Fukushima Journal of Medical Science最新文献_第8页

A muscle-preserving, spinous process-splitting approach for ossification of the ligamentum flavum in the thoracic spine in professional athletes: a report of three cases. 保留肌肉，棘突分离入路治疗专业运动员胸椎黄韧带骨化:三例报告。

IF 0.8

Fukushima Journal of Medical Science Pub Date : 2023-08-10 DOI: 10.5387/fms.2022-32

Kinshi Kato, Shoji Yabuki, Koji Otani, Takuya Nikaido, Kenichi Otoshi, Kazuyuki Watanabe, Hiroshi Kobayashi, Shin-Ichi Konno

{"title":"A muscle-preserving, spinous process-splitting approach for ossification of the ligamentum flavum in the thoracic spine in professional athletes: a report of three cases.","authors":"Kinshi Kato, Shoji Yabuki, Koji Otani, Takuya Nikaido, Kenichi Otoshi, Kazuyuki Watanabe, Hiroshi Kobayashi, Shin-Ichi Konno","doi":"10.5387/fms.2022-32","DOIUrl":"https://doi.org/10.5387/fms.2022-32","url":null,"abstract":"A muscle-preserving, spinous process-splitting approach may be a less invasive approach to conventional laminectomy in patients with thoracic ossification of the ligamentum flavum. Few reports have discussed the usefulness of this procedure for thoracic lesions in professional athletes who need highly active thoracic spinal function after surgery. The treatment of thoracic ossification of the ligamentum flavum using a spinous process-splitting approach in 3 professional athletes is presented. In all three cases the patients could return to play within 3 months after surgery without complications, and in two of the cases, there was no spinal deformity or local recurrence of ossification of the ligamentum flavum at the final follow-up at least 8 years after surgery. The spinous process-splitting approach could be a safe procedure for multi-level and all other forms of ossification of the ligamentum flavum and is less invasive to the paraspinal muscles, relieves back symptoms, and restores function for athletes.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"69 2","pages":"143-150"},"PeriodicalIF":0.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/05/56/2185-4610-69-143.PMC10480514.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10232372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of rehabilitation in patients undergoing hematopoietic stem cell transplantation. 康复对造血干细胞移植患者的影响。

IF 0.8

Fukushima Journal of Medical Science Pub Date : 2023-08-10 DOI: 10.5387/fms.2022-33

Takahiro Takekiyo, Shinichiro Morishita

引用次数: 0

Risk factors for anemia of prematurity among 30-35-week preterm infants. 30-35 周早产儿患早产儿贫血症的风险因素。

IF 0.7

Fukushima Journal of Medical Science Pub Date : 2023-08-10 Epub Date: 2023-05-11 DOI: 10.5387/fms.2022-21

Hiroki Kitaoka, Yoshihiko Shitara, Kohei Kashima, Shingo Ochiai, Hayato Chikai, Keiko Watanabe, Hiroto Ida, Tadayuki Kumagai, Naoto Takahashi

{"title":"Risk factors for anemia of prematurity among 30-35-week preterm infants.","authors":"Hiroki Kitaoka, Yoshihiko Shitara, Kohei Kashima, Shingo Ochiai, Hayato Chikai, Keiko Watanabe, Hiroto Ida, Tadayuki Kumagai, Naoto Takahashi","doi":"10.5387/fms.2022-21","DOIUrl":"10.5387/fms.2022-21","url":null,"abstract":"Background: The risk factors for anemia of prematurity (AOP) among late preterm infants are unelucidated. We identified risk factors for declining hemoglobin (Hb) concentration and triggering factors for AOP treatment in infants born at 30-35 gestational weeks.Methods: From 2012 to 2020, we conducted a single-center retrospective study of infants born at 30-35 weeks of gestation without congenital anomalies or severe hemorrhage. The primary outcome was AOP development, defined by initiation of treatments including red blood cell transfusion, subcutaneous injections of erythropoietin, and iron supplementation. A multivariable logistic regression model was used to investigate potential risk factors for AOP.Results: A total of 358 infants were included. Lower gestational age (odds ratio, 0.19; 95% confidence interval 0.11-0.32), small for gestational age (SGA; 7.17, 2.15-23.9), low maternal Hb level before birth (0.66, 0.49-0.87), low Hb at birth (0.71, 0.57-0.89), and multiple large blood samplings (1.79; 1.40-2.29) showed significantly higher odds for AOP development.Conclusions: Gestational age, SGA, low maternal Hb before birth, Hb at birth, and high number of large blood samplings were positively associated with AOP development in infants born at 30-35 gestational weeks.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"69 2","pages":"115-123"},"PeriodicalIF":0.7,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d6/cd/2185-4610-69-115.PMC10480510.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10167368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Staged hybrid repair for a patient with chronic type B aortic dissection. 慢性B型主动脉夹层分阶段混合修复术1例。

IF 0.8

Fukushima Journal of Medical Science Pub Date : 2023-08-10 DOI: 10.5387/fms.2022-24

Yuki Seto, Hitoshi Yokoyama, Shinya Takase, Tsuyoshi Fujimiya, Hiroharu Shinjo, Keiichi Ishida

{"title":"Staged hybrid repair for a patient with chronic type B aortic dissection.","authors":"Yuki Seto, Hitoshi Yokoyama, Shinya Takase, Tsuyoshi Fujimiya, Hiroharu Shinjo, Keiichi Ishida","doi":"10.5387/fms.2022-24","DOIUrl":"https://doi.org/10.5387/fms.2022-24","url":null,"abstract":"Vascular prosthesis replacement and thoracic endovascular repair (TEVAR) are used to treat patients with enlarged chronic type B aortic dissection. A case in which thrombosis of the false lumen was achieved by the staged combination of these two methods is presented. A 41-year-old woman with a thoracoabdominal aortic aneurysm (maximum short diameter 44 mm) identified 5 years earlier was being monitored as an outpatient in our department when she presented with back pain. Computed tomography (CT) showed acute type B aortic dissection (DeBakey type IIIa), which was managed conservatively. When CT showed an aortic dissection with a patent false lumen immediately below the left subclavian artery bifurcation, one-debranching TEVAR was performed to close the entry, along with right axillary artery to left axillary artery bypass surgery. Outpatient CT at 3 months postoperatively showed rapid enlargement in the vicinity of the celiac artery. Thoracoabdominal aortic replacement to prevent rupture was performed, and the patient was then monitored as an outpatient. CT at age 43 years showed enlargement of the residual false lumen. Additional TEVAR was successfully performed. Thus, three-stage treatment was conducted to enlarge the residual false lumen, causing successful thrombosis of the false lumen.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"69 2","pages":"151-155"},"PeriodicalIF":0.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e4/09/2185-4610-69-151.PMC10480512.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10175602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of general practice / family medicine training on Japanese junior residents:a descriptive study. 全科/家庭医学培训对日本初级住院医师的影响:一项描述性研究

IF 0.8

Fukushima Journal of Medical Science Pub Date : 2023-08-10 DOI: 10.5387/fms.2022-35

Koki Nakamura, Satoshi Kanke, Atsushi Ishii, Fuyuto Mori, Goro Hoshi, Kanako Kanto, Yoshihiro Toyoda, Ryuki Kassai

{"title":"Impact of general practice / family medicine training on Japanese junior residents:a descriptive study.","authors":"Koki Nakamura, Satoshi Kanke, Atsushi Ishii, Fuyuto Mori, Goro Hoshi, Kanako Kanto, Yoshihiro Toyoda, Ryuki Kassai","doi":"10.5387/fms.2022-35","DOIUrl":"https://doi.org/10.5387/fms.2022-35","url":null,"abstract":"Background: Despite international recognition of the impact of general practice / family medicine training on postgraduate training outcomes, there have been few reports from Japan.Methods: Junior residents who participated in community medicine training for one month between 2019 and 2022 were enrolled in the study. The settings were five medical institutions (one hospital and four clinics) that had full-time family doctors. The junior residents were assigned to one of these institutions. The training content mainly consisted of general ambulatory care, home medical care, community-based care, and reflection. The junior residents evaluated themselves at the beginning and end of their training, and the family doctors evaluated the junior residents at the end. The evaluation items were 36 items in 10 areas, based on the objectives outlined in the Guidelines for Residency Training - 2020 Edition, and were rated on a 10-point Likert scale. In the statistical analysis, Wilcoxon signed rank test of two related groups was performed to analyze changes between pre and post self-evaluation, and the effect size r was calculated.Results: Ninety-one junior residents completed the study. Their self-evaluations showed statistically significant increases in all 36 items. The effect size was large in 33 items. The family doctors' evaluation was 8-9 points for all 36 items.Conclusion: General practice / family medicine training may greatly contribute to the acquisition of various required clinical abilities in postgraduate training even in Japan.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"69 2","pages":"133-141"},"PeriodicalIF":0.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/eb/b4/2185-4610-69-133.PMC10480516.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10175578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Differences in response to treatment in children with severe IgA nephropathy according to patient age. 严重IgA肾病患儿治疗反应的年龄差异

IF 0.8

Fukushima Journal of Medical Science Pub Date : 2023-08-10 DOI: 10.5387/fms.2022-42

Yukihiko Kawasaki, Yohei Kume, Atsushi Ono, Ryo Maeda, Hayato Go

{"title":"Differences in response to treatment in children with severe IgA nephropathy according to patient age.","authors":"Yukihiko Kawasaki, Yohei Kume, Atsushi Ono, Ryo Maeda, Hayato Go","doi":"10.5387/fms.2022-42","DOIUrl":"https://doi.org/10.5387/fms.2022-42","url":null,"abstract":"Aim: To clarify whether the response to treatment of IgA nephropathy (IgAN) differs depending on patient age, we examined the response to treatment according to age of onset in children with IgAN.Methods: We collected data for 44 children with severe IgAN. The children were retrospectively divided into three groups based on their age at disease onset. Group 1 consisted of 24 children under 11 years old, group 2 consisted of 9 children aged 12 to 13 years, and group 3 consisted of 11 children aged over 14 years old. The clinical features and prognosis were analyzed for each group.Results: The urinary protein excretion and serum IgA values in group 3 were higher than those in groups 1 and 2 at the most recent follow up, and histological findings showed that the MESTCG scores in group 3 were higher than those in group 1. Furthermore, the incidence of patients with persistent nephropathy or renal insufficiency in group 3 was higher than those in groups 1 and 2.Conclusions: Patients aged 14 years and older with IgAN may respond poorly to treatment compared with those younger than 14 years old. Therefore, care must be taken regarding response to treatment and relapse when treating older children.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"69 2","pages":"125-132"},"PeriodicalIF":0.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d7/59/2185-4610-69-125.PMC10480517.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10167365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current progress in genomics and targeted therapies for neurofibromatosis type 2. 2型神经纤维瘤病基因组学和靶向治疗的最新进展。

IF 0.8

Fukushima Journal of Medical Science Pub Date : 2023-08-10 DOI: 10.5387/fms.2023-05

Ryo Hiruta, Kiyoshi Saito, Mudathir Bakhit, Masazumi Fujii

{"title":"Current progress in genomics and targeted therapies for neurofibromatosis type 2.","authors":"Ryo Hiruta, Kiyoshi Saito, Mudathir Bakhit, Masazumi Fujii","doi":"10.5387/fms.2023-05","DOIUrl":"https://doi.org/10.5387/fms.2023-05","url":null,"abstract":"Neurofibromatosis type 2 (NF2), a multiple neoplasia syndrome, is a manifestation of an impaired expression of the merlin protein, exerting inhibitory effects on cell proliferation signals due to abnormalities of the NF2 gene located on chromosome 22. About half of patients inherit a germline mutation from a parent, and nearly 60% of de novo NF2 patients are estimated to have somatic mosaicism. The development of technical methods to detect NF2 gene mutation, including targeted deep sequencing from multiple tissues, improved the diagnostic rate of mosaic NF2. With improved understanding of genetics and pathogenesis, the diagnostic criteria for NF2 were updated to assist in identifying and diagnosing NF2 at an earlier stage. The understanding of cell signaling pathways interacting with merlin has led to the development of molecular-targeted therapies. Currently, several translational studies are searching for possible therapeutic agents targeting VEGF or VEGF receptors. Bevacizumab, an anti-VEGF monoclonal antibody, is widely used in many clinical trials aiming for hearing improvement or tumor volume control. Currently, a randomized, double-masked trial to assess bevacizumab is underway. In this randomized control trial, 12 other Japanese institutions joined the principal investigators in the clinical trial originating at Fukushima Medical University. In this review, we will be discussing the latest research developments regarding NF2 pathophysiology, including molecular biology, diagnosis, and novel therapeutics.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"69 2","pages":"95-103"},"PeriodicalIF":0.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/7d/2185-4610-69-095.PMC10480513.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10233443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tau positron emission tomography in patients with cognitive impairment and suspected Alzheimer's disease. 认知障碍和疑似阿尔茨海默病患者的Tau正电子发射断层扫描。

IF 0.8

Fukushima Journal of Medical Science Pub Date : 2023-08-10 DOI: 10.5387/fms.2023-08

Hiroshi Matsuda, Tensho Yamao

{"title":"Tau positron emission tomography in patients with cognitive impairment and suspected Alzheimer's disease.","authors":"Hiroshi Matsuda, Tensho Yamao","doi":"10.5387/fms.2023-08","DOIUrl":"https://doi.org/10.5387/fms.2023-08","url":null,"abstract":"Alzheimer's disease (AD) is diagnosed by the presence of both amyloid β and tau proteins. Recent advances in molecular PET imaging have made it possible to assess the accumulation of these proteins in the living brain. PET ligands have been developed that bind to 3R/4R tau in AD, but not to 3R tau or 4R tau alone. Of the first-generation PET ligands, 18F-flortaucipir has recently been approved by the Food and Drug Administration. Several second-generation PET probes with less off-target binding have been developed and are being applied clinically. Visual interpretation of tau PET should be based on neuropathological neurofibrillary tangle staging instead of a simple positive or negative classification. Four visual read classifications have been proposed: \"no uptake,\" \"medial temporal lobe (MTL) only,\" \"MTL AND,\" and \"outside MTL.\" As an adjunct to visual interpretation, quantitative analysis has been proposed using MRI-based native space FreeSurfer parcellations. The standardized uptake value ratio of the target area is measured using the cerebellar gray matter as a reference region. In the near future, the Centiloid scale of tau PET is expected to be used as a harmonized value for standardizing each analytical method or PET ligand used, similar to amyloid PET.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"69 2","pages":"85-93"},"PeriodicalIF":0.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/79/2185-4610-69-085.PMC10480511.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10530203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of student self-assessment and teacher assessment of medical interview performance during bedside learning. 床边学习中学生自我评价与教师医学访谈绩效评价的比较。

IF 0.8

Fukushima Journal of Medical Science Pub Date : 2023-04-05 DOI: 10.5387/fms.2023-03

Zunyi Tang, Yayoi Shikama, Koji Otani

引用次数: 1

Four cases of pseudomyxoma peritonei with ovarian tumors at our hospital. 本院腹膜假性黏液瘤合并卵巢肿瘤4例。

IF 0.8

Fukushima Journal of Medical Science Pub Date : 2023-04-05 DOI: 10.5387/fms.2022-41

Riho Yazawa, Hiroyuki Yazawa, Kaoru Fukuda, Miki Ohara, Fumihiko Osuka

{"title":"Four cases of pseudomyxoma peritonei with ovarian tumors at our hospital.","authors":"Riho Yazawa, Hiroyuki Yazawa, Kaoru Fukuda, Miki Ohara, Fumihiko Osuka","doi":"10.5387/fms.2022-41","DOIUrl":"https://doi.org/10.5387/fms.2022-41","url":null,"abstract":"We describe four cases of pseudomyxoma peritonei (PMP) that were diagnosed and treated at our hospital.Case 1: A 26-year-old woman with a large multicystic ovarian tumor and massive ascites was diagnosed with PMP originating from a borderline mucinous ovarian tumor. She underwent fertility-preserving staging laparotomy and was treated with three courses of intraperitoneal chemotherapy. There has been no recurrence in the 15 years since her first operation. Case 2: A 72-year-old woman with a giant ovarian tumor and massive ascites was diagnosed with PMP originating from low-grade appendiceal mucinous neoplasm (LAMN). After laparotomy, the patient was managed conservatively because she did not want aggressive treatment. She has remained asymptomatic with a small amount of ascites for 3 years. Case 3: A 82-year-old woman with ovarian tumors, massive ascites, and suspected PMP underwent emergency laparotomy due to appendiceal perforation and pan-peritonitis. She was diagnosed with PMP originating from LAMN. She has remained asymptomatic with a small amount of ascites for 2 years. Case 4: A 42-year-old woman with multicystic ovarian tumors and massive ascites underwent laparotomy. She was diagnosed with PMP originating from LAMN. Since multidisciplinary treatment was indicated and desired, the patient was referred to a specialized facility where cytoreductive surgery and hyperthermic intraperitoneal chemotherapy was performed. The patient has done well since the treatment.Although most cases of PMP originate from mucinous tumors of the appendix, female patients with PMP often present with ovarian tumors and are commonly referred to gynecology clinics. It is therefore important for gynecologists to be familiar with PMP and to be able to diagnose it accurately and select the most suitable management including multidisciplinary treatments.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"69 1","pages":"57-65"},"PeriodicalIF":0.8,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e3/9e/2185-4610-69-057.PMC10122967.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9698734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0