Fukushima Journal of Medical Science最新文献_第7页

Evaluation and treatment of constipation in pregnancy:Examination using the Japanese version of the constipation evaluation scale. 孕期便秘的评估和治疗：使用日文版便秘评估量表进行检查。

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Fukushima Journal of Medical Science Pub Date : 2024-01-27 Epub Date: 2024-01-25 DOI: 10.5387/fms.2023-25

Makiho Ishibashi, Fumie Hashimoto, Yoshihiro Kouchi, Karin Imaizumi, Fumihiro Ito, Shun Yasuda

{"title":"Evaluation and treatment of constipation in pregnancy:Examination using the Japanese version of the constipation evaluation scale.","authors":"Makiho Ishibashi, Fumie Hashimoto, Yoshihiro Kouchi, Karin Imaizumi, Fumihiro Ito, Shun Yasuda","doi":"10.5387/fms.2023-25","DOIUrl":"10.5387/fms.2023-25","url":null,"abstract":"Objectives: No study has examined the effects of new constipation treatment drugs released in recent years in pregnant women. This prospective cohort study aimed to examine and compare the perinatal prognosis, efficacy rate, and safety of drugs frequently used to treat constipation.Methods: The study included 211 perinatally managed individuals who answered a self-administered questionnaire during the second trimester and after delivery. The Japanese version of the constipation evaluation scale (Constipation Assessment Scale [CAS] long-term [LT] version) was used for the subjective evaluation of defecation status.Results: Participants aware of constipation had significantly higher CAS scores than those who were unaware. Some participants with a CAS score of 5 points (treatment range) had no subjective symptoms of constipation, whereas some participants with a CAS score of ≤ 5 points were aware of constipation. Regarding the time of onset, 60% of those who had constipation before pregnancy had a high rate of constipation during pregnancy and after delivery. No significant difference was noted in conventional magnesium oxide and polyethylene glycol, a relatively new daily treatment drug, in perinatal prognosis or side effects.Conclusions: Polyethylene glycol preparations alleviate constipation without inducing diarrhea, making them an appropriate therapeutic option for pregnant women.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"35-47"},"PeriodicalIF":0.8,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10867430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139547467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTED ARTICLE. 被撤回的文章。

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Fukushima Journal of Medical Science Pub Date : 2024-01-27 Epub Date: 2024-01-25 DOI: 10.5387/fms.retraction

引用次数: 0

2022 Fukushima Medical University International Symposium on the Fukushima Health Management Survey Build Back Better, Together. "Science for Society: Advancing Fukushima's Well-Being". 2022 福岛医科大学 "福岛健康管理调查 "国际研讨会携手重建美好家园。"科学为社会服务：推进福岛的福祉"。

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Fukushima Journal of Medical Science Pub Date : 2024-01-01 DOI: 10.5387/fms.24-00006

Masaharu Tsubokura, Kenji Kamiya

{"title":"2022 Fukushima Medical University International Symposium on the Fukushima Health Management Survey Build Back Better, Together. \"Science for Society: Advancing Fukushima's Well-Being\".","authors":"Masaharu Tsubokura, Kenji Kamiya","doi":"10.5387/fms.24-00006","DOIUrl":"10.5387/fms.24-00006","url":null,"abstract":"The Fukushima Medical University (FMU) International Symposium on the Fukushima Health Management Survey (FHMS) convened for the fourth time in March 2022 to share FHMS findings within Fukushima and beyond. Dr. TAKENOSHITA Seiichi, FMU President, underscored Fukushima's restoration journey, while Governor UCHIBORI Masao committed to partnering with FMU for residents' welfare.The Introduction by Dr. KAMIYA Kenji highlighted FHMS results for more than 460,000 participants, of whom 99.8% were exposed to radiation doses below 5 mSv post-accident. Thyroid examinations detected tumors, but no dose-response relationship was found. The Comprehensive Health Check showed increased lifestyle-related diseases among evacuees, with improvements in some health markers. Mental health issues initially prevalent after the accident decreased over time, and perinatal outcomes were consistent with national data.Session 1 focused on radiation effects in Fukushima. The UNSCEAR 2020 Report indicated significantly reduced radiation exposure estimates and negligible cancer risks. Studies from Hiroshima, Nagasaki, and Chernobyl found no radiation-induced genetic effects.Session 2 explored post-disaster well-being, emphasizing the evolution of psychological responses. Practices like Psychological First Aid (PFA) and emotional resilience promotion were highlighted. Katsurao Village's post-evacuation health measures addressed lifestyle diseases, but faced challenges. The WHO framework for mental health and psychosocial support in nuclear emergencies emphasized the importance of mental health care throughout all disaster phases.The symposium facilitated valuable insights, underlining comprehensive health strategies and the significance of long-term studies for Fukushima's recovery and health management.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"70 2","pages":"103-106"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2023 Fukushima Medical University International Symposium on the Fukushima Health Management Survey, "Thinking Together about Health, Life, and our Future in Fukushima". 2023 年福岛医科大学福岛健康管理调查国际研讨会，"共同思考福岛的健康、生活和我们的未来"。

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Fukushima Journal of Medical Science Pub Date : 2024-01-01 DOI: 10.5387/fms.24-00007

Michio Shimabukuro, Kenji Kamiya

引用次数: 0

Development of a novel artificial intelligence algorithm to detect pulmonary nodules on chest radiography. 开发一种新的人工智能算法，用于在胸部造影中检测肺结节。

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Fukushima Journal of Medical Science Pub Date : 2023-11-15 Epub Date: 2023-10-17 DOI: 10.5387/fms.2023-14

Mitsunori Higuchi, Takeshi Nagata, Kohei Iwabuchi, Akira Sano, Hidemasa Maekawa, Takayuki Idaka, Manabu Yamasaki, Chihiro Seko, Atsushi Sato, Junzo Suzuki, Yoshiyuki Anzai, Takashi Yabuki, Takuro Saito, Hiroyuki Suzuki

{"title":"Development of a novel artificial intelligence algorithm to detect pulmonary nodules on chest radiography.","authors":"Mitsunori Higuchi, Takeshi Nagata, Kohei Iwabuchi, Akira Sano, Hidemasa Maekawa, Takayuki Idaka, Manabu Yamasaki, Chihiro Seko, Atsushi Sato, Junzo Suzuki, Yoshiyuki Anzai, Takashi Yabuki, Takuro Saito, Hiroyuki Suzuki","doi":"10.5387/fms.2023-14","DOIUrl":"10.5387/fms.2023-14","url":null,"abstract":"Background: In this study, we aimed to develop a novel artificial intelligence (AI) algorithm to support pulmonary nodule detection, which will enable physicians to efficiently interpret chest radiographs for lung cancer diagnosis.Methods: We analyzed chest X-ray images obtained from a health examination center in Fukushima and the National Institutes of Health (NIH) Chest X-ray 14 dataset. We categorized these data into two types: type A included both Fukushima and NIH datasets, and type B included only the Fukushima dataset. We also demonstrated pulmonary nodules in the form of a heatmap display on each chest radiograph and calculated the positive probability score as an index value.Results: Our novel AI algorithms had a receiver operating characteristic (ROC) area under the curve (AUC) of 0.74, a sensitivity of 0.75, and a specificity of 0.60 for the type A dataset. For the type B dataset, the respective values were 0.79, 0.72, and 0.74. The algorithms in both the type A and B datasets were superior to the accuracy of radiologists and similar to previous studies.Conclusions: The proprietary AI algorithms had a similar accuracy for interpreting chest radiographs when compared with previous studies and radiologists. Especially, we could train a high quality AI algorithm, even with our small type B data set. However, further studies are needed to improve and further validate the accuracy of our AI algorithm.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"177-183"},"PeriodicalIF":0.8,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing allogeneic CD4⁺ T cells to reinvigorate host endogenous antitumor immunity. 利用同种异体CD4+T细胞重振宿主内源性抗肿瘤免疫。

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Fukushima Journal of Medical Science Pub Date : 2023-11-15 Epub Date: 2023-10-26 DOI: 10.5387/fms.23-00001

Kazuhiro Mochizuki

{"title":"Harnessing allogeneic CD4+ T cells to reinvigorate host endogenous antitumor immunity.","authors":"Kazuhiro Mochizuki","doi":"10.5387/fms.23-00001","DOIUrl":"10.5387/fms.23-00001","url":null,"abstract":"Immune checkpoint blockade (ICB) therapies developed over the past decade have been among the most promising approaches for the treatment of patients with advanced cancers. However, the overall objective response rate of ICB therapy for various cancers remains insufficient. Hence, novel strategies are required to improve the efficacy of immunotherapy for advanced cancers. The graft-versus-tumor (GVT) effect, which reflects strong antitumor immunity, is known to occur after allogeneic hematopoietic stem cell transplantation (HSCT). The GVT effect is mainly caused by transplanted donor lymphocytes that recognize and react to distinct alloantigens on tumor cells. In contrast, transplanted allogeneic cells can, in some instances, induce endogenous antitumor immunity in recipients if the graft has been rejected. Because of this ability, allogeneic cells have also been used to induce endogenous antitumor immunity without HSCT, and their beneficial immune response is referred to as the \"allogenic effect.\" Here, we review the usefulness of allogeneic cells, particularly allogeneic CD4+ T cells, in cancer immunotherapy by highlighting their unique potential to induce host endogenous antitumor immunity.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"157-165"},"PeriodicalIF":0.8,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytokine profiles in an extremely preterm infant with congenital syphilis. 患有先天性梅毒的极早产儿的细胞因子谱。

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Fukushima Journal of Medical Science Pub Date : 2023-11-15 Epub Date: 2023-09-28 DOI: 10.5387/fms.2023-06

Eisuke Fukama, Tomoaki Nomura, Daisuke Hatanaka, Michiko Kusakari, Hidehiro Takahashi, Toshihiko Nakamura, Naoto Takahashi

引用次数: 0

A case of delayed postoperative bleeding after excision of endometrial polyp using resectoscope in an infertile woman with von Willebrand disease:a case report and literature review. 一例患有von Willebrand病的不孕妇女在子宫内膜息肉切除术后延迟出血的病例报告和文献复习。

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Fukushima Journal of Medical Science Pub Date : 2023-11-15 Epub Date: 2023-10-17 DOI: 10.5387/fms.2023-04

Chihiro Okoshi, Toshifumi Takahashi, Masahiko Fukatsu, Ryota Suganuma, Takayuki Ikezoe, Keiya Fujimori

{"title":"A case of delayed postoperative bleeding after excision of endometrial polyp using resectoscope in an infertile woman with von Willebrand disease:a case report and literature review.","authors":"Chihiro Okoshi, Toshifumi Takahashi, Masahiko Fukatsu, Ryota Suganuma, Takayuki Ikezoe, Keiya Fujimori","doi":"10.5387/fms.2023-04","DOIUrl":"10.5387/fms.2023-04","url":null,"abstract":"Von Willebrand disease (VWD) is a bleeding disorder caused by a congenital quantitative reduction, deficiency, or qualitative abnormality of the von Willebrand factor (VWF). Here, we report a case of delayed postoperative bleeding in an infertile woman with endometrial polyps complicated by VWD. The patient was a 39-year-old infertile woman with type 2A VWD. At 38 years of age, she was referred to our hospital for infertility and heavy menstrual bleeding. Hysteroscopy revealed a 15-mm polyp lesion in the uterus. The patient was scheduled for transcervical resection (TCR) of the endometrial polyp. Gonadotropin-releasing hormone agonists were preoperatively administered to prevent menstruation. The VWF-containing concentrate was administered for 3 days according to guidelines. The patient was discharged on postoperative day 3 after confirming the absence of uterine bleeding. Uterine bleeding began on postoperative day 6. The patient was readmitted on postoperative day 7 and treated with VWF-containing concentrate for 5 days, after which hemostasis was confirmed. TCR surgery for endometrial lesions is classified as a minor surgery, and guidelines recommend short-term VWF-containing concentrate replacement. However, it should be kept in mind that only short-term VWF-containing concentrate replacement may cause rebleeding postoperatively.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"197-204"},"PeriodicalIF":0.8,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension:its history and development, and regional medical cooperation in Fukushima. 球囊肺血管成形术治疗慢性血栓栓塞性肺动脉高压：其历史和发展，以及福岛地区的医疗合作。

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Fukushima Journal of Medical Science Pub Date : 2023-11-15 Epub Date: 2023-09-28 DOI: 10.5387/fms.2023-09

Kazuhiko Nakazato, Koichi Sugimoto, Masayoshi Oikawa, Yasuchika Takeishi

{"title":"Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension:its history and development, and regional medical cooperation in Fukushima.","authors":"Kazuhiko Nakazato, Koichi Sugimoto, Masayoshi Oikawa, Yasuchika Takeishi","doi":"10.5387/fms.2023-09","DOIUrl":"10.5387/fms.2023-09","url":null,"abstract":"Chronic thromboembolic pulmonary hypertension (CTEPH) is designated as an intractable disease by the Ministry of Health, Labour and Welfare of Japan, and has an extremely poor prognosis if untreated. Surgical pulmonary endarterectomy is the curative treatment for cases in which the organized thrombi are located in the central part of the pulmonary artery, but there had been no effective treatment for cases in which the thrombi are located in the peripheral part of the pulmonary artery. Recently, balloon pulmonary angioplasty (BPA), a transcatheter procedure to dilate stenotic or occluded lesions in the peripheral pulmonary artery, has been rapidly developed. Although BPA was once a globally abandoned procedure due to hemorrhagic complications, Japanese experts have improved the technique, and its safety and efficacy have been enhanced. As a result, BPA is now being reevaluated worldwide. This review describes the history and development of BPA in the treatment of CTEPH, as well as the status of this treatment in Fukushima Prefecture.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"167-176"},"PeriodicalIF":0.8,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41137171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal septic shock due to Acinetobacter lwoffii infection:a case report. lwoffii不动杆菌感染致产妇感染性休克一例报告。

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Fukushima Journal of Medical Science Pub Date : 2023-11-15 Epub Date: 2023-09-28 DOI: 10.5387/fms.2022-43

Hirotaka Isogami, Misa Sugeno, Karin Imaizumi, Toma Fukuda, Norihito Kamo, Shun Yasuda, Akiko Yamaguchi, Keiya Fujimori

{"title":"Maternal septic shock due to Acinetobacter lwoffii infection:a case report.","authors":"Hirotaka Isogami, Misa Sugeno, Karin Imaizumi, Toma Fukuda, Norihito Kamo, Shun Yasuda, Akiko Yamaguchi, Keiya Fujimori","doi":"10.5387/fms.2022-43","DOIUrl":"10.5387/fms.2022-43","url":null,"abstract":"The incidence of Acinetobacter infections has increased in recent years. Acinetobacter infections are resistant to most antibiotics and can be found in hospitalized patients. Pregnancies complicated by severe sepsis or septic shock are associated with a higher rate of preterm labor and delivery, fetal infection, and operative delivery. This case report describes septic shock due to Acinetobacter lwoffii infection in the 31st week of gestation. A 47-year-old woman, with a gestation of 31 weeks and one day, presented with a fever, and signs of bacterial infection on laboratory tests. Although the patient was started on tazobactam/piperacillin, she went into septic shock, and was transferred to our hospital. Cesarean section was performed at a gestation of 31 weeks and 4 days because of severe maternal pneumonia and non-reassuring fetal status. A. lwoffii was detected in blood cultures collected at the previous hospital, and susceptibility to piperacillin and meropenem to A. lwoffii was confirmed. The pneumonia responded to antibiotic treatment and there were no findings of infection in the neonate. Maternal sepsis is an infrequent but important complication, causing significant maternal and fetal morbidity and fetal and neonatal mortality; therefore, early antibiotic therapy is required to improve the clinical outcome.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"191-196"},"PeriodicalIF":0.8,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41177243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0