Fukushima Journal of Medical Science最新文献_第3页

The impact of motor function deterioration on swallowing function in older adults: a narrative review. 运动功能恶化对老年人吞咽功能的影响：一项叙述性回顾。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-09-04 DOI: 10.5387/fms.26-00008

Mari Sato, Tetsuo Hayashi

{"title":"The impact of motor function deterioration on swallowing function in older adults: a narrative review.","authors":"Mari Sato, Tetsuo Hayashi","doi":"10.5387/fms.26-00008","DOIUrl":"https://doi.org/10.5387/fms.26-00008","url":null,"abstract":"Similar to motor function, swallowing function declines with age. Dysphagia in older adults has detrimental effects, including an increased risk of pneumonia and mortality, highlighting the importance of early detection and intervention at the community level. This review aims to comprehensively discuss the relationship between motor and swallowing functions in older adults through a narrative review, including existing limitations, with the goal of contributing to the early detection of dysphagia and the development of treatment strategies.Regarding the relationship between swallowing and whole-body skeletal muscle strength, associations between swallowing or tongue pressure and grip strength have been reported. A relationship between tongue pressure and respiratory muscles has been hypothesized, given the association between tongue pressure and walking function, which focuses on age-related changes in neural function, and the fact that certain swallowing-related muscles contract in coordination with respiratory movements.Detailed assessment of research, such as endoscopic swallowing studies, and verification of causal relationships through intervention and longitudinal studies are expected to contribute to the early detection and treatment of dysphagia.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redo cardiac and great vessel surgery: necessity of meticulous preparation and contingency planning. 重做心脏和大血管手术：精心准备和应急计划的必要性。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-08-13 DOI: 10.5387/fms.25-00051

Ken-Ichi Imasaka

{"title":"Redo cardiac and great vessel surgery: necessity of meticulous preparation and contingency planning.","authors":"Ken-Ichi Imasaka","doi":"10.5387/fms.25-00051","DOIUrl":"10.5387/fms.25-00051","url":null,"abstract":"Recent advances in surgical techniques and perioperative management have significantly improved the outcomes of cardiac and/or thoracic aortic surgery compared with earlier decades. However, redo procedures remain particularly challenging, with surgical results still inferior to those of primary operations. The complexity arises from altered anatomy, dense adhesions, and increased risks of injury to vital structures. Careful surgical planning is therefore indispensable, and four strategic steps are especially critical. First, meticulous preoperative assessment with contrast-enhanced computed tomography is required to delineate the spatial relationship between the heart, great vessels, and sternum. Second, the optimal approach to intrapericardial access must be determined, including whether cardiopulmonary bypass should be instituted prior to median sternotomy. Third, safe and deliberate dissection of adhesions surrounding the heart and great vessels is essential to avoid catastrophic complications. Finally, effective organ protection strategies, particularly for the brain and myocardium, are paramount to ensure favorable outcomes. This review highlights common pitfalls encountered in redo cardiac and/or thoracic aortic surgery and discusses practical strategies to overcome them, aiming to provide surgeons with a structured framework for improving safety and results in these high-risk procedures.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathophysiological and clinical significance of hepatokine Fetuin-A and myocardial N-myristoylation in heart failure. 心衰患者肝因子Fetuin-A及心肌n-肉豆蔻酰化的病理生理及临床意义。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-08-13 DOI: 10.5387/fms.26-00021

Yusuke Tomita, Tomofumi Misaka, Tetsuro Yokokawa, Yasuchika Takeishi

{"title":"Pathophysiological and clinical significance of hepatokine Fetuin-A and myocardial N-myristoylation in heart failure.","authors":"Yusuke Tomita, Tomofumi Misaka, Tetsuro Yokokawa, Yasuchika Takeishi","doi":"10.5387/fms.26-00021","DOIUrl":"10.5387/fms.26-00021","url":null,"abstract":"Heart failure (HF) is a systemic syndrome in which myocardial remodeling and multiorgan dysfunction exacerbate each other. This review focuses on the hepatokine Fetuin-A and the post-translational modification N-myristoylation in HF. Regarding Fetuin-A, we first demonstrated that circulating Fetuin-A levels were significantly lower in HF patients than in control subjects without structural heart disease. This reduction was associated with hepatic hypoperfusion. In a prospective study of 202 HF patients who underwent cardiopulmonary exercise testing, the combination of lower Fetuin-A and impaired exercise tolerance was independently associated with increased risk of cardiac events, suggesting that Fetuin-A could serve as a novel mediator of cardiac-hepatic-peripheral interaction. Regarding N-myristoylation, expression of N-myristoyltransferase 2 (NMT2) was significantly reduced in failing hearts. Cardiac-specific NMT2 knockdown exacerbated cardiac dysfunction, whereas AAV9-mediated NMT2 gene transfer attenuated cardiac remodeling and HF. Click chemistry-based proteomics identified MARCKS as a crucial substrate, and N-myristoylation of MARCKS prevented pathological hypertrophy by promoting its membrane localization, thereby suppressing CaMKII-HDAC4 signaling. These findings indicate that Fetuin-A and NMT2-dependent N-myristoylation play important roles in HF pathophysiology and represent potential novel therapeutic targets.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of interscalene brachial plexus block with postural modification for inferior shoulder dislocation with fracture: a case report. 斜角肌间臂丛阻滞加体位改良治疗下肩脱位骨折1例。

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Fukushima Journal of Medical Science Pub Date : 2026-08-13 DOI: 10.5387/fms.25-00053

Takeru Yokota, Hiroki Sato, Toshiki Sato, Yota Kaneko, Michiyuki Hakozaki, Yoshihiro Matsumoto

{"title":"Utility of interscalene brachial plexus block with postural modification for inferior shoulder dislocation with fracture: a case report.","authors":"Takeru Yokota, Hiroki Sato, Toshiki Sato, Yota Kaneko, Michiyuki Hakozaki, Yoshihiro Matsumoto","doi":"10.5387/fms.25-00053","DOIUrl":"10.5387/fms.25-00053","url":null,"abstract":"Background: Inferior shoulder dislocation (luxation erecta) is a rare condition, accounting for approximately 0.5% of all shoulder dislocations, typically resulting from high-energy trauma, such as falls or motor vehicle accidents.Case presentation: This case involved a man in his late 50s who sustained an inferior left shoulder dislocation with a greater tuberosity fracture after falling 2 m during work-related activities. Due to the patient's elevated BMI and absence of an anesthesiologist, general anesthesia was not feasible and local anesthesia led to inadequate pain relief and complicated reduction. We employed an interscalene brachial plexus block, enhanced by a modified approach involving positional adjustment and elastic taping, to address the abducted arm position and potential cervical spine concerns. Reduction was successfully performed without complications, such as neurovascular injury and respiratory issues.Conclusions: This report describes a modified interscalene block technique that may serve as a practical alternative in selected cases where general anesthesia is unavailable.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain lesions associated with abnormal muscle tone during the swing phase in post-stroke hemiparesis. 卒中后偏瘫摇摆期与异常肌张力相关的脑损伤。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-08-13 DOI: 10.5387/fms.26-00010

Jun Mashiko, Tatsuya Ito, Masamitsu Otake, Hiroaki Abe

{"title":"Brain lesions associated with abnormal muscle tone during the swing phase in post-stroke hemiparesis.","authors":"Jun Mashiko, Tatsuya Ito, Masamitsu Otake, Hiroaki Abe","doi":"10.5387/fms.26-00010","DOIUrl":"10.5387/fms.26-00010","url":null,"abstract":"Background: Post-stroke spasticity may involve dynamic abnormalities that impair voluntary movement, such as muscle co-contraction during gait, which may be present even in patients without apparent spasticity at rest. This study aimed to identify brain lesion locations associated with abnormal lower-limb muscle co-contraction during walking using support vector regression lesion-symptom mapping.Methods: Thirty-two ambulatory patients with first-ever supratentorial stroke were included. Lower-limb motor impairment was defined as a Fugl-Meyer Assessment lower-extremity score of < 34. Surface electromyography recorded activity of the tibialis anterior and medial gastrocnemius muscles during gait. The co-activation index (CoI) was calculated from the overlap of normalized electromyography waveforms during the swing phase. Lesions were delineated on magnetic resonance imaging and analyzed using support vector regression lesion-symptom mapping, followed by disconnectome analysis to identify involved white matter tracts.Results: A higher CoI was associated with lesions in the premotor cortex, precentral gyrus, and superior longitudinal fasciculus, with a 100% probability of disconnection in the second and third branches of the superior longitudinal fasciculus.Conclusion: Lesions in regions involved in sensorimotor integration were associated with abnormal lower-limb muscle co-contraction during walking, supporting the importance of dynamic gait assessment and targeted rehabilitation after stroke.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy following childhood hemipelvectomy: labor dystocia attributable to absent bony guidance and pelvic distortion-a case report and literature review. 儿童半骨盆切除术后妊娠：由于骨引导缺失和骨盆扭曲导致的难产- 1例报告和文献复习。

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Fukushima Journal of Medical Science Pub Date : 2026-08-13 DOI: 10.5387/fms.26-00030

Tsubasa Hobo, Shun Yasuda, Yumiko Kitago, Tomoko Yamaguchi, Misa Sugeno, Ryo Matsuoka, Yuki Sato, Toma Fukuda, Hirotaka Isogami, Tsuyoshi Murata, Akiko Yamaguchi, Masatoshi Jimbo, Hideki Sano, Atsushi Kikuta, Keiya Fujimori

{"title":"Pregnancy following childhood hemipelvectomy: labor dystocia attributable to absent bony guidance and pelvic distortion-a case report and literature review.","authors":"Tsubasa Hobo, Shun Yasuda, Yumiko Kitago, Tomoko Yamaguchi, Misa Sugeno, Ryo Matsuoka, Yuki Sato, Toma Fukuda, Hirotaka Isogami, Tsuyoshi Murata, Akiko Yamaguchi, Masatoshi Jimbo, Hideki Sano, Atsushi Kikuta, Keiya Fujimori","doi":"10.5387/fms.26-00030","DOIUrl":"10.5387/fms.26-00030","url":null,"abstract":"Background: Pregnancy after childhood hemipelvectomy is rare, and contemporary guidance on fertility, preconception counseling, and delivery planning remains limited. Altered pelvic anatomy may affect fetal descent and rotation ; however, the optimal mode and delivery timing should be individualized.Case: A 30-year-old primigravida, with a history of right hemipelvectomy for osteosarcoma, conceived spontaneously after regular menstrual cycles. Fertility preservation was not performed during childhood treatment, and formal preconception counseling with an obstetric team was not provided. After antenatal assessment, a trial of labor was planned under close supervision. During induction at 38 weeks of gestation, vaginal examination and transabdominal ultrasonography revealed poor fetal head descent and deviation toward the pelvic defect, with suspected rotational failure. Cesarean delivery was performed after persistently poor progress and non-reassuring fetal heart rate patterns. Intraoperatively, uterine rotation with rightward cervical deviation and leftward fundal deviation was observed.Conclusion: After hemipelvectomy, delivery planning should consider the pelvic anatomy, maternal functional status, anesthetic issues, and risk of prolonged labor. Intrapartum ultrasonography may help identify fetal head deviation and malrotation ; however, timely transition to cesarean delivery should be considered when poor descent persists.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychiatric-onset prodromal dementia with lewy bodies: a comparative analysis of two cases. 精神性前驱痴呆伴路易体：两例比较分析。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-08-13 DOI: 10.5387/fms.26-00018

Yuka Iwasaki, Yuhei Mori, Risa Shishido, Manami Toride Tojo, Naoki Morita, Akiko Sato, Tetsuya Shiga, Shuntaro Itagaki, Itaru Miura

{"title":"Psychiatric-onset prodromal dementia with lewy bodies: a comparative analysis of two cases.","authors":"Yuka Iwasaki, Yuhei Mori, Risa Shishido, Manami Toride Tojo, Naoki Morita, Akiko Sato, Tetsuya Shiga, Shuntaro Itagaki, Itaru Miura","doi":"10.5387/fms.26-00018","DOIUrl":"10.5387/fms.26-00018","url":null,"abstract":"Psychiatric-onset DLB refers to a prodromal presentation of DLB in which late-life psychiatric symptoms precede the characteristic cognitive and neurological features of DLB, often leading to an initial diagnosis of a primary psychiatric disorder. We report two women with psychiatric-onset DLB presentations who were followed longitudinally at a single institution. Case 1 presented with late-onset severe depression and anxiety, together with clinically suspected rapid eye movement sleep behavior disorder (RBD). Cognitive function was preserved, and dopamine transporter scintigraphy showed reduced striatal uptake, whereas myocardial metaiodobenzylguanidine scintigraphy and cerebral perfusion single-photon emission computed tomography showed no clinically meaningful abnormalities. A psychiatric-onset prodromal DLB presentation was suspected. Case 2 initially presented with depressive symptoms and mild cognitive impairment after cerebral aneurysm surgery and was first diagnosed with an organic mental disorder. Longitudinal follow-up revealed progressive cognitive decline, parkinsonism, autonomic dysfunction, and subsequent biomarker abnormalities approximately 9 years after the initial presentation, leading to a diagnosis of DLB. The total follow-up period to date is approximately 15 years. These cases highlight the heterogeneity of psychiatric-onset DLB and the importance of careful longitudinal reassessment in older adults with new-onset psychiatric symptoms.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and pathophysiological roles of YKL-40 in obstructive airway diseases. YKL-40在阻塞性气道疾病中的临床及病理生理作用。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-08-13 DOI: 10.5387/fms.26-00034

Yasuhito Suzuki, Junpei Saito, Ryuki Yamada, Yoko Shibata

{"title":"Clinical and pathophysiological roles of YKL-40 in obstructive airway diseases.","authors":"Yasuhito Suzuki, Junpei Saito, Ryuki Yamada, Yoko Shibata","doi":"10.5387/fms.26-00034","DOIUrl":"10.5387/fms.26-00034","url":null,"abstract":"YKL-40 (chitinase-3-like protein 1) has emerged as a biomarker associated with inflammation and tissue remodeling. YKL-40 is produced by multiple cell types, including macrophages, neutrophils, and airway structural cells, and has been implicated in chronic inflammatory and remodeling processes. While the exact biological role of YKL-40 remains unclear, it has been studied in various respiratory and systemic diseases, including obstructive airway diseases. Clinical investigations in asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap have demonstrated that both serum and sputum YKL-40 levels correlate with sputum neutrophils and may reflect neutrophil-associated non-type 2 airway inflammation in these obstructive airway diseases. Specifically, serum YKL-40 levels are also associated with airflow limitation, disease severity, longitudinal lung function decline, and exacerbation risk. Sputum YKL-40 appears more closely related to symptom burden than to lung function indices. Overall, YKL-40 may represent an informative biomarker, supporting its potential clinical relevance. Future prospective studies incorporating standardized measurement and integrated biomarker approaches that combine YKL-40 with established type 2 indicators may improve inflammatory phenotyping and risk stratification, potentially supporting precision medicine strategies. In this review, we summarize the biological characteristics and clinical roles of YKL-40, with a particular focus on obstructive airway diseases.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of virtual non-contrast imaging and related metrics with variable iodine concentrations and flow rates in dual-energy CT: a phantom study. 双能CT中可变碘浓度和流速的虚拟非对比成像和相关指标的验证：一项虚幻研究。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-07-09 DOI: 10.5387/fms.25-00045

Masami Tashiro, Toshinori Shoji, Masaki Saito, Yuta Kaneko, Hideaki Takasumi

{"title":"Validation of virtual non-contrast imaging and related metrics with variable iodine concentrations and flow rates in dual-energy CT: a phantom study.","authors":"Masami Tashiro, Toshinori Shoji, Masaki Saito, Yuta Kaneko, Hideaki Takasumi","doi":"10.5387/fms.25-00045","DOIUrl":"https://doi.org/10.5387/fms.25-00045","url":null,"abstract":"Objectives: To validate virtual non-contrast (VNC) imaging accuracy and related dual-energy CT (DECT) metrics (CT, CM, and iodine density values) under varied iodine concentrations and flow rates using a phantom model.Methods: Iodine solutions (3.7-18.5 mg I/mL) were circulated through a phantom at five flow rates (120-500 mL/min). DECT scanning (SOMATOM go.Top) was performed three times per condition. Four metrics were measured from ROIs on ten central slices per scan (n = 3 per condition ; N = 75). Two-way ANOVA and Tukey's HSD test were applied (α = 0.05).Results: Iodine concentration was the predominant determinant for all metrics (p < .001). VNC values showed a consistent negative deviation that increased with concentration and high variability across conditions. A significant interaction between concentration and flow rate was observed for iodine density (p = .019), indicating that flow dynamics affect material decomposition. CT, CM, and iodine density values showed stable, predictable responses.Conclusion: VNC accuracy is compromised at high iodine concentrations, with flow-related disturbances introducing additional instability via material decomposition errors. Flow dynamics should be considered when interpreting VNC imaging, particularly in arterial-phase CTA.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between the osteoporosis self-assessment tool for Asians and the 25-question Geriatric Locomotive Function Scale: A cross-sectional study of 1,194 community-dwelling Japanese adults ≥65 years old. 亚洲人骨质疏松自我评估工具与25题老年运动功能量表之间的关系：对1,194名≥65岁的日本社区成年人的横断面研究

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-07-09 DOI: 10.5387/fms.25-00036

Takaomi Kobayashi, Tadatsugu Morimoto, Koji Otani

{"title":"Association between the osteoporosis self-assessment tool for Asians and the 25-question Geriatric Locomotive Function Scale: A cross-sectional study of 1,194 community-dwelling Japanese adults ≥65 years old.","authors":"Takaomi Kobayashi, Tadatsugu Morimoto, Koji Otani","doi":"10.5387/fms.25-00036","DOIUrl":"https://doi.org/10.5387/fms.25-00036","url":null,"abstract":"This study examined the association between the osteoporosis self-assessment tool for Asians (OSTA) index and the 25-question Geriatric Locomotive Function Scale (GLFS-25) as well as locomotive syndrome (LS) in community-dwelling elderly individuals in Japan. We conducted a cross-sectional study of 1,194 adults 65 years or older who participated in a health checkup in Fukushima Prefecture in 2018. To assess the association between the GLFS-25 total score and OSTA index, we conducted multivariable linear regression analyses to calculate the regression coefficient (β) with confidence interval (CI), adjusted for demographic, lifestyle, and medical factors. The dependent variable was the GLFS-25 total score, and the independent variable was the OSTA index. In addition, receiver operating characteristic (ROC) curve analyses were used to evaluate the discriminatory ability of the OSTA index and determine the optimal cutoff value. The OSTA index was significantly associated with the GLFS-25 total score (β = -0.55, 95% CI : -0.89 to -0.21). The optimal OSTA index cutoff value for identifying LS-1 or more was -4 (area under the ROC curve, 0.57 ; sensitivity, 67.4% ; specificity, 40.1%). Although the OSTA index was independently associated with the GLFS-25 total score, it is not a valid screening tool for LS in this population.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0