Peculiarities of the Innervation of Epicardial Adipose Tissue in a Rat with Aging (Immunohistochemical Study)

IF 0.6 Q4 GERIATRICS & GERONTOLOGY

Advances in Gerontology Pub Date : 2022-09-11 DOI:10.1134/S2079057022030055

E. I. Chumasov, E. S. Petrova, D. E. Korzhevskii

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Abstract

The aim of the research is to study the structure, innervation, and state of epicardial adipose tissue of the aortic-pulmonary region of the heart in rats at the age of 3–4 and 18–23 months using neural immunohistochemical markers. Using a complex of histological and immunohistochemical methods, different nervous apparatuses (ganglia, clusters of chromaffin cells, nerve trunks, nerve-fiber bundles, nerve plexuses, synaptic endings) with different mediators are detected in lobules of white and brown adipose tissue of the base of the rat heart. It is established that parasympathetic and sympathetic postganglionic nerve fibers are involved in the innervation of white and brown adipose tissue. They penetrate into the lobules as a part of Remak’s cords of varicose axons along arterial vessels, form terminal synaptic plexuses of the en-passant type, and are involved in the innervation of adipocytes of both types of epicardial adipose tissue. It is established that PGP 9.5+ cholinergic terminal nerve fibers prevail over catecholaminergic ones in mature rats. In the process of aging, common neurodegenerative, involutive (desimatization), and destructive pathological changes are noted in the epicardial adipose tissue of the studied animals.

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衰老大鼠心外膜脂肪组织神经支配的特点(免疫组织化学研究)

本研究的目的是使用神经免疫组织化学标记物研究3-4月龄和18-23月龄大鼠心脏主动脉-肺区心外膜脂肪组织的结构、神经支配和状态。使用复杂的组织学和免疫组织化学方法，在大鼠心脏底部白色和棕色脂肪组织的小叶中检测到具有不同介质的不同神经装置（神经节、嗜铬细胞簇、神经干、神经纤维束、神经丛、突触终末）。已经确定副交感神经和交感节后神经纤维参与白色和棕色脂肪组织的神经支配。它们作为雷马克静脉曲张轴突的一部分沿着动脉血管穿透小叶，形成过渡型的终末突触丛，并参与两种类型心外膜脂肪组织的脂肪细胞的神经支配。在成熟大鼠中，PGP 9.5+胆碱能末梢神经纤维占主导地位。在衰老过程中，研究动物的心外膜脂肪组织中出现了常见的神经退行性、退化（消退）和破坏性病理变化。

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来源期刊

Advances in Gerontology GERIATRICS & GERONTOLOGY-

CiteScore

0.80

自引率

16.70%

发文量

期刊介绍： Advances in Gerontology focuses on biomedical aspects of aging. The journal also publishes original articles and reviews on progress in the following research areas: demography of aging; molecular and physiological mechanisms of aging, clinical gerontology and geriatrics, prevention of premature aging, medicosocial aspects of gerontology, and behavior and psychology of the elderly.