Interrelation of MicroRNAs and Transposons in Aging and Carcinogenesis

IF 0.6 Q4 GERIATRICS & GERONTOLOGY

Advances in Gerontology Pub Date : 2022-09-11 DOI:10.1134/S2079057022030092

R. N. Mustafin

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引用次数: 0

Abstract

The dysregulation of transposable elements plays a key role in human carcinogenesis. Physiological aging in humans is also caused by the deregulation of transposons. Moreover, aging is associated with the development of cancer. We present the results of an analysis of data on the presence of common epigenetic changes during aging and carcinogenesis, associated with changes in the expression of microRNAs derived from transposons. We find that aging is characterized by changes in the expression of 21 specific transposon-derived microRNAs associated with the development of malignant neoplasms. Before us, evidence similar to ours on the relationship between the mechanisms of aging and carcinogenesis at the epigenetic level has not been presented. We hypothesize that one of the key mechanisms of aging is an imbalance in the programmed activation of mobile genetic elements, which is reflected in changes in the body’s epigenetic regulation and leads to an increased risk of cancer. Since microRNA precursors can be translated with the formation of functional molecules, peptides used in gerontology can be considered as potential anticancer drugs.

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微rna和转座子在衰老和癌变中的相互关系

转座元件的失调在人类致癌过程中起着关键作用。人类的生理衰老也是由转座子的失调引起的。此外，衰老与癌症的发展有关。我们对衰老和致癌过程中常见的表观遗传学变化的数据进行了分析，这些变化与转座子产生的微小RNA表达的变化有关。我们发现，衰老的特征是与恶性肿瘤发展相关的21种特异性转座子衍生的微小RNA的表达发生变化。在我们之前，在表观遗传学水平上，关于衰老和致癌机制之间关系的类似证据还没有出现。我们假设衰老的关键机制之一是移动遗传元件的程序性激活失衡，这反映在身体表观遗传调控的变化中，并导致癌症风险增加。由于微小RNA前体可以随着功能分子的形成而翻译，因此用于老年病学的肽可以被认为是潜在的抗癌药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Gerontology GERIATRICS & GERONTOLOGY-

CiteScore

0.80

自引率

16.70%

发文量

期刊介绍： Advances in Gerontology focuses on biomedical aspects of aging. The journal also publishes original articles and reviews on progress in the following research areas: demography of aging; molecular and physiological mechanisms of aging, clinical gerontology and geriatrics, prevention of premature aging, medicosocial aspects of gerontology, and behavior and psychology of the elderly.