided into severe and non-severe urinary incontinence groups according to this criterion.　Perioperative clinical parameters were compared between groups to identify predictors for prolonged severe urinary incontinence after RARP.Results: Twenty-seven patients (9.0%) were categorized into the severe urinary incontinence group.　The remaining 272 patients (91.0%) were categorized into the non-severe urinary incontinence group.　Univariate analysis revealed prolonged severe urinary incontinence as significantly associated with older age (P=0.011), high BMI (P=0.001), lymph node dissection (P=0.003), non-preservation of nerves (P=0.039), non-preservation of fascia of the levator ani muscle (P=0.009), and high risk in the D'Amico risk classification (P=0.010).　Multivariate analysis revealed prolonged severe urinary incontinence as significantly correlated with high BMI (P=0.009) and high risk in the D'Amico risk classification (P=0.007).Conclusions: High BMI and D'Amico high-risk status are associated with prolonged severe urinary incontinence after RARP.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"227-234"},"PeriodicalIF":0.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognosis of pregnant women with epilepsy and their neonates: a case series study. 癫痫孕妇及其新生儿的预后：一个病例系列研究。

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Fukushima Journal of Medical Science Pub Date : 2025-10-01 Epub Date: 2025-04-26 DOI: 10.5387/fms.24-00048

Hitoshi Masamoto, Momoko Murata, Miya Ooshiro, Morihiko Inamine, Tadakazu Uesato, Hiraku Nagasaki, Masato Hiyane, Masaya Nakamoto, Kouhei Hironaka

{"title":"Prognosis of pregnant women with epilepsy and their neonates: a case series study.","authors":"Hitoshi Masamoto, Momoko Murata, Miya Ooshiro, Morihiko Inamine, Tadakazu Uesato, Hiraku Nagasaki, Masato Hiyane, Masaya Nakamoto, Kouhei Hironaka","doi":"10.5387/fms.24-00048","DOIUrl":"10.5387/fms.24-00048","url":null,"abstract":"Objectives: To explore the outcomes of pregnant women with epilepsy and their neonates, including the incidence of neonatal withdrawal syndrome.Methods: In total, 26 pregnancies in 20 mothers with epilepsy were retrospectively examined for the presence of complications before and during pregnancy, number of antiseizure medications taken, gestational weeks at delivery, mode of delivery, number of seizure episodes during pregnancy and postpartum, neonatal birth weight, Apgar score, pH of the umbilical cord arterial blood, neonatal abnormalities, and neonatal withdrawal syndrome.Results: Overall, 25 of the 26 pregnancies resulted in live births, with 4 cases undergoing premature deliveries.　Ten cases underwent cesarean section, with only one case undergoing cesarean section due to the fear of experiencing seizure during vaginal delivery.　During pregnancy, two cases experienced one seizure episode.　The rate of small for gestational age was 8.0%, and three neonates had congenital abnormalities.　Withdrawal symptoms were observed in 75% of the neonates, but none of them obtained ≥8 points in the withdrawal checklist, the threshold for pharmacotherapy.Conclusions: For women with epilepsy who receive medical management and establish good control prior to pregnancy, child birth may be relatively safe, with a low rate of neonatal withdrawal syndrome requiring pharmacotherapy.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"235-241"},"PeriodicalIF":0.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A descriptive study of junior residents' encounters with patients presenting various signs, symptoms, and diseases during initial postgraduate general practice/family medicine training in Japan. 日本初级住院医师在初级研究生全科/家庭医学培训期间遇到各种症状、体征和疾病的患者的描述性研究。

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Fukushima Journal of Medical Science Pub Date : 2025-10-01 Epub Date: 2025-04-24 DOI: 10.5387/fms.24-00040

Koki Nakamura, Satoshi Kanke, Atsushi Ishii, Fuyuto Mori, Goro Hoshi, Kanako Kanto, Yoshihiro Toyoda

{"title":"A descriptive study of junior residents' encounters with patients presenting various signs, symptoms, and diseases during initial postgraduate general practice/family medicine training in Japan.","authors":"Koki Nakamura, Satoshi Kanke, Atsushi Ishii, Fuyuto Mori, Goro Hoshi, Kanako Kanto, Yoshihiro Toyoda","doi":"10.5387/fms.24-00040","DOIUrl":"10.5387/fms.24-00040","url":null,"abstract":"Background: In 2020, 29 signs/symptoms as well as 26 diseases/disorders to be encountered during initial postgraduate training were defined in Japan. The purpose of this study was to determine the extent to which junior residents can encounter the signs/symptoms and diseases/disorders during general practice/family medicine training.Methods: Junior residents who participated in general practice/family medicine training for four weeks between 2019 and 2022 were:enrolled in the study. They were each assigned to one of five medical institutions with full-time family doctors in Fukushima Prefecture. The rate of participants who encountered each sign/symptom and disease/disorder, as well as the number of signs/symptoms and diseases/disorders each participant encountered, were defined as outcomes and analyzed descriptively.Results: Ninety junior residents participated in the study. More than half of the participants encountered 11 out of the 29 signs/symptoms, and each participant encountered an average of nine signs/symptoms. As for diseases/disorders, more than half of the participants encountered 11 out of the 26 diseases/disorders, with an average of 11 per participant.Conclusion: General practice/family medicine training provided the junior residents with the opportunity to experience a wide range of signs/symptoms and diseases/disorders.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"203-211"},"PeriodicalIF":0.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical practice of a novel molecular diagnostic method for detecting Helicobacter pylori and clarithromycin resistance. 一种新型分子诊断方法检测幽门螺杆菌和克拉霉素耐药性的临床实践。

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Fukushima Journal of Medical Science Pub Date : 2025-10-01 Epub Date: 2025-06-20 DOI: 10.5387/fms.25-00004

Eisuke Kameoka, Takuto Hikichi, Naoki Konno, Hiroki Irie, Yukiko Kanno, Yuto Ishizaki, Sayuri Goto, Masahito Kuroda, Mitsuru Otsuka, Takumi Yanagita, Tsunetaka Kato, Jun Nakamura, Hiromasa Ohira, Kenta Kodama

{"title":"Clinical practice of a novel molecular diagnostic method for detecting Helicobacter pylori and clarithromycin resistance.","authors":"Eisuke Kameoka, Takuto Hikichi, Naoki Konno, Hiroki Irie, Yukiko Kanno, Yuto Ishizaki, Sayuri Goto, Masahito Kuroda, Mitsuru Otsuka, Takumi Yanagita, Tsunetaka Kato, Jun Nakamura, Hiromasa Ohira, Kenta Kodama","doi":"10.5387/fms.25-00004","DOIUrl":"10.5387/fms.25-00004","url":null,"abstract":"Objective: The Smart GeneTM system enables the rapid polymerase chain reaction-based detection of Helicobacter pylori (H. pylori) in gastric juice and determines clarithromycin (CAM) resistance. This study evaluated the clinical utility of the Smart GeneTM system for diagnosing and managing H. pylori infection.Methods: H. pylori diagnosis was obtained using the Smart GeneTM system and the effectiveness of individualized eradication therapy was evaluated. Treatment regimens were chosen based on CAM sensitivity in the Smart GeneTM test.Results: A total of forty-nine patients were assessed. Among them, 28 had H. pylori infection, while 3 had CAM resistance. Seventeen patients underwent H. pylori eradication therapy. Fourteen patients with CAM-sensitive strains underwent eradication therapy with vonoprazan (VPZ), amoxicillin (AMPC), and CAM. Two patients with CAM-resistant strains were treated with VPZ and AMPC, while one received VPZ, AMPC, and metronidazole. The eradication achievement rate was 100%. Of 31 outpatients, 61.5% began H. pylori eradication therapy on the same day as the Smart GeneTM test.Conclusion: Smart GeneTM enables rapid diagnosis of H. pylori infection and the detection of CAM resistance, allowing for personalized eradication regimens.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"257-264"},"PeriodicalIF":0.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 14-year-old boy with C3 glomerulopathy and Sjögren's syndrome identified by a school urinary screening program. 一个14岁的男孩C3肾小球病变和Sjögren's综合征由学校泌尿筛查程序确定。

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Fukushima Journal of Medical Science Pub Date : 2025-09-23 DOI: 10.5387/fms.25-00022

Yukihiko Kawasaki, Atsushi Ono, Jun Shirota, Yohei Kume, Rho Maeda, Hayato Go

{"title":"A 14-year-old boy with C3 glomerulopathy and Sjögren's syndrome identified by a school urinary screening program.","authors":"Yukihiko Kawasaki, Atsushi Ono, Jun Shirota, Yohei Kume, Rho Maeda, Hayato Go","doi":"10.5387/fms.25-00022","DOIUrl":"https://doi.org/10.5387/fms.25-00022","url":null,"abstract":"C3 glomerulopathy (C3G) is a type of complement-associated glomerulopathy caused by a defect in the alternative complement pathway and is regarded as a rare disease. We report a 14-year-old boy with C3G and Sjögren's syndrome (SS) whose school urinary screening revealed abnormalities, but the diagnosis was delayed because he refused to consult a medical institution. Histopathological examination revealed histologic features of membranoproliferative glomerulonephritis. He was diagnosed with C3G and Sjögren's syndrome based on proteinuria, the histopathological findings, high levels of antibodies against SS-A, and lymphocytic infiltration around the salivary glands. He was treated with combination therapy, consisting of methylprednisolone pulse, prednisolone, and mycophenolate mofetil. At 3 months after treatment, urinary protein excretion was decreased and hematuria had disappeared, and improvement in hypocomplementemia and the levels of antibodies against SS-A were observed. The course of our case suggests that the management of patients with C3G should take into consideration the possibility of the coexistence of SS, and that those with positive findings on school urine screening should be encouraged to visit a medical institution.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0