Advances in Gerontology最新文献_第8页

Age-Associated Features of the Expression Level of Apoptosis Markers in Cardiomyocytes of Patients with Dilated Cardiomyopathy 扩张型心肌病患者心肌细胞凋亡标志物表达水平的年龄相关特征

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Advances in Gerontology Pub Date : 2022-07-12 DOI: 10.1134/S2079057022020126

K. P. Kravchenko, K. L. Kozlov, A. O. Drobintseva, D. S. Medvedev, V. O. Polyakova

{"title":"Age-Associated Features of the Expression Level of Apoptosis Markers in Cardiomyocytes of Patients with Dilated Cardiomyopathy","authors":"K. P. Kravchenko, K. L. Kozlov, A. O. Drobintseva, D. S. Medvedev, V. O. Polyakova","doi":"10.1134/S2079057022020126","DOIUrl":"10.1134/S2079057022020126","url":null,"abstract":"To understand the pathogenesis of dilated cardiomyopathy (DCMP), it is necessary to establish the molecular and cellular mechanisms of myocardial aging, including those associated with programmed cell death, the molecular mechanisms of which have not been extensively studied. The aim of this work is to study markers of apoptosis in cardiomyocytes of patients with DCMP in vitro. We used the method of primary dissociated cell cultures and the method of immunofluorescence confocal laser microscopy. Cells of the 3rd and 14th passages, corresponding to “young” and “old” cultures, were used to simulate cellular senescence. At the molecular level, aging of cardiomyocyte cells was accompanied by a twofold increase in the expression of p16INK4a compared to “young” cultures, both in the control group and in the group with DCMP. It was also found that the expression of p16INK4a in cultures taken from patients with pathology was two times higher than in similar cultures from healthy patients. The expression of p21 was increased in the group with DCMP compared to the control; however, with aging of the culture, the expression of p21 did not change, remaining at a significant level. The most significant (3.2-fold) differences were obtained when comparing the expression of Bax in the cell culture of cardiomyocytes from the group with DCMP in the “young” culture compared with the control. Aging of myocardial cells at the molecular level was manifested in an increase in the expression of the Bax protein, which is the triggering mechanism of the mitochondrial apoptosis pathway. It is possible that this pathway of cell death is prevalent in DCMP.","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49218360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astragalus membranaceus Increases Leukocyte Telomere Length, but Does Not Suppress Development of Accelerated Senescence Signs in OXYS Rats 黄芪增加OXYS大鼠白细胞端粒长度，但不抑制加速衰老迹象的发展

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Advances in Gerontology Pub Date : 2022-07-12 DOI: 10.1134/S2079057022020114

O. S. Kozhevnikova, V. A. Devyatkin, M. A. Tyumentsev, E. A. Rudnitskaya, A. Zh. Fursova, N. G. Kolosova

{"title":"Astragalus membranaceus Increases Leukocyte Telomere Length, but Does Not Suppress Development of Accelerated Senescence Signs in OXYS Rats","authors":"O. S. Kozhevnikova, V. A. Devyatkin, M. A. Tyumentsev, E. A. Rudnitskaya, A. Zh. Fursova, N. G. Kolosova","doi":"10.1134/S2079057022020114","DOIUrl":"10.1134/S2079057022020114","url":null,"abstract":"Astragalus membranaceus (AM) was used for millennia by traditional Chinese medicine to slow down aging and extend lifespan. It has been shown that AM can affect all key hallmarks of aging including compensating telomere shortening which is recognized as one of the most reliable biomarkers of aging. The telomere shortening in peripheral blood leukocytes is viewed as a promising biomarker in predicting the risk of age-related diseases as well as a biomarker of the effectiveness of treatment. However, findings from epidemiological studies on the links between leukocyte telomere length (LTL) and age-related diseases are rather contradictory. The present study is aimed to investigate the effect of AM on the LTL and the AM influence on the manifestation and development of the sings of accelerated senescence in OXYS rats. Animals were given AM root powder (100 mg/kg) from 3 to 6 months of age. Our study confirmed the ability of AM to activate telomerase, as evidenced by an increase in LTL in OXYS rats. However, LTL lengthening was not accompanied by a delay of the accelerated senescence of OXYS rats, manifested as the early development of cataract, retinopathy similar to age-related macular degeneration and accelerated brain aging. Thus, we have demonstrated a limitation of using LTL as indicator for assessing the effectiveness of anti-aging therapy.","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45529304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Morphological Signs of Neurogenic Inflammation in the Heart of Rats during Aging 衰老过程中大鼠心脏神经源性炎症的形态学特征

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Advances in Gerontology Pub Date : 2022-07-12 DOI: 10.1134/S2079057022020059

E. I. Chumasov, E. S. Petrova, D. E. Korzhevskii

{"title":"Morphological Signs of Neurogenic Inflammation in the Heart of Rats during Aging","authors":"E. I. Chumasov, E. S. Petrova, D. E. Korzhevskii","doi":"10.1134/S2079057022020059","DOIUrl":"10.1134/S2079057022020059","url":null,"abstract":"Cellular changes in different parts of the heart of Wistar rats at the age of 18–23 months are studied using histological methods of staining with toluidine blue, hematoxylin-eosin, and immunohistochemical reactions for PGP 9.5 protein, tyrosine hydroxylase (TH), and Iba-1 protein. Focal inflammatory infiltrates are found in the connective tissue of the heart base, near which PGP 9.5+ and TH+ plexuses consisting of parasympathetic and sympathetic nerve fibers are detected. In the area of the valvular heart apparatus and at the border between the fibrous ring and myocardium of the right atrium, the following pathological changes in nerve structures are observed: degeneration of nerve fibers and granular destruction of varicose axons of the terminal plexus. A close relationship is established between the axons of the terminal neural network and cells of inflammatory infiltrates and blood capillaries. The features of the localization of neurocellular inflammatory complexes consisting of nerve fibers, blood capillaries, and cells participating in the local inflammatory process (mast cells, macrophages, fibroblasts, and plasma cells) are described in various parts of the myocardium in old animals. The chronic nature of neurogenic inflammation is determined for the heart during aging.","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46402727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Evaluation of an Educational Intervention to Prepare Close-to-Retirement Employees for Retirement 为接近退休的员工做好退休准备的教育干预的设计和评估

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Advances in Gerontology Pub Date : 2022-07-12 DOI: 10.1134/S2079057022020138

H. Najafipour, G. H. Sepehri, S. H. Saberi, H. Kashef, V. Borhaninejad

引用次数: 1

Comparison of Older Primary Healthcare Workers with Non-Older Workers in Terms of Working Life, Quality of Life and Health Problems in Turkey 土耳其老年初级保健工作者与非老年工作者在工作寿命、生活质量和健康问题方面的比较

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Advances in Gerontology Pub Date : 2022-07-12 DOI: 10.1134/S2079057022020023

V. Akkaya, M. Picakciefe, M. N. Ilhan

{"title":"Comparison of Older Primary Healthcare Workers with Non-Older Workers in Terms of Working Life, Quality of Life and Health Problems in Turkey","authors":"V. Akkaya, M. Picakciefe, M. N. Ilhan","doi":"10.1134/S2079057022020023","DOIUrl":"10.1134/S2079057022020023","url":null,"abstract":"With the rapid growth of aging all over the world, it was reported that the proportion of older workers in employment would increase. It was aimed to comparison of older primary healthcare workers with non-older workers in terms of working life, quality of life and health problems in Mugla, Turkey. This cross-sectional was conducted in primary healthcare workers in Mugla. In the study population of 176 workers, 171 were responded, 73 of them were older and 98 of them were non-older workers. Older and non-older healthcare workers were compared in terms of working life, quality of life and health problems. In terms of working life characteristics; the thought of difficulty in finding a new work, exposure to physical violence and to chemical solids or liquids were found to be more favorable in non-older healthcare workers, other characteristics were found to be more favorable in older healthcare workers. In terms of quality of life characteristics; older healthcare workers were generally better. In terms of health problems characteristics; the presence of chronic disease, the frequency of going to a health institution and the difficulty of urination were found to be more favorable in non-older healthcare workers, other characteristics were found to be more favorable in older healthcare workers. It was concluded that older healthcare workers were in a better condition than non-older healthcare workers in terms of many characteristics. With this study which was a pioneer in the field, researches on older workers should be supported with funding.","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42297700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leukocyte Telomere Length and Response to Antiangiogenic Therapy in Patients with Neovascular Age-Related Macular Degeneration 新生血管性年龄相关性黄斑变性患者白细胞端粒长度和对抗血管生成治疗的反应

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Advances in Gerontology Pub Date : 2022-07-12 DOI: 10.1134/S2079057022020072

A. Zh. Fursova, A. S. Derbeneva, M. S. Tarasov, I. F. Nikulich, V. A. Devyatkin, D. V. Telegina, N. G. Kolosova, O. S. Kozhevnikova

{"title":"Leukocyte Telomere Length and Response to Antiangiogenic Therapy in Patients with Neovascular Age-Related Macular Degeneration","authors":"A. Zh. Fursova, A. S. Derbeneva, M. S. Tarasov, I. F. Nikulich, V. A. Devyatkin, D. V. Telegina, N. G. Kolosova, O. S. Kozhevnikova","doi":"10.1134/S2079057022020072","DOIUrl":"10.1134/S2079057022020072","url":null,"abstract":"Age-related macular degeneration (AMD) is becoming the leading cause of vision loss in people over 60 yr of age. The neovascular form of AMD (nAMD) is characterized by choroidal neovascularization (CNV), the main trigger of which is vascular endothelial growth factor (VEGF), the inhibition of which is the current standard of treatment. Significant variability of response to anti-VEGF therapy determines the relevance of the search for biological markers—prognostic criteria of treatment response. We analyzed the response of 110 nAMD patients to anti-VEGF therapy depending on the functional and anatomical parameters of the retina (according to optical coherence tomography, OCT) and leukocyte telomere length (LTL, was assessed by quantitative PCR). Positive dynamics of best corrected visual acuity (BCVA) was observed in 100% of eyes. The central retinal thickness (CRT) decreased after the 3rd injection to 265 [234–306] µm, by the end of the observation period—to 211 [190–262] µm. The retention of activity of the subretinal neovascular membrane (SNM) at the end of the observation period correlated with lower values of the initial BCVA and high values of the initial CRT. An association of LTL with response to treatment was revealed: in patients with longer LTL the active form of SNM was more often switched to inactive after three injections, while with shorter LTL, the activity of SNM was more often preserved, which determined the need for more intravitreal injections.","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46799276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Changes in the Number of p23-Positive Fibroblasts in Human Dermis with Aging 人皮肤p23阳性成纤维细胞数随年龄的变化

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Advances in Gerontology Pub Date : 2022-07-12 DOI: 10.1134/S2079057022020084

A. G. Gunin, N. N. Golubtzova

引用次数: 0

Piezopulsometric Analysis of Autonomous Regulation of the Cardiovascular System in an Elderly Person under Stress 压力下老年人心血管系统自主调节的压电脉冲分析

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Advances in Gerontology Pub Date : 2022-07-12 DOI: 10.1134/S207905702202014X

V. P. Nesterov, A. I. Burdygin, K. B. Ivanov, S. V. Nesterov, S. I. Soroko

{"title":"Piezopulsometric Analysis of Autonomous Regulation of the Cardiovascular System in an Elderly Person under Stress","authors":"V. P. Nesterov, A. I. Burdygin, K. B. Ivanov, S. V. Nesterov, S. I. Soroko","doi":"10.1134/S207905702202014X","DOIUrl":"10.1134/S207905702202014X","url":null,"abstract":"The results of the application of a new method of arterial piezopulsometry for noninvasive assessment of the functional state and physiological mechanisms of autonomous regulation of the cardiovascular system (CVS) in an elderly person with acute pain associated with unexpected physical trauma are described. Such exposure caused a negative stress response in the muscle effectors (MEs) of CVS on the first day, provoking an abnormal increase and acceleration of LV myocardial contractility. Analysis of the arterial blood pressure pulse (PP) wave graphs shows that the maximum rate of PP growth, VmaxPP, reflecting the myocardial contractility, increased from 625 ± 74 before the trauma to 2117 ± 173 mm Hg/s after the trauma, distorting the waveform of the normal graph. The cause of this increase could be the rapid total effect of transmitters of the neuroendocrine sympathoadrenal system on the adrenergic receptors (ARs) of cardiomyocytes (CMs). The results of the spectral analysis of the variability of the PP wave parameters confirm this possibility. It is shown that under stress, norepinephrine from activated sympathetic efferents is added to the already increased content of humoral catecholamines in the extracellular environment of the myocardium near ARs of CMs, which is typical for older people. At the same time, the activity of parasympathetic efferents that release acetylcholine, which inhibits the contractile reaction of the myocardium and, thereby, performs a restraining cardioprotective function, significantly increases. A personalized approach was used to study the mechanisms of autonomous regulation of CVS MEs under stress.","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44101560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ageist Attitudes: Youth Identity, Subjective Time to Become Older, and Impressions of the General Older Population’s Physical and Mental Health 老年态度：青年身份、主观变老时间与一般老年人身心健康印象

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Advances in Gerontology Pub Date : 2022-07-12 DOI: 10.1134/S2079057022020163

Y. Shimizu, T. Hashimoto, K. Karasawa

引用次数: 4

Is Ketogenic Diet Therapy a Remedy for Alzheimer’s Disease or Mild Cognitive Impairments?: A Narrative Review of Randomized Controlled Trials 生酮饮食疗法能治疗阿尔茨海默病或轻度认知障碍吗?随机对照试验的叙述性回顾

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Advances in Gerontology Pub Date : 2022-07-12 DOI: 10.1134/S2079057022020175

H. Şimşek, A. Uçar

{"title":"Is Ketogenic Diet Therapy a Remedy for Alzheimer’s Disease or Mild Cognitive Impairments?: A Narrative Review of Randomized Controlled Trials","authors":"H. Şimşek, A. Uçar","doi":"10.1134/S2079057022020175","DOIUrl":"10.1134/S2079057022020175","url":null,"abstract":"Alzheimer’s disease (AD) is the most common form of dementia and is estimated to increase further due to the aging of the world population. Since preventive strategies or effective treatment for AD have not been defined yet, studies on metabolism and nutritional approaches have gained attention. A present literature review aimed to provide a summary of current evidence on the neuroprotective roles of ketogenic diets. A literature search was conducted on the MEDLINE, EMBASE, and CENTRAL databases for clinical trials that published in English and focused ketogenic therapy in AD or mild cognitive impairment. The neuroprotective potential of ketone bodies is based on mitochondrial dysfunction, suppression of oxidative damage and inflammation, reduction of the negative effects of impaired glucose metabolism in the brain, and effects at the genomic level. Clinical studies mainly provide evidence of improved verbal memory, attention, and total cognitive function. But optimal procedures have not yet been clarified. Also, ketogenic diet practices in older adults may pose several risks in long term. Therefore, further clinical research will shed more light on the neuroprotective effect, safety, and sustainability of the ketogenic diet, which is promising in the protection or improvement of cognitive functions.","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46039695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2