Fukushima Journal of Medical Science最新文献

{"title":"Feasibility of methotrexate discontinuation following tocilizumab and methotrexate combination therapy in patients with long-standing and advanced rheumatoid arthritis: a 3-year observational cohort study.","authors":"Masayuki Miyata, Yasuhiko Hirabayashi, Yasuhiko Munakata, Yukitomo Urata, Koichi Saito, Hiroshi Okuno, Masaaki Yoshida, Takao Kodera, Ryu Watanabe, Seiya Miyamoto, Tomonori Ishii, Shigeshi Nakazawa, Hiromitsu Takemori, Takanobu Ando, Takashi Kanno, Masataka Komagamine, Ichiro Kato, Yuichi Takahashi, Atsushi Komatsuda, Kojiro Endo, Chihiro Murai, Yuya Takakubo, Takao Miura, Yukio Sato, Kazunobu Ichikawa, Tsuneo Konta, Noriyuki Chiba, Tai Muryoi, Hiroko Kobayashi, Hiroshi Fujii, Yukio Sekiguchi, Akira Hatakeyama, Ken Ogura, Hirotake Sakuraba, Tomoyuki Asano, Hiroshi Kanazawa, Eiji Suzuki, Satoshi Takasaki, Kenichi Asakura, Yoko Suzuki, Michiaki Takagi, Takahiro Nakayama, Hiroshi Watanabe, Keiki Miura, Yu Mori","doi":"10.5387/fms.2022-06","DOIUrl":"10.5387/fms.2022-06","url":null,"abstract":"<p><strong>Objectives: </strong>Methotrexate (MTX) is associated with extensive side effects, including myelosuppression, interstitial pneumonia, and infection. It is, therefore, critical to establish whether its administration is required after achieving remission with tocilizumab (TCZ) and MTX combination therapy in patients with rheumatoid arthritis (RA). Therefore, the aim of this multicenter, observational, cohort study was to evaluate the feasibility of MTX discontinuation for the safety of these patients.</p><p><strong>Methods: </strong>Patients with RA were administered TCZ, with or without MTX, for 3 years; those who received TCZ+MTX combination therapy were selected. After remission was achieved, MTX was discontinued without flare development in one group (discontinued [DISC] group, n = 33) and continued without flare development in another group (maintain [MAIN] group, n = 37). The clinical efficacy of TCZ+MTX therapy, patient background characteristics, and adverse events were compared between groups.</p><p><strong>Results: </strong>The disease activity score in 28 joints-erythrocyte sedimentation rate (DAS28-ESR) at 3, 6, and 9 months was significantly lower in the DISC group (P < .05, P < .01, and P < .01, respectively). Further, the DAS28-ESR remission rate at 6 and 9 months and Boolean remission rate at 6 months were significantly higher in the DISC group (P < .01 for all). Disease duration was significantly longer in the DISC group (P < .05). Furthermore, the number of patients with stage 4 RA was significantly higher in the DISC group (P < .01).</p><p><strong>Conclusions: </strong>Once remission was achieved, MTX was discontinued in patients who responded favorably to TCZ+MTX therapy, despite the prolonged disease duration and stage progression.</p>","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"69 1","pages":"11-20"},"PeriodicalIF":0.8,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/03/0d/2185-4610-69-011.PMC10122970.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9698736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different prognostic outcomes in two cases of FDG-PET/CT-Positive and -negative cardiac angiosarcoma.","authors":"Ryo Yamakuni,&nbsp;Shiro Ishii,&nbsp;Shoki Yamada,&nbsp;Junko Hara,&nbsp;Hiroki Suenaga,&nbsp;Shigeyasu Sugawara,&nbsp;Hirofumi Sekino,&nbsp;Takayoshi Yamaki,&nbsp;Keiichi Ishida,&nbsp;Yuko Hashimoto,&nbsp;Hiroshi Ito","doi":"10.5387/fms.2022-13","DOIUrl":"https://doi.org/10.5387/fms.2022-13","url":null,"abstract":"<p><p>Cardiac angiosarcoma is a rare malignant tumor with a poor prognosis, characterized by the high uptake of ¹⁸F-fluorodeoxyglucose (FDG). This case report presents two cases of cardiac angiosarcoma with a marked difference in FDG uptake and prognosis.Case Summary:Case 1: A 40-year-old male presented with syncope. Ultrasound echocardiography demonstrated a cardiac tumor with a high uptake of ¹⁸F-FDG (maximum standardized uptake value=9.2). The patient underwent heart catheterization and tumor biopsy. The pathological result was high-grade angiosarcoma, and the MIB-1(Ki-67) proliferation index was approximately 20%. Systemic chemotherapy was administered; however, the patient died 2 years and 5 months after disease onset.Case 2: A 65-year-old female had a right atrial tumor incidentally diagnosed during routine ultrasound echocardiography. The tumor exhibited a low uptake of ¹⁸F-FDG (maximum standardized uptake value=1.8). Open heart surgery was performed, and the tumor was completely resected. Histological analysis revealed low-grade angiosarcoma, and the MIB-1(Ki-67) proliferation index was less than 5%. The patient was followed-up and had not relapsed 2 years after surgery.Conclusion: ¹⁸F-FDG uptake may reflect pathological tumor grade and prognosis in cardiac angiosarcoma.</p>","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"69 1","pages":"45-49"},"PeriodicalIF":0.8,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a8/23/2185-4610-69-045.PMC10122971.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9341484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of biomarkers in a rare case of fulminant necrotizing enterocolitis in a preterm infant.","authors":"Toshihiko Nakamura,&nbsp;Shota Inoue,&nbsp;Kana Ito,&nbsp;Eisuke Fukama,&nbsp;Tomoaki Nomura,&nbsp;Daisuke Hatanaka,&nbsp;Michiko Kusakari,&nbsp;Hidehiro Takahashi,&nbsp;Shingo Yamada","doi":"10.5387/fms.2022-25","DOIUrl":"https://doi.org/10.5387/fms.2022-25","url":null,"abstract":"<p><p>We encountered a very rare case of fulminant necrotizing enterocolitis (F-NEC) in a preterm male baby. The course of NEC and sepsis in this case was clearly different from the usual course. After onset at 14 days of life, catheter-related bloodstream infection was first assumed, and antibiotics and γ-globulin administration were started. However, 12 hours after onset, the baby's abdominal distension increased remarkably, and his entire abdominal wall turned red to purple. Escherichia coli were isolated from the blood culture, but the catheter tip culture was negative. Exchange transfusion was performed 32 hours after onset, but no significant changes were observed in the baby's general condition, and he died 46 hours after onset. The acute phase reactants of CRP and α1-acid glycoprotein increased, but haptoglobin did not. Although IL-1β and TNFα increased as expected with sepsis, IL-6, IL-8, IL-10, and G-CSF however increased to a greater extent than expected. From the above, we diagnosed the development of intestinal necrosis as a result of widespread intestinal ischemia, and that sepsis was associated with this poor condition.</p>","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"69 1","pages":"29-36"},"PeriodicalIF":0.8,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b2/75/2185-4610-69-029.PMC10122973.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9696660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian strumal carcinoid: a case report.","authors":"Masaru Kanasugi,&nbsp;Hiroshi Nishiyama,&nbsp;Minoru Sanpei,&nbsp;Shigeyuki Asano,&nbsp;Tsuyoshi Honda","doi":"10.5387/fms.2022-22","DOIUrl":"https://doi.org/10.5387/fms.2022-22","url":null,"abstract":"<p><strong>Background: </strong>Carcinoid tumors of the ovary are rare tumors, histopathologically classified as monodermal teratomas and somatic-type tumors arising from dermoid cysts. Their malignancy varies from borderline to malignant. Carcinoid tumors can occur in young and elderly women, and are sometimes seen in mature teratoma, struma ovarii, or mucinous cystadenoma as a nodule or tumor. Strumal carcinoid and mucinous carcinoid present as special types of carcinoid tumors of the ovary.</p><p><strong>Case report: </strong>This report describes a 56-year-old woman who presented with a large pelvic mass on abdominal ultrasonography during a medical examination. The diameter of the pelvic tumor was approximately 11 cm and was suspected to be ovarian cancer. The values of CA125 and CEA were above their reference intervals on preoperative examination. Abdominal total hysterectomy and bilateral salpingo-oophorectomy were performed. Intraoperative frozen-section histopathology suggested a diagnosis of mucinous adenocarcinoma; therefore, partial omentectomy and pelvic lymphadenectomy were also performed. Permanent-section histopathology led to a final diagnosis of strumal carcinoid of the ovary, stage IA (FIGO 2014). Six years post-operation, the patient had no sign of recurrence.</p>","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"69 1","pages":"51-55"},"PeriodicalIF":0.8,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/de/2185-4610-69-051.PMC10122969.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9342000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chopart amputation with tendon balancing.","authors":"Kazuo Ouchi,&nbsp;Naoyuki Oi,&nbsp;Mari Sato,&nbsp;Shoji Yabuki,&nbsp;Shin-Ichi Konno","doi":"10.5387/fms.2022-40","DOIUrl":"https://doi.org/10.5387/fms.2022-40","url":null,"abstract":"<p><strong>Background: </strong>When foot necrosis occurs due to lower limb blood flow disorder caused by diabetes or peripheral arterial occlusion, many patients require lower limb amputation. The functional prognosis after lower limb amputation largely depends on whether the heel can be preserved. However, there are many reports that Chopart amputation causes varus and equinus deformity, and is functionally unfavorable. We herein report a case of Chopart amputation performed with muscle balancing. Postoperatively, the foot was not deformed and the patient was able to walk independently with a foot prosthesis.</p><p><strong>Case: </strong>A 78-year-old man presented with ischemic necrosis of his right forefoot. The range of necrosis extended to the central part of the sole, so Chopart amputation was performed. In the operation, to prevent varus and equinus deformity, the Achilles tendon was lengthened, the tibialis anterior tendon was transferred through a tunnel created in the neck of talus, and the peroneus brevis tendon was transferred through a tunnel created in the anterior part of the calcaneus. At the final follow-up 7 years after the operation, no varus or equinus deformity was observed. The patient became able to stand up and walk on his heel without a prosthesis. In addition, step motion was possible by wearing a foot prosthesis.</p>","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"69 1","pages":"67-71"},"PeriodicalIF":0.8,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e5/9f/2185-4610-69-067.PMC10122968.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9698735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of trunk rotation during baseball batting with lumbar disc degeneration.","authors":"Naoki Taguchi,&nbsp;Shigeki Izumi,&nbsp;Shumpei Miyakawa","doi":"10.5387/fms.2022-14","DOIUrl":"https://doi.org/10.5387/fms.2022-14","url":null,"abstract":"<p><p>Lower back pain (LBP) is common among baseball players, and the occurrence of lumbar intervertebral disc degeneration is high. The dynamic load on the lumbar spine due to the postures and movements characteristic of baseball is suspected of aggravating LBP caused by degeneration, but the difference in batting action between players with and without degeneration is not known. The purpose of this study was to investigate the difference in batting motion in the presence and absence of lumbar disc degeneration (LDD). The subjects were 18 male baseball players belonging to the University League Division I: seven with disc degeneration and 11 without. The motion task analyzed tee batting. The items examined were the angles of rotation of shoulder, pelvis, hip, and twisting motion; rotation angular velocity; time to maximum angular velocity; and muscle activity potentials of the bilateral latissimus dorsi, erector spinae, multifidus, external oblique, internal oblique, rectus abdominis, and gluteus medius muscles; at each stage of batting action. There were significant differences between the shoulder and pelvis in rotation angle, time to maximum angular velocity, and muscle activity in the presence and absence of LDD, and in the time to maximum angular velocity between the shoulder and pelvis. We infer that these differences are characteristic of batting motion due to LDD.</p>","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"69 1","pages":"1-10"},"PeriodicalIF":0.8,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4c/ff/2185-4610-69-001.PMC10122975.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9335388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Struma ovarii with massive ascites mimicking ovarian carcinoma treated with conservative laparoscopic surgery: a case report.","authors":"Riho Yazawa,&nbsp;Hiroyuki Yazawa,&nbsp;Kaoru Fukuda,&nbsp;Miki Ohara","doi":"10.5387/fms.2022-30","DOIUrl":"https://doi.org/10.5387/fms.2022-30","url":null,"abstract":"<p><p>Struma ovarii is a rare taratoma that accounts for 0.5-1% of all ovarian tumors. It is sometimes difficult to differentiate struma ovarii from ovarian carcinoma. We encountered a case of struma ovarii that was suspected to be malignant due to the accumulation of massive ascites and an elevated CA125 level. It was successfully treated with laparoscopic surgery.A 37-year-old nulliparous woman consulted a local physician with a chief complaint of abdominal distention. Computed tomography (CT) of the abdomen revealed a pelvic tumor with a large amount of ascites. She was referred to our department. Contrast-enhanced magnetic resonance imaging (MRI) and CT showed bilateral ovarian tumors with multicystic and solid components. CA125 level was markedly elevated. Two cytological examinations of ascites showed no malignant cells. Preoperatively, malignancy was strongly suspected, but considering the possibility of a benign ovarian tumor, laparoscopic surgery was scheduled. During laparoscopic surgery, 4,850 mL of ascites were aspirated, and the left adnexa was removed. Intraoperative rapid pathology suggested struma ovarii with no evidence of malignancy. Postoperative pathology showed mature teratoma and struma ovarii.Although struma ovarii is benign in 90-95% of cases, there have been scattered case reports in which suspected malignancy led to unnecessary or excessive surgery. We propose that appropriate preoperative imaging and accurate intraoperative rapid pathology can prevent excessive surgery, conservative or laparoscopic excisions should be considered.</p>","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"69 1","pages":"37-43"},"PeriodicalIF":0.8,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e8/7c/2185-4610-69-037.PMC10122974.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9696661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of polypoid endometriosis mimicking advanced ovarian carcinoma with rapid growth, invasion, and dissemination.","authors":"Hiroyuki Yazawa,&nbsp;Riho Yazawa,&nbsp;Kaoru Fukuda,&nbsp;Miki Ohara","doi":"10.5387/fms.2022-23","DOIUrl":"https://doi.org/10.5387/fms.2022-23","url":null,"abstract":"<p><p>Polypoid endometriosis is a rare form of endometriosis characterized by polypoid masses that histologically often resemble endometrial polyps. We report a case of rapidly progressing polypoid endometriosis that was preoperatively assumed to be advanced ovarian cancer. A 46-year-old woman, para 0, underwent laparoscopic myomectomy and left adnexectomy for uterine fibroids and a left ovarian endometrial cyst after administration of gonadotropin releasing hormone (GnRH) agonist for 4 months. Eleven months postoperatively, rapid right ovarian enlargement occurred. CT and MRI (both contrast-enhanced) showed masses in the right adnexa, cecum, sigmoid colon, and omentum, and PET-CT demonstrated increased uptake, suggesting ovarian cancer and peritoneal dissemination. The patient later developed intestinal obstruction, and colonoscopy revealed multiple polypoid lesions in the sigmoid colon. The omental tumor and right adnexa were biopsied during exploratory laparotomy, and diagnosed as polypoid endometriosis with no malignancy by permanent pathology. The right adnexal tumor shrunk markedly after 4 months of GnRH antagonist treatment. Second laparotomy was then performed for right adnexal tumor resection and ileocecectomy. Pathological examination revealed polypoid endometriosis extending from the ovary to the cecal mucosa. The patient has been asymptomatic for over 1 year postoperatively. The sigmoid colon tumor shrunk but is still present.Polypoid endometriosis predominantly affects the ovaries, colon, peritoneum, and omentum of patients in their 40s and 50s. It is a benign disease but is often difficult to distinguish from malignancy preoperatively because it rapidly forms numerous solid lesions. Although polypoid endometriosis is rare, with no specific imaging findings, including it in a differential diagnosis may facilitate preoperative identification.</p>","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 3","pages":"183-190"},"PeriodicalIF":0.8,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9f/36/2185-4610-68-183.PMC9840886.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9162254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population analysis of oseltamivir-resistant variants for the rapid prediction of drug susceptibility by real-time reverse transcription polymerase chain reaction.","authors":"Masatoki Sato,&nbsp;Koichi Hashimoto,&nbsp;Mitsuaki Hosoya","doi":"10.5387/fms.2022-15","DOIUrl":"https://doi.org/10.5387/fms.2022-15","url":null,"abstract":"<p><p>This study investigated whether quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), using specific probes composed of locked nucleic acids (LNA/qRT-PCR), designed to evaluate H1N1 pdm09 H275Y, H3N2 E119V and R292K variant populations, could replace a neuraminidase (NA) inhibition assay to determine the 50% inhibitory concentration (IC₅₀) of NA activity.For H1N1 pdm09, when the H275Y variant RNA load was 50% or 70% and the infective H275Y variant load was 40% or 70%, the IC₅₀ were >10- and 100-fold higher, respectively, than that of the wild-type (WT) strain. For H3N2, when the E119V RNA load and infective E119V variant load were >90% and >60%, respectively, the IC₅₀ of the mixed sample was >10-fold higher than that of the WT strain. The variant-mixed samples with a 70% or 80% R292K variant RNA load and a 60% or 70% infective R292K variant load exhibited >10- and 100-fold decreased susceptibility, respectively, compared with that of the WT. A positive correlation between the variant RNA load and infective variant load populations was observed.The LNA/qRT-PCR method can be used to improve the treatment and management of patients during antiviral therapy for influenza virus infection.</p>","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 3","pages":"153-159"},"PeriodicalIF":0.8,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/29/2185-4610-68-153.PMC9840889.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10606472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the presence of bacteria in prostate tissue and histopathology in biopsies from men not complaining of lower urinary tract symptoms.","authors":"Ruriko Honda-Takinami,&nbsp;Junya Hata,&nbsp;Kanako Matsuoka,&nbsp;Seiji Hoshi,&nbsp;Tomoyuki Koguchi,&nbsp;Yuichi Sato,&nbsp;Hidenori Akaihata,&nbsp;Masao Kataoka,&nbsp;Soichiro Ogawa,&nbsp;Kyoko Nishiyama,&nbsp;Tatsuo Suzutani,&nbsp;Yoshiyuki Kojima","doi":"10.5387/fms.2022-34","DOIUrl":"https://doi.org/10.5387/fms.2022-34","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the presence of bacteria in prostate tissue, and relationships between the bacteria and histopathological findings.</p><p><strong>Methods: </strong>Samples were collected from prostate biopsy patients with no obvious lower urinary tract symptoms (LUTS). Detection and identification of bacterial species in the prostate tissues were performed with PCR for 16SrDNA and DNA sequencing. Histopathology was also evaluated. LUTS and lower urinary tract function were assessed by questionnaires, uroflowmetry, and ultrasonography.</p><p><strong>Results: </strong>DNA was extracted from 97 prostate biopsies, with 5 bacterial species detected among samples from 7 patients (7.2%). The stroma-to-gland ratio in the prostate tissues from patients with bacteria was lower than in those without bacteria (p < 0.01). Glandular epithelial hyperplasia was also identified in the prostates harboring bacteria. International Prostate Symptom Score (IPSS), IPSS-quality of life (IPSS-QOL), Overactive Bladder Symptom Score (OABSS), maximum flow rate, urine volume by uroflowmetry, and post-voided residual urine were not significantly different when comparing patients with and without bacteria in their prostate samples.</p><p><strong>Conclusions: </strong>The present study demonstrated that 7.2% of men without obvious LUTS had bacteria in their prostate tissues. The presence of such bacteria might induce glandular hyperplasia and contribute to pathological changes in the early stages of benign prostate enlargement before affecting LUTS.</p>","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 3","pages":"161-167"},"PeriodicalIF":0.8,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/df/9b/2185-4610-68-161.PMC9840884.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10611125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}