Fukushima Journal of Medical Science最新文献

A case of late retrograde type A aortic dissection after hybrid aortic arch repair. 复合主动脉弓修复术后晚期逆行A型主动脉夹层1例。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-05-02 DOI: 10.5387/fms.25-00044

Keiichi Ishida, Yuki Seto, Shinya Takase

{"title":"A case of late retrograde type A aortic dissection after hybrid aortic arch repair.","authors":"Keiichi Ishida, Yuki Seto, Shinya Takase","doi":"10.5387/fms.25-00044","DOIUrl":"https://doi.org/10.5387/fms.25-00044","url":null,"abstract":"Retrograde type A aortic dissection (RTAD) after thoracic endovascular aortic repair (TEVAR) is a rare but potentially fatal complication. We report a case of very late-onset RTAD occurring 9 years after hybrid aortic arch repair. An 81-year-old man with a history of TEVAR with cervical debranching for subacute thrombosed RTAD, which later developed an ulcer-like projection, presented with dizziness and back pain. Acute RTAD with cardiac tamponade was diagnosed, and emergent ascending aortic replacement with resection of the entry tear-located at the proximal edge of the stent on the lesser curvature-was performed. Postoperatively, the patient required prolonged ventilatory support for respiratory failure and developed pyothorax secondary to aspiration pneumonia. He was ultimately discharged home on postoperative day 188 after rehabilitation. This case underscores the importance of a distinct pathophysiology in late RTAD, in which progressive aortic wall degeneration and biomechanical fatigue over time-rather than procedural factors-may contribute to dissection. Continuous imaging surveillance and strict cardiovascular risk factor management are essential, even in the absence of early complications.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abdominal organ injury caused by seemingly minor blunt trauma with focal impact in children. 看似轻微的钝性创伤伴局灶性冲击致儿童腹部器官损伤。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-05-02 DOI: 10.5387/fms.26-00006

Takahiro Hosokawa, Yutaka Tanami, Yohei Sanmoto, Tetsuya Ishimaru, Hiroshi Kawashima

{"title":"Abdominal organ injury caused by seemingly minor blunt trauma with focal impact in children.","authors":"Takahiro Hosokawa, Yutaka Tanami, Yohei Sanmoto, Tetsuya Ishimaru, Hiroshi Kawashima","doi":"10.5387/fms.26-00006","DOIUrl":"https://doi.org/10.5387/fms.26-00006","url":null,"abstract":"Abdominal organ injuries in children are usually caused by traffic accidents, which are typically defined as high-energy injuries. We report abdominal organ injury cases not attributed to high-energy blunt trauma but seemingly minor blunt trauma with focal impact.Case 1:A 6-year-old patient was running in a park and slipped one day before. The FAST examination was positive, revealing hepatic injury. Computed tomography demonstrated a massive subcapsular hemorrhage of the liver.Case 2:A 6-year-old patient fell in a room the day before. She experienced trauma to the epigastrium after hitting a water bottle during the fall. The FAST examination was positive, revealing pancreatic injury. Computed tomography was performed and showed a hematoma anterior to the pancreas.Case 3:A 7-year-old girl was practicing bar pullovers one day before. FAST examination was negative;however, targeted ultrasonography revealed a hyperechoic lesion, and computed tomography revealed a hematoma in the duodenal wall.These cases had abdominal organ injury caused by seemingly minor blunt trauma with focal impact. Physical examination and abdominal ultrasound examination, including FAST and targeted ultrasonography, are essential for the early identification of pediatric patients requiring computed tomography.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prognostic significance of pharmacological therapy after cardiac resynchronization therapy. 心脏再同步化治疗后药物治疗对预后的影响。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-04-24 DOI: 10.5387/fms.25-00040

Takamasa Sato, Sadahiro Murota, Minoru Nodera, Shinya Yamada, Takashi Kaneshiro, Takafumi Ishida, Yasuchika Takeishi

{"title":"The prognostic significance of pharmacological therapy after cardiac resynchronization therapy.","authors":"Takamasa Sato, Sadahiro Murota, Minoru Nodera, Shinya Yamada, Takashi Kaneshiro, Takafumi Ishida, Yasuchika Takeishi","doi":"10.5387/fms.25-00040","DOIUrl":"https://doi.org/10.5387/fms.25-00040","url":null,"abstract":"Background: Pharmacological therapy is essential in heart failure with reduced ejection fraction (HFrEF), but its prognostic role at the time of cardiac resynchronization therapy (CRT) remains uncertain.Methods: We retrospectively studied 272 patients (mean age 66 years;72% male) who underwent CRT between 2005 and 2023. Pharmacological therapy was assessed only at baseline. Medication included β-blockers (97.4%), renin-angiotensin system inhibitors or angiotensin receptor-neprilysin inhibitors (RAS inhibitors/ARNIs, 81.3%), mineralocorticoid receptor antagonists (64.7%), and loop diuretics (76.8%). The primary outcome was cardiac death or left ventricular assist device (LVAD) implantation. Cox models evaluated associations between baseline medication use, medication doses, and outcomes.Results: During a median follow-up of 4.2 years, 126 patients (46.3%) experienced the primary outcome. Baseline use and higher β-blocker dose were independently associated with a lower risk of the primary outcome. RAS inhibitors/ARNIs use was also associated with a lower risk of cardiac death or LVAD implantation. In contrast, higher loop diuretic dose and inotrope use tended to be associated with worse outcomes.Conclusion: Baseline use and dosing of β-blockers and RAS inhibitors/ARNIs were prognostically significant in CRT recipients, underscoring the importance of optimizing pharmacotherapy at the time of device implantation.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overcoming itraconazole limitations via proline cocrystals: improved solubility, dissolution, and antifungal efficacy. 通过脯氨酸共晶克服伊曲康唑的局限性：改善溶解度、溶解性和抗真菌效果。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-04-24 DOI: 10.5387/fms.25-00012

Dhanashri D Chavan, Vandana M Thorat, Amol S Shete, Rohit R Bhosale, Nikhil D Awale, Priti L Patil

{"title":"Overcoming itraconazole limitations via proline cocrystals: improved solubility, dissolution, and antifungal efficacy.","authors":"Dhanashri D Chavan, Vandana M Thorat, Amol S Shete, Rohit R Bhosale, Nikhil D Awale, Priti L Patil","doi":"10.5387/fms.25-00012","DOIUrl":"https://doi.org/10.5387/fms.25-00012","url":null,"abstract":"Crystal engineering plays a crucial role in the efficient design of pharmaceutical cocrystals, hinging on a deep understanding of intermolecular interactions that influence crystal packing. By leveraging these interactions, researchers can create innovative solid forms with customized physical and chemical properties. This versatile approach is especially valuable for tackling the solubility and bioavailability issues commonly associated with poorly soluble drugs. In this study, we focused on synthesizing cocrystals of itraconazole (ITZ) and proline via the kneading technique, an eco-friendly crystal engineering technique. Our work included comprehensive solid-state characterization, stability assessments, and in vitro efficacy evaluations. We specifically examined how these cocrystals performed in terms of dissolution, solubility, and antifungal activity. Our solid-state characterization results highlighted the formation of significant intermolecular interactions within the cocrystals, particularly hydrogen bonds between ITZ and the functional groups of proline. Notably, the ITZ-proline cocrystals demonstrated superior solubility and faster dissolution rates compared to pure ITZ, alongside increased crystallinity in the newly formed solid state. Additionally, the cocrystals exhibited enhanced antifungal activity and stability. Consequently, our findings have indicated that forming ITZ cocrystals with proline significantly enhances the solubility as well as stability of ITZ, thereby offering a promising antifungal strategy to combat fungal infections.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cornelia de Lange syndrome in an extremely low birth weight infant: a case report. 极低出生体重婴儿的科尼利亚·德·兰格综合征1例报告。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-04-24 DOI: 10.5387/fms.25-00062

Shun Hiruta, Hayato Go, Hajime Maeda, Kei Ogasawara, Mitsuaki Hosoya

{"title":"Cornelia de Lange syndrome in an extremely low birth weight infant: a case report.","authors":"Shun Hiruta, Hayato Go, Hajime Maeda, Kei Ogasawara, Mitsuaki Hosoya","doi":"10.5387/fms.25-00062","DOIUrl":"https://doi.org/10.5387/fms.25-00062","url":null,"abstract":"Cornelia de Lange syndrome (CdLS) is a rare genetic disorder characterized by distinctive facial features, fetal growth restriction, intellectual disability, and hirsutism. Few reports have described extremely low birth weight (ELBW) infants with CdLS. We report an ELBW infant diagnosed with CdLS. The infant was delivered by emergency cesarean section at 34 weeks and 1 day of gestation, weighing 994 g (-3.7 SD score). A diagnosis of CdLS was suspected based on dysmorphic features, including forehead hirsutism, cleft palate, long philtrum, wide nostrils, syndactyly of toes, femoral hirsutism, and hypospadias. Chromosomal analysis revealed a normal male karyotype (46,XY). Bilateral sensorineural hearing loss was also confirmed. Additional findings included atrial and ventricular septal defects. During hospitalization, the infant developed urinary tract infection and gastric volvulus but survived without severe complications. This case highlights that early recognition of CdLS, even in ELBW infants, is important for anticipating complications and providing timely multidisciplinary interventions to mitigate severe complications and facilitate long-term management.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevation of non-esterified fatty acids induced by hemodialysis sessions : pathophysiology and management strategies. 血液透析引起的非酯化脂肪酸升高：病理生理学和管理策略。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-04-24 DOI: 10.5387/fms.25-00048

Masako Fujiwara, Hiroyuki Terawaki, Itiro Ando, You Shishido, Takafumi Ito

{"title":"Elevation of non-esterified fatty acids induced by hemodialysis sessions : pathophysiology and management strategies.","authors":"Masako Fujiwara, Hiroyuki Terawaki, Itiro Ando, You Shishido, Takafumi Ito","doi":"10.5387/fms.25-00048","DOIUrl":"https://doi.org/10.5387/fms.25-00048","url":null,"abstract":"Background: Although increases in plasma levels of non-esterified fatty acids (NEFA) during hemodialysis (HD) have been reported, the precise time course of this elevation, its underlying pathophysiology, and effective therapeutic strategies remain unclear.Methods: The time course of plasma NEFA and immunoreactive insulin (IRI) concentrations during HD sessions was examined in seven patients with end-stage kidney disease across three phases : no intervention (control phase), intradialytic parenteral nutrition with an amino acid solution (IVAA phase), and intradialytic parenteral nutrition with amino acid and glucose solutions (IVAA + IVG phase).Results: Plasma NEFA concentrations, which increased beyond the normal range during the control and IVAA phases, remained within normal limits in the IVAA + IVG phase, likely due to the maintenance of plasma IRI concentrations above the fasting range.Conclusion: Hemodialysis elevated plasma NEFA concentrations to abnormally high levels, but this increase was suppressed by intradialytic parenteral nutrition containing amino acids and glucose.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ruptured tubal pregnancy after low hCG prompted discontinuation of luteal support: a case report of vitrified-warmed embryo transfer in a hormone replacement cycle. 低hCG后输卵管妊娠破裂提示停止黄体支持：在激素替代周期中玻璃化加热胚胎移植的一例报告。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-04-24 DOI: 10.5387/fms.25-00041

Kuniaki Ota, Toshifumi Takahashi, Yuka Furukawa, Atsuhiro Takanashi, Yoshiyuki Iizawa, Kazuyuki Takeichi

{"title":"Ruptured tubal pregnancy after low hCG prompted discontinuation of luteal support: a case report of vitrified-warmed embryo transfer in a hormone replacement cycle.","authors":"Kuniaki Ota, Toshifumi Takahashi, Yuka Furukawa, Atsuhiro Takanashi, Yoshiyuki Iizawa, Kazuyuki Takeichi","doi":"10.5387/fms.25-00041","DOIUrl":"https://doi.org/10.5387/fms.25-00041","url":null,"abstract":"Frozen-thawed embryo transfer (FET) in hormone replacement cycles (HRC) is widely used in assisted reproductive technology (ART). However, interpreting early serum human chorionic gonadotropin (hCG) levels remains challenging, especially in the absence of endogenous luteal function. This case report describes a 30-year-old woman who underwent FET with a high-quality blastocyst under HRC. At 4+1 weeks, her serum hCG level was 6.6 mIU/mL ; hormone support was discontinued, assuming a biochemical pregnancy loss. No follow-up hCG testing or transvaginal ultrasound was done. At 8+1 weeks, she presented with acute abdominal pain and was diagnosed with a ruptured tubal ectopic pregnancy with massive hemoperitoneum. Emergency laparoscopy revealed 1,500 mL of intra-abdominal bleeding ; right salpingectomy was performed and histopathological examination confirmed a tubal pregnancy. This case highlights the diagnostic limitations of relying on a single low hCG measurement during FET cycles. Even low or borderline hCG levels are compatible with ongoing or ectopic pregnancies. Clinicians should be cautious before discontinuing luteal support and should consider continued follow-up when hCG is detectable. In ART settings where early hCG testing is routine, integrating serial hCG measurements with early imaging can avoid life-threatening delays in the diagnosis of ectopic pregnancy.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An exploratory study of human papillomavirus detection in oral rinses from patients with recurrent respiratory papillomatosis. 复发性呼吸道乳头状瘤病患者口腔冲洗液中人乳头状瘤病毒检测的探索性研究。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-04-01 Epub Date: 2025-09-02 DOI: 10.5387/fms.25-00026

Shigeyuki Murono, Hiroshi Yoshida, Tomokazu Yoshizaki

引用次数: 0

Clinical characteristics of pediatric attention deficit hyperactivity disorder patients born with low birth weight, small for gestational age, or preterm. 低出生体重、小胎龄或早产儿童注意缺陷多动障碍的临床特征

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-04-01 Epub Date: 2025-08-26 DOI: 10.5387/fms.25-00021

Yukihiko Kawasaki, Yuichi Suzuki, Kyohei Miyazaki, Naoko Suzuki, Megumi Hoshina, Asako Kato, Hiroyuki Morita, Hayato Go

{"title":"Clinical characteristics of pediatric attention deficit hyperactivity disorder patients born with low birth weight, small for gestational age, or preterm.","authors":"Yukihiko Kawasaki, Yuichi Suzuki, Kyohei Miyazaki, Naoko Suzuki, Megumi Hoshina, Asako Kato, Hiroyuki Morita, Hayato Go","doi":"10.5387/fms.25-00021","DOIUrl":"10.5387/fms.25-00021","url":null,"abstract":"Aim: To clarify the frequency and characteristics of patients with attention deficit hyperactivity disorder (ADHD) born with low birth weight (LBW), very low birth weight (VLBW), small for gestational age (SGA), or preterm, we examined the clinical characteristics of ADHD patients.Methods: We collected data for 168 ADHD children, and the patients were retrospectively divided into each group according to birth weight, height, and gestational age.Results: 1) Patients with ADHD born with LBW, VLBW, SGA, or preterm accounted for 10.1%, 3.0%, 3.6%, or 6.5% of all patients, respectively. 2) ADHD-RS scores for hyperactivity disorder and the frequency of patients requiring ADHD drugs in the LBW infant group were higher than those in the non-LBW infant group. 3) ADHD-RS scores for hyperactivity disorder and total in the VLBW infant group were higher than those in the non-VLBW infant (birth weight:1,500-2,500 g) group. 4) The ADHD scores for attention-deficit and trouble score at the most recent follow-up patients born with SGA were higher than for non-SGA patients.Conclusions: These results suggest that it is necessary to pay attention to the appearance of neurodevelopment disorders such as ADHD when monitoring the progress of patients born with LBW or VLBW, and it is important to provide more appropriate management and therapeutic guidance for patients born with VLBW or SGA.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"79-87"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positive outcomes of disease awareness information conveyed by high school students to their guardians. 高中生向其监护人传达疾病意识信息的积极效果。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-04-01 Epub Date: 2025-11-15 DOI: 10.5387/fms.25-00020

Hiroyuki Terawaki, Masaru Isoyama, Yoshikazu Nemoto, Megumi Nakamura, Lihua Wang, Takafumi Ito

{"title":"Positive outcomes of disease awareness information conveyed by high school students to their guardians.","authors":"Hiroyuki Terawaki, Masaru Isoyama, Yoshikazu Nemoto, Megumi Nakamura, Lihua Wang, Takafumi Ito","doi":"10.5387/fms.25-00020","DOIUrl":"10.5387/fms.25-00020","url":null,"abstract":"Background: This questionnaire-based study aimed to evaluate whether health information conveyed by high school students can encourage their guardians to undergo annual health checks, regardless of their guardians' health literacy (HL) level.Methods: After a lecture to students by an internist on lifestyle-related diseases and chronic kidney disease (CKD), we asked their guardians (n = 1,027) if the students had shared information about the lecture with them and their willingness to participate in an annual health check. We also measured guardian HL using a self-administered questionnaire from which an HL score (minimum=1;maximum=5) could be derived.Results: The median HL score (with interquartile range) of guardians was 3.8 (3.2-4.0). Guardians whose children informed them about CKD were more likely than those who were not informed to plan health checks in the year ahead, regardless of their HL level.Conclusion: Our study demonstrated that the transmission of CKD information from high school students significantly encourages their guardians to schedule health checks, regardless of their HL level.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"141-151"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0