Fukushima Journal of Medical Science最新文献_第7页

Population analysis of oseltamivir-resistant variants for the rapid prediction of drug susceptibility by real-time reverse transcription polymerase chain reaction. 实时逆转录聚合酶链反应快速预测奥司他韦耐药变异的群体分析。

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Fukushima Journal of Medical Science Pub Date : 2022-12-21 DOI: 10.5387/fms.2022-15

Masatoki Sato, Koichi Hashimoto, Mitsuaki Hosoya

{"title":"Population analysis of oseltamivir-resistant variants for the rapid prediction of drug susceptibility by real-time reverse transcription polymerase chain reaction.","authors":"Masatoki Sato, Koichi Hashimoto, Mitsuaki Hosoya","doi":"10.5387/fms.2022-15","DOIUrl":"https://doi.org/10.5387/fms.2022-15","url":null,"abstract":"This study investigated whether quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), using specific probes composed of locked nucleic acids (LNA/qRT-PCR), designed to evaluate H1N1 pdm09 H275Y, H3N2 E119V and R292K variant populations, could replace a neuraminidase (NA) inhibition assay to determine the 50% inhibitory concentration (IC50) of NA activity.For H1N1 pdm09, when the H275Y variant RNA load was 50% or 70% and the infective H275Y variant load was 40% or 70%, the IC50 were >10- and 100-fold higher, respectively, than that of the wild-type (WT) strain. For H3N2, when the E119V RNA load and infective E119V variant load were >90% and >60%, respectively, the IC50 of the mixed sample was >10-fold higher than that of the WT strain. The variant-mixed samples with a 70% or 80% R292K variant RNA load and a 60% or 70% infective R292K variant load exhibited >10- and 100-fold decreased susceptibility, respectively, compared with that of the WT. A positive correlation between the variant RNA load and infective variant load populations was observed.The LNA/qRT-PCR method can be used to improve the treatment and management of patients during antiviral therapy for influenza virus infection.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 3","pages":"153-159"},"PeriodicalIF":0.8,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/29/2185-4610-68-153.PMC9840889.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10606472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between the presence of bacteria in prostate tissue and histopathology in biopsies from men not complaining of lower urinary tract symptoms. 前列腺组织中细菌的存在与没有下尿路症状的男性活检组织病理学之间的关系

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Fukushima Journal of Medical Science Pub Date : 2022-12-21 DOI: 10.5387/fms.2022-34

Ruriko Honda-Takinami, Junya Hata, Kanako Matsuoka, Seiji Hoshi, Tomoyuki Koguchi, Yuichi Sato, Hidenori Akaihata, Masao Kataoka, Soichiro Ogawa, Kyoko Nishiyama, Tatsuo Suzutani, Yoshiyuki Kojima

{"title":"Association between the presence of bacteria in prostate tissue and histopathology in biopsies from men not complaining of lower urinary tract symptoms.","authors":"Ruriko Honda-Takinami, Junya Hata, Kanako Matsuoka, Seiji Hoshi, Tomoyuki Koguchi, Yuichi Sato, Hidenori Akaihata, Masao Kataoka, Soichiro Ogawa, Kyoko Nishiyama, Tatsuo Suzutani, Yoshiyuki Kojima","doi":"10.5387/fms.2022-34","DOIUrl":"https://doi.org/10.5387/fms.2022-34","url":null,"abstract":"Objective: To investigate the presence of bacteria in prostate tissue, and relationships between the bacteria and histopathological findings.Methods: Samples were collected from prostate biopsy patients with no obvious lower urinary tract symptoms (LUTS). Detection and identification of bacterial species in the prostate tissues were performed with PCR for 16SrDNA and DNA sequencing. Histopathology was also evaluated. LUTS and lower urinary tract function were assessed by questionnaires, uroflowmetry, and ultrasonography.Results: DNA was extracted from 97 prostate biopsies, with 5 bacterial species detected among samples from 7 patients (7.2%). The stroma-to-gland ratio in the prostate tissues from patients with bacteria was lower than in those without bacteria (p < 0.01). Glandular epithelial hyperplasia was also identified in the prostates harboring bacteria. International Prostate Symptom Score (IPSS), IPSS-quality of life (IPSS-QOL), Overactive Bladder Symptom Score (OABSS), maximum flow rate, urine volume by uroflowmetry, and post-voided residual urine were not significantly different when comparing patients with and without bacteria in their prostate samples.Conclusions: The present study demonstrated that 7.2% of men without obvious LUTS had bacteria in their prostate tissues. The presence of such bacteria might induce glandular hyperplasia and contribute to pathological changes in the early stages of benign prostate enlargement before affecting LUTS.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 3","pages":"161-167"},"PeriodicalIF":0.8,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/df/9b/2185-4610-68-161.PMC9840884.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10611125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A neonatal case of an elongated soft palate. 新生儿软腭拉长一例。

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Fukushima Journal of Medical Science Pub Date : 2022-12-21 DOI: 10.5387/fms.2022-19

Kana Ito, Toshihiko Nakamura, Daisuke Hatanaka, Hisaya Hasegawa

引用次数: 0

Temperature management for deliberate mild hypothermia during neurosurgical procedures. 神经外科手术过程中故意轻度低温的温度管理。

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Fukushima Journal of Medical Science Pub Date : 2022-12-21 DOI: 10.5387/fms.2022-28

Satoki Inoue

{"title":"Temperature management for deliberate mild hypothermia during neurosurgical procedures.","authors":"Satoki Inoue","doi":"10.5387/fms.2022-28","DOIUrl":"https://doi.org/10.5387/fms.2022-28","url":null,"abstract":"Deliberate mild hypothermia is safer from the point of view of adverse events and does not require a specific technique, unlike deep or moderate hypothermia. Therefore, mild hypothermia was widely used for neurosurgical procedures. Unfortunately, the neuroprotective efficacy of intraoperative mild hypothermia has not yet been proven; however, temperature management for intraoperative deliberate mild hypothermia has been improved over the past two decades. It is very important to achieve mild hypothermia before the commencement of the main surgery, and to maintain the patient's body temperature until the procedure is completed. In addition, it is also important to complete rewarming by the end of the surgery so that an accurate neurological evaluation can be made. Regarding the effects of mild hypothermia on outcomes, a large randomized controlled study reported that unfavorable outcomes did not differ between participants with or without hypothermia. Apart from these unfavorable outcomes, it is known that temperature management during deliberate intraoperative mild hypothermia has contributed to improvement of anesthesia practice. The accumulation of experience in this field is important. Clinical interest in deliberate mild hypothermia is currently low; however, anesthesiologists should be prepared for the time when it is required again in the future.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 3","pages":"143-151"},"PeriodicalIF":0.8,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4e/14/2185-4610-68-143.PMC9840888.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10602342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Successful management of unstable angina in a ravulizumab-treated patient with paroxysmal nocturnal hemoglobinuria. 雷夫利单抗治疗的阵发性夜间血红蛋白尿患者不稳定型心绞痛的成功治疗。

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Fukushima Journal of Medical Science Pub Date : 2022-12-21 DOI: 10.5387/fms.2022-16

Hiroshi Takahashi, Hirotaka Mori, Masahiko Fukatsu, Takahiro Sano, Kayo Harada, Masayoshi Oikawa, Yasuchika Takeishi, Satoshi Kimura, Hiroshi Ohkawara, Tsutomu Shichishima, Takayuki Ikezoe

引用次数: 0

Successful management of pelvic recurrence of MSI-High endometrial cancer by total pelvic exenteration followed by administration of pembrolizumab:A case report. 全盆腔切除术后给予派姆单抗成功治疗msi -高子宫内膜癌盆腔复发:一例报告。

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Fukushima Journal of Medical Science Pub Date : 2022-12-21 DOI: 10.5387/fms.2022-10

Manabu Kojima, Shu Soeda, Chikako Okabe, Tetsu Sato, Norihito Kamo, Makiko Ueda, Yuta Endo, Shinji Nomura, Emi Tokuda, Shigenori Furukawa, Masao Kataoka, Shotaro Fujita, Shigehira Saji, Takafumi Watanabe, Keiya Fujimori

{"title":"Successful management of pelvic recurrence of MSI-High endometrial cancer by total pelvic exenteration followed by administration of pembrolizumab:A case report.","authors":"Manabu Kojima, Shu Soeda, Chikako Okabe, Tetsu Sato, Norihito Kamo, Makiko Ueda, Yuta Endo, Shinji Nomura, Emi Tokuda, Shigenori Furukawa, Masao Kataoka, Shotaro Fujita, Shigehira Saji, Takafumi Watanabe, Keiya Fujimori","doi":"10.5387/fms.2022-10","DOIUrl":"https://doi.org/10.5387/fms.2022-10","url":null,"abstract":"Surgery can be curative treatment for pelvic locoregional recurrence of endometrial cancer; however, a cure is contingent on complete resection. Here, we report the case of a patient in whom recurrent endometrial tumor remained in the pelvis after resection; long-term control was achieved with postoperative administration of pembrolizumab.The patient had recurrent endometrial cancer of stage IA and was treated with chemotherapy and radiation, but tumor persisted in the pelvic cavity. We therefore attempted total pelvic exenteration, but the tumor was adherent to the pelvic wall and complete resection could not be achieved. However, postoperative administration of pembrolizumab controlled the residual tumor for more than two years without regrowth. We believe that since the resected tumor was MSI-High, the residual tumor responded well to pembrolizumab. It is not known whether cytoreductive surgery contributes to a long-term response to pembrolizumab, but at least in our patient, pembrolizumab appeared to be a very effective drug therapy for MSI-High endometrial cancer that was refractory to chemotherapy and radiotherapy.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 3","pages":"191-195"},"PeriodicalIF":0.8,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/18/fc/2185-4610-68-191.PMC9840885.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9162717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinical features of neck and shoulder pain (Katakori) in Japanese hospital workers 日本医院工作人员颈肩痛的临床特征

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Fukushima Journal of Medical Science Pub Date : 2022-06-03 DOI: 10.5387/fms.2022-02

Akira Onda, Keiko Onozato, Masashi Kimura

{"title":"Clinical features of neck and shoulder pain (Katakori) in Japanese hospital workers","authors":"Akira Onda, Keiko Onozato, Masashi Kimura","doi":"10.5387/fms.2022-02","DOIUrl":"https://doi.org/10.5387/fms.2022-02","url":null,"abstract":"Abstract Background: Non-specific pain or discomfort in the neck and shoulder girdle, called katakori in Japanese, is a common, chronic musculoskeletal condition worldwide. However, its various clinical features are incompletely characterized, even among medical professionals. We aimed to clarify factors affecting katakori and to investigate objectively the associated neck muscle stiffness and skeletal muscle volume. Methods: All staff members at our private hospital were surveyed about their lifestyle, physical and mental status, and katakori symptoms, using a self-administered questionnaire. Multiple logistic regression analysis was used to explore possible katakori risk factors. On secondary assessment, ultrasound elastography of the trapezius muscle as well as limb/trunk muscle mass were compared between subjects with severe symptoms and subjects without katakori, using propensity score matching. Results: Of 359 participants enrolled, nearly 75% had katakori to some degree. Spending time on a computer during work (adjusted odds ratio [aOR]: 1.82 for 3-6 hours, aOR: 2.48 for > 6 hours), being female (aOR: 3.75), and having unsatisfactory sleep (aOR: 2.92) were potential risk factors for katakori. Comparison of 13 matched pairs showed a significantly stiffer trapezius in subjects with severe katakori symptoms, but no apparent differences in limb/trunk muscle mass. Conclusions: Katakori was particularly prevalent in our hospital staff. Possible risk factors for disabling katakori were doing long-term computer work, being female, and having unsatisfactory sleep. Symptoms seem to be associated with elevated neck muscle stiffness. These findings could guide working condition improvements to mitigate katakori.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 1","pages":"79 - 87"},"PeriodicalIF":0.8,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48563471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A case of spontaneous parasitic myoma in a patient without a history of myomectomy treated laparoscopically 无子宫肌瘤切除术史的自发性寄生虫肌瘤1例

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Fukushima Journal of Medical Science Pub Date : 2022-06-01 DOI: 10.5387/fms.2022-08

H. Kyozuka, Toki Jin, Misa Sugeno, Katsunori Kuratsune, Hiroki Ando, Fumihiro Ito, H. Odajima, Daisuke Suzuki, Y. Nomura

引用次数: 1

Home-visit rehabilitation in a repopulated village after the Fukushima nuclear disaster 福岛核灾难后一个人口稠密的村庄的家访康复

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Fukushima Journal of Medical Science Pub Date : 2022-05-19 DOI: 10.5387/fms.2021-30

Y. Saito, Keiichiro Sato, Tatsuya Itagaki, F. Omata, T. Sawano, Y. Kobashi, Y. Nishikawa, M. Tsubokura, Wataru Hoshi

{"title":"Home-visit rehabilitation in a repopulated village after the Fukushima nuclear disaster","authors":"Y. Saito, Keiichiro Sato, Tatsuya Itagaki, F. Omata, T. Sawano, Y. Kobashi, Y. Nishikawa, M. Tsubokura, Wataru Hoshi","doi":"10.5387/fms.2021-30","DOIUrl":"https://doi.org/10.5387/fms.2021-30","url":null,"abstract":"Abstract Following the evacuation of areas affected by Japan’s 2011 Fukushima Daiichi Nuclear Power Plant (FDNPP) accident, Kawauchi Village was one of the first municipalities repopulated. Although rehabilitation resources were limited, a healthcare facility near the municipality initiated home-visit rehabilitation in 2016. To the best of our knowledge, reports of home-visit rehabilitation in repopulated villages that were evacuated following a nuclear accident are lacking. This article describes a case study of home-visit rehabilitation in Kawauchi Village. The purpose of this study was to explore how users of home-visit rehabilitation services in Kawauchi Village perceive home-visit rehabilitation, and whether it had a positive impact on their daily life. A questionnaire survey was conducted, and their ability to perform activities of daily living was assessed, to understand the living conditions of the visiting-rehabilitation service users. We studied 10 rehabilitation-service users, with a mean age of 86.8 years, who had used the services for an average of 591.4 days. Themes that emerged from the open-ended questionnaire were “established exercise habits and improved physical functions,” “the joy of returning to the village,” “challenges in the mountainous areas” and “changes in relationships due to the earthquake or evacuation.” In conclusion, home-visit rehabilitation was successfully implemented in the repopulated village, and helped maintain the users’ physical functions. This may thus be a viable choice for rehabilitation care in repopulated areas after disasters.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 1","pages":"71 - 77"},"PeriodicalIF":0.8,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45640894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Introduction and utility of resuscitative endovascular balloon occlusion of the aorta for cases with a potential high risk of postpartum hemorrhage: A single tertiary care center experience of two cases 介绍和应用复苏血管内球囊闭塞主动脉的病例与潜在的产后出血的高风险:一个单一的三级保健中心的经验，两例

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Fukushima Journal of Medical Science Pub Date : 2022-04-20 DOI: 10.5387/fms.2022-01

H. Kyozuka, Misa Sugeno, Tsuyoshi Murata, Toki Jin, Fumihiro Ito, Y. Nomura, T. Hirano, K. Shinohara, Daisuke Suzuki, T. Ishida

{"title":"Introduction and utility of resuscitative endovascular balloon occlusion of the aorta for cases with a potential high risk of postpartum hemorrhage: A single tertiary care center experience of two cases","authors":"H. Kyozuka, Misa Sugeno, Tsuyoshi Murata, Toki Jin, Fumihiro Ito, Y. Nomura, T. Hirano, K. Shinohara, Daisuke Suzuki, T. Ishida","doi":"10.5387/fms.2022-01","DOIUrl":"https://doi.org/10.5387/fms.2022-01","url":null,"abstract":"Abstract Postpartum hemorrhage is an important obstetric complication and the leading cause of maternal mortality worldwide. Occasionally, we encounter unexpected massive postpartum hemorrhage diagnosed for the first time after delivery. Therefore, it is essential to pay attention to patients with a high risk of postpartum hemorrhage. The authors report two cases of patients at high risk of postpartum hemorrhage that were successfully managed by resuscitative endovascular balloon occlusion of the aorta before cesarean section. Case 1: A 32-year-old woman with a history of cesarean section and who conceived using assisted reproductive technology was diagnosed with partial placenta previa at 25 weeks of gestation. Because of tocolysis failure, emergent cesarean section with resuscitative endovascular balloon occlusion of the aorta was performed at 36 weeks of gestation. Natural placental resorption was observed. She was discharged at 5 days after delivery without significant hemorrhage. Case 2: A 41-year-old woman with suspected placenta accreta spectrum due to a cesarean scar pregnancy was referred to our hospital at 33 weeks of gestation. A planned cesarean section with resuscitative endovascular balloon occlusion of the aorta was conducted at 37 weeks of gestation. There was no visual evidence of abnormal placental invasion of the myometrium, and natural placental resorption was observed. She was discharged at 5 days after delivery without significant hemorrhage.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":"68 1","pages":"117 - 122"},"PeriodicalIF":0.8,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42559613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3