Fukushima Journal of Medical Science最新文献_第2页

An exploratory study of human papillomavirus detection in oral rinses from patients with recurrent respiratory papillomatosis. 复发性呼吸道乳头状瘤病患者口腔冲洗液中人乳头状瘤病毒检测的探索性研究。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2025-09-02 DOI: 10.5387/fms.25-00026

Shigeyuki Murono, Hiroshi Yoshida, Tomokazu Yoshizaki

引用次数: 0

Single pancreatic and multiple hepatic metastases developing 6 years after left hemicolectomy for colon cancer: A case report. 结肠癌左半结肠切除术后6年发生单胰多发肝转移1例。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2025-09-02 DOI: 10.5387/fms.25-00017

Eisuke Kameoka, Takuto Hikichi, Naoki Konno, Hiroyuki Asama, Kenta Kodama, Jun Nakamura, Daiki Nemoto, Tsunetaka Kato, Takumi Yanagita, Mitsuru Otsuka, Masao Kobayakawa, Kazuhiro Tasaki, Hiromasa Ohira

{"title":"Single pancreatic and multiple hepatic metastases developing 6 years after left hemicolectomy for colon cancer: A case report.","authors":"Eisuke Kameoka, Takuto Hikichi, Naoki Konno, Hiroyuki Asama, Kenta Kodama, Jun Nakamura, Daiki Nemoto, Tsunetaka Kato, Takumi Yanagita, Mitsuru Otsuka, Masao Kobayakawa, Kazuhiro Tasaki, Hiromasa Ohira","doi":"10.5387/fms.25-00017","DOIUrl":"https://doi.org/10.5387/fms.25-00017","url":null,"abstract":"A 50-year-old woman presented with a pancreatic tumor and multiple hepatic tumors identified via computed tomography (CT). The patient had undergone surgical resection for colon cancer 6 years earlier, followed by resection of a metastatic lung tumor 3 years ago. In the current presentation, primary pancreatic cancer with metastatic hepatic tumors was initially suspected. However, the possibility of previously resected colon cancer metastasizing to the pancreas also had to be considered. CT findings alone could not make this distinction. Therefore, endoscopic ultrasound-guided fine-needle aspiration was performed. Histopathological examination of the pancreatic tumor indicated adenocarcinoma, with features similar to those of the previously resected colon cancer. Immunohistochemical staining was negative for cytokeratin 7 but positive for cytokeratin 20, caudal-type homeobox 2, and special AT-rich sequence-binding protein 2. These findings indicated a pancreatic metastasis of colonic origin. In addition, a percutaneous ultrasound-guided biopsy of one of the hepatic tumors had histopathological findings that were similar to those of the pancreatic tumor. Hence, the patient was diagnosed with pancreatic and hepatic metastases from the previously resected colon cancer. Chemotherapy was initiated after this diagnosis.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of combinatorial immunotherapy for patients with advanced gastric cancer from the perspective of immunosuppressive mechanisms in the tumor microenvironment. 从肿瘤微环境免疫抑制机制看晚期胃癌联合免疫治疗进展

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2025-09-02 DOI: 10.5387/fms.25-00009

Kosaku Mimura, Koji Kono

{"title":"Development of combinatorial immunotherapy for patients with advanced gastric cancer from the perspective of immunosuppressive mechanisms in the tumor microenvironment.","authors":"Kosaku Mimura, Koji Kono","doi":"10.5387/fms.25-00009","DOIUrl":"https://doi.org/10.5387/fms.25-00009","url":null,"abstract":"Combinatorial immunotherapy using anti-programmed cell death 1 (PD-1) monoclonal antibody (mAb) is being developed to overcome the limited efficacy of monotherapy with anti-PD-1 mAb for patients with advanced gastric cancer (GC). Anti-PD-1 mAb exhibits clinical efficacy by enhancing the function of cytotoxic T lymphocyte (CTL) through the inhibition of the PD-1 pathway;however, there are various immunosuppressive mechanisms that inhibit CTL function, as well as the PD-1 pathway in the tumor microenvironment (TME). Immune suppressive cells and expression of the inhibitory immune checkpoint molecules are included as main inhibitory mechanisms against CTL in the TME. On the other hand, increasing the number of CTLs enhances the efficacy of anti-PD-1 mAb, and immunogenic tumor cell death (ICD) is crucial to induce CTL through the activation of the cancer immunity cycle. In the present review, we discuss the therapeutic potential of developing combinatorial immunotherapy focusing on the inhibitory immune checkpoint molecules and immune suppressive cells in the TME, as well as on the ICD induced by radiotherapy for patients with advanced GC.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in phosphoethanolamine during the postpartum period and its association with depression. 产后磷乙醇胺的变化及其与抑郁症的关系。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2025-08-26 DOI: 10.5387/fms.25-00005

Aya Kanno, Hiromi Yoshida-Komiya, Akiko Yamaguchi, Hidekazu Nishigori, Aya Goto, Keiya Fujimori

{"title":"Changes in phosphoethanolamine during the postpartum period and its association with depression.","authors":"Aya Kanno, Hiromi Yoshida-Komiya, Akiko Yamaguchi, Hidekazu Nishigori, Aya Goto, Keiya Fujimori","doi":"10.5387/fms.25-00005","DOIUrl":"https://doi.org/10.5387/fms.25-00005","url":null,"abstract":"Aim: This study aimed to examine phosphoethanolamine (PEA) in postpartum women and its association with postpartum depression (PPD).Methods: This prospective study, performed between July 2020 and August 2021 at Fukushima Medical University Hospital, included 67 women. They answered two questionnaires, the Edinburgh Postpartum Depression Scale (EPDS) and the Patient Health Questionnaire-9 (PHQ-9). EPDS is the screening tool for PPD, and the PHQ-9 scores can evaluate the degree of depressive symptom severity. Blood was collected at 5 and 40 days postpartum, and PEA levels were measured.Results: The PEA levels of all postpartum women on day 5 were significantly lower than those on day 40. EPDS and PHQ-9 scores were significantly lower on day 40 than those on day 5 postpartum. No significant correlation was observed between the PPD-suspected (EPDS≥9) women and PEA levels, and no significant correlation was found between plasma PEA levels and PHQ-9 scores on postpartum days 5 and 40.Conclusions: This study found that PEA levels on postpartum day 5 were lower than on postpartum day 40. It also suggested that there was no association between the degree of postpartum depression and plasma PEA concentrations.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of perioperative changes in sciatic nerve stiffness in patients with lumbar disc herniation using shear wave elastography:A longitudinal cohort study. 横波弹性成像研究腰椎间盘突出症患者坐骨神经僵硬度围手术期变化：一项纵向队列研究。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2025-08-26 DOI: 10.5387/fms.24-00060

Ryohei Shoji, Masumi Iwabuchi, Toshikazu Ito, Tatsuya Endo, Osamu Shirado

{"title":"Investigation of perioperative changes in sciatic nerve stiffness in patients with lumbar disc herniation using shear wave elastography:A longitudinal cohort study.","authors":"Ryohei Shoji, Masumi Iwabuchi, Toshikazu Ito, Tatsuya Endo, Osamu Shirado","doi":"10.5387/fms.24-00060","DOIUrl":"https://doi.org/10.5387/fms.24-00060","url":null,"abstract":"Purpose: This study aimed to investigate changes in sciatic nerve stiffness in patients with lumbar disc herniation (LDH) using shear wave elastography (SWE) before and after diskectomy. In addition, we explored the relationship between preoperative sciatic nerve stiffness in the affected side and patient characteristics, leg pain severity, and numbness.Methods: We assessed sciatic nerve stiffness in 27 patients with LDH (nine females, mean age 45.1±15.3 years) preoperatively and one week postoperatively after diskectomy using SWE. We also measured patient characteristics such as age, height, body weight, leg pain severity, and numbness surgery.Results: We found a significant decrease in sciatic nerve stiffness on the affected side postoperatively. However, there was no significant change on the unaffected side. In addition, preoperative nerve stiffness on the affected side correlated with preoperative leg pain intensity.Conclusion: Sciatic nerve stiffness on the affected side was decreased at one week postoperatively compared with preoperatively. In addition, sciatic nerve stiffness on the affected side was correlated with leg pain severity.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics of pediatric attention deficit hyperactivity disorder patients born with low birth weight, small for gestational age, or preterm. 低出生体重、小胎龄或早产儿童注意缺陷多动障碍的临床特征

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2025-08-26 DOI: 10.5387/fms.25-00021

Yukihiko Kawasaki, Yuichi Suzuki, Kyohei Miyazaki, Naoko Suzuki, Megumi Hoshina, Asako Kato, Hiroyuki Morita, Hayato Go

{"title":"Clinical characteristics of pediatric attention deficit hyperactivity disorder patients born with low birth weight, small for gestational age, or preterm.","authors":"Yukihiko Kawasaki, Yuichi Suzuki, Kyohei Miyazaki, Naoko Suzuki, Megumi Hoshina, Asako Kato, Hiroyuki Morita, Hayato Go","doi":"10.5387/fms.25-00021","DOIUrl":"https://doi.org/10.5387/fms.25-00021","url":null,"abstract":"Aim: To clarify the frequency and characteristics of patients with attention deficit hyperactivity disorder (ADHD) born with low birth weight (LBW), very low birth weight (VLBW), small for gestational age (SGA), or preterm, we examined the clinical characteristics of ADHD patients.Methods: We collected data for 168 ADHD children, and the patients were retrospectively divided into each group according to birth weight, height, and gestational age.Results: 1) Patients with ADHD born with LBW, VLBW, SGA, or preterm accounted for 10.1%, 3.0%, 3.6%, or 6.5% of all patients, respectively. 2) ADHD-RS scores for hyperactivity disorder and the frequency of patients requiring ADHD drugs in the LBW infant group were higher than those in the non-LBW infant group. 3) ADHD-RS scores for hyperactivity disorder and total in the VLBW infant group were higher than those in the non-VLBW infant (birth weight:1,500-2,500 g) group. 4) The ADHD scores for attention-deficit and trouble score at the most recent follow-up patients born with SGA were higher than for non-SGA patients.Conclusions: These results suggest that it is necessary to pay attention to the appearance of neurodevelopment disorders such as ADHD when monitoring the progress of patients born with LBW or VLBW, and it is important to provide more appropriate management and therapeutic guidance for patients born with VLBW or SGA.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of transient abnormal myelopoiesis with trisomy 21, tetrasomy 21, and trisomy 19. 21三体、21四体、19三体暂时性骨髓异常1例。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2025-08-05 DOI: 10.5387/fms.24-00045

Miku Munakata, Hayato Go, Shun Hiruta, Hirotaka Ichikawa, Hajime Maeda, Kei Ogasawara, Shingo Kudo, Yoshihiro Ohara, Mitsuaki Hosoya

{"title":"A case of transient abnormal myelopoiesis with trisomy 21, tetrasomy 21, and trisomy 19.","authors":"Miku Munakata, Hayato Go, Shun Hiruta, Hirotaka Ichikawa, Hajime Maeda, Kei Ogasawara, Shingo Kudo, Yoshihiro Ohara, Mitsuaki Hosoya","doi":"10.5387/fms.24-00045","DOIUrl":"https://doi.org/10.5387/fms.24-00045","url":null,"abstract":"Background: Transient abnormal myelopoiesis (TAM) is a transient abnormal leukemoid reaction that occurs in approximately 5-10% of Down syndrome cases. TAM is typically self-limiting, however, it can be life-threatening because of severe pulmonary or hepatic complications. Approximately 20% of these patients develop acute megakaryoblastic leukemia after remission by the age of 4 years. Here, we report a case of TAM with trisomy 21, tetrasomy 21, and trisomy 19.Case report: The patient was a 1-day-old male neonate with nuchal translucency measured by fetal ultrasonography at 16 weeks of gestation. He was suspected to have Down syndrome due to his characteristic facial appearance at birth. G-band staining of the peripheral blood when TAM was diagnosed showed trisomy 21, tetrasomy 21, and trisomy 19. The blasts disappeared from the peripheral blood at 4 months of age. G-band staining of the peripheral blood at the time of blast disappearance demonstrated that tetrasomy 21 and trisomy 19 had resolved.Conclusion: It was inferred from the course of the disease that the cells with tetrasomy 21 and trisomy 19 might be blast cells of TAM.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of Harvard's Inaugural Fukushima Field Trip Course. 哈佛大学首届福岛实地考察课程概述。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2025-08-05 DOI: 10.5387/fms.25-00007

Riho Isaji, Nihaal Rahman, Mateo Diaz-Quiroz, Richard Kowel, Chen Wang, Chelsie Wong, Naho Yamane, Aisha Arsyaningrum, Jeremy Berger, Zili Huang, Allen Wang, Marykate Kenney, Sana Basheer, Casey Dai, Analise Hober, Mahnoor Nawab, Kenneth E Nollet, Yurie Kobashi, Isamu Amir, Michio Murakami, Andrew Gordon, Michael R Reich, Aya Goto

{"title":"Overview of Harvard's Inaugural Fukushima Field Trip Course.","authors":"Riho Isaji, Nihaal Rahman, Mateo Diaz-Quiroz, Richard Kowel, Chen Wang, Chelsie Wong, Naho Yamane, Aisha Arsyaningrum, Jeremy Berger, Zili Huang, Allen Wang, Marykate Kenney, Sana Basheer, Casey Dai, Analise Hober, Mahnoor Nawab, Kenneth E Nollet, Yurie Kobashi, Isamu Amir, Michio Murakami, Andrew Gordon, Michael R Reich, Aya Goto","doi":"10.5387/fms.25-00007","DOIUrl":"https://doi.org/10.5387/fms.25-00007","url":null,"abstract":"The Fukushima Field Trip Course (Harvard T.H. Chan School of Public Health, GHP549, Winter Session 2025) offered a unique educational experience for 15 graduate students from various disciplines at Harvard University, to examine ongoing recovery challenges in Fukushima following Japan's 2011 triple disaster, which included a massive earthquake with powerful aftershocks, a tsunami, and explosive meltdowns at a coastal nuclear power plant. The course included interactions with diverse stakeholders in Fukushima and Tokyo and site visits to foster a comprehensive understanding. Organized into three groups (Health Monitoring, Risk Communication, and Environmental Decontamination), students presented their reports and results at Fukushima Medical University on January 21, 2025. The Health Monitoring group recommended enhancing the Fukushima Health Management Survey through community engagement, mixed-method approaches, and integrated data systems. The Risk Communication group proposed a national 15th anniversary campaign to revise and renew public perceptions of Fukushima in Japan and abroad. The Environmental Decontamination group suggested leveraging international solidarity to create a global network around reconstruction after disasters and promoting \"Hope Tourism.\" The course is designed to connect Fukushima with the world and prepare future leaders in community rebuilding after major crises.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A retrospective single-center study on the characteristics of children with attention-deficit hyperactivity disorder requiring early drug therapy from 2013 to 2022 and changes in treatment over time. 2013 - 2022年需要早期药物治疗的注意缺陷多动障碍儿童特征及治疗随时间变化的回顾性单中心研究

IF 0.7

Fukushima Journal of Medical Science Pub Date : 2025-07-23 DOI: 10.5387/fms.25-00016

Yukihiko Kawasaki, Yuichi Suzuki, Kyohei Miyazaki, Naoko Suzuki, Megumi Hoshina, Asako Kato, Hiroyuki Morita, Hayato Go

{"title":"A retrospective single-center study on the characteristics of children with attention-deficit hyperactivity disorder requiring early drug therapy from 2013 to 2022 and changes in treatment over time.","authors":"Yukihiko Kawasaki, Yuichi Suzuki, Kyohei Miyazaki, Naoko Suzuki, Megumi Hoshina, Asako Kato, Hiroyuki Morita, Hayato Go","doi":"10.5387/fms.25-00016","DOIUrl":"https://doi.org/10.5387/fms.25-00016","url":null,"abstract":"To clarify the characteristics of children with attention deficit hyperactivity disorder (ADHD) requiring early drug therapy and changes in ADHD treatment over time, we undertook a clinical survey of ADHD children. We retrospectively classified 168 children with ADHD into groups based on the presence [Group 1, (the early treatment Group A, non-early treatment Group B)] or absence (Group 2) of ADHD drug therapy. The older age at first examination and the frequency of patients born with low birth weight in Group 1 were higher than those in Group 2. The ADHD-Rating Scale (ADHD-RS) scores for total (ADHD-RS-T) and trouble scores (TS) in Group 1 were higher than those in Group 2. All patients requiring early drug medication were diagnosed with ADHD at age 6 or older and showed significantly higher ADHD-RS hyperactivity disorder (ADHD-RS-H) and TS. Guanfacine was the main drug prescribed, being the first-line drug in 45.0% of cases. These results suggest that characteristics of patients requiring early ADHD drug medication include age 6 years or older at first examination and high ADHD-RS-H, ADHD-RS-T and TS. Furthermore, an increase in the frequency of prescriptions for guanfacine was observed as a prescription trend for ADHD medications.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

De novo overactive bladder after robot-assisted radical prostatectomy is predicted by a high preoperative overactive bladder symptom score, preoperative dyslipidemia, and non-nerve-sparing surgery. 机器人辅助根治性前列腺切除术后新发膀胱过度活动可通过术前膀胱过度活动症状评分高、术前血脂异常和非神经保留手术来预测。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2025-07-03 Epub Date: 2025-04-11 DOI: 10.5387/fms.24-00057

Hitomi Imai, Hidenori Akaihata, Yuki Harigane, Kei Yaginuma, Satoru Meguro, Ruriko Honda-Takinami, Kanako Matsuoka, Seiji Hoshi, Junya Hata, Yuichi Sato, Soichiro Ogawa, Motohide Uemura, Yoshiyuki Kojima

{"title":"De novo overactive bladder after robot-assisted radical prostatectomy is predicted by a high preoperative overactive bladder symptom score, preoperative dyslipidemia, and non-nerve-sparing surgery.","authors":"Hitomi Imai, Hidenori Akaihata, Yuki Harigane, Kei Yaginuma, Satoru Meguro, Ruriko Honda-Takinami, Kanako Matsuoka, Seiji Hoshi, Junya Hata, Yuichi Sato, Soichiro Ogawa, Motohide Uemura, Yoshiyuki Kojima","doi":"10.5387/fms.24-00057","DOIUrl":"10.5387/fms.24-00057","url":null,"abstract":"Objectives: This study investigated whether preoperative patient characteristics and surgery-related factors affect postoperative de novo overactive bladder (OAB) after robot-assisted radical prostatectomy (RARP), and identified three predictive markers.Methods: Patients without preoperative OAB who underwent RARP at our hospital between February 2013 and October 2020 were included.　At 12 months post-RARP, patients were divided into OAB-free and de novo OAB groups based on the presence of overactive bladder.　Preoperative patient characteristics and surgery-related factors were compared between the two groups.Results: A total of 404 patients were analyzed (OAB-free group, 338; de novo OAB group, 66).　The preoperative Overactive Bladder Symptom Score (OABSS) and the percentage of patients with dyslipidemia were significantly higher in the de novo OAB group than in the OAB-free group (OABSS, 3.2 ± 1.6 points vs 2.1 ± 1.4, P<0.01; dyslipidemia, 45.5% vs 32.0%, P=0.04).　Nerve-sparing surgery was significantly less common in the de novo OAB group (10.6% vs 27.1%, P<0.01).　Preoperative age, blood pressure, BMI, HbA1c, uroflowmetry parameters, prostate volume, operative time and blood loss showed no significant differences between two groups.Conclusions: High preoperative OABSS, preoperative dyslipidemia and non-nerve-sparing surgery may be predictive markers for de novo OAB after RARP.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"169-175"},"PeriodicalIF":0.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0