Advances in Gerontology最新文献

{"title":"Social Virtual Reality as a Solution for Aging Services and Gerontology: Understanding the Older Adults’ Acceptance of Virtual Reality Applications","authors":"K. W. Lau","doi":"10.1134/S207905702460068X","DOIUrl":"10.1134/S207905702460068X","url":null,"abstract":"<p>A demographic shift towards an ageing population necessitates a comprehensive examination of the quality of life of the older adults and a new development on aging service as well as gerontology. Current research has shown that virtual reality has the potential to enhance the well-being of them, including those with social isolation. Technology-mediated communication is vital for social connections in society. Virtual technologies enhance social engagement through social virtual reality. These platforms unite users in simulated virtual reality settings, enabling socialization. Contrary to misconceptions, the older adults have demonstrated high levels of engagement with virtual reality. The older adults have elicited positive responses, engagement and enjoyment. This research aims to enhance the well-being of the older adults by understanding their attitudes toward using social virtual reality for their social life. By investigating the older adults’ acceptance of using these applications, all the factors were tested and correlations were found from the Technology Acceptance Model. The findings also reveal that the “Use of Context” strongly influences “Perceived Ease of Use.” Social virtual reality eliminates the need for face-to-face chatting and enables virtual communication and activities to take place among friends. However, there is a comparatively low recognition rate of adoption among the participating elderly. Interaction designers and academics should emphasize the need for human-computer interaction in these applications.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"14 4","pages":"161 - 170"},"PeriodicalIF":0.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Universal Markers of Cellular and Replicative Senescence","authors":"M. S. Arbatskiy,&nbsp;D. E. Balandin","doi":"10.1134/S2079057025600028","DOIUrl":"10.1134/S2079057025600028","url":null,"abstract":"<p>The investigation into cellular and replicative senescence is crucial for both biology and medicine, particularly in light of the increasing percentage of the elderly population. Gaining a deeper understanding of the mechanisms of these forms of aging can help develop strategies aimed at prolonging active longevity. By comparing the processes of cellular and replicative senescence, researchers can reveal both common and distinct molecular mechanisms, thus opening up innovative approaches to diagnosing and treating age-related diseases. The identified aging markers can contribute to personalized medicine and improving the diagnosis and treatment of aging cells. Thus, these studies greatly facilitate the development of methods for combating age-related diseases. The study aims to analyze cellular and replicative senescence in order to identify common mechanisms underlying the aging process. The goal is to understand the relationship between these processes and their influence on age-related changes. The specific objectives of this work include identifying aspects of aging and molecular markers that can be used for the diagnosis and monitoring of age-related disorders. The findings from this study will contribute to the prevention and treatment of age-related conditions, thereby improving overall population health. The public datasets E-MTAB-4879 (cellular senescence) and GSE130727 (replicative senescence) are analyzed. Quality control is carried out using the FastQC program. Adapter removal is performed by sequencing using the cutadapt 2.3 and Trimmomatic-0.38 programs. Mapping is carried out using the bowtie2-2.4.0 program. Reverification of the mapping results is performed using the kallisto-v0.45.0 pseudo-alignment algorithm. Quantification is carried out using featureCounts. RPKM (Read Per Kilobase per Million) normalization is applied (to average the total reads, coverage depth, and gene length). The mirnet.ca online service is used to search for regulatory miRNAs. For groups of genes that showed decreased (7275) and increased (5059) expression levels in the E-MTAB-4879 and GSE130727 datasets after filtering, we identify the biological processes they are involved in. For lists of the top 15 genes, we provide information on their role in the aging process. Additionally, for a group of commonly expressed genes, functional groups are determined using GO. The study compares two aging-related gene datasets and a total of 7275 genes with decreased expression are identified. Of these, 1342 show significant decreases in expression, with processes related to G-protein signaling, cholesterol metabolism, and cytokine signaling standing out. Some genes affect aging through inflammatory responses, membrane potential control, neurodegeneration, and cell differentiation. 143 noncoding RNAs associated with aging and cancer are identified upon further analysis. In a separate group, 1673 genes exhibit increased expression, involving processes such as glycero","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"14 3","pages":"127 - 134"},"PeriodicalIF":0.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the Role of Sleep in the Aging Processes","authors":"R. I. Isaev,&nbsp;E. A. Mkhitaryan,&nbsp;M. A. Cherdak,&nbsp;V. V. Vasilevskaya,&nbsp;E. A. Marakhovskaya,&nbsp;M. S. Arbatskiy","doi":"10.1134/S2079057025600053","DOIUrl":"10.1134/S2079057025600053","url":null,"abstract":"<p>Sleep, as a fundamental requirement for the body’s well-being, plays a crucial role in various essential biological processes. Aging is one of the natural biological processes that affects all functions of the human body. The relationship between sleep and aging has been the subject of significant interest of researchers in recent years. The work discusses modern views on the role of sleep in the aging processes and its geroprotective potential. The work provides data on studying the effect of sleep disorders on hallmarks of aging. The influence of sleep deprivation, insomnia, and obstructive sleep apnea syndrome on nine hallmarks of aging according to the classification developed by López-Otín et al., is discussed: genomic instability, telomere attrition, loss of proteostasis, epigenetic alterations, dysregulated nutrient sensing, mitochondrial dysfunction, stem cell exhaustion, cellular senescence, and altered intracellular communication. Data on somnological biomarkers and their relationship to the brain age index are also provided, and the influence of sleep on the formation of neurodegenerative disorders, including Alzheimer’s disease, is discussed. One of the sections is a review of published data on the significance of circadian rhythms in the development of neurodegeneration and aging processes. The use of light therapy and melatonin is considered as a geroprotective methods. In conclusion, the work discusses the importance of developing the area of gerontosomnology.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"14 4","pages":"138 - 150"},"PeriodicalIF":0.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of IGF-1 and IGFBP-3 with Aging and the Development of Age-Associated Diseases","authors":"A. K. Ilyushchenko,&nbsp;L. V. Matchekhina,&nbsp;A. A. Melnitskaia,&nbsp;I. D. Strazhesko","doi":"10.1134/S2079057025600041","DOIUrl":"10.1134/S2079057025600041","url":null,"abstract":"<p>Aging is a complex biological process that impacts various systems of the body with changes occurring at molecular, cellular, and physiological levels. One of the key elements in the study of aging is determination of the role of insulin-like growth factors (IGF) and insulin-like binding proteins (IGFBP). IGF, in particular IGF-1, are crucial for the regulation of cell growth, metabolism, and apoptosis. IGFBP, in particular IGFBP-3, modulate the bioavailability of IGFs by binding to them and influencing their receptor interactions. This work outlines the mechanisms of action of IGF-1 and IGFBP-3 and discusses clinical research findings on their significance in aging, longevity, and the development of age-associated diseases. To investigate the relationship between IGF and IGFBP and aging processes, a search is conducted in the Scopus and PubMed article databases. Basic and clinical studies published primarily between 2010 and 2024 are selected. The search utilized keywords such as “insulin-like growth factors,” “insulin-like growth factor-binding proteins,” “aging,” and “age-associated diseases.”</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"14 3","pages":"118 - 126"},"PeriodicalIF":0.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the Gut Microbiome as a Central Player in Aging: Mechanisms and Health Outcomes","authors":"A. A. Melnitskaia,&nbsp;L. V. Matchekhina,&nbsp;A. K. Ilyushchenko,&nbsp;I. D. Strazhesko","doi":"10.1134/S207905702560003X","DOIUrl":"10.1134/S207905702560003X","url":null,"abstract":"<p>The work explores the mechanisms by which the gut microbiome influences human aging and associated diseases. We examine age-related changes in the composition of the microbiota and their effects on inflammation, immune response, and intestinal-barrier permeability. Special attention is given to the pathogenic interactions between the gut microbiota and the development of cardiovascular, metabolic, and neurodegenerative diseases. The role of microbiome imbalance, known as dysbiosis, is highlighted as one of the key mechanisms accelerating the aging process. The review provides a comprehensive analysis of recent studies that demonstrate the impact of microbial metabolites on various systems of the body through the “gut—brain,” “gut—cardiovascular,” and “gut–endocrine brain” axes.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"14 3","pages":"111 - 117"},"PeriodicalIF":0.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Gerontology: Data-Driven Health Management and Precision Medicine","authors":"S. Zhang,&nbsp;L. Wu,&nbsp;Z. Zhao,&nbsp;J. R. Fernández Massó,&nbsp;M. Chen","doi":"10.1134/S2079057024600691","DOIUrl":"10.1134/S2079057024600691","url":null,"abstract":"<p>As the global population ages, healthcare systems face increasing challenges in managing the complex health needs of older adults, including multimorbidity, cognitive decline, and frailty. Artificial intelligence (AI) holds significant potential to address these challenges by offering advanced tools for personalized health management, disease prediction, and real-time monitoring. This paper reviews key AI applications in gerontology, focusing on its role in analyzing multimodal data such as electronic health records, genomic data, medical imaging, and wearable device metrics. AI’s ability to integrate and analyze these diverse data types enhances the precision of disease management and treatment personalization, particularly in chronic disease care and cognitive function assessment. However, challenges related to data quality, privacy concerns, and model interpretability remain. This review highlights both the transformative potential and the limitations of AI in elderly healthcare, advocating for future research aimed at improving model transparency, scalability, and interdisciplinary integration to enhance geriatric care.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"14 3","pages":"97 - 110"},"PeriodicalIF":0.6,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Sclerosis. Some Features of Pathology and Prospects for Therapy. Part 2","authors":"E. K. Fetisova,&nbsp;N. V. Vorobjeva,&nbsp;M. S. Muntyan","doi":"10.1134/S2079057024600769","DOIUrl":"10.1134/S2079057024600769","url":null,"abstract":"<p>Multiple sclerosis (MS) is among the most common neurological diseases. The number of MS affected people is constantly growing worldwide. Untreated MS leads to disability of the most capable part of the population of young age, and in recent years it has been diagnosed more often in elderly patients. The second part of our review is focused on the prospects of MS therapies under development. Mitochondria and the use of mitochodria-targeted antioxidants, neutrophils, as well as immune cells affected by pathology and other specialized cells, which can be reprogrammed and replaced by healthy cells using stem cells, pre-oligodendrocytes able to accelerate maturation and remyelinating ability on the antihistamine action, are considered as targets in MS treatment. Helminth therapy, accompanied by a shift in the composition of the microbiota of MS patients and the release of antioxidants in the tissues of humans and model animals, may lead to immunomodulation and reduction of oxidative stress, providing significant mitigation of the disease. Approaches to the treatment of elderly MS patients are discussed.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"14 3","pages":"87 - 96"},"PeriodicalIF":0.6,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peculiar Relations of Life Expectancy with Economics according to the Preston Curve and with Cultural Values according to the Hofstede Dimensions in Former Soviet Union and Yugoslavia Countries","authors":"A. G. Golubev,&nbsp;A. I. Michalski","doi":"10.1134/S2079057024600654","DOIUrl":"10.1134/S2079057024600654","url":null,"abstract":"<p>We checked whether national cultural differences according to Hofstede dimensions (HD) contribute to differences in life expectancy (LE) irrespective of per capita gross domestic product (GDP) in the countries, such as the Russian Federation (RF), where LE is markedly below the general LE-vs.-GDP trend (Preston curve, PC). The sample of 102 countries included those from the lists available at World Bank, Human Mortality Database and Hofstede Insight websites that feature all required data on GDP, LE and HD. Partial Kendall correlations between LE, GDP and five HD scores were calculated for GDP ranges distinguished based on different patterns of LE-vs.-GDP relations. It was found that, among the countries where LE is higher at GDP lower than in RF (Group Q; 37 countries), RF stands at the tops of lists ranged by HD scores for power distance (PD) and uncertainty avoidance (UA). Generally, PD and UA are uncorrelated. In Group Q, the combination of high UA and PD scores is specific for former Soviet Union and Yugoslavia states. Correlations with LE are negative and significant for this combination and for separate UA but not PD scores. UA does not correlate with LE in all countries and in groups where GDP &gt; 30 000 or &lt; 30 000 US$. The main cultural correlates of LE there are long-term orientation (both groups) and individualism (at GDP &lt; 30 000), which do not correlate with LE in Group Q. These observations may be useful for judging about prospects for increasing LE in Q countries by measures limited to economics, administration and public health.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"14 2","pages":"68 - 77"},"PeriodicalIF":0.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Time-of-Day on the Expression of Autophagy Genes at the Different Stages of Age-Related Macular Degeneration-Like Retinopathy in Rat’s Retina","authors":"O. S. Kozhevnikova,&nbsp;D. V. Telegina,&nbsp;Yu. V. Timofeeva,&nbsp;V. A. Devyatkin,&nbsp;N. G. Kolosova","doi":"10.1134/S2079057024600642","DOIUrl":"10.1134/S2079057024600642","url":null,"abstract":"<p>Age-related macular degeneration (AMD) is a complex progressive eye disease, resulting in loss of central vision in the aging population. The senescence-accelerated OXYS rats reproduce the major signs of AMD. Autophagy is a cellular degradation pathway for the breakdown of cytoplasmic components. Defects in the autophagy are linked to aging and disease pathology. The purpose of this study was to determine the daily pattern of autophagy genes expression in the retina of young and old OXYS and Wistar control rats. Retina from 3-month and 21-month-old OXYS rats and Wistar rats were collected at ZT1, ZT8 and ZT16 in Zeitgeber time units, where ZT0 represents lights on (8:00) and ZT12 represents lights off (20:00). Levels of autophagy genes expression (<i>Atg5</i>, <i>Atg7</i>, <i>Becn1</i>, <i>Gabarapl1</i>, <i>Nbr1</i>, <i>Map1lc3b</i>, <i>p62</i>/<i>Sqstm1</i>, and <i>Ulk1</i>) were evaluated by quantitative reverse-transcription PCR. At the age of 21 months, OXYS rats had altered diurnal expression of three key autophagy genes (<i>Atg7</i>, <i>p62</i>/<i>Sqstm1</i>, and <i>Ulk1</i>) in the retina compared to age-matched Wistar rats and 3-month-old OXYS rats. No time-of-day or age-related changes in the expression of other autophagy genes were detected in control Wistar rats. Therefore, the regulation of autophagy is impaired in OXYS rats in late stages of retinopathy. Our study highlights the importance of the autophagy pathway in the pathogenesis of AMD and suggests that dysregulation of the autophagy daily rhythms accompanies the progression of AMD-like retinopathy.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"14 2","pages":"78 - 86"},"PeriodicalIF":0.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Sclerosis. Some Features of Pathology and Prospects for Therapy. Part 1","authors":"E. K. Fetisova,&nbsp;N. V. Vorobjeva,&nbsp;M. S. Muntyan","doi":"10.1134/S2079057024600630","DOIUrl":"10.1134/S2079057024600630","url":null,"abstract":"<p>Multiple sclerosis (MS) is among the most common diseases of the central nervous system. The disease leads to pathological demyelination of axons in the white matter of the brain, followed by demyelination of gray matter, and is accompanied by progressive neurodegeneration in patients. The etiology of the disease is not fully understood. However, a number of external and internal factors that increase the likelihood of MS among the active capable part of the population have been established. The characteristics of age patients exacerbating the course of MS have been identified. The review discusses the mechanism of inflammation activation at MS involving NLRP3 inflammasome and neutrophils identified in recent years, the effect of inflammation on damage to the blood-brain barrier and MS progression, as well as reactive oxygen species-mediated participation of mitochondria in MS pathology development.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"14 2","pages":"35 - 48"},"PeriodicalIF":0.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}