Fukushima Journal of Medical Science最新文献_第2页

Current status of research on sarcopenia in post-treatment cancer survivors in Japan:A narrative review. 日本癌症治疗后幸存者肌肉疏松症的研究现状：叙述性综述。

IF 0.7

Fukushima Journal of Medical Science Pub Date : 2024-07-24 Epub Date: 2024-06-26 DOI: 10.5387/fms.23-00019

Keiichi Osaki, Takuya Fukushima, Katsuyoshi Suzuki, Akiho Kamimura, Saki Yanai, Shinichiro Morishita

{"title":"Current status of research on sarcopenia in post-treatment cancer survivors in Japan:A narrative review.","authors":"Keiichi Osaki, Takuya Fukushima, Katsuyoshi Suzuki, Akiho Kamimura, Saki Yanai, Shinichiro Morishita","doi":"10.5387/fms.23-00019","DOIUrl":"10.5387/fms.23-00019","url":null,"abstract":"Sarcopenia is prevalent among 11-25% of adult cancer survivors, depending on the cancer type, although the available data on post-treatment survivors in Japan are limited. If cancer patients develop cachexia, they may experience sustained weight loss as a result, ultimately leading to sarcopenia. Conversely, some patients experience post-treatment weight gain, resulting in sarcopenic obesity. Both sarcopenia and obesity elevate the risk of cardiovascular diseases and mortality; therefore, the importance of sarcopenia prevention and management is undeniable. The Guidelines for Exercise for Cancer Survivors recommend continued physical activity. Recent studies have reported the effectiveness of multimodal interventions, combining pharmacological, nutritional, and exercise approaches, necessitating multidisciplinary care for post-treatment sarcopenia. Innovative health interventions using mobile devices have also gained attention. However, studies on sarcopenia in post-treatment cancer survivors, especially those regarding exercise interventions, remain scarce in Japan, primarily due to limited insurance coverage for such post-treatment interventions and workforce challenges. It is clear that some cancer survivors have sarcopenia, which can lead to worse survival and secondary illness. While the benefits of exercise are clear, a comprehensive approach to sarcopenia is a further challenge for the future.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11330266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organ injury and its management in heart failure: Liver, kidney, and thyroid gland dysfunction. 心力衰竭的器官损伤及其处理：肝、肾和甲状腺功能障碍。

IF 0.7

Fukushima Journal of Medical Science Pub Date : 2024-07-24 Epub Date: 2024-07-13 DOI: 10.5387/fms.24-00002

Yu Sato, Akiomi Yoshihisa, Yasuchika Takeishi

引用次数: 0

Structural associations between self-perception of support and knowledge of disability characteristics of autism spectrum disorder among staff in facilities providing after-school day services. 提供课后日间服务机构的员工对自闭症谱系障碍残疾特征的自我支持感和知识之间的结构性关联。

IF 0.7

Fukushima Journal of Medical Science Pub Date : 2024-07-24 Epub Date: 2024-07-13 DOI: 10.5387/fms.23-00010

Yoshinobu Tanaka, Shigeki Kurasawa, Kazuo Ouchi, Naoyuki Oi

{"title":"Structural associations between self-perception of support and knowledge of disability characteristics of autism spectrum disorder among staff in facilities providing after-school day services.","authors":"Yoshinobu Tanaka, Shigeki Kurasawa, Kazuo Ouchi, Naoyuki Oi","doi":"10.5387/fms.23-00010","DOIUrl":"10.5387/fms.23-00010","url":null,"abstract":"Background: We constructed a hypothetical model of the knowledge of autism spectrum disorder (ASD) and self-perception of support of staff working in after-school day services to clarify structural relationships.Methods: A questionnaire survey was conducted at 194 facilities providing after-school day services in Fukushima Prefecture (October 2020), including a basic attributes questionnaire, the Literacy Scale of Characteristics of Autistic Spectrum Disorder (LS-ASD), and a staff questionnaire. We developed a hypothetical model of the relationship between self-perception and LS-ASD total scores of after-school service staff. To obtain latent variables for structural equation modeling (SEM) to confirm factor extraction and the interrelationships among variables, exploratory factor analysis was performed. SEM was used to examine the fit of the hypothetical model to the data and the relationships among variables.Results: The study included 302 staff members from 58 of 194 facilities. Four factors (Factor 1, motivation; 2, self-perception of knowledge; 3, information sharing; 4, self-confidence) were extracted. The final model showed that Factor 2 had a positive direct effect (path coefficient = 0.64) and Factor 4 had a negative direct effect (path coefficient = -0.22) on LS-ASD scores. The model goodness of fit was acceptable (Goodness-of-Fit Index = 0.890; Comparative Fit Index = 0.912; Root Mean Square Error of Approximation = 0.086; Akaike's Information Criterion = 392.7).Conclusion: Self-perception of knowledge contributes greatly to knowledge acquisition, while excessive confidence may hinder knowledge retention.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11330262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydropic leiomyoma-like ovarian tumor: a case report. 水瘤样卵巢肿瘤：病例报告。

IF 0.8

Fukushima Journal of Medical Science Pub Date : 2024-04-26 Epub Date: 2024-03-15 DOI: 10.5387/fms.2023-22

Tomoko Yamaguchi, Hyo Kyozuka, Yoshihiro Kochi, Fumihiro Ito, Hajime Odajima, Daisuke Suzuki, Yasuhisa Nomura

引用次数: 0

Investigation of walking speed and plantar pressure after chopart amputation. 髋关节截肢后行走速度和足底压力的调查。

IF 0.8

Fukushima Journal of Medical Science Pub Date : 2024-04-26 Epub Date: 2024-03-15 DOI: 10.5387/fms.23-00003

Kazuo Ouchi, Mari Sato, Yuki Kashiwabara, Mutsumi Shimazaki, Shoji Yabuki

{"title":"Investigation of walking speed and plantar pressure after chopart amputation.","authors":"Kazuo Ouchi, Mari Sato, Yuki Kashiwabara, Mutsumi Shimazaki, Shoji Yabuki","doi":"10.5387/fms.23-00003","DOIUrl":"10.5387/fms.23-00003","url":null,"abstract":"Background: In foot amputation, Chopart amputation is considered to have a high risk of deformity, and can result in poor function. We experienced a case in which Chopart amputation combined with tendon transfer and tendon lengthening was performed, and the patient was eventually able to walk independently with a foot prosthesis without experiencing deformity of the foot. We investigated walking speed and plantar pressure after Chopart amputation with and without a foot prosthesis.Case: A 78-year-old man underwent Chopart amputation with tendon transfer and tendon lengthening. As a result, he was able to stand up and walk, both while bearing weight on the heel of the affected foot, but he was unable to push off the ground using that foot. When a foot prosthesis was introduced, the patient's walking speed increased from 0.6 m/s without the prosthesis to 0.8 m/s with the prosthesis, which was an increase of 33%. The plantar pressure at the stump decreased from 129.3 N/cm2 on average without the prosthesis to 51.6 N/cm2 with the prosthesis, which was a 59% decrease. Wearing a foot prosthesis improved the patient's walking speed and decreased plantar pressure at the amputation stump.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of testicular stiffness in boys with unilateral cryptorchidism after orchiopexy by ultrasound strain elastography. 通过超声应变弹性成像评估单侧隐睾男童睾丸切除术后的睾丸硬度。

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Fukushima Journal of Medical Science Pub Date : 2024-04-26 Epub Date: 2024-03-09 DOI: 10.5387/fms.2023-19

Yuichi Sato, Yusuke Kirihana, Satoru Meguro, Ryo Tanji, Akifumi Onagi, Ruriko Honda-Takinami, Kanako Matsuoka, Seiji Hoshi, Junya Hata, Hidenori Akaihata, Soichiro Ogawa, Motohide Uemura, Yoshiyuki Kojima

{"title":"Evaluation of testicular stiffness in boys with unilateral cryptorchidism after orchiopexy by ultrasound strain elastography.","authors":"Yuichi Sato, Yusuke Kirihana, Satoru Meguro, Ryo Tanji, Akifumi Onagi, Ruriko Honda-Takinami, Kanako Matsuoka, Seiji Hoshi, Junya Hata, Hidenori Akaihata, Soichiro Ogawa, Motohide Uemura, Yoshiyuki Kojima","doi":"10.5387/fms.2023-19","DOIUrl":"10.5387/fms.2023-19","url":null,"abstract":"Purpose: We assessed the stiffness of unilateral undescended testes after orchiopexy, examining its value in tracking histopathological changes and fertility potential during postoperative follow-up. Additionally, we explored the optimal timing for surgery based on testicular stiffness.Patients and methods: Thirty-six boys who had been diagnosed with unilateral undescended testis and treated with orchiopexy were included in the study. Testicular stiffness was evaluated several times over respective follow-up periods by ultrasound strain elastography after orchiopexy. The strain ratios were measured as the ratios of the elasticities of the descended testis to those of the operated testes. The patients were divided into two groups based on the age at which they underwent orchiopexy:under < 2 years (Group A) and ≥ 2 years (Group B).Results: The mean strain ratios were 0.90 ± 0.32 and 0.92 ± 0.20 in Groups A and B, respectively. In Group A, the strain ratio was constant regardless of postoperative months (r = 0.01, p = 0.99); however, in Group B, it tended to increase with postoperative months (r = 0.42, p = 0.07).Conclusions: Evaluation of testicular stiffness may be useful for the estimation of histopathological changes and fertility potential in boys with unilateral undescended testes at follow-up appointments after orchiopexy. Our data indicate that performing orchiopexy as early as possible may be recommended to avoid testicular damage.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139724417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differentiation of ovarian serous carcinoma from ovarian clear cell carcinoma using a 10-gene signature selected by comprehensive gene expression analysis. 利用综合基因表达分析选出的 10 个基因特征区分卵巢浆液性癌和卵巢透明细胞癌。

IF 0.8

Fukushima Journal of Medical Science Pub Date : 2024-04-26 Epub Date: 2024-03-15 DOI: 10.5387/fms.23-00011

Shinji Nomura, Takafumi Watanabe, Reiko Honma, Susumu Matsukura, Emi Ito, Jun-Ichi Imai, Yuichiro Kiko, Osamu Suzuki, Yuko Hashimoto, Manabu Kojima, Shigenori Furukawa, Shu Soeda, Shinya Watanabe, Keiya Fujimori

{"title":"Differentiation of ovarian serous carcinoma from ovarian clear cell carcinoma using a 10-gene signature selected by comprehensive gene expression analysis.","authors":"Shinji Nomura, Takafumi Watanabe, Reiko Honma, Susumu Matsukura, Emi Ito, Jun-Ichi Imai, Yuichiro Kiko, Osamu Suzuki, Yuko Hashimoto, Manabu Kojima, Shigenori Furukawa, Shu Soeda, Shinya Watanabe, Keiya Fujimori","doi":"10.5387/fms.23-00011","DOIUrl":"10.5387/fms.23-00011","url":null,"abstract":"Aim: Ovarian serous carcinoma (OSC) and ovarian clear cell carcinoma (OCCC) are two major histological types of epithelial ovarian carcinoma (EOC), each with different biological features and clinical behaviors. Although immunostaining is commonly used for differential diagnosis between OSC and OCCC, correct identification of EOC with mixed-type histology is sometimes a diagnostic challenge. The aim of the present study was to explore candidate genes as potential diagnostic biomarkers that distinguish OSC from OCCC.Methods: A total of 57 surgical specimens were obtained from EOC patients who had previously undergone primary debulking surgery. Total RNAs were extracted from fresh-frozen tissues of EOC patients, and were used for comprehensive gene expression analysis using DNA microarray technology.Results: Ten candidate genes, FXYD2, TMEM101, GABARAPL1, ARG2, GLRX, RBPMS, GDF15, PPP1R3B, TOB1, and GSTM3 were up-regulated in OCCC compared to OSC. All EOC patients were divided into two groups according to hierarchical clustering using a 10-gene signature.Conclusion: Our data suggest that the 10 candidate genes would be an excellent marker for distinguishing OSC from OCCC. Furthermore, the molecular signatures of the 10 genes may enlighten us on the differences in carcinogenesis, and provide a theoretical basis for OCCC's resistance to chemotherapy in the future.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A reduction method for anterior opening displacement in thoracolumbarvertebral fractures with diffuse idiopathic skeletal hyperostosis using the skull clamp-assisted position. 弥漫性特发性骨骼增生症胸腰椎骨折患者使用颅骨钳辅助体位的前开口移位还原法。

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Fukushima Journal of Medical Science Pub Date : 2024-04-26 Epub Date: 2024-03-20 DOI: 10.5387/fms.23-00014

Hiroshi Kobayashi, Kazuyuki Watanabe, Yoshihiro Kobayashi, Kinshi Kato, Takuya Nikaido, Koji Otani, Shoji Yabuki, Shin-Ichi Konno, Yoshihiro Matsumoto

{"title":"A reduction method for anterior opening displacement in thoracolumbarvertebral fractures with diffuse idiopathic skeletal hyperostosis using the skull clamp-assisted position.","authors":"Hiroshi Kobayashi, Kazuyuki Watanabe, Yoshihiro Kobayashi, Kinshi Kato, Takuya Nikaido, Koji Otani, Shoji Yabuki, Shin-Ichi Konno, Yoshihiro Matsumoto","doi":"10.5387/fms.23-00014","DOIUrl":"10.5387/fms.23-00014","url":null,"abstract":"Diffuse idiopathic skeletal hyperostosis (DISH) frequently occurs in the spine, resulting in unstable fractures. Treating thoracolumbar fractures in patients with DISH is often difficult because the anterior opening of the vertebral body is exacerbated by dislocation in the prone position, making reduction difficult. In this study, we introduced a novel skull clamp-assisted positioning (SAP) technique. The patient is placed in a supine position with a skull clamp used in cervical spine surgery before surgery to prevent the progression of dislocation and to restore the patient's position. Using this method, the mean difference in local kyphosis angle improved from -2.9 (±8.4)° preoperatively to 10.9 (±7.7)° postoperatively. Furthermore, posterior displacement decreased from a preoperative mean of 5.5 (±4.3) mm to 0.3 (±0.7) mm postoperatively. Complications such as neurological sequelae, implant fracture, and surgical site infection were not observed through one year of postoperative follow-up. SAP may decrease invasiveness and complications. Longer-term studies and larger sample sizes are needed to establish long-term efficacy and benefits.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of metabolic parameters between oral and total parenteral nutrition in children with severe eating disorders. 严重进食障碍儿童口服营养与全肠外营养代谢参数的比较。

IF 0.8

Fukushima Journal of Medical Science Pub Date : 2024-04-09 DOI: 10.5387/fms.2023-02

Yuichi Suzuki, Shuntaro Itagaki, M. Nodera, K. Suyama, H. Yabe, M. Hosoya

{"title":"Comparison of metabolic parameters between oral and total parenteral nutrition in children with severe eating disorders.","authors":"Yuichi Suzuki, Shuntaro Itagaki, M. Nodera, K. Suyama, H. Yabe, M. Hosoya","doi":"10.5387/fms.2023-02","DOIUrl":"https://doi.org/10.5387/fms.2023-02","url":null,"abstract":"BACKGROUND\u0000This study investigated changes of lipid parameters in children with severe eating disorders during refeeding in order to explore the optimal timing for lipid preparation administration.\u0000\u0000\u0000METHODS\u0000We prospectively assessed the physical conditions of patients with eating disorders after the start of nutrition therapy. The assessments were performed at admission and at 2 and 4 weeks. Lipid metabolism was assessed based on triglyceride (TG), total cholesterol (TC), and free carnitine (FC) levels, as well as acylcarnitine/free carnitine (AC/FC) ratio.\u0000\u0000\u0000RESULTS\u0000A total of 18 patients were included. Of these, 12 and 6 received an oral diet (OD group) and total parenteral nutrition (TPN group), respectively. The mean body mass indexes at hospital admission were 12.8 kg/m2 in the OD group and 12.7 kg/m2 in the TPN group. At 2 weeks after the start of refeeding, TC, TG, and AC/FC levels were significantly lower in the TPN group than in the OD group. Other blood test results did not show any significant differences between the two groups.\u0000\u0000\u0000CONCLUSIONS\u0000Fat-free glucose-based nutrition promoted lipid metabolism over a 2-week period after the start of refeeding, suggesting that balanced energy and lipid intake are essential, even in TPN.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140725056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of metabolic parameters between oral and total parenteral nutrition in children with severe eating disorders. 严重进食障碍儿童口服营养与全肠外营养代谢参数的比较。

IF 0.8

Fukushima Journal of Medical Science Pub Date : 2024-03-22 DOI: 10.5387/fms.2023_02

Yuichi Suzuki, Shuntaro Itagaki, Maki Nodera, Kazuhide Suyama, Hirooki Yabe, Mitsuaki Hosoya

{"title":"Comparison of metabolic parameters between oral and total parenteral nutrition in children with severe eating disorders.","authors":"Yuichi Suzuki, Shuntaro Itagaki, Maki Nodera, Kazuhide Suyama, Hirooki Yabe, Mitsuaki Hosoya","doi":"10.5387/fms.2023_02","DOIUrl":"https://doi.org/10.5387/fms.2023_02","url":null,"abstract":"Background: This study investigated changes of lipid parameters in children with severe eating disorders during refeeding in order to explore the optimal timing for lipid preparation administration.Methods: We prospectively assessed the physical conditions of patients with eating disorders after the start of nutrition therapy. The assessments were performed at admission and at 2 and 4 weeks. Lipid metabolism was assessed based on triglyceride (TG), total cholesterol (TC), and free carnitine (FC) levels, as well as acylcarnitine/free carnitine (AC/FC) ratio.Results: A total of 18 patients were included. Of these, 12 and 6 received an oral diet (OD group) and total parenteral nutrition (TPN group), respectively. The mean body mass indexes at hospital admission were 12.8 kg/m2 in the OD group and 12.7 kg/m2 in the TPN group. At 2 weeks after the start of refeeding, TC, TG, and AC/FC levels were significantly lower in the TPN group than in the OD group. Other blood test results did not show any significant differences between the two groups.Conclusions: Fat-free glucose-based nutrition promoted lipid metabolism over a 2-week period after the start of refeeding, suggesting that balanced energy and lipid intake are essential, even in TPN.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140207844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0