Advances in Gerontology最新文献

{"title":"Proposal of a Training Protocol for Muscle Strength and Postural Balance in Older Adults: An Integrative Review","authors":"I. C. Vendramini,&nbsp;R. O. Machado,&nbsp;D. C. Ribeiro,&nbsp;C. Papcke,&nbsp;T. Lisboa,&nbsp;E. M. Scheeren","doi":"10.1134/S2079057025600454","DOIUrl":"10.1134/S2079057025600454","url":null,"abstract":"<p>Guidelines promote high-quality care for older adults. Exercise training recommendations have not been fully characterized. Objective: To propose a training protocol for functional muscle strength and postural balance in older adults, based on main literature findings. Methods: A systematic review, including studies for individuals aged 65 years or older, providing recommendations for strength and balance training between 2017 and March 2025. Results: A total of 1979 articles were initially identified. After removing duplicates and applying filters, 1880 articles were screened, and 11 studies met the inclusion criteria. These studies assessed multicomponent, concurrent, and strength training, and their effects on muscle strength, physical performance, balance, quality of life, and fall-related outcomes. Methodological quality was assessed using the Physiotherapy Evidence Database (PEDro) scale. Significant improvements were observed in muscle strength, physical performance, and balance in the intervention groups. Training protocols typically included exercises targeting both upper and lower limbs, with variations in intensity, frequency, and progression. Recommendations from the American College of Sports Medicine emphasized gradual progression and balance across muscle groups. The findings highlight studies that recommend exercise training for diverse older adult populations and various health outcomes, establishing exercise as a recognized component of care. These findings contrast with clinical reports indicating low implementation rates of exercise training, suggesting guideline recommendations may often be overlooked. Conclusions: Improving adherence to guideline-concordant exercise training could enhance function and quality of life in older adults. The presence of qualified fitness professionals during training sessions is essential to ensure safety and efficacy.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"15 4","pages":"207 - 222"},"PeriodicalIF":0.5,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the Reference Values for Hand Grip Strength and Its Influencing Factors in the Elderly of Amirkola","authors":"M. Faramarzi,&nbsp;S. Pourhadi,&nbsp;S. R. Hosseini,&nbsp;A. Bijani,&nbsp;R. Ghadimi,&nbsp;F. Mehriyan","doi":"10.1134/S2079057025600223","DOIUrl":"10.1134/S2079057025600223","url":null,"abstract":"<p>Background: The aging phenomenon is occurring at a faster rate in the developing countries compared to the developed countries. The most important issue in aging is promoting health, maintaining the independence of the elderly, and continuing to live an active life. Since reference values for hand grip strength vary across different populations and geographic regions, this study aimed to determine the reference values for hand grip strength and its influencing factors in the elderly of Amirkola. Methods: This cross-sectional study was a part of the second phase of the Amirkola Elderly Cohort and was conducted on 1375 elderly individuals aged 60 years and above willing to participate in the study. Muscle strength was measured using a dynamometer (Digital Hand Grip Dynamometer) in kilograms (kg). Other variables examined included demographic and anthropometric information, which were extracted using appropriate questionnaires and tools. Results: Based on the data, the median hand grip strength for women was 18 kg (range 11–26 kg), and for men was 32 kg (range 18–44 kg). Age and sex had the greatest impact on hand grip strength. A significant relationship was also observed between chronic disease, physical activity, bone mineral density, and fat-free mass with hand grip strength (<i>P</i> = 0.0001). Body Mass Index (BMI) and fat mass had a positive and significant effect in men. Educational level and marital status had a significant effect in both groups. Conclusion: The main factors affecting hand grip strength were age and sex. Other influential factors included chronic disease, physical activity, bone mineral density, and fat-free mass.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"15 4","pages":"240 - 245"},"PeriodicalIF":0.5,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eight-week Combined Exercise Reduces Fall Risk in Older Females: Posttest-Only Randomized Experimental Study","authors":"Z. Miçooğulları,&nbsp;M. Miçooğulları,&nbsp;S. Angın","doi":"10.1134/S2079057025600533","DOIUrl":"10.1134/S2079057025600533","url":null,"abstract":"<p>Falls among older adults represent a significant public health concern. This study, using a two-group posttest-only randomized experimental design aimed to investigate whether an 8-week combined exercise program reduces fall risk by improving vibration sense, proprioception, muscle strength, static balance, reaction time, and postural stability in women aged 65 years and older, compared to their matched sedentary counterparts. A total of 42 individuals who performed regular exercise (study group) and 42 age-matched participants with a sedentary lifestyle (control group) were included. Participants in the exercise group engaged in a combined exercise program under the supervision of a physiotherapist, 2–3 days per week for 8 weeks. Physical activity levels were assessed using the International Physical Activity Questionnaire (IPAQ)-Short Form. The variables evaluated included vibration and proprioception senses, isometric ankle muscle strength, static balance, postural stability, and reaction time. The Morse Fall Scale (MFS) was used to assess fall risk for each participant. The study group showed statistically significant improvements in ankle proprioception, isometric plantar and dorsiflexor muscle strength, static balance, ankle reaction time, postural stability, and fall risk outcomes compared to the control group (<i>p</i> &lt; 0.050). In contrast, vibration sense and isometric invertor and evertor muscle strength did not differ significantly between the two groups (<i>p</i> &gt; 0.050). Regular participation in an 8-week combined exercise program significantly enhances sensory-motor functions, reduces fall risk, and improves overall postural stability in older females aged 65 and above. These findings highlight the critical role of structured exercise in fall prevention strategies for this population.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"15 4","pages":"257 - 270"},"PeriodicalIF":0.5,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rural-Urban Gaps in Elderly E-Health Utilisation in the Digital Age: Insights from Assam","authors":"Arnob Paul,&nbsp;Kanchan Devi,&nbsp;Sushanta Kumar Nayak","doi":"10.1134/S2079057025600661","DOIUrl":"10.1134/S2079057025600661","url":null,"abstract":"<p>This study investigates rural-urban disparities in digital healthcare utilisation among elderly populations in Assam, with a focus on the mediating role of digital literacy. Primary survey data from 400 respondents aged 60 and above were used to construct a Digital Literacy Index (DLI) and a Digital Healthcare Utilisation Index (DHUI) via Principal Component Analysis. Multiple regression analysis identified age, education, income, living arrangements, and digital literacy as significant determinants, with rural residence linked to lower utilisation odds. The Oaxaca-Blinder decomposition revealed a DHUI gap of 2.946 units, of which 73% was explained by differences in characteristics, primarily digital literacy, education, and income. Digital literacy alone accounted for over one-third of the explained gap, while the unexplained component pointed to infrastructural, contextual, and socio-cultural barriers. Findings show that low education, economic constraints, and limited digital skills disproportionately hinder rural elderly from accessing e-health services despite greater healthcare needs. The study indicates digital literacy as the most actionable factor, advocating tailored, age-sensitive training, simplified interfaces, and social support mechanisms. Addressing these disparities is essential to prevent digital health initiatives from exacerbating inequalities and to ensure equitable inclusion of elderly populations in India’s evolving digital health ecosystem.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"15 4","pages":"283 - 297"},"PeriodicalIF":0.5,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of the mAgeing Mobile Program on Loneliness, Depression, and Resilience in Older Adults","authors":"N. Alizadeh,&nbsp;S. Pourhadi,&nbsp;H. Matlabi,&nbsp;S. Sum,&nbsp;A. Delbari,&nbsp;Z. Geraili","doi":"10.1134/S2079057025600132","DOIUrl":"10.1134/S2079057025600132","url":null,"abstract":"<p>Background and Objectives: Loneliness and depression are major public health issues among the elderly. Self-management and self-care interventions can enhance resilience and promote well-being. The World Health Organization’s (WHO) mobile-Ageing (mAgeing) program, which delivers daily health messages to older adults, aims to promote healthy aging and strengthen intrinsic capacity and functional ability. This study evaluated the effects of the WHO mAgeing smartphone-based program on loneliness, depression, and resilience among retired education professionals. Methods: This one-group pretest–posttest quasi-experimental study included 210 older adults aged over 60, recruited through convenience sampling. Participants received daily mAgeing messages and activity instructions via WhatsApp for eight weeks. Loneliness, depressive symptoms, and resilience were measured at baseline, week 8, and week 12 using the UCLA Loneliness Scale, Geriatric Depression Scale-5 (GDS-5), and the Connor-Davidson Resilience Scale (CD-RISC) questionnaires. Results: Among participants, 109 (54.8%) were women and 90 (45.2%) were men, with a mean age of 64.68 ± 3.23 years. After the intervention, the mean loneliness score decreased from 46.21 to 41.56, and the mean depression score declined from 1.25 to 0.89. The mean resilience score increased from 43.83 to 47.84. Statistical analyses showed significant reductions in depression and loneliness (<i>p</i> &lt; 0.001) and a significant improvement in resilience and its five components (<i>p</i> &lt; 0.001). Older age, male gender, being widowed or divorced, and a history of illness were negative demographic predictors of loneliness. Older age and male gender also predicted higher depression and lower resilience, whereas higher educational level and time progression positively predicted all three outcomes. Conclusion: The mAgeing program is feasible for use among older adults and can effectively reduce loneliness and depressive symptoms while improving resilience after an eight-week intervention. We emphasize that, given the single-group design, results indicate associations rather than causal effects.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"15 4","pages":"246 - 256"},"PeriodicalIF":0.5,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between Number of Different Medications per Day and Physical Function in Icelandic Community Dwelling Older Adults","authors":"A. Hafsteinsson,&nbsp;A. Ramel","doi":"10.1134/S207905702560051X","DOIUrl":"10.1134/S207905702560051X","url":null,"abstract":"<p>The number of different medications per day has been linked to reduced physical function in older adults. The aim of the present study was to investigate the associations between medication count and physical function in older adults with particular consideration of the potentially mediating effects of physical activity, skeletal muscle mass, cognitive function and the body’s fluid balance. This was a cross-sectional study conducted in 2022 including 69 community dwelling participants (age = 82.5 ± 6.5 years) who were service users provided by a nursing home in Reykjavik, Iceland. Each participant attended one session of ~60 min with the study staff for doing physical tests (anthropometrics, muscle strength, physical function) and answering questionnaires on lifestyle and health. Among the 46 women and 23 men, the prevalence of sarcopenia was 60.3%, and 52.2% of participants reported using ≥5 medications/day. When adjusted for sex and age, medication count was significantly associated with lower grip strength (B = –0.46 kg, <i>P</i> = 0.039), lower chair-rise test score (B = –0.15, <i>P</i> = 0.004) and lower short-physical-performance-battery score (B = –0.23, <i>P</i> = 0.040). Further adjustment for skeletal muscle mass and cognitive function only slightly attenuated the associations. However, adjusting for physical activity and extracellular/total body water ratio reduced the effect sizes by approximately 35–65%, and most associations were no longer statistically significant. In this specific, highly frail group of older adults there was a high prevalence of sarcopenia, low muscular strength and low physical function. The number of medications per day was found to be significantly associated with low muscle strength and poor physical function. Our study further indicates that the associations between the number of different medications per day and strength and physical function are partly mediated by low physical activity and high extracellular/total body water ratio in participants with higher daily medication use.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"15 4","pages":"271 - 282"},"PeriodicalIF":0.5,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Sleep Habits on 5-Year Survival in Elderly Individuals and Long-Livers","authors":"N. M. Vorobyeva,&nbsp;R. I. Isaev,&nbsp;E. A. Marakhovskaya,&nbsp;I. P. Malaya,&nbsp;Yu. V. Kotovskaya,&nbsp;O. N. Tkacheva","doi":"10.1134/S2079057025600399","DOIUrl":"10.1134/S2079057025600399","url":null,"abstract":"<p>Background. Healthy, good quality sleep is one of the necessary conditions for achieving longevity and improving survival. Numerous general population studies have revealed a relationship between some sleep-related habits and mortality, but the results of similar studies conducted in older age groups are not so unambiguous. Aim. To study the impact of sleep-related habits on 5-year survival in subjects aged ≥75 years. Materials and methods. The study included 223 subjects (24% men) aged 75–98 years (median 87 years) who lived in Moscow and Moscow region and were undergoing preplanned inpatient treatment at the Russian Gerontology Research and Clinical Center in 2011–2013. Upon admission to hospital, the patients were surveyed using a specially developed questionnaire in order to assess social and behavioral factors such as lifestyle, habits, diet, and physical activity. The sleep-related questionnaire included the following: (i) bedtime; (ii) wake-up time; (iii) nighttime sleep duration; (iv) daytime napping. After discharge, the patients were under follow-up for 5 years. Deaths from all causes were recorded. Results. During the 5 years of follow-up (median 3.63 years), 88 (39.5%) people died. Accordingly, the 5-year survival rate was 60.5%, and the mean survival time was 4.44 [95% confidence interval (CI): 4.19–4.71] years. The study demonstrates that most of the subjects went to bed at 22:00–00:00 (65%), woke up 6:00–8:00 (58%), had a daytime nap (61%), and 68% of the participants had a nighttime sleep duration of between 7 and 9 h. Univariate regression analysis shows that a late (after midnight) bedtime, waking up after 8:00, and a long (≥10 h) nighttime sleep are associated with a 1.7–2.1-fold increased risk of death over 5 years. On the contrary, an early (before midnight) bedtime, waking up between 4:00 and 8:00, and nighttime sleep of 5–9 h, are associated with a 43–52% decreased risk of death over this period. Daytime napping had no effect on 5-year survival. Multivariate regression analysis demonstrates that age (hazard ratio [HR] 1.09; 95% CI: 1.02–1.17; <i>p</i> = 0.019), early (before midnight) bedtimes (HR 0.55; 95% CI: 0.31–0.97; <i>p</i> = 0.040), and 5–9 h nighttime sleep duration (HR 0.44; 95% CI: 0.26–0.76; <i>p</i> = 0.003) are independent predictors of 5-year survival. Conclusions. In subjects aged ≥75 years who lived in Moscow and Moscow region, early (before midnight) bedtime and moderate (5–9 h) nighttime sleep duration are independent predictors of 5-year survival and are associated with a 45 and 56% reduction in the risk of mortality, respectively, which indicates that sleep may be a geroprotective factor.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"15 2","pages":"71 - 80"},"PeriodicalIF":0.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Association between Persistent Subjective Cognitive Decline and Frailty Progression: A Three-Year Study","authors":"S. Tanaka,&nbsp;K. Saida,&nbsp;A. Murayama,&nbsp;D. Higuchi,&nbsp;T. Shinohara","doi":"10.1134/S2079057025600211","DOIUrl":"10.1134/S2079057025600211","url":null,"abstract":"<p>Subjective cognitive decline (SCD) is a self-perceived deterioration in cognitive function and has been linked to both cognitive and physical decline. This study aimed to examine whether persistent SCD is associated with frailty after 3 years. A longitudinal cohort study using mailed questionnaires was conducted among community-dwelling older adults in Japan. Questionnaires were distributed at baseline, 6 months, and 3 years, assessing subjective cognitive complaints and frailty using validated screening tool. Sociodemographic and health related data were also collected. Participants who responded at all three time points and remained traceable throughout the study were included. Participants were divided into persistent SCD (consistently complaining of SCD for six months) and non-persistent SCD (had no complaint or complained intermittently) groups. Multiple regression analysis was employed to examine the association between frailty three years later and persistent SCD. In total, 268 participants were included in the analysis: 38 (14.2%) and 230 (85.8%) in the persistent and non-persistent (180 (67.2%) had no complaint and 50 (18.6%) complained intermittently) SCD groups, respectively. Multiple logistic regression analysis showed that persistent SCD was associated with frailty after 3 years, even after adjusting for age, sex, comorbidity, cohabitants, and frailty status at baseline (OR = 3.13, 95% CI: 1.25–7.79). Persistence of SCD over 6 months was significantly associated with frailty after 3 years. Our findings suggest that persistent SCD may contribute to frailty progression through psychological factors, particularly depression or anxiety, thereby highlighting the importance of early intervention and targeted support for individuals with SCD.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"15 2","pages":"81 - 89"},"PeriodicalIF":0.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the Regulation of Cerebral Vasoactive Reactions in Aging: The Contribution of H2S to cGMP-Induced Dilation","authors":"O. P. Gorshkova,&nbsp;V. N. Shuvaeva","doi":"10.1134/S207905702560034X","DOIUrl":"10.1134/S207905702560034X","url":null,"abstract":"<p>The signaling cascade “NO → soluble guanylate cyclase (sGC) → cyclic guanosine monophosphate (cGMP) → protein kinase G (PKG)” plays a significant role in vascular dilation, and its dysfunction can cause the development of cerebrovascular diseases. The key element in the NO → PKG signaling system is cGMP. Intracellular cGMP levels are largely regulated by cGMP-hydrolyzing phosphodiesterase (PDE) enzymes that break down cGMP. Aging is accompanied by a decrease in NO synthesis and cGMP levels and an increase in PDE activity. Under these conditions, it is possible to increase the contribution of compensatory mechanisms of the activation of individual sections of the NO → PKG signaling pathway, in particular with the participation of intermediaries that change the cGMP level. Hydrogen sulfide (H₂S) is currently considered one of the activators of the NO → PKG pathway, which can increase cGMP levels in cells by inhibiting PDE or its direct interaction with cGMP to form biologically active compounds that are less susceptible to enzymatic breakdown. H₂S-mediated cGMP activation has been shown in cardiomyocytes and smooth muscle cells of the mesenteric and aortic vessels, but this mechanism has not been studied in cerebral vessels. The aim of the work is to study the contribution of H₂S to the regulation of cGMP-induced vasodilation in cerebral vessels and how this mechanism of regulation changes with aging. In Sprague-Dawley 4 (young) and 18-month-old (aging) rats, a comparative study of the dilatation of pial arteries to the effect of 8-Br-cGMP (8-bromine-cyclic guanosine monophosphate), which is a cell-permeable analog of cGMP, is performed using intravital microphotography, and an assessment of the effect of exogenous (donor is NaHS) and endogenous H₂S on the cGMP-induced vasodilation is carried out. Propargylglycine is used as a blocker of endogenous H₂S. It is shown that in 4-month-old rats, the H₂S-mediated regulation of cGMP-induced dilation of pial arteries is expressed only at the level of large arteries with a diameter of more than 40 μm. Aging leads to an increased contribution of endogenous H₂S to the cGMP-induced dilation of pial arteries of all calibers and an increased sensitivity of cGMP-mediated reactions of small pial arteries to exogenous H₂S.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"15 2","pages":"64 - 70"},"PeriodicalIF":0.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal Overexpression of Circadian Clock Genes Modulates Lifespan and Thermotolerance in Male Drosophila melanogaster","authors":"E. V. Shchegoleva,&nbsp;L. A. Koval,&nbsp;M. V. Shaposhnikov,&nbsp;A. A. Moskalev","doi":"10.1134/S2079057025600193","DOIUrl":"10.1134/S2079057025600193","url":null,"abstract":"<p>This study investigates how overexpression of circadian clock genes affects longevity and stress resistance in male <i>Drosophila melanogaster</i>. Through analysis of transgenic strains containing <i>UAS</i>-controlled <i>cryptochrome</i> (<i>cry</i>) and <i>period</i> (<i>per</i>) genes with gut-specific <i>GAL4</i> driver, we demonstrate that circadian gene overexpression produces temporally dependent physiological outcomes. Chronic overexpression throughout lifespan resulted in reduced median lifespan by 9–17% for <i>cryptochrome</i> genes and 4% for <i>period</i> genes (<i>p</i> &lt; 0.05), while transient activation in young-imago ages of <i>cry12</i>, <i>cry24</i>, and <i>per2.4</i> enhanced thermotolerance, increasing median survival under hyperthermic conditions by 18–25% (<i>p</i> &lt; 0.05). These findings demonstrate that circadian genes act as bidirectional regulators of organismal physiology. The duration of overactivation determines whether the effects are beneficial or detrimental. Future studies are needed to distinguish the effects of stress tolerance from the costs of lifespan in order to enhance stress resistance without compromising longevity.</p>","PeriodicalId":44756,"journal":{"name":"Advances in Gerontology","volume":"15 2","pages":"46 - 55"},"PeriodicalIF":0.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}