Peculiarities of Venous Trophic Ulcers Course in Gerontoligical Patients according to Local Immunity and Morphological Manifestations

Abstract

As organs age morpho-functional changes of organs and tissues become pathological disrupting the quality of life and providing an aggravating effect on the course of underlying disease which requires a special treatment approach. The research purpose is the study of particular features of the clinical, immunological and morphological manifestations of the venous trophic ulcers in the elderly and senile aged patients. All 375 patients are suffering from venous trophic ulcers have been examined. All the patients are divided into three age groups according to the WHO classification: 1st group (middle-aged)—94 patients; 2nd group (elderly)—146 patients; 3rd group (seniors)—135 persons. Levels of IgA, IgG, IgM, IL-1β, TNF-α were measured in wound exudate. The content of vascular endothelial growth factor in wound exudate samples had been studied as well. The morphological examination of the bottom and edge parts of trophic ulcers has been carried out. It has been revealed that elderly and senile aged patients with involutional changes and long-term chronic inflammation in the zone of trophic ulcers had more prominent morphological changes and disruption synthesis of non-specific immunity proteins that slow down processes of recovery.