Fukushima Journal of Medical Science最新文献_第3页

Short-term Outcomes of Robotic Lateral Pelvic Lymph Node Dissection for Lower Rectal Cancer. 机器人骨盆外侧淋巴结清扫治疗下段直肠癌的近期疗效。

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Fukushima Journal of Medical Science Pub Date : 2025-04-19 Epub Date: 2025-02-08 DOI: 10.5387/fms.24-00039

Wataru Sakamoto, Satoshi Fukai, Takahiro Sato, Misato Ito, Takuro Matsumoto, Mai Ashizawa, Shun Chida, Hisashi Onozawa, Hirokazu Okayama, Hisahito Endo, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Koji Kono

{"title":"Short-term Outcomes of Robotic Lateral Pelvic Lymph Node Dissection for Lower Rectal Cancer.","authors":"Wataru Sakamoto, Satoshi Fukai, Takahiro Sato, Misato Ito, Takuro Matsumoto, Mai Ashizawa, Shun Chida, Hisashi Onozawa, Hirokazu Okayama, Hisahito Endo, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Koji Kono","doi":"10.5387/fms.24-00039","DOIUrl":"10.5387/fms.24-00039","url":null,"abstract":"Introduction: Rectal cancer is among the main causes of cancer-related mortalities worldwide, necessitating more effective treatment strategies.　It is considered that lateral pelvic lymph node dissection (LPND) for rectal cancer patients can contribute to local tumor control and that robotic LPND (Rob-LPND) may be more suitable for LPND, due to technical advantages of precise manipulation in a narrow pelvic space.Methods: In this retrospective study, we evaluated the short-term outcomes of laparoscopic-LPND (Lap-LPND) versus Rob-LPND in patients undergoing radical surgery for rectal cancer.　Operative time, blood loss, urethral catheter reinsertion, duration of pelvic drainage tube placement, drainage volume, and postoperative hospital stay were compared between Lap-LPND and Rob-LPND.Results: Our findings revealed that Rob-LPND was associated with longer total operation time, but there was no significant difference in operation time between the two LPND techniques.　Urinary catheter re-insertion rates were lower in Rob-LPND; also, significant reductions in drainage tube duration, total drainage volume, and postoperative hospital stay were observed.Conclusion: Rob-LPND may reduce postoperative total drainage volume and shorten postoperative hospital stays.　These improvement in short-term outcomes suggest potential clinical advantages of Rob-LPND.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"97-103"},"PeriodicalIF":0.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between quality of life before treatment and survival in patients with hematological malignancies: A meta-analysis. 恶性血液病患者治疗前生活质量与生存的关系：一项荟萃分析。

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Fukushima Journal of Medical Science Pub Date : 2025-04-19 Epub Date: 2025-02-08 DOI: 10.5387/fms.24-00042

Keiichi Osaki, Shinichiro Morishita, Jiro Nakano, Junichiro Inoue, Taro Okayama, Katsuyoshi Suzuki, Takashi Tanaka, Takuya Fukushima

{"title":"Relationship between quality of life before treatment and survival in patients with hematological malignancies: A meta-analysis.","authors":"Keiichi Osaki, Shinichiro Morishita, Jiro Nakano, Junichiro Inoue, Taro Okayama, Katsuyoshi Suzuki, Takashi Tanaka, Takuya Fukushima","doi":"10.5387/fms.24-00042","DOIUrl":"10.5387/fms.24-00042","url":null,"abstract":"This meta-analysis aimed to investigate the impact of pretreatment quality of life (QoL) on overall survival (OS) in patients with hematological malignancies. The observational studies with relationship between QoL and OS in patients undergoing either hematopoietic stem cell transplantation (HSCT) or chemotherapy were collected. Stratification by treatment was performed to examine the association between QoL and OS. Six articles were included in the analysis. Overall, significant associations with OS were observed for global QoL (hazard ratio [HR] = 1.04, 95% confidence interval [CI] = 1.01-1.08), physical QoL (HR = 1.06, 95% CI:1.02-1.10), and social QoL (HR = 1.02, 95% CI: 1.00-1.03). When stratified by treatment, HSCT showed significant associations between OS and both global QoL (HR = 1.05, 95% CI:1.00-1.11) and physical QoL (HR = 1.03, 95% CI:1.00-1.06). For chemotherapy, significant associations were also observed between OS and global QoL (HR = 1.04, 95% CI:1.00-1.09), physical QoL (HR = 1.08, 95% CI:1.00-1.17), role QoL (HR = 1.02, 95% CI:1.00-1.04), and social QoL (HR = 1.02, 95% CI:1.00-1.04). No significant associations were observed regarding emotional QoL, which was only analyzed in HSCT. The factors influencing OS may vary depending on the treatment, emphasizing the importance of recognizing QoL from the pretreatment stage.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"73-84"},"PeriodicalIF":0.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring conceptions of medical unprofessionalism in Japan and the UK: a Q-methodology study. 探索日本和英国的医学非专业性概念：一项q -方法论研究。

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Fukushima Journal of Medical Science Pub Date : 2025-04-19 Epub Date: 2025-02-08 DOI: 10.5387/fms.24-00055

Maham Stanyon, Yayoi Shikama, Jo Horsburgh, Ravi Parekh, Gautham Benoy, Sayaka Oikawa, Megumi Yasuda, Zoe Moula, Koji Otani

{"title":"Exploring conceptions of medical unprofessionalism in Japan and the UK: a Q-methodology study.","authors":"Maham Stanyon, Yayoi Shikama, Jo Horsburgh, Ravi Parekh, Gautham Benoy, Sayaka Oikawa, Megumi Yasuda, Zoe Moula, Koji Otani","doi":"10.5387/fms.24-00055","DOIUrl":"10.5387/fms.24-00055","url":null,"abstract":"Western professionalism frameworks dominate medical education yet cause translational and ethical challenges when applied across cultures.　Increasing globalisation brings an impetus to examine these perspectives in non-dominating cultures, with a cultural understanding about what constitutes unprofessional behaviour urgently needed.　In the absence of comparative data from dominating and non-dominating cultures, we sought to use Q-methodology to examine perceptions of unprofessional behaviour amongst stakeholders in Japan and the UK.Statements describing 48 unprofessional behaviours were sorted according to perceived severity by 58 Japanese and UK students, clinical educators, and administrators.　Factor analysis using judgemental rotation flagging factors at p<0.05 was performed.　Follow-up questionnaire responses were coded and supported the interpretation of factors.A four-factor solution showing four distinct constructs of unprofessional behaviour was extracted: clinical responsibility (international factor), relational responsibility (Japanese-only factor), moral responsibility (UK-dominant factor), and personal responsibility (Japanese-dominant factor).　Japanese-only constructs identified behaviours disrupting personal and group relationships as more unprofessional, whereas the UK factor focused on personal motivation and ethical reasoning.Our multi-stakeholder data provides empirical evidence into the contrasting conceptualisations of unprofessional behaviour that co-exist in practice.　We identify culturally constructed perspectives unique to both contexts, which warrant recognition and integration in local teaching and national guidelines.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"105-118"},"PeriodicalIF":0.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful cord blood transplantation for a unique case of bone marrow failure presenting t(2;19)(p23;q13.3) translocation suggesting disruption of DPY30. 成功的脐带血移植治疗一例骨髓衰竭，表现为t(2;19)（p23;q13.3）易位，提示DPY30的破坏。

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Fukushima Journal of Medical Science Pub Date : 2025-04-19 Epub Date: 2025-02-08 DOI: 10.5387/fms.24-00044

Yuki Sato, Daisuke Koyama, Shoki Yamada, Naomi Kamei, Koichiro Fukuchi, Kengo Suzuki, Yasuhiro Uchida, Manabu Suzuki, Masahiko Fukatsu, Yuko Hashimoto, Takayuki Ikezoe

{"title":"Successful cord blood transplantation for a unique case of bone marrow failure presenting t(2;19)(p23;q13.3) translocation suggesting disruption of DPY30.","authors":"Yuki Sato, Daisuke Koyama, Shoki Yamada, Naomi Kamei, Koichiro Fukuchi, Kengo Suzuki, Yasuhiro Uchida, Manabu Suzuki, Masahiko Fukatsu, Yuko Hashimoto, Takayuki Ikezoe","doi":"10.5387/fms.24-00044","DOIUrl":"10.5387/fms.24-00044","url":null,"abstract":"H3K4 methylation, primarily mediated by MLL family proteins, plays a pivotal role in the epigenetic regulation of gene transcription. Among the MLL family, KMT2A is known for its critical role in hematopoiesis. MLL family proteins feature C-terminal SET catalytic domains, requiring the formation of MLL complexes with proteins like DPY30 to maximize their enzymatic activity. Deletion of DPY30 results in a significant reduction in H3K4me1, H3K4me2, and H3K4me3 levels in bone marrow (BM) cells, underscoring the essential role of DPY30 in facilitating optimal catalytic activity within MLL family complexes. Here, we present a unique case of myelodysplastic neoplasms (MDS) associated with a novel t(2;19)(p23;q13.3) translocation. A 22-year-old pregnant woman initially sought consultation due to thrombocytopenia, which temporarily improved following a miscarriage. However, she later presented with progressive pancytopenia. RNA sequencing analysis of BM mononuclear cells using STAR-Fusion revealed the translocation breakpoint on chromosomes, resulting in the disruption of the DPY30 and CEACAM6 genes. BM failure showed marked improvement following cord blood transplantation. This case represents a novel form of MDS associated with the disruption of the DPY30 gene. Our findings underscore the importance of considering early hematopoietic stem cell transplantation for MDS cases attributed to DPY30 dysfunction.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"129-134"},"PeriodicalIF":0.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent topics in diagnosis and treatment of malignant spinal tumors. 恶性脊柱肿瘤的诊断与治疗。

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Fukushima Journal of Medical Science Pub Date : 2025-04-19 Epub Date: 2025-02-08 DOI: 10.5387/fms.24-00008

Yoshihiro Matsumoto

{"title":"Recent topics in diagnosis and treatment of malignant spinal tumors.","authors":"Yoshihiro Matsumoto","doi":"10.5387/fms.24-00008","DOIUrl":"10.5387/fms.24-00008","url":null,"abstract":"The diagnosis and treatment of malignant spinal tumors are complex and require an integrated approach known as Jaffe's triangle.　This review discusses recent topics in the diagnosis and treatment of primary and metastatic malignant spinal tumors.　Integrated diagnostic methods, including the development of a dumbbell scoring system for benign-malignant differentiation and the use of positron emission tomography and magnetic resonance imaging (PET-MRI), have improved diagnostic accuracy.　Curative resection techniques such as vertebrectomy, sagittal resection, and posterior resection are crucial for primary malignant tumors.　Heavy particle radiation therapy, such as carbon-ion radiotherapy, shows promise against radiation-resistant tumors, whereas novel drug therapies, such as denosumab, are effective for giant cell tumors of the bone arising in the spine.　For metastatic spinal tumors, the collaborative efforts of the Bone Metastasis Cancer Board and minimally invasive spine stabilization have expanded surgical indications and improved patient outcomes.　The treatment system has shifted towards preventive surgery and outpatient management, aiming to maintain quality of life and continue chemotherapy.　Interdisciplinary collaboration is essential for improving treatment outcomes in both primary and metastatic malignant spinal tumors.Primary malignant spinal cord tumors (PMST) and metastatic spinal tumors (MST) are among the most difficult areas of orthopedic surgery.　Their diagnosis and treatment require multidisciplinary diagnostic and therapeutic strategies that integrate knowledge and skills in orthopedics, pathology, and diagnostic radiology (the so-called Jaffe triangle), as well as in clinical oncology and tumor biology, which have made remarkable progress in recent years.　Here, we review recent topics related to the diagnosis and treatment of PMST and MST.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"85-95"},"PeriodicalIF":0.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three cases of gastrointestinal stromal tumors with metaiodobenzylguanidine (MIBG) accumulation. 胃肠道间质瘤合并甲氧十二苄基胍积累3例。

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Fukushima Journal of Medical Science Pub Date : 2025-04-19 Epub Date: 2025-02-08 DOI: 10.5387/fms.24-00003

Honami Kobiyama, Shiro Ishii, Yumi Saito, Natsumi Kawamoto, Shigeyasu Sugawara, Hiroshi Ito

引用次数: 0

Clinical outcomes of simultaneous pancreas-kidney transplantation: experience of a single center. 同时胰肾移植的临床结果：单一中心的经验。

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Fukushima Journal of Medical Science Pub Date : 2025-04-19 Epub Date: 2025-02-08 DOI: 10.5387/fms.24-00052

Akira Kenjo, Naoya Sato, Takayasu Azuma, Atsushi Nishimagi, Shigeyuki Tsukida, Seiko Suzushino, Makoto Muto, Hiroto Chiba, Junichiro Watanabe, Junichiro Haga, Yasuhide Kofunato, Teruhide Ishigame, Takashi Kimura, Shigeru Marubashi

{"title":"Clinical outcomes of simultaneous pancreas-kidney transplantation: experience of a single center.","authors":"Akira Kenjo, Naoya Sato, Takayasu Azuma, Atsushi Nishimagi, Shigeyuki Tsukida, Seiko Suzushino, Makoto Muto, Hiroto Chiba, Junichiro Watanabe, Junichiro Haga, Yasuhide Kofunato, Teruhide Ishigame, Takashi Kimura, Shigeru Marubashi","doi":"10.5387/fms.24-00052","DOIUrl":"10.5387/fms.24-00052","url":null,"abstract":"This study evaluated the outcomes of simultaneous pancreas-kidney transplantation (SPK) at Fukushima Medical University between 2001 and 2024.　We retrospectively reviewed ten adult patients who underwent SPK.　We aimed to clarify the important aspects of patient management in patients undergoing SPK, focusing on perioperative outcomes and long-term complications.The median postoperative observation period was 1,968 days.　Postoperative complications were observed in all patients.　Most were classified as Clavien-Dindo (CD) grade I or II, but major complications, including CD grade IIIa or higher, were observed in four patients (40%) with zero mortality.　Despite the loss of one kidney graft due to primary non-function, the 5-year survival rates for both patients and pancreatic grafts remained at 100%.　However, there was one case each of pancreatic graft loss, kidney graft loss, and patient death after 5 years post-transplantation, all attributed to late-onset complications, including recurrent type 1 diabetes, focal segmental glomerulosclerosis, and cardiovascular disease.The short-term outcomes of SPK at our institution were favorable, with a trend toward a reduction in the comprehensive complication index (CCI) observed in the latter five cases compared with the first five cases, suggesting potential improvements in perioperative management.　Long-term monitoring and collaboration with physicians are essential to enhance patient outcomes.　.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"119-128"},"PeriodicalIF":0.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in peripheral blood test results among adults in the six years following the Great East Japan Earthquake: the Fukushima Health Management Survey. 日本东部大地震后6年成人外周血检测结果的变化：福岛健康管理调查

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Fukushima Journal of Medical Science Pub Date : 2025-04-11 DOI: 10.5387/fms.24-00041

Akira Sakai, Hironori Nakano, Koichi Hashimoto, Kanako Okazaki, Masanori Nagao, Michio Shimabukuro, Tetsuya Ohira, Tetsuo Ishikawa, Masaharu Tsubokura, Mitsuaki Hosoya, Atsushi Takahashi, Junichiro J Kazama, Shigeatsu Hashimoto, Kazuyuki Watanabe, Gen Kobashi, Hiroaki Satoh, Hideto Takahashi, Fumikazu Hayashi, Shiho Sato, Hitoshi Ohto, Seiji Yasumura

{"title":"Changes in peripheral blood test results among adults in the six years following the Great East Japan Earthquake: the Fukushima Health Management Survey.","authors":"Akira Sakai, Hironori Nakano, Koichi Hashimoto, Kanako Okazaki, Masanori Nagao, Michio Shimabukuro, Tetsuya Ohira, Tetsuo Ishikawa, Masaharu Tsubokura, Mitsuaki Hosoya, Atsushi Takahashi, Junichiro J Kazama, Shigeatsu Hashimoto, Kazuyuki Watanabe, Gen Kobashi, Hiroaki Satoh, Hideto Takahashi, Fumikazu Hayashi, Shiho Sato, Hitoshi Ohto, Seiji Yasumura","doi":"10.5387/fms.24-00041","DOIUrl":"https://doi.org/10.5387/fms.24-00041","url":null,"abstract":"The Fukushima Health Management Survey, conducted by Fukushima Prefecture since the 2011 Great East Japan Earthquake (GEJE), has not identified any health effects from radiation exposure.　Complete blood counts (CBC), which are sensitive to radiation exposure, have not shown lymphocytopenia, neutropenia, anemia, or thrombocytopenia, but the white blood cell fractions have not yet been analyzed since 2011.　We classified 25,885 residents (11,383 male, 14,502 female;age range, 16-84 years) in evacuation areas with external exposure dose estimates based on behavioral surveys conducted 4 months after the GEJE into two groups (0-1 [≥0 and <1] and ≥1 mSv) and analyzed changes in CBC and leukocyte fractions from fiscal year (FY) 2011 to FY2017 and their influencing factors.　Compared with FY2011, no significant increase in the number of residents with leukopenia was seen, but the rate of male residents with anemia increased through 2017, regardless of the radiation exposure dose, but factors contributing to the development of anemia were more critical in males.　No links were found between the development of anemia and smoking, evacuation, or heavy alcohol drinking, whereas significant associations were found with thinness and older age.　These findings suggest that malnutrition is a cause of anemia, especially in males.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zinner syndrome, a rare congenital urogenital tract malformation: the first reported case in Indonesia. 津纳综合征，一种罕见的先天性泌尿生殖道畸形：印度尼西亚首例报告病例。

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Fukushima Journal of Medical Science Pub Date : 2025-04-11 DOI: 10.5387/fms.24-00059

Cecilia N Salim, Novelia P Widyanto, Adsel Kartadinata, Richardo R Handoko, Budiawan Atmadja

{"title":"Zinner syndrome, a rare congenital urogenital tract malformation: the first reported case in Indonesia.","authors":"Cecilia N Salim, Novelia P Widyanto, Adsel Kartadinata, Richardo R Handoko, Budiawan Atmadja","doi":"10.5387/fms.24-00059","DOIUrl":"https://doi.org/10.5387/fms.24-00059","url":null,"abstract":"Zinner syndrome (ZS) is a rare urogenital anomaly characterized by cystic seminal vesicles, obstructed ejaculatory duct, and ipsilateral renal agenesis, complicating diagnosis and management due to its rarity and nonspecific symptoms.　ZS incidence is 0.0021%, with symptoms typically appearing in the 2nd and 3rd decades of life, including dysuria, urinary frequency, perianal pain, and infertility.　MRI is the gold standard for diagnosis, while surgery is reserved for symptomatic patients.　Mildly symptomatic patients receive conservative management, including antibiotics and regular monitoring.　We report the first case of ZS in Indonesia, involving a 36-year-old male presenting with perineal pain similar to an episode a decade earlier.　MRI revealed right kidney agenesis, ejaculatory duct obstruction, a 4.95 cm cyst on the right seminal vesicle, and a right ectopic ureter.　Semen analysis was unremarkable.　Diagnosis of ZS was confirmed, and the patient opted for conservative management.This case highlights the importance of diagnosing ZS in underrepresented regions, where limited awareness and access to advanced tools delay identification.　The conservative approach reflected the patient's preference to avoid surgical risks while achieving effective symptom relief through tailored, patient-centered care.　Clinicians should consider ZS in cases of unilateral renal agenesis with cystic pelvic masses.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Agents and Patient Characteristics Affecting Metabolism of Thiopurines in Patients with Inflammatory Bowel Disease. 影响炎症性肠病患者硫嘌呤代谢的治疗药物和患者特征。

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Fukushima Journal of Medical Science Pub Date : 2025-01-18 Epub Date: 2025-01-07 DOI: 10.5387/fms.24-00009

Masato Aizawa, Kohei Suzuki, Yuki Nakajima, Kenichi Utano, Kana Tamazawa, Kenta Ueda, Jun Wada, Kentaro Sato, Goro Shibukawa, Noriko Tanaka, Kazutomo Togashi

{"title":"Therapeutic Agents and Patient Characteristics Affecting Metabolism of Thiopurines in Patients with Inflammatory Bowel Disease.","authors":"Masato Aizawa, Kohei Suzuki, Yuki Nakajima, Kenichi Utano, Kana Tamazawa, Kenta Ueda, Jun Wada, Kentaro Sato, Goro Shibukawa, Noriko Tanaka, Kazutomo Togashi","doi":"10.5387/fms.24-00009","DOIUrl":"10.5387/fms.24-00009","url":null,"abstract":"Objectives: In inflammatory bowel disease therapy, thiopurines have been essential.　However, several reports have investigated factors affecting thiopurine metabolism to date.　This study investigated factors affecting intracellular concentrations of 6-thioguanine nucleotide (6-TGN) and 6-methylmercaptopurine (6-MMP) in a real-world setting.Methods: Between May 2013 and October 2021 in one institution, 44 patients (median age 44 years;male 35, female 9;ulcerative colitis 32, Crohn's disease 12) receiving thiopurines were reviewed.　Intracellular 6-TGN/6-MMP concentrations were measured by high-performance liquid chromatography, and the initial measurement in each patient was used for the study.Results: The 6-TGN level was significantly higher in females, with mild disease activity, absence of NUDT15 polymorphism, and allopurinol administration.　A higher trend was observed with high thiopurine dosage (>50 mg).　6-MMP levels were significantly lower with concomitant use of time-dependent 5-aminosalicylic acid (5-ASA) and allopurinol, and higher with high thiopurine dosage.　On multivariate analysis of variance, logarithmically transformed 6-TGN levels were significantly higher in females, with high thiopurine dosage, and allopurinol administration.　Similarly, logarithmically transformed 6-MMP levels were significantly higher with time-dependent 5-ASA administration and high thiopurine dosage.Conclusions: Patients who received allopurinol, a high dose of thiopurine, or were female showed higher 6-TGN levels.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"47-55"},"PeriodicalIF":0.7,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0