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The Role of the Serotonin Pathway of Tryptophan Metabolism in the Development of Neuroinflammation in Alzheimer’s Disease 色氨酸代谢的羟色胺通路在阿尔茨海默病神经炎症发展中的作用
IF 0.6
Advances in Gerontology Pub Date : 2024-03-07 DOI: 10.1134/S207905702460023X
A. S. Fomin, S. P. Sergeeva
{"title":"The Role of the Serotonin Pathway of Tryptophan Metabolism in the Development of Neuroinflammation in Alzheimer’s Disease","authors":"A. S. Fomin,&nbsp;S. P. Sergeeva","doi":"10.1134/S207905702460023X","DOIUrl":"10.1134/S207905702460023X","url":null,"abstract":"<p>Despite the fact that more than 90% of tryptophan is metabolized via the kynurenine pathway, the serotonin pathway is of great importance for the functioning of the central nervous system. The main products of this pathway are serotonin and melatonin. They provide maintenance of the sleep–wake mode, modulation of oxidative stress activity, apoptosis of neurons and glial elements, regeneration and neuroinflammation. In the pathogenesis of Alzheimer’s disease, neuroinflammation plays one of the main roles. Melatonin and serotonin, being modulators of its intensity, as well as an important component of neurochemical interactions that provide cognitive functions, can be considered as targets for preventive and therapeutic effects.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"13 3","pages":"130 - 137"},"PeriodicalIF":0.6,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140075508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Rate of Aging and Its Association with Risk Factors of Cardiovascular Diseases 衰老速度及其与心血管疾病风险因素的关系
IF 0.6
Advances in Gerontology Pub Date : 2024-03-07 DOI: 10.1134/S2079057024600228
A. A. Akopyan, I. D. Strazhesko, A. A. Moskalev, I. A. Orlova
{"title":"The Rate of Aging and Its Association with Risk Factors of Cardiovascular Diseases","authors":"A. A. Akopyan,&nbsp;I. D. Strazhesko,&nbsp;A. A. Moskalev,&nbsp;I. A. Orlova","doi":"10.1134/S2079057024600228","DOIUrl":"10.1134/S2079057024600228","url":null,"abstract":"<p>Background: Biological age is a better predictor of morbidity and mortality associated with chronic age-related diseases than chronological age. The estimated difference between biological and chronological age can reveal an individual’s rate of aging. Aim: The aim of this study was to assess the association of cardiovascular risk factors with the rate of aging in people without cardiovascular diseases. Materials and methods: We calculated biological artery age and found associations of “old” arteries and rate of aging with risk factors of cardiovascular diseases in 143 adults without cardiovascular diseases. The data were analyzed by their categorization into 3 tertiles using regression methods. Results: The increased biological age of the arteries compared to the chronological age was associated with the chronological age (<i>p</i> &lt; 0.001; ОR = 0.55; 95% CI: 0.43–0.71) and hypertension (<i>p</i> = 0.002; ОR = 6.04; 95% CI: 1.98–18.42) in general group, age (<i>p</i> &lt; 0.001; ОR = 0.45; 95% CI: 0.30–0.68), hypertension (<i>p</i> = 0.004; ОR = 12.79; 95% CI: 2.25–72.55) and family history of oncology (<i>p</i> = 0.036; ОR = 0.14; 95% CI: 0.02–0.88) in women subgroup and age (<i>p</i> = 0.001; ОR = 0.45; 95% CI: 0.28–0.76) and 3rd tertile of glycated hemoglobin (<i>p</i> = 0.041; ОR = 65.05; 95% CI: 1.19–3548.29) in men subgroup. Difference between biological and chronological age in a group of “old” arteries was associated with chronological age (<i>p</i> = 0.001; β = –1.24; 95% CI: –1.95…–0.53) and with chronological age (<i>p</i> &lt; 0.001; β = 1.71; 95% CI: 1.06–2.36) and 3rd tertile of glycated hemoglobin (<i>p</i> = 0.009; β = –4.78; 95% CI: –8.32…–1.24) in group of “young” arteries. Conclusion: This study demonstrates that accelerated arterial aging is associated with hypertension and high levels of glycated hemoglobin.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"13 3","pages":"148 - 155"},"PeriodicalIF":0.6,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140075519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Telomere Length and Geriatric Status in Centenarians 百岁老人端粒长度与老年状态之间的关系
IF 0.6
Advances in Gerontology Pub Date : 2024-03-07 DOI: 10.1134/S2079057024600253
K. A. Eruslanova, S. O. Zhikrivetskaya, Yu. V. Kotovskaya, O. N. Tkacheva
{"title":"Association between Telomere Length and Geriatric Status in Centenarians","authors":"K. A. Eruslanova,&nbsp;S. O. Zhikrivetskaya,&nbsp;Yu. V. Kotovskaya,&nbsp;O. N. Tkacheva","doi":"10.1134/S2079057024600253","DOIUrl":"10.1134/S2079057024600253","url":null,"abstract":"<p>Aim: To evaluate the association between telomere length and frailty and individual geriatric syndromes in older adults. Materials and methods: The database of a hundred-year-old citizen of the city of Moscow was analyzed. The analysis was carried out using the data driven from the Comprehensive Geriatric Assessment (CGA), in particular, Age is not a Hindrance Scale, the Barthel index, Instrumental Activities of Daily Living (IADL), Mini Nutritional Assessment (MNA), Mini-Mental State Examination (MMSE), and Geriatric Depression Scale (GDS-15). DNA was isolated from frozen blood and a study of telomere length was performed. The comparison of telomere length in groups of patients with frailty and individual geriatric syndromes was carried out. Results: The study involved 60 people (98 ± 1.8 years old, 86.7% women). The analysis found no differences in telomere length in research participants with and without frailty, as well as in the analysis of individual geriatric syndromes. No correlation was found between telomere length and the results of comprehensive geriatric assessment scales. There was no difference in telomere length in patients who died within 3 years of follow-up and those who did not. Conclusion: No relationship was found between telomere length and frailty. Thus, telomere length cannot be considered as a reliable biomarker of functional aging.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"13 2","pages":"99 - 103"},"PeriodicalIF":0.6,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140076266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of Neurocognitive Adaptation during Aging Process 衰老过程中的神经认知适应机制
IF 0.6
Advances in Gerontology Pub Date : 2024-03-07 DOI: 10.1134/S2079057024600204
M. A. Cherdak
{"title":"Mechanisms of Neurocognitive Adaptation during Aging Process","authors":"M. A. Cherdak","doi":"10.1134/S2079057024600204","DOIUrl":"10.1134/S2079057024600204","url":null,"abstract":"<p>Human aging is associated with an increased risk of various geriatric syndromes, cognitive impairment being among the most frequent. The most prominent form of the cognitive impairment—dementia—has become one of the major course of dependency in older and oldest old patients. Nevertheless, it has been shown that despite the fact that various parts of the brain change structurally over time due to natural aging or diseases, it does not necessarily manifest into clinical symptoms for some older people. Therefore, there is a dissociation of the severity of morphological and functional brain changes. The review presents current data on adaptive mechanisms that ensure the preservation of neurocognitive activity during aging process. In addition to the concept of brain and cognitive reserves, it discusses different mechanisms of neurocognitive maintenance and compensation both in the norm and in the development of Alzheimer’s disease. The possibility of their clinical and instrumental assessment and practical significance are discussed.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"13 3","pages":"123 - 129"},"PeriodicalIF":0.6,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140075521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Basic Epigenetic Mechanisms of Aging 衰老的基本表观遗传机制
IF 0.6
Advances in Gerontology Pub Date : 2024-03-07 DOI: 10.1134/S2079057024600241
I. D. Strazhesko, A. P. Yesakova, A. A. Akopyan, O. N. Tkacheva
{"title":"Basic Epigenetic Mechanisms of Aging","authors":"I. D. Strazhesko,&nbsp;A. P. Yesakova,&nbsp;A. A. Akopyan,&nbsp;O. N. Tkacheva","doi":"10.1134/S2079057024600241","DOIUrl":"10.1134/S2079057024600241","url":null,"abstract":"<p>The process of aging is a complex biological phenomenon that is influenced by multiple factors, including genetics, environment, and lifestyle. Recent studies have shown that epigenetic modifications play an important role in the aging process, as they regulate gene expression and ultimately affect cellular function. Epigenetic modifications include DNA methylation, histone modification, and non-coding RNA expression, among others. The authors of the review discuss the role of DNA methylation in regulating gene expression and its relationship to age-related diseases such as cancer and neurodegeneration. Also, the role of histone modification and its impact on chromatin structure and gene expression is reviewed in the article. Additionally, review provides information on the involvement of molecular hallmarks of aging in age-related diseases. Understanding the role of epigenetic mechanisms in aging is crucial for developing new interventions that could potentially slow down or even reverse the aging process.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"13 2","pages":"78 - 83"},"PeriodicalIF":0.6,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140075392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain Aging 大脑老化
IF 0.6
Advances in Gerontology Pub Date : 2024-03-07 DOI: 10.1134/S2079057024600198
M. A. Cherdak
{"title":"Brain Aging","authors":"M. A. Cherdak","doi":"10.1134/S2079057024600198","DOIUrl":"10.1134/S2079057024600198","url":null,"abstract":"<p>Brain aging is part of the aging of the whole body, largely determining the success of general aging and the quality of life of an older person. Brain aging is a complex multifactorial process that occurs throughout a human’s life, which includes changes at subcellular, tissue, and organ levels as well as at physiological level, mediating changes in neurophysiological (cognitive) functions. The review provides up-to-date data on morphological and physiological changes observed during natural aging; it discusses various phenotypes of brain aging, including both pathologically accelerated and “supernormal” aging; questions of the division between the norm and pathology are raised in the context of changes observed during brain aging; the factors both accelerating and decelerating the aging processes of the brain are considered along with linkage of natural aging with neurodegenerative and cerebrovascular diseases.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"13 2","pages":"70 - 77"},"PeriodicalIF":0.6,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140075472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Senolytic Drugs: Implications for Clinical Practice 衰老药物：对临床实践的影响
IF 0.6
Advances in Gerontology Pub Date : 2024-03-07 DOI: 10.1134/S2079057024600186
A. K. Ilyushchenko, L. V. Matchekhina, O. N. Tkacheva, A. V. Balashova, A. A. Melnitskaia, A. V. Churov, I. D. Strazhesko
{"title":"Senolytic Drugs: Implications for Clinical Practice","authors":"A. K. Ilyushchenko,&nbsp;L. V. Matchekhina,&nbsp;O. N. Tkacheva,&nbsp;A. V. Balashova,&nbsp;A. A. Melnitskaia,&nbsp;A. V. Churov,&nbsp;I. D. Strazhesko","doi":"10.1134/S2079057024600186","DOIUrl":"10.1134/S2079057024600186","url":null,"abstract":"<p>Studying the mechanisms of aging is one of the most important goals of modern science. A significant amount of data on the processes associated with a decrease in the functional ability to regenerate, cell proliferation and resistance to adverse factors with age has been accumulated due to fundamental research. The aim of the review was to study the mechanism of drugs with the senolytic activity, to determine the main targets of their effect at the cellular level, and also to evaluate the prospects for their clinical use. The relevance of this topic is confirmed by the increasing number of clinical trials of senolytics, many of which have ambiguous results and require further analysis and elimination of revealed difficulties and shortcomings. We reviewed the literature on Pubmed and Scopus platforms over the past 10 years in order to find information about the mechanisms of senotherapy and the possibility of using senolytics in clinical medicine. The focus was on those senolytic drugs that were used in clinical studies.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"13 2","pages":"62 - 69"},"PeriodicalIF":0.6,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140075518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial Antioxidant SkQ1 Affects the GABAergic but Not the Glutamatergic System in the Hippocampus of Wistar and Senescence Accelerated OXYS Rats 线粒体抗氧化剂 SkQ1 影响 Wistar 大鼠和衰老加速 OXYS 大鼠海马的 GABA 能系统而非谷氨酸能系统
IF 0.6
Advances in Gerontology Pub Date : 2024-02-22 DOI: 10.1134/S2079057024600058
D. V. Telegina, N. G. Kolosova
{"title":"Mitochondrial Antioxidant SkQ1 Affects the GABAergic but Not the Glutamatergic System in the Hippocampus of Wistar and Senescence Accelerated OXYS Rats","authors":"D. V. Telegina,&nbsp;N. G. Kolosova","doi":"10.1134/S2079057024600058","DOIUrl":"10.1134/S2079057024600058","url":null,"abstract":"<p>Numerous studies have shown that mitochondria-targeted antioxidant SkQ1 can increase the lifespan of many species and suppress the development of various age-related diseases. Previously we demonstrated that SkQ1 suppresses all manifestations of accelerated senescence in OXYS rats, including the development of the main signs of Alzheimer’s disease (AD). GABA and glutamate are two of the most abundant neurotransmitters in the central nervous system, and it was showed that changes in their signaling accompany aging and the development of AD. Previously, we showed delicate age-related changes of the components of glutamate/GABA system in Wistar and OXYS rats, a unique model of AD. Here we investigated the influence of the treatment with SkQ1 from 12 through 18 months of age (that is, during the active progression of AD-like pathology) on glutamate/GABA system in the rat hippocampus. Our data demonstrated that the neuroprotective effects of long-term administration of SkQ1 are mediated by its effect on the GABAergic but not the glutamatergic system in the hippocampus of Wistar and OXYS rats. Western blotting revealed an increase in the level of glutamate decarboxylase GAD67 in rats of both strains, a decrease in the GABA transporter GAT1 in Wistar rats, and a tendency towards abrogation of the increased level of GABA receptor subunits GABAAr1 in OXYS rats. Thus, we showed that the neuroprotective effects of long-term treatment with SkQ1 are mediated by its effect on the GABAergic but not the glutamatergic system in the hippocampus of Wistar and OXYS rats.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"13 1","pages":"36 - 43"},"PeriodicalIF":0.6,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139947169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gerontology in the 21st Century: From Failures to Advances. Hopefully 21 世纪的老年学：从失败到进步。希望
IF 0.6
Advances in Gerontology Pub Date : 2024-02-22 DOI: 10.1134/S2079057024600289
A. N. Khokhlov
{"title":"Gerontology in the 21st Century: From Failures to Advances. Hopefully","authors":"A. N. Khokhlov","doi":"10.1134/S2079057024600289","DOIUrl":"10.1134/S2079057024600289","url":null,"abstract":"<p>Editor-in-Chief of <i>Advances in Gerontology</i> describes the current editorial policy and the strategy of future development of the renewed journal which since 2023 is published as a separate independent edition. It is emphasized that now priority is given to publications devoted to (1) the fundamental mechanisms which may determine the increase in the probability of death of living organisms, including humans, with age, and to (2) identifying various factors of both chemical and physical nature that could potentially help to slow down the aging process. In addition, papers included in Volume 13, Issue 1 are shortly reviewed.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"13 1","pages":"1 - 3"},"PeriodicalIF":0.6,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139947154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-Related Changes in the Metabolomic Composition of Macaque (Macaca fascicularis) Ocular Tissues 猕猴眼组织中与年龄有关的代谢组成分变化
IF 0.6
Advances in Gerontology Pub Date : 2024-02-22 DOI: 10.1134/S2079057023600246
V. V. Yanshole, M. V. Fomenko, L. V. Yanshole, N. A. Osik, E. Y. Radomskaya, D. V. Bulgin, Y. P. Tsentalovich
{"title":"Age-Related Changes in the Metabolomic Composition of Macaque (Macaca fascicularis) Ocular Tissues","authors":"V. V. Yanshole,&nbsp;M. V. Fomenko,&nbsp;L. V. Yanshole,&nbsp;N. A. Osik,&nbsp;E. Y. Radomskaya,&nbsp;D. V. Bulgin,&nbsp;Y. P. Tsentalovich","doi":"10.1134/S2079057023600246","DOIUrl":"10.1134/S2079057023600246","url":null,"abstract":"<p>The study is aimed at determining age-related changes in ocular tissues of crab-eating macaque (<i>Macaca fascicularis</i>). To this end, we measured the concentrations of a total of 71 major metabolites in aqueous humor, vitreous humor, and lens of two groups of animals, young (4-year-old, <i>n</i> = 6) and aged (21-year-old and 27-year-old, <i>n</i> = 2) macaques. Significant age-related changes were revealed for all three tissues. In the lens, the most significant changes were found for cytoprotective compounds – antioxidants, osmolytes, and molecular ultraviolet (UV) filters: the concentrations of these metabolites in the lenses of aged animals are much lower. The observed changes contribute to increased oxidative stress and predispose the lens to the development of cataracts. The majority of cytoprotective metabolites are synthetized in the lens epithelium. Findings of this work indicate that the observed age-related changes may be caused by the impairment of the lens epithelial cells leading to the increase of oxidative stress in the lens nucleus and developing of age-related cataracts.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"13 1","pages":"9 - 15"},"PeriodicalIF":0.6,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139947046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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