Fukushima Journal of Medical Science最新文献

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Clinical features of neck and shoulder pain (Katakori) in Japanese hospital workers 日本医院工作人员颈肩痛的临床特征
IF 0.8
Fukushima Journal of Medical Science Pub Date : 2022-06-03 DOI: 10.5387/fms.2022-02
Akira Onda, Keiko Onozato, Masashi Kimura
{"title":"Clinical features of neck and shoulder pain (Katakori) in Japanese hospital workers","authors":"Akira Onda, Keiko Onozato, Masashi Kimura","doi":"10.5387/fms.2022-02","DOIUrl":"https://doi.org/10.5387/fms.2022-02","url":null,"abstract":"Abstract Background: Non-specific pain or discomfort in the neck and shoulder girdle, called katakori in Japanese, is a common, chronic musculoskeletal condition worldwide. However, its various clinical features are incompletely characterized, even among medical professionals. We aimed to clarify factors affecting katakori and to investigate objectively the associated neck muscle stiffness and skeletal muscle volume. Methods: All staff members at our private hospital were surveyed about their lifestyle, physical and mental status, and katakori symptoms, using a self-administered questionnaire. Multiple logistic regression analysis was used to explore possible katakori risk factors. On secondary assessment, ultrasound elastography of the trapezius muscle as well as limb/trunk muscle mass were compared between subjects with severe symptoms and subjects without katakori, using propensity score matching. Results: Of 359 participants enrolled, nearly 75% had katakori to some degree. Spending time on a computer during work (adjusted odds ratio [aOR]: 1.82 for 3-6 hours, aOR: 2.48 for > 6 hours), being female (aOR: 3.75), and having unsatisfactory sleep (aOR: 2.92) were potential risk factors for katakori. Comparison of 13 matched pairs showed a significantly stiffer trapezius in subjects with severe katakori symptoms, but no apparent differences in limb/trunk muscle mass. Conclusions: Katakori was particularly prevalent in our hospital staff. Possible risk factors for disabling katakori were doing long-term computer work, being female, and having unsatisfactory sleep. Symptoms seem to be associated with elevated neck muscle stiffness. These findings could guide working condition improvements to mitigate katakori.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 1","pages":"79 - 87"},"PeriodicalIF":0.8,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48563471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
A case of spontaneous parasitic myoma in a patient without a history of myomectomy treated laparoscopically 无子宫肌瘤切除术史的自发性寄生虫肌瘤1例
IF 0.8
Fukushima Journal of Medical Science Pub Date : 2022-06-01 DOI: 10.5387/fms.2022-08
H. Kyozuka, Toki Jin, Misa Sugeno, Katsunori Kuratsune, Hiroki Ando, Fumihiro Ito, H. Odajima, Daisuke Suzuki, Y. Nomura
{"title":"A case of spontaneous parasitic myoma in a patient without a history of myomectomy treated laparoscopically","authors":"H. Kyozuka, Toki Jin, Misa Sugeno, Katsunori Kuratsune, Hiroki Ando, Fumihiro Ito, H. Odajima, Daisuke Suzuki, Y. Nomura","doi":"10.5387/fms.2022-08","DOIUrl":"https://doi.org/10.5387/fms.2022-08","url":null,"abstract":"Abstract Parasitic myoma (PM) is a rare disease in which multiple leiomyomas are intraperitoneally formed. Recently, an increasing number of cases due to specimen morcellation during minimally invasive surgery has been reported. We present the first case of a PM identified intraoperatively during laparoscopic hysterectomy. A 40-year-old Japanese multiparous woman presented to our hospital with heavy menstrual bleeding. She had no history of previous surgery. Magnetic resonance imaging showed uterine myomas. As the patient did not wish for further pregnancy, she underwent oral gonadotropin-releasing hormone antagonist therapy followed by a total laparoscopic hysterectomy. Intraoperatively, we identified a thumb-sized tumor on the left side of the peritoneum. Histopathological examination showed evidence of benign leiomyoma.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 1","pages":"123 - 127"},"PeriodicalIF":0.8,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44819938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Home-visit rehabilitation in a repopulated village after the Fukushima nuclear disaster 福岛核灾难后一个人口稠密的村庄的家访康复
IF 0.8
Fukushima Journal of Medical Science Pub Date : 2022-05-19 DOI: 10.5387/fms.2021-30
Y. Saito, Keiichiro Sato, Tatsuya Itagaki, F. Omata, T. Sawano, Y. Kobashi, Y. Nishikawa, M. Tsubokura, Wataru Hoshi
{"title":"Home-visit rehabilitation in a repopulated village after the Fukushima nuclear disaster","authors":"Y. Saito, Keiichiro Sato, Tatsuya Itagaki, F. Omata, T. Sawano, Y. Kobashi, Y. Nishikawa, M. Tsubokura, Wataru Hoshi","doi":"10.5387/fms.2021-30","DOIUrl":"https://doi.org/10.5387/fms.2021-30","url":null,"abstract":"Abstract Following the evacuation of areas affected by Japan’s 2011 Fukushima Daiichi Nuclear Power Plant (FDNPP) accident, Kawauchi Village was one of the first municipalities repopulated. Although rehabilitation resources were limited, a healthcare facility near the municipality initiated home-visit rehabilitation in 2016. To the best of our knowledge, reports of home-visit rehabilitation in repopulated villages that were evacuated following a nuclear accident are lacking. This article describes a case study of home-visit rehabilitation in Kawauchi Village. The purpose of this study was to explore how users of home-visit rehabilitation services in Kawauchi Village perceive home-visit rehabilitation, and whether it had a positive impact on their daily life. A questionnaire survey was conducted, and their ability to perform activities of daily living was assessed, to understand the living conditions of the visiting-rehabilitation service users. We studied 10 rehabilitation-service users, with a mean age of 86.8 years, who had used the services for an average of 591.4 days. Themes that emerged from the open-ended questionnaire were “established exercise habits and improved physical functions,” “the joy of returning to the village,” “challenges in the mountainous areas” and “changes in relationships due to the earthquake or evacuation.” In conclusion, home-visit rehabilitation was successfully implemented in the repopulated village, and helped maintain the users’ physical functions. This may thus be a viable choice for rehabilitation care in repopulated areas after disasters.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 1","pages":"71 - 77"},"PeriodicalIF":0.8,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45640894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Introduction and utility of resuscitative endovascular balloon occlusion of the aorta for cases with a potential high risk of postpartum hemorrhage: A single tertiary care center experience of two cases 介绍和应用复苏血管内球囊闭塞主动脉的病例与潜在的产后出血的高风险:一个单一的三级保健中心的经验,两例
IF 0.8
Fukushima Journal of Medical Science Pub Date : 2022-04-20 DOI: 10.5387/fms.2022-01
H. Kyozuka, Misa Sugeno, Tsuyoshi Murata, Toki Jin, Fumihiro Ito, Y. Nomura, T. Hirano, K. Shinohara, Daisuke Suzuki, T. Ishida
{"title":"Introduction and utility of resuscitative endovascular balloon occlusion of the aorta for cases with a potential high risk of postpartum hemorrhage: A single tertiary care center experience of two cases","authors":"H. Kyozuka, Misa Sugeno, Tsuyoshi Murata, Toki Jin, Fumihiro Ito, Y. Nomura, T. Hirano, K. Shinohara, Daisuke Suzuki, T. Ishida","doi":"10.5387/fms.2022-01","DOIUrl":"https://doi.org/10.5387/fms.2022-01","url":null,"abstract":"Abstract Postpartum hemorrhage is an important obstetric complication and the leading cause of maternal mortality worldwide. Occasionally, we encounter unexpected massive postpartum hemorrhage diagnosed for the first time after delivery. Therefore, it is essential to pay attention to patients with a high risk of postpartum hemorrhage. The authors report two cases of patients at high risk of postpartum hemorrhage that were successfully managed by resuscitative endovascular balloon occlusion of the aorta before cesarean section. Case 1: A 32-year-old woman with a history of cesarean section and who conceived using assisted reproductive technology was diagnosed with partial placenta previa at 25 weeks of gestation. Because of tocolysis failure, emergent cesarean section with resuscitative endovascular balloon occlusion of the aorta was performed at 36 weeks of gestation. Natural placental resorption was observed. She was discharged at 5 days after delivery without significant hemorrhage. Case 2: A 41-year-old woman with suspected placenta accreta spectrum due to a cesarean scar pregnancy was referred to our hospital at 33 weeks of gestation. A planned cesarean section with resuscitative endovascular balloon occlusion of the aorta was conducted at 37 weeks of gestation. There was no visual evidence of abnormal placental invasion of the myometrium, and natural placental resorption was observed. She was discharged at 5 days after delivery without significant hemorrhage.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 1","pages":"117 - 122"},"PeriodicalIF":0.8,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42559613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Psychologic distress and QOL in medical staff after a disaster: A longitudinal 4-year study. 灾后医务人员的心理困扰与生活质量:一项为期4年的纵向研究。
IF 0.8
Fukushima Journal of Medical Science Pub Date : 2022-04-08 Epub Date: 2022-02-08 DOI: 10.5387/fms.2021-19
Shoji Yabuki, Kozue Takatsuki, Kazuo Ouchi
{"title":"Psychologic distress and QOL in medical staff after a disaster: A longitudinal 4-year study.","authors":"Shoji Yabuki,&nbsp;Kozue Takatsuki,&nbsp;Kazuo Ouchi","doi":"10.5387/fms.2021-19","DOIUrl":"https://doi.org/10.5387/fms.2021-19","url":null,"abstract":"<p><p>Aiming to improve post-disaster care of medical staff, we conducted an early and ongoing assessment of post-disaster psychologic distress and quality of life (QOL) in one center of a disaster-response hospital. Twelve days after the Great East Japan Earthquake, as the Fukushima Daiichi Nuclear Power Plant crisis was unfolding, we began a survey to examine the physical and mental state of medical staff to assess their motivation toward work. Surveys were administered in March 2011 (Survey 1), March 2012 (Survey 2), March 2013 (Survey 3), March 2014 (Survey 4), and March 2015 (Survey 5). Participants completed the Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), EuroQol (EQ-5D), and MOS Short-Form 36-item Health Survey (SF-36). Although BDI scores significantly improved over time following Survey 1, participants in their 30s had significantly higher Survey 2 scores than those in their 40s/50s, and significantly higher Survey 3 scores than those in their 20s. STAI scores significantly improved over time following Survey 1. However, participants in their 30s had significantly higher Survey 3 scores than those in their 20s. EQ-5D scores did not significantly vary among survey time points or age groups. SF-36 physical functioning, role physical, social functioning, role emotional, and mental health subscale scores significantly improved over time. In conclusion, post-disaster longitudinal changes, including recovery period, differed among age groups. Thus, age should be taken into account in longitudinal evaluations of psychologic distress and QOL in medical staff after a disaster and, as more recent events suggest, during a pandemic.</p>","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 1","pages":"25-35"},"PeriodicalIF":0.8,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/df/9a/2185-4610-68-025.PMC9071357.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39604971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Association between subjective economic status and refusal of life-prolonging treatment: a cross-sectional study using content analysis with stratified random sampling. 主观经济状况与拒绝延长生命治疗之间的关系:一项采用分层随机抽样内容分析的横断面研究。
IF 0.8
Fukushima Journal of Medical Science Pub Date : 2022-04-08 Epub Date: 2022-01-20 DOI: 10.5387/fms.2021-13
Hideaki Kasuga, Shota Endo, Yusuke Masuishi, Tomoo Hidaka, Takeyasu Kakamu, Keiko Saito, Koichi Abe, Tetsuhito Fukushima
{"title":"Association between subjective economic status and refusal of life-prolonging treatment: a cross-sectional study using content analysis with stratified random sampling.","authors":"Hideaki Kasuga,&nbsp;Shota Endo,&nbsp;Yusuke Masuishi,&nbsp;Tomoo Hidaka,&nbsp;Takeyasu Kakamu,&nbsp;Keiko Saito,&nbsp;Koichi Abe,&nbsp;Tetsuhito Fukushima","doi":"10.5387/fms.2021-13","DOIUrl":"https://doi.org/10.5387/fms.2021-13","url":null,"abstract":"<p><strong>Introduction: </strong>Older adults tend to refuse life-prolonging treatment for various reasons, and it is important to respect their choice of treatment at the end-of-life stage. The present study examines the associations of subjective economic status and gender with reasons for refusal of life-prolonging treatment in older adults in general population.</p><p><strong>Methods: </strong>In this cross-sectional study, using stratified random sampling, 1,595 older adults living in Koriyama City, Japan, as of 2016, completed self-administered questionnaires on subjective economic status and preference for life-prolonging treatment, with free-description regarding reasons for refusal. We analyzed the associations between the combination of subjective economic status and gender with frequently mentioned terms and their clusters regarding such reasons, using χ<sup>2</sup> test, content analysis, text mining and hierarchical cluster analysis.</p><p><strong>Results: </strong>The combinations of subjective economic status and gender were significantly associated with clustered reasons for refusal of life-prolonging treatment (p < 0.01). The reasons frequently mentioned were: 'avoidance of unnecessary medical care' and 'dignity' in well-off females; and 'financial burden on family' in poor males.</p><p><strong>Conclusions: </strong>Our findings suggest that older adults who at first glance appear to be freely refusing life-prolonging treatment, may have their decision making restricted through economic constraints.</p>","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 1","pages":"11-18"},"PeriodicalIF":0.8,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ba/48/2185-4610-68-011.PMC9071350.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39923426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Impact of general practice / family medicine clerkships on Japanese medical students: Using text mining to analyze reflective writing. 全科/家庭医学实习对日本医学生的影响:使用文本挖掘分析反思性写作。
IF 0.8
Fukushima Journal of Medical Science Pub Date : 2022-04-08 Epub Date: 2022-02-08 DOI: 10.5387/fms.2021-24
Koki Nakamura, Satoshi Kanke, Goro Hoshi, Yoshihiro Toyoda, Kazutaka Yoshida, Ryuki Kassai
{"title":"Impact of general practice / family medicine clerkships on Japanese medical students: Using text mining to analyze reflective writing.","authors":"Koki Nakamura,&nbsp;Satoshi Kanke,&nbsp;Goro Hoshi,&nbsp;Yoshihiro Toyoda,&nbsp;Kazutaka Yoshida,&nbsp;Ryuki Kassai","doi":"10.5387/fms.2021-24","DOIUrl":"https://doi.org/10.5387/fms.2021-24","url":null,"abstract":"<p><strong>Background: </strong>In order for general practice / family medicine clerkships to be improved in undergraduate medical education, it is necessary to clarify the impacts of general practice / family medicine clerkships. Using text mining to analyze the reflective writing of medical students may be useful for further understanding the impacts of clinical clerkships on medical students.</p><p><strong>Methods: </strong>The study involved 125 fifth-year Fukushima Medical University School of Medicine students in the academic year 2018-2019. The settings were three clinics and the study period was 5 days. The clerkships included outpatient and home visits. Students' reflective writing on their clerkship experience was collected on the final day. Text mining was used to extract the most frequent words (nouns) from the reflective writing. A co-occurrence network map was created to illustrate the relationships between the most frequent words.</p><p><strong>Results: </strong>124 students participated in the study. The total number of sentences extracted was 321 and the total number of words was 10,627. The top five frequently-occurring words were patient, home-visit, medical practice, medical care, and family. From the co-occurrence network map, a co-occurrence relationship was recognized between home-visit and family.</p><p><strong>Conclusion: </strong>Data suggest that medical students may learn the necessity of care for the family as well as the patient in a home-care setting.</p>","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 1","pages":"19-24"},"PeriodicalIF":0.8,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8e/eb/2185-4610-68-019.PMC9071354.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39604972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visualizing the decline of public interest in the Great East Japan Earthquake and Fukushima Daiichi nuclear power plant accident by analyzing letters to the editor in Japanese newspapers. 通过分析日本报纸给编辑的信件,可视化公众对东日本大地震和福岛第一核电站事故的兴趣下降。
IF 0.8
Fukushima Journal of Medical Science Pub Date : 2022-04-08 Epub Date: 2022-02-08 DOI: 10.5387/fms.2021-18
Tomoo Hidaka, Shota Endo, Hideaki Kasuga, Yusuke Masuishi, Takeyasu Kakamu, Tetsuhito Fukushima
{"title":"Visualizing the decline of public interest in the Great East Japan Earthquake and Fukushima Daiichi nuclear power plant accident by analyzing letters to the editor in Japanese newspapers.","authors":"Tomoo Hidaka,&nbsp;Shota Endo,&nbsp;Hideaki Kasuga,&nbsp;Yusuke Masuishi,&nbsp;Takeyasu Kakamu,&nbsp;Tetsuhito Fukushima","doi":"10.5387/fms.2021-18","DOIUrl":"https://doi.org/10.5387/fms.2021-18","url":null,"abstract":"<p><p>This study aimed to delineate the decline in public interest toward the March 2011 Great East Japan Earthquake (GEJE) and the Fukushima Daiichi nuclear power plant (FNPP) accident in Japan over a ten-year period. In this longitudinal descriptive study, we searched for publications within a ten-year period in Letters to the Editor that mentioned the GEJE, the FNPP accident, or the January 1995 Great Hanshin-Awaji Earthquake (GHAE) that occurred in Japan, using the official databases of the three largest Japanese newspapers. The GEJE- and GHAE-related publications (4,809 and 2,092, respectively) are depicted as scatter plots. The results show a gradual decrease in the publications mentioning GEJE or GHAE. The impact of GEJE and FNPP on Japanese society was enormous, but the public interest waned over time. Communication strategies that maintain a high public interest in previous disasters may be necessary.</p>","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 1","pages":"63-66"},"PeriodicalIF":0.8,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9c/7a/2185-4610-68-063.PMC9071356.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39777465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Drug treatment for chemotherapy-induced peripheral neuropathy in patients with pancreatic cancer. 胰腺癌患者化疗所致周围神经病变的药物治疗。
IF 0.8
Fukushima Journal of Medical Science Pub Date : 2022-04-08 Epub Date: 2022-02-23 DOI: 10.5387/fms.2021-32
Mitsuru Sugimoto, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Hiroki Irie, Yoshinori Okubo, Jun Nakamura, Mika Takasumi, Minami Hashimoto, Tsunetaka Kato, Ryoichiro Kobashi, Takuto Hikichi, Hiromasa Ohira
{"title":"Drug treatment for chemotherapy-induced peripheral neuropathy in patients with pancreatic cancer.","authors":"Mitsuru Sugimoto, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Hiroki Irie, Yoshinori Okubo, Jun Nakamura, Mika Takasumi, Minami Hashimoto, Tsunetaka Kato, Ryoichiro Kobashi, Takuto Hikichi, Hiromasa Ohira","doi":"10.5387/fms.2021-32","DOIUrl":"10.5387/fms.2021-32","url":null,"abstract":"<p><p>Pancreatic cancer (PC) is a lethal disease where most tumors are too advanced at diagnosis for resection, leaving chemotherapy as the mainstay of treatment. Although the prognosis of unresectable PC is poor, it has been dramatically improved by new chemotherapy treatments, such as the combination of 5-fluorouracil, oxaliplatin, irinotecan, and leucovorin (FOLFIRINOX) or gemcitabine plus nab-paclitaxel. However, as oxaliplatin and paclitaxel are common neurotoxic drugs, chemotherapy-induced peripheral neuropathy (CIPN) is a common and severe adverse effect of both treatments. As there are no agents recommended in the ASCO guidelines, we review the methods used to treat CIPN caused by PC treatment. The efficacy of duloxetine was observed in a large randomized controlled trial (RCT). In addition, pregabalin was more effective than duloxetine for CIPN in two RCTs. Although duloxetine and pregabalin can be effective for CIPN, they have several side effects. Therefore, the choice between the two drugs should be determined according to effect and tolerability. Mirogabalin is also used in patients with PC and there is hope it will yield positive outcomes when treating CIPN in the future.</p>","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 1","pages":"1-10"},"PeriodicalIF":0.8,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/1f/2185-4610-68-001.PMC9071352.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39658268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Spinal cord stimulation for the treatment of pain and toe ulceration associated with systemic sclerosis: a case report 脊髓刺激治疗与系统性硬化相关的疼痛和脚趾溃疡1例
IF 0.8
Fukushima Journal of Medical Science Pub Date : 2022-02-25 DOI: 10.5387/fms.2021-33
Hiroyuki Ito, Takafumi Tanei, Kyoko Sugawara, Y. Sando, Naohiro Hori
{"title":"Spinal cord stimulation for the treatment of pain and toe ulceration associated with systemic sclerosis: a case report","authors":"Hiroyuki Ito, Takafumi Tanei, Kyoko Sugawara, Y. Sando, Naohiro Hori","doi":"10.5387/fms.2021-33","DOIUrl":"https://doi.org/10.5387/fms.2021-33","url":null,"abstract":"Abstract Systemic sclerosis is a complex disease characterized by extensive fibrosis, microvascular alterations, and additional sequelae. Microvascular alterations can cause painful ulcers and necrosis; however, conservative or surgical treatment is often challenging in terms of healing. The study aimed to describe a toe ulcer with systemic sclerosis and its’ successful treatment with spinal cord stimulation. An 83-year-old woman, who was diagnosed with systemic sclerosis over the past decade, was distressed by a non-healing toe ulcer for an extended period of time. The patient underwent spinal cord stimulation treatment with the expectation of pain relief and an improvement in microcirculatory insufficiency. Her pain scales and microcirculation improved, and the toe ulcer healed. Furthermore, the frequency of Raynaud’s symptoms was reduced, and the patient’s pain decreased. There was no recurrence of the ulcer and she no longer needed a cane for walking.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 1","pages":"37 - 41"},"PeriodicalIF":0.8,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45670860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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