Fukushima Journal of Medical Science最新文献_第8页

A case of peritonsillar abscess: a diagnostic challenge aided by point-of-care ultrasound. 一例腹膜周围脓肿：一个诊断挑战辅助点护理超声。

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Fukushima Journal of Medical Science Pub Date : 2026-01-05 Epub Date: 2025-06-20 DOI: 10.5387/fms.24-00063

Daiki Tabata, Tomoyuki Watanabe, Shuhei Honda

{"title":"A case of peritonsillar abscess: a diagnostic challenge aided by point-of-care ultrasound.","authors":"Daiki Tabata, Tomoyuki Watanabe, Shuhei Honda","doi":"10.5387/fms.24-00063","DOIUrl":"10.5387/fms.24-00063","url":null,"abstract":"AbstractA 27-year-old man with no medical history developed a fever and sore throat 5 days before visiting a primary care doctor. He was admitted to our hospital due to worsening symptoms, with a fever of 38.3ºC, redness of the pharynx, left tonsillar hypertrophy, uvular deviation to the right, and left submandibular lymph node enlargement with tenderness. Plain computed tomography (CT) revealed an enlarged left tonsil and lymph node. As it was difficult to differentiate between peritonsillar abscess (PTA) and peritonsillar cellulitis by plain CT, bedside cervical ultrasonography as point-of-care ultrasound (POCUS) was performed. A low echogenic area was observed in the center of the image. The mass with a low signal area on contrast-enhanced CT (CECT) was diagnosed as PTA. The patient was transferred to the otolaryngology department for pus drainage and was discharged 5 days later.Complications of PTA are rare but potentially fatal, warranting early diagnosis and prompt, appropriate management. CECT is useful for the diagnosis of PTA, but given the risk of complications by contrast agents and radiation, appropriate patient selection is important when performing CECT. POCUS was useful in diagnosing PTA that could not be diagnosed by plain CT.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"57-61"},"PeriodicalIF":0.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12861315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of American Association for the Surgery of Trauma (AAST) and Japanese Association for the Surgery of Trauma (JAST) classification systems for predicting mortality in surgically managed liver trauma: A single-center experience. 美国创伤外科协会（AAST）和日本创伤外科协会（JAST）分类系统预测手术处理肝损伤死亡率的比较：单中心经验

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Fukushima Journal of Medical Science Pub Date : 2026-01-05 Epub Date: 2025-07-02 DOI: 10.5387/fms.25-00014

Hiroto Chiba, Atsushi Ozeki, Ryota Sugawara, Satoshi Ueno, Takayasu Azuma, Shigeyuki Tsukida, Makoto Muto, Naoya Sato, Yasuhide Kofunato, Teruhide Ishigame, Takashi Kimura, Akira Kenjo, Shigeru Marubashi

{"title":"Comparison of American Association for the Surgery of Trauma (AAST) and Japanese Association for the Surgery of Trauma (JAST) classification systems for predicting mortality in surgically managed liver trauma: A single-center experience.","authors":"Hiroto Chiba, Atsushi Ozeki, Ryota Sugawara, Satoshi Ueno, Takayasu Azuma, Shigeyuki Tsukida, Makoto Muto, Naoya Sato, Yasuhide Kofunato, Teruhide Ishigame, Takashi Kimura, Akira Kenjo, Shigeru Marubashi","doi":"10.5387/fms.25-00014","DOIUrl":"10.5387/fms.25-00014","url":null,"abstract":"Background: Advances in treatment strategies and interventional radiology have led to the widespread adoption of nonoperative management for liver trauma;however, severe cases still require surgery, and are associated with high mortality. While the widely used American Association for the Surgery of Trauma (AAST) Liver Injury Scale is regularly updated and includes computed tomography (CT) findings, the Japanese Association for the Surgery of Trauma (JAST) Liver Injury Classification is also utilized in Japan but may have limitations in predicting prognosis based solely on imaging. Few studies have compared the prognostic utility of the two systems.Methods: This retrospective study analyzed patients who underwent laparotomy for liver injury at Fukushima Medical University Hospital (2013-2023). Liver injury-related mortality cases were compared with survivors to assess the predictive accuracy of the AAST and JAST classifications.Results: Among 23 patients, the overall mortality rate was 34.8%, with 5 liver injury-related deaths. AAST grades IV-V yielded 100% sensitivity and 80% specificity for predicting mortality (p=0.001), whereas JAST had lower sensitivity (60.0%) and specificity (86.7%, p=0.073).Conclusion: AAST grading may be more effective than the JAST classification for predicting liver injury-related mortality. Future JAST revisions should integrate imaging findings and treatment strategies to enhance its prognostic accuracy.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"23-30"},"PeriodicalIF":0.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12861323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A retrospective single-center study on the characteristics of children with attention-deficit hyperactivity disorder requiring early drug therapy from 2013 to 2022 and changes in treatment over time. 2013 - 2022年需要早期药物治疗的注意缺陷多动障碍儿童特征及治疗随时间变化的回顾性单中心研究

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Fukushima Journal of Medical Science Pub Date : 2026-01-05 Epub Date: 2025-07-23 DOI: 10.5387/fms.25-00016

Yukihiko Kawasaki, Yuichi Suzuki, Kyohei Miyazaki, Naoko Suzuki, Megumi Hoshina, Asako Kato, Hiroyuki Morita, Hayato Go

{"title":"A retrospective single-center study on the characteristics of children with attention-deficit hyperactivity disorder requiring early drug therapy from 2013 to 2022 and changes in treatment over time.","authors":"Yukihiko Kawasaki, Yuichi Suzuki, Kyohei Miyazaki, Naoko Suzuki, Megumi Hoshina, Asako Kato, Hiroyuki Morita, Hayato Go","doi":"10.5387/fms.25-00016","DOIUrl":"10.5387/fms.25-00016","url":null,"abstract":"To clarify the characteristics of children with attention deficit hyperactivity disorder (ADHD) requiring early drug therapy and changes in ADHD treatment over time, we undertook a clinical survey of ADHD children. We retrospectively classified 168 children with ADHD into groups based on the presence [Group 1, (the early treatment Group A, non-early treatment Group B)] or absence (Group 2) of ADHD drug therapy. The older age at first examination and the frequency of patients born with low birth weight in Group 1 were higher than those in Group 2. The ADHD-Rating Scale (ADHD-RS) scores for total (ADHD-RS-T) and trouble scores (TS) in Group 1 were higher than those in Group 2. All patients requiring early drug medication were diagnosed with ADHD at age 6 or older and showed significantly higher ADHD-RS hyperactivity disorder (ADHD-RS-H) and TS. Guanfacine was the main drug prescribed, being the first-line drug in 45.0% of cases. These results suggest that characteristics of patients requiring early ADHD drug medication include age 6 years or older at first examination and high ADHD-RS-H, ADHD-RS-T and TS. Furthermore, an increase in the frequency of prescriptions for guanfacine was observed as a prescription trend for ADHD medications.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"31-40"},"PeriodicalIF":0.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12861314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of combinatorial immunotherapy for patients with advanced gastric cancer from the perspective of immunosuppressive mechanisms in the tumor microenvironment. 从肿瘤微环境免疫抑制机制看晚期胃癌联合免疫治疗进展

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Fukushima Journal of Medical Science Pub Date : 2026-01-05 Epub Date: 2025-09-02 DOI: 10.5387/fms.25-00009

Kosaku Mimura, Koji Kono

{"title":"Development of combinatorial immunotherapy for patients with advanced gastric cancer from the perspective of immunosuppressive mechanisms in the tumor microenvironment.","authors":"Kosaku Mimura, Koji Kono","doi":"10.5387/fms.25-00009","DOIUrl":"10.5387/fms.25-00009","url":null,"abstract":"Combinatorial immunotherapy using anti-programmed cell death 1 (PD-1) monoclonal antibody (mAb) is being developed to overcome the limited efficacy of monotherapy with anti-PD-1 mAb for patients with advanced gastric cancer (GC). Anti-PD-1 mAb exhibits clinical efficacy by enhancing the function of cytotoxic T lymphocyte (CTL) through the inhibition of the PD-1 pathway;however, there are various immunosuppressive mechanisms that inhibit CTL function, as well as the PD-1 pathway in the tumor microenvironment (TME). Immune suppressive cells and expression of the inhibitory immune checkpoint molecules are included as main inhibitory mechanisms against CTL in the TME. On the other hand, increasing the number of CTLs enhances the efficacy of anti-PD-1 mAb, and immunogenic tumor cell death (ICD) is crucial to induce CTL through the activation of the cancer immunity cycle. In the present review, we discuss the therapeutic potential of developing combinatorial immunotherapy focusing on the inhibitory immune checkpoint molecules and immune suppressive cells in the TME, as well as on the ICD induced by radiotherapy for patients with advanced GC.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"1-14"},"PeriodicalIF":0.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12861317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bladder inguinal hernias: diagnostic value of CT and surgical outcomes with TAPP. 膀胱腹股沟疝：CT和TAPP的诊断价值。

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Fukushima Journal of Medical Science Pub Date : 2026-01-05 Epub Date: 2025-06-20 DOI: 10.5387/fms.25-00002

Yasunori Uesato, Susumu Inamine

{"title":"Bladder inguinal hernias: diagnostic value of CT and surgical outcomes with TAPP.","authors":"Yasunori Uesato, Susumu Inamine","doi":"10.5387/fms.25-00002","DOIUrl":"10.5387/fms.25-00002","url":null,"abstract":"Background: Bladder inguinal hernias are relatively rare, accounting for 0.5-5% of all inguinal hernias. They often present with nonspecific symptoms, making diagnosis challenging. Without timely treatment, complications such as urinary tract infection, bladder obstruction, or renal dysfunction may occur. Early recognition is crucial, and computed tomography (CT) is particularly effective in identifying bladder involvement, providing detailed anatomical information needed for surgical planning.Methods: We evaluated three cases of bladder inguinal hernia successfully diagnosed preoperatively using CT and treated with transabdominal preperitoneal repair (TAPP). These cases highlight the diagnostic value of CT and the safety and efficacy of TAPP.Results: Three patients, aged 65, 80, and 81, presented with groin pain or urinary symptoms. CT confirmed bladder prolapse in all cases. TAPP was performed without major complications. Operative times ranged from 97 to 106 minutes, with minimal blood loss. All patients were discharged within 3 days, and no recurrences were observed during 1-4 years of follow-up.Conclusions: CT is effective for diagnosing bladder involvement in inguinal hernias and should be considered for all suspected cases. TAPP offers a safe and effective way to manage this condition.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"63-68"},"PeriodicalIF":0.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12861320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in peripheral blood test results among adults in the six years following the Great East Japan Earthquake: the Fukushima Health Management Survey. 日本东部大地震后6年成人外周血检测结果的变化：福岛健康管理调查

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Fukushima Journal of Medical Science Pub Date : 2025-10-01 Epub Date: 2025-04-11 DOI: 10.5387/fms.24-00041

Akira Sakai, Hironori Nakano, Koichi Hashimoto, Kanako Okazaki, Masanori Nagao, Michio Shimabukuro, Tetsuya Ohira, Tetsuo Ishikawa, Masaharu Tsubokura, Mitsuaki Hosoya, Atsushi Takahashi, Junichiro J Kazama, Shigeatsu Hashimoto, Kazuyuki Watanabe, Gen Kobashi, Hiroaki Satoh, Hideto Takahashi, Fumikazu Hayashi, Shiho Sato, Hitoshi Ohto, Seiji Yasumura

{"title":"Changes in peripheral blood test results among adults in the six years following the Great East Japan Earthquake: the Fukushima Health Management Survey.","authors":"Akira Sakai, Hironori Nakano, Koichi Hashimoto, Kanako Okazaki, Masanori Nagao, Michio Shimabukuro, Tetsuya Ohira, Tetsuo Ishikawa, Masaharu Tsubokura, Mitsuaki Hosoya, Atsushi Takahashi, Junichiro J Kazama, Shigeatsu Hashimoto, Kazuyuki Watanabe, Gen Kobashi, Hiroaki Satoh, Hideto Takahashi, Fumikazu Hayashi, Shiho Sato, Hitoshi Ohto, Seiji Yasumura","doi":"10.5387/fms.24-00041","DOIUrl":"10.5387/fms.24-00041","url":null,"abstract":"The Fukushima Health Management Survey, conducted by Fukushima Prefecture since the 2011 Great East Japan Earthquake (GEJE), has not identified any health effects from radiation exposure.　Complete blood counts (CBC), which are sensitive to radiation exposure, have not shown lymphocytopenia, neutropenia, anemia, or thrombocytopenia, but the white blood cell fractions have not yet been analyzed since 2011.　We classified 25,885 residents (11,383 male, 14,502 female;age range, 16-84 years) in evacuation areas with external exposure dose estimates based on behavioral surveys conducted 4 months after the GEJE into two groups (0-1 [≥0 and <1] and ≥1 mSv) and analyzed changes in CBC and leukocyte fractions from fiscal year (FY) 2011 to FY2017 and their influencing factors.　Compared with FY2011, no significant increase in the number of residents with leukopenia was seen, but the rate of male residents with anemia increased through 2017, regardless of the radiation exposure dose, but factors contributing to the development of anemia were more critical in males.　No links were found between the development of anemia and smoking, evacuation, or heavy alcohol drinking, whereas significant associations were found with thinness and older age.　These findings suggest that malnutrition is a cause of anemia, especially in males.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"213-226"},"PeriodicalIF":0.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12591389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two cases of low-grade appendiceal mucinous neoplasm (LAMN) mimicking ovarian tumors successfully treated with laparoscopic surgery. 腹腔镜手术成功治疗低级别阑尾黏液性肿瘤2例。

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Fukushima Journal of Medical Science Pub Date : 2025-10-01 Epub Date: 2025-05-17 DOI: 10.5387/fms.24-00051

Kazuki Anjo, Hiroyuki Yazawa, Tsukasa Sanpei Ojima, Riho Yazawa, Akari Inazuki

{"title":"Two cases of low-grade appendiceal mucinous neoplasm (LAMN) mimicking ovarian tumors successfully treated with laparoscopic surgery.","authors":"Kazuki Anjo, Hiroyuki Yazawa, Tsukasa Sanpei Ojima, Riho Yazawa, Akari Inazuki","doi":"10.5387/fms.24-00051","DOIUrl":"10.5387/fms.24-00051","url":null,"abstract":"We report two cases of low-grade appendiceal mucinous neoplasm (LAMN) mimicking ovarian tumors that were treated with laparoscopic surgery. Case 1: A 57-year-old woman was referred to our hospital because of a pelvic mass noted during physical examination. Imaging revealed an oval, cystic, 81×39-mm mass diagnosed as a right ovarian tumor, and surgery was performed. Intraoperative findings revealed an appendiceal tumor, and laparoscopic appendectomy was conducted. The pathological diagnosis was LAMN.Case 2: A 76-year-old woman was referred to our hospital because of a pelvic mass noted during physical examination. Imaging revealed an oval, cystic, 36×23-mm mass in the pelvic cavity, which was suspected to be a right ovarian tumor. Since it was slightly displaced to the cephalic side, surgery was performed with the possibility of a gastrointestinal tumor in mind. Intraoperative findings revealed an appendiceal tumor, and a laparoscopic appendectomy was conducted. The pathological diagnosis was LAMN.LAMN is a rare lesion with a risk of serious complications if the appendiceal wall ruptures and the tumor extends beyond the appendix. Although its preoperative diagnosis is challenging, it is important that gynecologists differentiate it from adnexal tumors.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"271-276"},"PeriodicalIF":0.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12591390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zinner syndrome, a rare congenital urogenital tract malformation: the first reported case in Indonesia. 津纳综合征，一种罕见的先天性泌尿生殖道畸形：印度尼西亚首例报告病例。

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Fukushima Journal of Medical Science Pub Date : 2025-10-01 Epub Date: 2025-04-11 DOI: 10.5387/fms.24-00059

Cecilia N Salim, Novelia P Widyanto, Adsel Kartadinata, Richardo R Handoko, Budiawan Atmadja

{"title":"Zinner syndrome, a rare congenital urogenital tract malformation: the first reported case in Indonesia.","authors":"Cecilia N Salim, Novelia P Widyanto, Adsel Kartadinata, Richardo R Handoko, Budiawan Atmadja","doi":"10.5387/fms.24-00059","DOIUrl":"10.5387/fms.24-00059","url":null,"abstract":"Zinner syndrome (ZS) is a rare urogenital anomaly characterized by cystic seminal vesicles, obstructed ejaculatory duct, and ipsilateral renal agenesis, complicating diagnosis and management due to its rarity and nonspecific symptoms.　ZS incidence is 0.0021%, with symptoms typically appearing in the 2nd and 3rd decades of life, including dysuria, urinary frequency, perianal pain, and infertility.　MRI is the gold standard for diagnosis, while surgery is reserved for symptomatic patients.　Mildly symptomatic patients receive conservative management, including antibiotics and regular monitoring.　We report the first case of ZS in Indonesia, involving a 36-year-old male presenting with perineal pain similar to an episode a decade earlier.　MRI revealed right kidney agenesis, ejaculatory duct obstruction, a 4.95 cm cyst on the right seminal vesicle, and a right ectopic ureter.　Semen analysis was unremarkable.　Diagnosis of ZS was confirmed, and the patient opted for conservative management.This case highlights the importance of diagnosing ZS in underrepresented regions, where limited awareness and access to advanced tools delay identification.　The conservative approach reflected the patient's preference to avoid surgical risks while achieving effective symptom relief through tailored, patient-centered care.　Clinicians should consider ZS in cases of unilateral renal agenesis with cystic pelvic masses.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"265-269"},"PeriodicalIF":0.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12591383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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Fukushima Journal of Medical Science Pub Date : 2025-10-01 Epub Date: 2025-05-17 DOI: 10.5387/fms.25-00003

Kengo Suzuki, Daisuke Koyama, Yasuhito Suzuki, Kiyohito Hayashi, Yasuhiro Uchida, Yuki Sato, Koichiro Fukuchi, Masahiko Fukatsu, Yoko Shibata, Takayuki Ikezoe

{"title":"Dasatinib-related diffuse alveolar hemorrhage in de novo blast phase chronic myeloid leukemia: a case report.","authors":"Kengo Suzuki, Daisuke Koyama, Yasuhito Suzuki, Kiyohito Hayashi, Yasuhiro Uchida, Yuki Sato, Koichiro Fukuchi, Masahiko Fukatsu, Yoko Shibata, Takayuki Ikezoe","doi":"10.5387/fms.25-00003","DOIUrl":"10.5387/fms.25-00003","url":null,"abstract":"Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm driven by the BCR::ABL tyrosine kinase. Tyrosine kinase inhibitors (TKIs) have significantly improved the outcome of CML patients. Dasatinib, a second-generation TKI, is highly effective but associated with off-target effects, including pulmonary toxicities. While pleural effusion induced by dasatinib has been linked to therapeutic efficacy, its role remains controversial. Severe pulmonary complications, such as diffuse alveolar hemorrhage (DAH), can lead to treatment failure and increased mortality. We report a 72-year-old man with de novo blast-phase CML on clopidogrel who developed respiratory failure due to DAH 16 days after initiating dasatinib and prednisolone as induction therapy. Immediate steroid pulse therapy with methylprednisolone (1,000 mg/day for three days) was administered, and both dasatinib and clopidogrel were discontinued. Maintenance prednisolone (1 mg/kg/day) was then tapered by 10 mg per week. The patient's symptoms and radiographic findings improved without recurrence during tapering. This case highlights the importance of early recognition and management of severe complications like DAH in patients receiving dasatinib. Careful monitoring is essential to mitigate the risk of life-threatening respiratory failure and optimize CML treatment outcomes.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"277-282"},"PeriodicalIF":0.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12591382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge of genetic effects of radiation exposure in Fukushima after the nuclear accident in relation to health literacy. 福岛核事故后辐射暴露对遗传影响的知识与健康素养的关系。

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Fukushima Journal of Medical Science Pub Date : 2025-10-01 Epub Date: 2025-05-17 DOI: 10.5387/fms.2023-15

Natsuki Tsuchiya, Chihiro Nakayama, Seiji Yasumura

{"title":"Knowledge of genetic effects of radiation exposure in Fukushima after the nuclear accident in relation to health literacy.","authors":"Natsuki Tsuchiya, Chihiro Nakayama, Seiji Yasumura","doi":"10.5387/fms.2023-15","DOIUrl":"10.5387/fms.2023-15","url":null,"abstract":"Purpose: Since the nuclear power plant accident in Fukushima, there has been anxiety about the effects of radiation exposure on future generations, specifically that the effects of radiation exposure may be inherited by descendants. We explored the relationship between health literacy and knowledge of the genetic effects of radiation exposure on this anxiety in both men and women.Methods: In August 2016, a mail survey was conducted among 2,000 Fukushima residents aged 20-79 years. The objective variable was a true/false question, \"No genetic effects have been observed among second- and third-generation atomic bomb survivors of Hiroshima and Nagasaki.\" The explanatory variable was the Critical and Communicative Health Literacy (CCHL) scale score. We also asked about variables including attributes of age, sex, affiliation with an organization or group, and media used for information about radiation.Results: There were 861 valid responses (43.4%). Logistic regression analysis revealed that both men and women with higher CCHL scores were more knowledgeable about genetic effects. Men who were older and women who used government publications were knowledgeable about genetic effects, but men who belonged to community groups and women in evacuation areas who used private national broadcast TV or word-of-mouth were not knowledgeable about genetic effects.Conclusions: CCHL was significantly associated with knowledge about genetic effects of radiation exposure. For men and women in Fukushima, the results suggest that improvement in health literacy is necessary to select media that disseminate accurate information. For men, recommendations regarding suitable sources of information cannot be ascertained through this study, because the source of information for men was not significantly associated with KOGEORE by multivariate logistic regression analysis.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"243-255"},"PeriodicalIF":0.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12591381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0