Fukushima Journal of Medical Science最新文献_第2页

2025 Fukushima Medical University International Symposium on the Fukushima Health Management Survey, "Fukushima's lessons for the future: promoting health and responding to disasters." 2025年福岛医科大学福岛健康管理调查国际研讨会，“福岛对未来的教训：促进健康和应对灾害。”

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Fukushima Journal of Medical Science Pub Date : 2026-04-01 Epub Date: 2026-03-25 DOI: 10.5387/fms.25-00047

Hiroki Shimura, Seiji Yasumura

引用次数: 0

Fundamental study of digital subtraction angiography using dose characteristic analysis of different protocols in lower limb arterial disease. 数字减影血管造影在下肢动脉疾病不同治疗方案剂量特征分析中的基础研究。

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Fukushima Journal of Medical Science Pub Date : 2026-04-01 Epub Date: 2025-10-23 DOI: 10.5387/fms.25-00015

Kazuya Kakuta, Koichi Chida, Masamichi Naruse, Shumpei Nemoto, Masamitsu Ikeda, Arifumi Hasegawa

{"title":"Fundamental study of digital subtraction angiography using dose characteristic analysis of different protocols in lower limb arterial disease.","authors":"Kazuya Kakuta, Koichi Chida, Masamichi Naruse, Shumpei Nemoto, Masamitsu Ikeda, Arifumi Hasegawa","doi":"10.5387/fms.25-00015","DOIUrl":"10.5387/fms.25-00015","url":null,"abstract":"AbstractWe clarified the differences between the two pre-set protocols for iodine-digital subtraction angiography (ICM-DSA) and carbon dioxide (CO2)-DSA in terms of radiation exposure to patients and physicians when patients diagnosed with lower extremity artery disease (LEAD) undergo ICM-DSA or CO2-DSA, and identified factors that affect radiation exposure when patients undergo ICM-DSA or CO2-DSA. CO2-and ICM-DSA yielded 149 and 272 vessels in 21 and 49 patients, respectively. Multiple regression analyses revealed strong positive linear correlations between total air kerma (kinetic energy released per unit mass) at the patient entrance reference point (Ka,r), the total kerma area product (KAP), and the total number of acquisitions for ICM-DSA and CO2-DSA, respectively. Compared to Ka,r, there were significant differences in the tube potentials, KAP, and spectral shaping filters in both DSA procedures. The linear correlations between Ka,r and the number of ICM-DSA and CO2-DSA images varied among dose types, with strong linear correlations observed when Ka,r was classified into the above three groups. The X-ray conditions for each DSA image differed, with CO2-DSA using a significantly higher tube potential and different spectral shaping filters compared to ICM-DSA. When performing DSA for LEAD, an optimized protocol for each type of ontrast agent should be used.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"97-107"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating preoperative gemcitabine-based chemoradiation for resectable and borderline resectable pancreatic cancer: a phase 1 study. 评估术前以吉西他滨为基础的放化疗对可切除和临界可切除胰腺癌的疗效：一项1期研究。

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Fukushima Journal of Medical Science Pub Date : 2026-04-01 Epub Date: 2025-10-23 DOI: 10.5387/fms.25-00013

Naoya Sato, Akira Kenjo, Teruhide Ishigame, Yasuhide Kofunato, Junichiro Haga, Makoto Muto, Shigeyuki Tsukida, Hiroto Chiba, Takayasu Azuma, Takashi Kimura, Shigeru Marubashi

{"title":"Evaluating preoperative gemcitabine-based chemoradiation for resectable and borderline resectable pancreatic cancer: a phase 1 study.","authors":"Naoya Sato, Akira Kenjo, Teruhide Ishigame, Yasuhide Kofunato, Junichiro Haga, Makoto Muto, Shigeyuki Tsukida, Hiroto Chiba, Takayasu Azuma, Takashi Kimura, Shigeru Marubashi","doi":"10.5387/fms.25-00013","DOIUrl":"10.5387/fms.25-00013","url":null,"abstract":"Purpose: Neoadjuvant pancreatic ductal adenocarcinoma (PDAC) treatment is evolving, and chemoradiotherapy (CRT) is emerging as a promising strategy for neoadjuvant therapy. Given the variability in radiotherapy protocols, this study aimed to evaluate the feasibility and safety of gemcitabine-based neoadjuvant chemoradiotherapy.Methods: In this single-arm, phase 1 clinical trial, 31 patients with PDAC were enrolled between April 2016 and August 2019. All patients received preoperative gemcitabine-based chemoradiotherapy with adverse events as the primary endpoint. Multichannel radiation was administered at a total dose of 54 Gy in daily fractions of 1.8 Gy (five fractions per week), which represents a novel aspect of this study.Results: Neoadjuvant therapy was completed in 24 patients, while seven were discontinued due to disease progression. The common adverse events included leukopenia (48.3%), thrombocytopenia (12.9%), and anemia (3.2%). Among the patients who underwent pancreatectomy, the R0 resection rate was 95.8%. Intention-to-treat analysis indicated a 2-year overall survival rate of 49.8% and a 2-year recurrence-free survival rate of 42.4%. High pretreatment CA19-9 levels were identified as predictive factors for overall survival (HR = 28.7, 95% CI:5.00-164.3).Conclusions: Gemcitabine-based neoadjuvant chemoradiotherapy is a feasible and effective approach for achieving high R0 resection rates in resectable and borderline PDAC.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"109-120"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Participants' characteristics influencing pupillometry parameters in a community in Japan. 日本某社区参与者特征对瞳孔测量参数的影响

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Fukushima Journal of Medical Science Pub Date : 2026-04-01 Epub Date: 2025-10-22 DOI: 10.5387/fms.24-00061

Yuki Ohashi, Yurie Kobashi, Hiromi Kawamata

引用次数: 0

Expressive rhythm training improves consistency of rhythm production abilities in patients with schizophrenia. 表达性节奏训练提高精神分裂症患者节奏产生能力的一致性。

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Fukushima Journal of Medical Science Pub Date : 2026-04-01 Epub Date: 2025-11-27 DOI: 10.5387/fms.25-00008

Yuichi Takahashi, Shinya Fujii, Hiroshi Hoshino, Takeyasu Kakamu, Takatomo Matsumoto, Shuntaro Aoki, Kazuko Kanno, Yuka Ueda, Ken Suzutani, Aya Sato, Yuhei Mori, Tomohiro Wada, Tetsuya Shiga, Shuntaro Itagaki, Hirooki Yabe, Itaru Miura

{"title":"Expressive rhythm training improves consistency of rhythm production abilities in patients with schizophrenia.","authors":"Yuichi Takahashi, Shinya Fujii, Hiroshi Hoshino, Takeyasu Kakamu, Takatomo Matsumoto, Shuntaro Aoki, Kazuko Kanno, Yuka Ueda, Ken Suzutani, Aya Sato, Yuhei Mori, Tomohiro Wada, Tetsuya Shiga, Shuntaro Itagaki, Hirooki Yabe, Itaru Miura","doi":"10.5387/fms.25-00008","DOIUrl":"10.5387/fms.25-00008","url":null,"abstract":"Patients with schizophrenia often experience deficits in timing and rhythm-processing abilities, yet the impact of group-based expressive rhythm training on these functions remains unclear. In this study, we examined the effects of short, daily rhythm training sessions on rhythm perception and production in patients with schizophrenia. Participants (N = 15) in an acute care ward received an average of 18.6 training sessions (15 minutes each). Rhythm abilities were assessed before and after the intervention using the Harvard Beat Assessment Test (H-BAT). Group-level analyses showed no significant changes in the mean values of H-BAT measures. However, correlation analysis revealed that the association between the two rhythm production subtests strengthened considerably post-training (from ρ = -0.539 to ρ = -0.896), indicating greater consistency in rhythm production performance. These findings suggest that expressive rhythm training may help stabilize rhythm output in patients with schizophrenia, even when average performance levels do not significantly change. This improvement in internal consistency provides new insights into the potential mechanisms linking schizophrenia pathology to impaired rhythmic processing and may contribute to the development of novel rehabilitation strategies for this population.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"121-130"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 14-year-old boy with C3 glomerulopathy and Sjögren's syndrome identified by a school urinary screening program. 一个14岁的男孩C3肾小球病变和Sjögren's综合征由学校泌尿筛查程序确定。

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Fukushima Journal of Medical Science Pub Date : 2026-04-01 Epub Date: 2025-09-23 DOI: 10.5387/fms.25-00022

Yukihiko Kawasaki, Atsushi Ono, Jun Shirota, Yohei Kume, Rho Maeda, Hayato Go

{"title":"A 14-year-old boy with C3 glomerulopathy and Sjögren's syndrome identified by a school urinary screening program.","authors":"Yukihiko Kawasaki, Atsushi Ono, Jun Shirota, Yohei Kume, Rho Maeda, Hayato Go","doi":"10.5387/fms.25-00022","DOIUrl":"10.5387/fms.25-00022","url":null,"abstract":"C3 glomerulopathy (C3G) is a type of complement-associated glomerulopathy caused by a defect in the alternative complement pathway and is regarded as a rare disease. We report a 14-year-old boy with C3G and Sjögren's syndrome (SS) whose school urinary screening revealed abnormalities, but the diagnosis was delayed because he refused to consult a medical institution. Histopathological examination revealed histologic features of membranoproliferative glomerulonephritis. He was diagnosed with C3G and Sjögren's syndrome based on proteinuria, the histopathological findings, high levels of antibodies against SS-A, and lymphocytic infiltration around the salivary glands. He was treated with combination therapy, consisting of methylprednisolone pulse, prednisolone, and mycophenolate mofetil. At 3 months after treatment, urinary protein excretion was decreased and hematuria had disappeared, and improvement in hypocomplementemia and the levels of antibodies against SS-A were observed. The course of our case suggests that the management of patients with C3G should take into consideration the possibility of the coexistence of SS, and that those with positive findings on school urine screening should be encouraged to visit a medical institution.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"171-176"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single pancreatic and multiple hepatic metastases developing 6 years after left hemicolectomy for colon cancer: A case report. 结肠癌左半结肠切除术后6年发生单胰多发肝转移1例。

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Fukushima Journal of Medical Science Pub Date : 2026-04-01 Epub Date: 2025-09-02 DOI: 10.5387/fms.25-00017

Eisuke Kameoka, Takuto Hikichi, Naoki Konno, Hiroyuki Asama, Kenta Kodama, Jun Nakamura, Daiki Nemoto, Tsunetaka Kato, Takumi Yanagita, Mitsuru Otsuka, Masao Kobayakawa, Kazuhiro Tasaki, Hiromasa Ohira

{"title":"Single pancreatic and multiple hepatic metastases developing 6 years after left hemicolectomy for colon cancer: A case report.","authors":"Eisuke Kameoka, Takuto Hikichi, Naoki Konno, Hiroyuki Asama, Kenta Kodama, Jun Nakamura, Daiki Nemoto, Tsunetaka Kato, Takumi Yanagita, Mitsuru Otsuka, Masao Kobayakawa, Kazuhiro Tasaki, Hiromasa Ohira","doi":"10.5387/fms.25-00017","DOIUrl":"10.5387/fms.25-00017","url":null,"abstract":"A 50-year-old woman presented with a pancreatic tumor and multiple hepatic tumors identified via computed tomography (CT). The patient had undergone surgical resection for colon cancer 6 years earlier, followed by resection of a metastatic lung tumor 3 years ago. In the current presentation, primary pancreatic cancer with metastatic hepatic tumors was initially suspected. However, the possibility of previously resected colon cancer metastasizing to the pancreas also had to be considered. CT findings alone could not make this distinction. Therefore, endoscopic ultrasound-guided fine-needle aspiration was performed. Histopathological examination of the pancreatic tumor indicated adenocarcinoma, with features similar to those of the previously resected colon cancer. Immunohistochemical staining was negative for cytokeratin 7 but positive for cytokeratin 20, caudal-type homeobox 2, and special AT-rich sequence-binding protein 2. These findings indicated a pancreatic metastasis of colonic origin. In addition, a percutaneous ultrasound-guided biopsy of one of the hepatic tumors had histopathological findings that were similar to those of the pancreatic tumor. Hence, the patient was diagnosed with pancreatic and hepatic metastases from the previously resected colon cancer. Chemotherapy was initiated after this diagnosis.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"163-169"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The change in the proportion of positive cases of dengue fever and influenza tests before and after the first case of COVID-19 in Cambodia: a preliminary observational prospective descriptive study. 柬埔寨第一例COVID-19病例前后登革热和流感检测阳性病例比例的变化：一项初步观察性前瞻性描述性研究

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Fukushima Journal of Medical Science Pub Date : 2026-04-01 Epub Date: 2026-01-08 DOI: 10.5387/fms.25-00028

Bun Kimchheng, Takachika Takimoto, Yurie Kobashi, Manabu Okawada

引用次数: 0

Attenuated neurovirulence of dUTPase-deficient herpes simplex virus type 1 in suckling mice but not in newborn mice. dutpase缺陷型单纯疱疹病毒1型在哺乳小鼠中的神经毒力减弱，但在新生小鼠中没有。

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Fukushima Journal of Medical Science Pub Date : 2026-04-01 Epub Date: 2025-10-29 DOI: 10.5387/fms.24-00050

Takehiro Kitabatake, Ken Ishioka, Takato Suzuki, Nozomu Miyazaki, Tatsuo Suzutani

{"title":"Attenuated neurovirulence of dUTPase-deficient herpes simplex virus type 1 in suckling mice but not in newborn mice.","authors":"Takehiro Kitabatake, Ken Ishioka, Takato Suzuki, Nozomu Miyazaki, Tatsuo Suzutani","doi":"10.5387/fms.24-00050","DOIUrl":"10.5387/fms.24-00050","url":null,"abstract":"The HSV-1 UL50 gene encodes dUTPase (DUT), which dephosphorylates dUTP into dUMP, and its mutant strain is known to reduce neurovirulence in mice over 3 weeks old. Therefore, the UL50-deficient strain may be a candidate as a vaccine strain or viral vector. In this study, the UL50-deficient strain demonstrated reduced levels of replication in brain and neurovirulence compared to the wild strain in 4-week-old mice, but not in newborn mice. Furthermore, the expression level of cellular DUT in the mouse brain was not detectable in 4-week-old mice, but was detectable in newborn mice. In vitro experiments showed replication of the UL50-deficient strain was reduced due to the knockdown of cellular DUT. These results suggest that in actively dividing cells, such as the brain neurons of newborn mice, efficient cellular DUT expression helps with the sufficient replication of the UL50 mutant, resulting in the same level of neurovirulence as that in the wild type. However, in the brains of 4-week-old mice, DUT expression is insufficient, resulting in reduced neurovirulence of the UL50 mutant. These results suggest that when using the UL50 mutant strain as a vaccine or virus vector, it is necessary to pay attention to the timing of inoculation.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"131-140"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145402323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-term outcomes of robot-assisted and conventional lung segmentectomy: a single-center retrospective comparative study. 机器人辅助和传统肺段切除术的短期疗效：一项单中心回顾性比较研究。

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Fukushima Journal of Medical Science Pub Date : 2026-04-01 Epub Date: 2025-11-15 DOI: 10.5387/fms.25-00027

Satoshi Muto, Yoshiyuki Maruya, Sho Inomata, Hikaru Yamaguchi, Masayuki Watanabe, Yuki Ozaki, Naoyuki Okabe, Yuki Matsumura, Kazuyuki Hamada, Kenya Kanazawa, Yoko Shibata, Hiroyuki Suzuki

{"title":"Short-term outcomes of robot-assisted and conventional lung segmentectomy: a single-center retrospective comparative study.","authors":"Satoshi Muto, Yoshiyuki Maruya, Sho Inomata, Hikaru Yamaguchi, Masayuki Watanabe, Yuki Ozaki, Naoyuki Okabe, Yuki Matsumura, Kazuyuki Hamada, Kenya Kanazawa, Yoko Shibata, Hiroyuki Suzuki","doi":"10.5387/fms.25-00027","DOIUrl":"10.5387/fms.25-00027","url":null,"abstract":"This retrospective single-center study evaluated and compared the short-term outcomes of robot-assisted thoracic surgery (RATS) segmentectomy with those of conventional segmentectomy performed via thoracotomy or video-assisted thoracic surgery (VATS). The primary objective was to assess the safety of RATS segmentectomy. Our findings demonstrated that RATS segmentectomy was found to be as safe as conventional segmentectomy, with shorter operation times and hospital stays. No significant differences were observed in intraoperative blood loss and rates of surgical complications. However, prolonged postoperative air leaks are a potential concern. Among simple segmentectomy cases, RATS still showed shorter operation time and hospital stay. The longer experience of the surgeons in the RATS group may be a reason for the shorter operation time in this group. Additionally, the use of preoperative transbronchial marking with indocyanine green dye and barium, and intraoperative identification of intersegmental boundaries using intravenously administered indocyanine green dye may contribute to shorter operation time. Further studies are warranted to clarify the long-term oncological outcomes.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"153-162"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0