Fukushima Journal of Medical Science最新文献_第3页

Outpatient rehabilitation for an older couple in a repopulated village 10 years after the Fukushima nuclear disaster:An embedded case study. 福岛核灾难10年后，一个重新人口稠密的村庄里一对老年夫妇的门诊康复:一个嵌入式案例研究。

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Fukushima Journal of Medical Science Pub Date : 2024-01-27 Epub Date: 2023-11-11 DOI: 10.5387/fms.2023-01

Yuta Saito, Sora Sato, Yoshitaka Nishikawa, Fumiya Oguro, Nobuaki Moriyama, Keiichiro Sato, Yurie Kobashi, Toyoaki Sawano, Akihiko Ozaki, Takeo Nakayama, Masaharu Tsubokura, Seiji Yasumura, Shohei Sakai

{"title":"Outpatient rehabilitation for an older couple in a repopulated village 10 years after the Fukushima nuclear disaster:An embedded case study.","authors":"Yuta Saito, Sora Sato, Yoshitaka Nishikawa, Fumiya Oguro, Nobuaki Moriyama, Keiichiro Sato, Yurie Kobashi, Toyoaki Sawano, Akihiko Ozaki, Takeo Nakayama, Masaharu Tsubokura, Seiji Yasumura, Shohei Sakai","doi":"10.5387/fms.2023-01","DOIUrl":"10.5387/fms.2023-01","url":null,"abstract":"BackgroundLittle information is available on the role of community-based rehabilitation after a nuclear disaster. Here, we report the case of an older couple living in an area repopulated after the Fukushima nuclear disaster of 2011 who received outpatient rehabilitation.Case presentationAn 84-year-old woman underwent total hip arthroplasty (THA) after she fell and sustained a trochanteric fracture while caring for her husband with Alzheimer's disease. The 85-year-old husband experienced worsening behavioral and psychological symptoms of dementia (BPSD) following his wife's hospitalization. The couple received rehabilitation at an outpatient facility in a nearby village using a shuttle service. The woman's postoperative anxiety was relieved and her physical function improved. Moreover, the husband's BPSD symptoms decreased.ConclusionA wife and husband showed improvement in physical function after THA and alleviation of BPSD, respectively, following rehabilitation. In post-disaster, resource-scarce areas, older adults may benefit from utilizing the outpatient rehabilitation services available in the surrounding area.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10867431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89719927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of extracellular matrix in lung diseases. 细胞外基质在肺部疾病中的作用。

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Fukushima Journal of Medical Science Pub Date : 2024-01-27 Epub Date: 2024-01-25 DOI: 10.5387/fms.2023-07

Yoshinori Tanino

引用次数: 0

Reference values of lumbar spine range of motion by sex and age based on the assessment of supine trunk lateral bending-A preliminary study. 基于仰卧躯干侧弯评估的腰椎活动范围参考值（按性别和年龄）--初步研究。

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Fukushima Journal of Medical Science Pub Date : 2024-01-27 Epub Date: 2023-12-20 DOI: 10.5387/fms.2023-24

Shigetaka Nakanishi, Kazuyuki Watanabe, Kazuo Ouchi, Michiyuki Hakozaki, Naoyuki Oi, Shinichi Konno

{"title":"Reference values of lumbar spine range of motion by sex and age based on the assessment of supine trunk lateral bending-A preliminary study.","authors":"Shigetaka Nakanishi, Kazuyuki Watanabe, Kazuo Ouchi, Michiyuki Hakozaki, Naoyuki Oi, Shinichi Konno","doi":"10.5387/fms.2023-24","DOIUrl":"10.5387/fms.2023-24","url":null,"abstract":"[Purpose] The purpose of this study was to clarify the preliminary reference values for the lumbar spine range of motion associated with lateral bending exercises by gender and age group. [Methods] Subjects were 82 volunteers without low back pain, including five males and five females in each age group from 16-19 to 80-89 years. All subjects underwent radiographs of the lumbar spine with lateral flexion; the range of lateral flexion of the vertebrae from T12 to the sacrum (ROLB) was measured twice by three observers. [Results] The ROLB of the entire T12-S1 of all subjects showed a significant negative correlation with age in both sexes (p < 0.01). The ROLB of the lumbar spine tended to be greater in females, with a statistically significant difference between those aged 16-19 and 70-79 (p < 0.05). Lateral flexion angles for each intervertebral segment were largest at L3-L4 and smallest at L5-S1 (0.7°). [Conclusion] Lumbar ROLB reference values were examined by gender and age group; ROLB was greatest in L3-L4, and ROLB tended to be lower in older age groups.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10867432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138832129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular carcinogenesis in preleukemic conditions:drivers and defenses. 白血病前期的细胞癌变:驱动因素和防御因素。

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Fukushima Journal of Medical Science Pub Date : 2024-01-27 Epub Date: 2023-11-11 DOI: 10.5387/fms.2023-17

Koki Ueda, Kazuhiko Ikeda

{"title":"Cellular carcinogenesis in preleukemic conditions:drivers and defenses.","authors":"Koki Ueda, Kazuhiko Ikeda","doi":"10.5387/fms.2023-17","DOIUrl":"10.5387/fms.2023-17","url":null,"abstract":"Acute myeloid leukemia (AML) arises from preleukemic conditions. We have investigated the pathogenesis of typical preleukemia, myeloproliferative neoplasms, and clonal hematopoiesis. Hematopoietic stem cells in both preleukemic conditions harbor recurrent driver mutations; additional mutation provokes further malignant transformation, leading to AML onset. Although genetic alterations are defined as the main cause of malignant transformation, non-genetic factors are also involved in disease progression. In this review, we focus on a non-histone chromatin protein, high mobility group AT-hook2 (HMGA2), and a physiological p53 inhibitor, murine double minute X (MDMX). HMGA2 is mainly overexpressed by dysregulation of microRNAs or mutations in polycomb components, and provokes expansion of preleukemic clones through stem cell signature disruption. MDMX is overexpressed by altered splicing balance in myeloid malignancies. MDMX induces leukemic transformation from preleukemia via suppression of p53 and p53-independent activation of WNT/β-catenin signaling. We also discuss how these non-genetic factors can be targeted for leukemia prevention therapy.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10867434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89719926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation and treatment of constipation in pregnancy:Examination using the Japanese version of the constipation evaluation scale. 孕期便秘的评估和治疗：使用日文版便秘评估量表进行检查。

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Fukushima Journal of Medical Science Pub Date : 2024-01-27 Epub Date: 2024-01-25 DOI: 10.5387/fms.2023-25

Makiho Ishibashi, Fumie Hashimoto, Yoshihiro Kouchi, Karin Imaizumi, Fumihiro Ito, Shun Yasuda

{"title":"Evaluation and treatment of constipation in pregnancy:Examination using the Japanese version of the constipation evaluation scale.","authors":"Makiho Ishibashi, Fumie Hashimoto, Yoshihiro Kouchi, Karin Imaizumi, Fumihiro Ito, Shun Yasuda","doi":"10.5387/fms.2023-25","DOIUrl":"10.5387/fms.2023-25","url":null,"abstract":"Objectives: No study has examined the effects of new constipation treatment drugs released in recent years in pregnant women. This prospective cohort study aimed to examine and compare the perinatal prognosis, efficacy rate, and safety of drugs frequently used to treat constipation.Methods: The study included 211 perinatally managed individuals who answered a self-administered questionnaire during the second trimester and after delivery. The Japanese version of the constipation evaluation scale (Constipation Assessment Scale [CAS] long-term [LT] version) was used for the subjective evaluation of defecation status.Results: Participants aware of constipation had significantly higher CAS scores than those who were unaware. Some participants with a CAS score of 5 points (treatment range) had no subjective symptoms of constipation, whereas some participants with a CAS score of ≤ 5 points were aware of constipation. Regarding the time of onset, 60% of those who had constipation before pregnancy had a high rate of constipation during pregnancy and after delivery. No significant difference was noted in conventional magnesium oxide and polyethylene glycol, a relatively new daily treatment drug, in perinatal prognosis or side effects.Conclusions: Polyethylene glycol preparations alleviate constipation without inducing diarrhea, making them an appropriate therapeutic option for pregnant women.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10867430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139547467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTED ARTICLE. 被撤回的文章。

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Fukushima Journal of Medical Science Pub Date : 2024-01-27 Epub Date: 2024-01-25 DOI: 10.5387/fms.retraction

引用次数: 0

2022 Fukushima Medical University International Symposium on the Fukushima Health Management Survey Build Back Better, Together. "Science for Society: Advancing Fukushima's Well-Being". 2022 福岛医科大学 "福岛健康管理调查 "国际研讨会携手重建美好家园。"科学为社会服务：推进福岛的福祉"。

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Fukushima Journal of Medical Science Pub Date : 2024-01-01 DOI: 10.5387/fms.24-00006

Masaharu Tsubokura, Kenji Kamiya

{"title":"2022 Fukushima Medical University International Symposium on the Fukushima Health Management Survey Build Back Better, Together. \"Science for Society: Advancing Fukushima's Well-Being\".","authors":"Masaharu Tsubokura, Kenji Kamiya","doi":"10.5387/fms.24-00006","DOIUrl":"10.5387/fms.24-00006","url":null,"abstract":"The Fukushima Medical University (FMU) International Symposium on the Fukushima Health Management Survey (FHMS) convened for the fourth time in March 2022 to share FHMS findings within Fukushima and beyond. Dr. TAKENOSHITA Seiichi, FMU President, underscored Fukushima's restoration journey, while Governor UCHIBORI Masao committed to partnering with FMU for residents' welfare.The Introduction by Dr. KAMIYA Kenji highlighted FHMS results for more than 460,000 participants, of whom 99.8% were exposed to radiation doses below 5 mSv post-accident. Thyroid examinations detected tumors, but no dose-response relationship was found. The Comprehensive Health Check showed increased lifestyle-related diseases among evacuees, with improvements in some health markers. Mental health issues initially prevalent after the accident decreased over time, and perinatal outcomes were consistent with national data.Session 1 focused on radiation effects in Fukushima. The UNSCEAR 2020 Report indicated significantly reduced radiation exposure estimates and negligible cancer risks. Studies from Hiroshima, Nagasaki, and Chernobyl found no radiation-induced genetic effects.Session 2 explored post-disaster well-being, emphasizing the evolution of psychological responses. Practices like Psychological First Aid (PFA) and emotional resilience promotion were highlighted. Katsurao Village's post-evacuation health measures addressed lifestyle diseases, but faced challenges. The WHO framework for mental health and psychosocial support in nuclear emergencies emphasized the importance of mental health care throughout all disaster phases.The symposium facilitated valuable insights, underlining comprehensive health strategies and the significance of long-term studies for Fukushima's recovery and health management.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2023 Fukushima Medical University International Symposium on the Fukushima Health Management Survey, "Thinking Together about Health, Life, and our Future in Fukushima". 2023 年福岛医科大学福岛健康管理调查国际研讨会，"共同思考福岛的健康、生活和我们的未来"。

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Fukushima Journal of Medical Science Pub Date : 2024-01-01 DOI: 10.5387/fms.24-00007

Michio Shimabukuro, Kenji Kamiya

引用次数: 0

Development of a novel artificial intelligence algorithm to detect pulmonary nodules on chest radiography. 开发一种新的人工智能算法，用于在胸部造影中检测肺结节。

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Fukushima Journal of Medical Science Pub Date : 2023-11-15 Epub Date: 2023-10-17 DOI: 10.5387/fms.2023-14

Mitsunori Higuchi, Takeshi Nagata, Kohei Iwabuchi, Akira Sano, Hidemasa Maekawa, Takayuki Idaka, Manabu Yamasaki, Chihiro Seko, Atsushi Sato, Junzo Suzuki, Yoshiyuki Anzai, Takashi Yabuki, Takuro Saito, Hiroyuki Suzuki

{"title":"Development of a novel artificial intelligence algorithm to detect pulmonary nodules on chest radiography.","authors":"Mitsunori Higuchi, Takeshi Nagata, Kohei Iwabuchi, Akira Sano, Hidemasa Maekawa, Takayuki Idaka, Manabu Yamasaki, Chihiro Seko, Atsushi Sato, Junzo Suzuki, Yoshiyuki Anzai, Takashi Yabuki, Takuro Saito, Hiroyuki Suzuki","doi":"10.5387/fms.2023-14","DOIUrl":"10.5387/fms.2023-14","url":null,"abstract":"Background: In this study, we aimed to develop a novel artificial intelligence (AI) algorithm to support pulmonary nodule detection, which will enable physicians to efficiently interpret chest radiographs for lung cancer diagnosis.Methods: We analyzed chest X-ray images obtained from a health examination center in Fukushima and the National Institutes of Health (NIH) Chest X-ray 14 dataset. We categorized these data into two types: type A included both Fukushima and NIH datasets, and type B included only the Fukushima dataset. We also demonstrated pulmonary nodules in the form of a heatmap display on each chest radiograph and calculated the positive probability score as an index value.Results: Our novel AI algorithms had a receiver operating characteristic (ROC) area under the curve (AUC) of 0.74, a sensitivity of 0.75, and a specificity of 0.60 for the type A dataset. For the type B dataset, the respective values were 0.79, 0.72, and 0.74. The algorithms in both the type A and B datasets were superior to the accuracy of radiologists and similar to previous studies.Conclusions: The proprietary AI algorithms had a similar accuracy for interpreting chest radiographs when compared with previous studies and radiologists. Especially, we could train a high quality AI algorithm, even with our small type B data set. However, further studies are needed to improve and further validate the accuracy of our AI algorithm.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing allogeneic CD4⁺ T cells to reinvigorate host endogenous antitumor immunity. 利用同种异体CD4+T细胞重振宿主内源性抗肿瘤免疫。

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Fukushima Journal of Medical Science Pub Date : 2023-11-15 Epub Date: 2023-10-26 DOI: 10.5387/fms.23-00001

Kazuhiro Mochizuki

{"title":"Harnessing allogeneic CD4+ T cells to reinvigorate host endogenous antitumor immunity.","authors":"Kazuhiro Mochizuki","doi":"10.5387/fms.23-00001","DOIUrl":"10.5387/fms.23-00001","url":null,"abstract":"Immune checkpoint blockade (ICB) therapies developed over the past decade have been among the most promising approaches for the treatment of patients with advanced cancers. However, the overall objective response rate of ICB therapy for various cancers remains insufficient. Hence, novel strategies are required to improve the efficacy of immunotherapy for advanced cancers. The graft-versus-tumor (GVT) effect, which reflects strong antitumor immunity, is known to occur after allogeneic hematopoietic stem cell transplantation (HSCT). The GVT effect is mainly caused by transplanted donor lymphocytes that recognize and react to distinct alloantigens on tumor cells. In contrast, transplanted allogeneic cells can, in some instances, induce endogenous antitumor immunity in recipients if the graft has been rejected. Because of this ability, allogeneic cells have also been used to induce endogenous antitumor immunity without HSCT, and their beneficial immune response is referred to as the \"allogenic effect.\" Here, we review the usefulness of allogeneic cells, particularly allogeneic CD4+ T cells, in cancer immunotherapy by highlighting their unique potential to induce host endogenous antitumor immunity.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0