Fukushima Journal of Medical Science最新文献_第4页

The efficacy of ultrasonography-guided transvaginal needle biopsy for the preoperative diagnosis of uterine neoplasm: a case report of a young woman with low-grade endometrial stromal sarcoma and literature review. 超声引导下经阴道穿刺活检在子宫肿瘤术前诊断中的作用：1例年轻女性低级别子宫内膜间质肉瘤并文献复习。

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Fukushima Journal of Medical Science Pub Date : 2026-07-09 DOI: 10.5387/fms.26-00001

Chikako Okabe, Shigenori Furukawa, Chihiro Okoshi, Yuki Yoshimoto, Takeshi Watanabe, Mimori Fujimori, Asami Kato, Hideki Miura, Tetsu Sato, Norihito Kamo, Yuta Endo, Norshalena Shakespear, Yuko Hashimoto, Tsuyoshi Honda, Shu Soeda, Keiya Fujimori

{"title":"The efficacy of ultrasonography-guided transvaginal needle biopsy for the preoperative diagnosis of uterine neoplasm: a case report of a young woman with low-grade endometrial stromal sarcoma and literature review.","authors":"Chikako Okabe, Shigenori Furukawa, Chihiro Okoshi, Yuki Yoshimoto, Takeshi Watanabe, Mimori Fujimori, Asami Kato, Hideki Miura, Tetsu Sato, Norihito Kamo, Yuta Endo, Norshalena Shakespear, Yuko Hashimoto, Tsuyoshi Honda, Shu Soeda, Keiya Fujimori","doi":"10.5387/fms.26-00001","DOIUrl":"https://doi.org/10.5387/fms.26-00001","url":null,"abstract":"We report the case of a 23-year-old nulligravida woman with low-grade endometrial stromal sarcoma (LGESS) diagnosed using ultrasonography-guided transvaginal needle biopsy. The patient presented with severe anemia and heavy menstrual bleeding. MRI revealed a 10-cm uterine tumor with irregular signal intensity. Due to her virginal status and the intramural location of the tumor, conventional endometrial sampling was not feasible. Transvaginal ultrasound-guided needle biopsy was successfully performed under general anesthesia, providing an accurate preoperative diagnosis. Following oocyte cryopreservation, she underwent modified radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy. Pathological examination confirmed LGESS with stage IIB disease. The patient remains disease-free at 30 months post-surgery with adjuvant letrozole therapy. This case demonstrates the efficacy of ultrasound-guided needle biopsy for preoperative diagnosis of uterine sarcoma in young women when conventional sampling methods are not applicable.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Japanese spotted fever and adjunctive fluoroquinolones: a critical appraisal of hard outcome evidence. 日本斑疹热和辅助氟喹诺酮类药物：对硬结果证据的关键评估。

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Fukushima Journal of Medical Science Pub Date : 2026-07-09 DOI: 10.5387/fms.26-00024

Eiichiro Sando

引用次数: 0

A case of idiopathic portal hypertension complicated by cronkhite-canada syndrome presenting with refractory ascites. 特发性门静脉高压症合并cronkite -canada综合征，表现为难治性腹水。

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Fukushima Journal of Medical Science Pub Date : 2026-07-01 Epub Date: 2025-10-29 DOI: 10.5387/fms.25-00024

Jun Wada, Kana Tamazawa, Kenta Ueda, Sayuri Watanabe, Kohei Suzuki, Masato Aizawa, Yuki Nakajima, Goro Shibukawa, Kazutomo Togashi, Hiromasa Ohira

{"title":"A case of idiopathic portal hypertension complicated by cronkhite-canada syndrome presenting with refractory ascites.","authors":"Jun Wada, Kana Tamazawa, Kenta Ueda, Sayuri Watanabe, Kohei Suzuki, Masato Aizawa, Yuki Nakajima, Goro Shibukawa, Kazutomo Togashi, Hiromasa Ohira","doi":"10.5387/fms.25-00024","DOIUrl":"10.5387/fms.25-00024","url":null,"abstract":"The patient was a 40-year-old woman who initially presented with ascites in September 2016. She was observed for suspected fatty liver disease and IgA nephropathy. In April 2023, she was admitted to the hospital after sustaining a self-inflicted injury. She presented with ascites and impaired liver and kidney function. A liver biopsy revealed no significant fibrosis, and she was diagnosed with idiopathic portal hypertension (IPH). The ascites did not improve with diuretics or paracentesis. A colonoscopy revealed multiple hyperplastic polyps, and a protein leakage scintigraphy identified protein leakage from the sigmoid colon. This led to a diagnosis of Cronkhite-Canada syndrome (CCS). She presented with characteristic skin symptoms of CCS, including nail atrophy and taste disturbances. Prior to the onset of symptoms, she reported experiencing psychological stress. Steroid therapy improved the ascites and pleural effusion, and the liver dysfunction gradually improved. This case suggests that an autoimmune background may have triggered or exacerbated the IPH and that CCS should be considered in the differential diagnosis of refractory ascites.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"253-259"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145402420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-invasive prenatal genetic testing in Fukushima prefecture: a retrospective cohort analysis. 福岛县无创产前基因检测：回顾性队列分析。

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Fukushima Journal of Medical Science Pub Date : 2026-07-01 Epub Date: 2026-02-05 DOI: 10.5387/fms.25-00032

Chihiro Okoshi, Takafumi Watanabe, Asako Yoshie, Makiko Ueda, Tsuyoshi Murata, Shun Yasuda, Toma Fukuda, Rika Suzuki, Yasuhisa Nomura, Keiya Fujimori

{"title":"Non-invasive prenatal genetic testing in Fukushima prefecture: a retrospective cohort analysis.","authors":"Chihiro Okoshi, Takafumi Watanabe, Asako Yoshie, Makiko Ueda, Tsuyoshi Murata, Shun Yasuda, Toma Fukuda, Rika Suzuki, Yasuhisa Nomura, Keiya Fujimori","doi":"10.5387/fms.25-00032","DOIUrl":"10.5387/fms.25-00032","url":null,"abstract":"Non-invasive prenatal genetic testing (NIPT) began in Japan in 2013 as clinical research. Fukushima Medical University Hospital (FMU) was the only accredited facility for NIPT in Fukushima Prefecture from 2016 until 2022, when two additional collaborative facilities were accredited. This study aimed to describe the current status of NIPT at FMU through a retrospective analysis of the medical records of 1,123 individuals who sought NIPT and received genetic counseling at FMU between January 2016 and December 2023. Of these individuals, 1,078 underwent NIPT, while 45 did not. The total NIPT uptake corresponded to 1.2% of all births in Fukushima during this period. Although the number of patients undergoing NIPT at FMU has been continuously decreasing since 2022, overall uptake in the prefecture increased in 2023. All three accredited facilities are located in highly populated, easily accessible parts of Fukushima Prefecture, leading to higher uptake among those living in these and surrounding areas. After genetic counseling, some opted against NIPT, while others chose to undergo other tests, which indicates the importance of informed decision- making. In large regions like Fukushima, increasing the number of accredited facilities and improving access to appropriate genetic counseling are crucial for ensuring informed decision-making about NIPT.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"215-224"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146120695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential diagnosis of retroperitoneal lymphangioma mimicking an ovarian tumor in the right adnexal region in a woman with a giant fibroid: a case report and literature review. 巨大肌瘤女性右附件区模仿卵巢肿瘤的腹膜后淋巴管瘤的鉴别诊断：1例报告及文献复习。

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Fukushima Journal of Medical Science Pub Date : 2026-07-01 Epub Date: 2026-02-18 DOI: 10.5387/fms.25-00030

Yuki Sato, Toshifumi Takahashi, Osamu Hasegawa, Osamu Suzuki, Yuta Endo, Shigenori Furukawa, Mariko Ogawa, Shu Soeda, Keiya Fujimori

{"title":"Differential diagnosis of retroperitoneal lymphangioma mimicking an ovarian tumor in the right adnexal region in a woman with a giant fibroid: a case report and literature review.","authors":"Yuki Sato, Toshifumi Takahashi, Osamu Hasegawa, Osamu Suzuki, Yuta Endo, Shigenori Furukawa, Mariko Ogawa, Shu Soeda, Keiya Fujimori","doi":"10.5387/fms.25-00030","DOIUrl":"10.5387/fms.25-00030","url":null,"abstract":"Background: Lymphangiomas are rare benign tumors typically occurring in children's head andneck regions. Pelvic lymphangiomas in adults are extremely uncommon and often mimic ovariantumors, making preoperative diagnosis challenging in peri- and postmenopausal women.Case presentation: A 53-year-old Japanese woman with a duodenal ulcer history developed amulticystic right adnexal mass during follow-up for uterine fibroid (initially diagnosed at age43). The uterine fibroid measured 11 cm on imaging at the start of follow-up, with no abnormalitiesdetected in the adnexa. Magnetic resonance imaging (MRI) performed at age 52 revealed a58×37 mm multicystic mass in the right adnexa, which enlarged to 80 mm over the followingyear. MRI revealed a multicystic mass near the right ovarian vessels ; the left adnexa appearednormal. Surgery included right adnexectomy, total hysterectomy, and left salpingo-oophorectomy.Intraoperatively, a well-defined multicystic lesion was identified along the infundibulopelvicligament with normal right ovary appearance. Histopathological examination confirmed lymphangioma,with positive immunostaining for D2-40 and CD31. The postoperative course was uneventful,with no recurrence at the 3-year follow-up.Conclusion: Pelvic lymphangioma should be considered in the differential diagnosis of multilocularpelvic masses. Comprehensive imaging and histopathological analysis are crucial for accurate diagnosisand management.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"281-288"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rectal neuroendocrine tumor (G1) with widespread metastasis 8 years after endoscopic resection. 直肠神经内分泌肿瘤（G1），内镜切除后8年发生广泛转移。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-07-01 Epub Date: 2025-12-12 DOI: 10.5387/fms.25-00025

Masato Aizawa, Kenichi Utano, Noriyuki Isohata, Yuka Utano, Daiki Nemoto, Shungo Endo, Kazutomo Togashi

{"title":"Rectal neuroendocrine tumor (G1) with widespread metastasis 8 years after endoscopic resection.","authors":"Masato Aizawa, Kenichi Utano, Noriyuki Isohata, Yuka Utano, Daiki Nemoto, Shungo Endo, Kazutomo Togashi","doi":"10.5387/fms.25-00025","DOIUrl":"10.5387/fms.25-00025","url":null,"abstract":"AbstractRectal neuroendocrine tumor (NET) G1 is a docile-looking tumor. We herein report a 77-year-old male whose rectal NET G1 measuring 10 mm recurred eight years after endoscopic mucosal resection. Tumor recurrence was detected by his mild general fatigue. Abdominal computed tomography revealed widespread metastasis, including the liver, lymph nodes around the rectum, and cervical spines. Subsequent somatostatin receptor scintigraphy, as well as histological reassessment of previously resected specimen, proved that these metastatic diseases originated from the rectal NET G1 with vascular invasion and possible positive vertical margin. First, octreotide long-acting repeatable 30 mg i.m. was administered every four weeks. Second, transcatheter arterial chemoembolization (TACE) for multiple liver metastases and irradiation therapy for spinal metastasis were carried out. One year after these treatments started, everolimus (mTOR inhibitor) 10 mg p.o. was administered every day. For the last five years, he received two rounds of TACE treatments and one round of irradiation. Although recurrent diseases were temporally controlled by these multidisciplinary treatments for the last month, he died of multiple metastases six years later, after tumor recurrence was detected. This case underscores the potential for late recurrence even in rectal NET G1 with unfavorable histological features, highlighting the importance of long-term surveillance.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"261-265"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145757716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Initial characteristics to predict the duration of multidisciplinary pain treatment in chronic pain patients: a cross-sectional study. 预测慢性疼痛患者多学科疼痛治疗持续时间的初始特征：一项横断面研究。

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Fukushima Journal of Medical Science Pub Date : 2026-07-01 Epub Date: 2025-11-27 DOI: 10.5387/fms.25-00031

Naoto Takahashi, Shoji Yabuki

{"title":"Initial characteristics to predict the duration of multidisciplinary pain treatment in chronic pain patients: a cross-sectional study.","authors":"Naoto Takahashi, Shoji Yabuki","doi":"10.5387/fms.25-00031","DOIUrl":"10.5387/fms.25-00031","url":null,"abstract":"AbstractChronic pain patients can achieve substantial improvement within six months, but some require prolonged care. This study aimed to explore differences in baseline characteristics and questionnaire responses between patients who showed significant improvement within six months (completion group) and those requiring treatment beyond six months (continuation group). A cross-sectional study was conducted among 131 patients. Patients were classified into completion group (n = 97) or continuation group (n = 34). Baseline data included demographic information (sex, age), ICD-11J classification, average pain intensity using the numeric rating scale (NRS) and scores from the Brief Pain Inventory (BPI), Pain Catastrophizing Scale (PCS), Pain Disability Assessment Scale (PDAS), Hospital Anxiety and Depression Scale (HADS), Pain Self-Efficacy Questionnaire (PSEQ), EuroQol Five Dimensions Questionnaire (EQ-5D), and Athens Insomnia Scale (AIS). There were no significant differences in age, sex, or ICD-11J classification between the groups. However, the continuation group exhibited significantly higher baseline scores for average pain intensity, PDAS, and HADS depression than the completion group. Patients with higher baseline pain intensity, greater functional impairment, and more severe depressive symptoms were more likely to require extended multidisciplinary treatment. Early identification of these risk factors is critical for optimizing treatment planning and improving outcomes in chronic pain management.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"199-206"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing clinical outcomes of robot-assisted versus total laparoscopic hysterectomy for symptomatic uterine fibroids. 机器人辅助与腹腔镜全子宫切除术治疗症状性子宫肌瘤的临床效果比较。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-07-01 Epub Date: 2025-12-25 DOI: 10.5387/fms.25-00018

Riho Yazawa, Hyo Kyozuka, Kazuki Anjo, Toma Fukuda, Daisuke Suzuki, Yasuhisa Nomura

{"title":"Comparing clinical outcomes of robot-assisted versus total laparoscopic hysterectomy for symptomatic uterine fibroids.","authors":"Riho Yazawa, Hyo Kyozuka, Kazuki Anjo, Toma Fukuda, Daisuke Suzuki, Yasuhisa Nomura","doi":"10.5387/fms.25-00018","DOIUrl":"10.5387/fms.25-00018","url":null,"abstract":"Objective: This study aimed to compare the clinical outcomes of total laparoscopic hysterectomy (TLH) and robot-assisted laparoscopic hysterectomy (RALH) for treating symptomatic uterine fibroids at a single institution in Japan. Additionally, we identified factors associated with operative time in each surgical approach.Methods: This retrospective cohort study included 163 premenopausal women with symptomatic uterine fibroids who underwent TLH (n = 119) or RALH (n = 44) between October 2021 and March 2025. Clinical characteristics, magnetic resonance imaging findings, and surgical outcomes were reviewed. Operative time was defined as the time from skin incision to closure. Multivariate linear regression analyses stratified by surgical method were performed to identify factors influencing operative time.Results: Operative time was significantly longer in the RALH than in the TLH group (median:208 vs. 176 min, p < 0.001). Multivariate analysis revealed that uterine length (LU) was associated with longer operative time in both groups, whereas parity was associated with reduced operative time in the RALH group.Conclusion: Both UL and parity were independent factors influencing operative time and highlighted the clinical implications of longer operative time in early-phase RALH compared with TLH.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"207-214"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preliminary analysis for the ADD-BP study: Atypical femoral fractures and physical activity levels in bisphosphonate users. ADD-BP研究的初步分析：非典型股骨骨折和双膦酸盐使用者的身体活动水平。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-07-01 Epub Date: 2026-02-05 DOI: 10.5387/fms.25-00019

Takeru Yokota, Takuya Kameda, Takuya Nikaido, Shunsuke Sato, Yoichi Kaneuchi, Hitoshi Yamada, Miho Sekiguchi, Koichiro Sato, Takahiro Tajino, Hideya Asakuma, Katsuhiko Sato, Yasufumi Sekiguchi, Noriyoshi Sato, Kazuya Murakami, Yoshihiro Matsumoto

{"title":"Preliminary analysis for the ADD-BP study: Atypical femoral fractures and physical activity levels in bisphosphonate users.","authors":"Takeru Yokota, Takuya Kameda, Takuya Nikaido, Shunsuke Sato, Yoichi Kaneuchi, Hitoshi Yamada, Miho Sekiguchi, Koichiro Sato, Takahiro Tajino, Hideya Asakuma, Katsuhiko Sato, Yasufumi Sekiguchi, Noriyoshi Sato, Kazuya Murakami, Yoshihiro Matsumoto","doi":"10.5387/fms.25-00019","DOIUrl":"10.5387/fms.25-00019","url":null,"abstract":"Objective: To investigate the relationship between physical activity levels and atypical femoral fractures (AFF) in bisphosphonate (BP) users.Methods: In the Assessing Daily-Activity-Level for Decisions on Bisphosphonate Prescription (ADD-BP) study, we retrospectively analyzed 27 women with AFF from five hospitals (2019-2023), categorized into BP (n = 18) and no-BP (n = 9) groups. Pre-injury physical activity was assessed via mobility aid usage, Long-Term Care Insurance System status, and independence in daily living.Results: Median ages were 77 years (BP) and 86 years (no-BP). In the BP vs. no-BP groups, 83.3% vs. 33.3% used no mobility aids, 11.1% vs. 22.2% used canes, and 5.6% vs. 33.3% used walkers. No BP users (0%) vs. 33.0% of no-BP users were housebound ; others were independent.Conclusion: BP users with AFF exhibited higher physical activity levels than non-users, suggesting low activity may not elevate AFF risk in long-term BP use. These findings support the safety of extended BP therapy for fragility fracture prevention in less active patients. Future case-control studies are needed to confirm these results. This study was approved by the Fukushima Medical University Ethics Committee (REC2023-176).","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"233-243"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146120731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of systemic sarcoidosis with pituitary adrenal insufficiency complicated by eosinophilic gastroenteritis. 系统性结节病合并垂体肾上腺功能不全并发嗜酸性胃肠炎1例。

IF 0.9

Fukushima Journal of Medical Science Pub Date : 2026-07-01 Epub Date: 2025-12-12 DOI: 10.5387/fms.25-00001

Yuya Sumichika, Shuhei Yoshida, Shuzo Sato, Natsumi Norikawa, Ryuichi Togawa, Yuichiro Kiko, Kenji Saito, Haruki Matsumoto, Jumpei Temmoku, Yuya Fujita, Naoki Matsuoka, Tomoyuki Asano, Kiyoshi Migita

{"title":"A case of systemic sarcoidosis with pituitary adrenal insufficiency complicated by eosinophilic gastroenteritis.","authors":"Yuya Sumichika, Shuhei Yoshida, Shuzo Sato, Natsumi Norikawa, Ryuichi Togawa, Yuichiro Kiko, Kenji Saito, Haruki Matsumoto, Jumpei Temmoku, Yuya Fujita, Naoki Matsuoka, Tomoyuki Asano, Kiyoshi Migita","doi":"10.5387/fms.25-00001","DOIUrl":"10.5387/fms.25-00001","url":null,"abstract":"This paper reports a rare case of coexisting systemic sarcoidosis and eosinophilic gastroenteritis. Multiple inflammatory lesions were detected by computed tomography and (18)F-fluorodeoxyglucose positron emission tomography, and a diagnosis of systemic sarcoidosis was established by biopsies from the hilar lymph node and palpable purpura. The patient exhibited peripheral blood eosinophilia. Upper endoscopy revealed duodenitis, and histological examination confirmed marked eosinophilic infiltration of the duodenal mucosa, consistent with eosinophilic gastroenteritis (EGE). The patient also had hypopituitary adrenal insufficiency, thought to be caused by neurosarcoidosis, based on medical history and evidence of systemic sarcoidosis. Early administration of corticosteroids resulted in improvement without sequelae. Our case suggests that hypereosinophilia and EGE may manifest as a lethal disease phenotype, such as adrenal insufficiency or neurosarcoidosis.","PeriodicalId":44831,"journal":{"name":"Fukushima Journal of Medical Science","volume":" ","pages":"245-252"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145757748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0