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Progress on Chemistry and Application of Chitin and its Derivatives最新文献

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INFLUENCE OF CHITOSAN ON THE PROPERTIES OF GELS PROTECTING OF THE ESOPHAGEAL MUCOSA 壳聚糖对食管黏膜保护凝胶性能的影响
IF 0.6
Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2019-09-30 DOI: 10.15259/pcacd.24.012
K. Małolepsza-Jarmołowska
{"title":"INFLUENCE OF CHITOSAN ON THE PROPERTIES OF GELS PROTECTING OF THE ESOPHAGEAL MUCOSA","authors":"K. Małolepsza-Jarmołowska","doi":"10.15259/pcacd.24.012","DOIUrl":"https://doi.org/10.15259/pcacd.24.012","url":null,"abstract":"Gastro-esophageal reflux is a term that defines the reverse flow of acid gastric contents into the esophagus. On the other hand, alkaline reflux occurs in the case when alkaline intestinal contents enter the esophagus. The aim of the study was to examine the pharmaceutical properties of gels for the treatment of gastro-esophageal reflux, covering the mucosa, allowing prolonged contact with the esophageal mucosa. Formulations containing the PVP K-30 showed the lowest pH, which is an important feature and can be used in the treatment of advanced alkaline reflux. Gels containing PVP K-90 and chitosan can be used in the treatment of acid reflux. The addition of chitosan significantly increased the dynamic viscosity of the tested gels. The study of the work of adhesion showed the effect of PVP K-30 and PVP K-90 and their concentration on the value of the work of adhesion. The presented studies have shown that it is possible to obtain gels with high adhesion to the esophageal mucous membrane.","PeriodicalId":44461,"journal":{"name":"Progress on Chemistry and Application of Chitin and its Derivatives","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67092219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
THE PROPERTIES OF INTRAVAGINAL GLOBULES CONTAINING A LACTIC ACID-CHITOSAN COMPLEX 含有乳酸-壳聚糖复合物的阴道内球蛋白的性质
IF 0.6
Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2019-09-30 DOI: 10.15259/pcacd.24.011
K. Małolepsza-Jarmołowska
{"title":"THE PROPERTIES OF INTRAVAGINAL GLOBULES CONTAINING A LACTIC ACID-CHITOSAN COMPLEX","authors":"K. Małolepsza-Jarmołowska","doi":"10.15259/pcacd.24.011","DOIUrl":"https://doi.org/10.15259/pcacd.24.011","url":null,"abstract":"Continuing the implementation of research on the problem of treatment of vaginal pH disorders, intravaginal globules were examined as vaginal drug form which carries the lactic acid complexes with chitosan. The intravaginal application of globules that transform into gel under natural conditions is aimed at achieving the physiological pH of the vaginal environment. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of 1:1 and 2:1 of lactic acid to chitosan showed a pH in the physiological range at 37°C. Additional hydroxypropylmethylcellulose and excipients allows various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and hydroxypropylmethylcellulose in comparison to the gels without hydroxypropylmethylcellulose. The study of the work of adhesion showed the effect of hydroxypropylmethylcellulose and their concentration on the value of the work of adhesion. The determinations were performed in I a and II a range on a K-1 cone with a diameter of 36 mm and a 0.917 fissure at 37°C. The shear angle was measured using 12 shear rates in ascending direction and 11 rates in the descending direction. All gels were tested three times, and the results were reported as the average of three measurements. The values of the shear stress and viscosity were calculated from measurements at 37°C.","PeriodicalId":44461,"journal":{"name":"Progress on Chemistry and Application of Chitin and its Derivatives","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47320120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NONWOVEN CHITOSAN - PREPARATION AND PROPERTIES 非织造壳聚糖的制备及其性能
IF 0.6
Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2019-09-30 DOI: 10.15259/pcacd.24.017
D. Wawro, Chemical Fibres, W. Stęplewski, W. Marcol, E. Skrzetuska, I. Krucinska
{"title":"NONWOVEN CHITOSAN - PREPARATION AND PROPERTIES","authors":"D. Wawro, Chemical Fibres, W. Stęplewski, W. Marcol, E. Skrzetuska, I. Krucinska","doi":"10.15259/pcacd.24.017","DOIUrl":"https://doi.org/10.15259/pcacd.24.017","url":null,"abstract":"","PeriodicalId":44461,"journal":{"name":"Progress on Chemistry and Application of Chitin and its Derivatives","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42521933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
FORMATION OF FIBRES AND SPHERES FROM CHITIN SOLUTION 甲壳素溶液中纤维和球体的形成
IF 0.6
Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2018-09-10 DOI: 10.15259/PCACD.23.002
D. Biniaś, W. Biniaś, J. Janicki
{"title":"FORMATION OF FIBRES AND SPHERES FROM CHITIN SOLUTION","authors":"D. Biniaś, W. Biniaś, J. Janicki","doi":"10.15259/PCACD.23.002","DOIUrl":"https://doi.org/10.15259/PCACD.23.002","url":null,"abstract":"The applications of chitin are limited due to its insolubility in most organic solvents. The chemical modification of chitin to generate new bio-functional materials can bring more desirable properties. A concentration of 5% can be obtained. We have successfully prepared chitin fibres and spheres by dissolving chitin in 85% phosphoric acid in various coagulating agents and then regenerating it in 10% sodium hydroxide.\u0000The change in molecular structure was studied by Fourier Transform Infrared Spectroscopy (FTIR). The surface morphology of different biomaterials was observed using scanning electron microscopy (SEM) and optical microscopy (OM).","PeriodicalId":44461,"journal":{"name":"Progress on Chemistry and Application of Chitin and its Derivatives","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2018-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48948983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RESEARCH OF THE INFLUENCE OF CHITIN-CONTAINING FOOD ADDITIVES ON THE RHEOLOGICAL PROPERTIES AND BIOLOGICAL VALUE OF MINCED FISH 含几丁质食品添加剂对鱼糜流变学特性及生物学价值影响的研究
IF 0.6
Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2018-09-10 DOI: 10.15259/PCACD.23.011
E. Kuprina, E. Kiprushkina, I. Shestopalova, A. N. Yakkola, A. Manuylov, N. V. Odegova, E. E. Shcherbakova, Aleksey I. Mushits
{"title":"RESEARCH OF THE INFLUENCE OF CHITIN-CONTAINING FOOD ADDITIVES ON THE RHEOLOGICAL PROPERTIES AND BIOLOGICAL VALUE OF MINCED FISH","authors":"E. Kuprina, E. Kiprushkina, I. Shestopalova, A. N. Yakkola, A. Manuylov, N. V. Odegova, E. E. Shcherbakova, Aleksey I. Mushits","doi":"10.15259/PCACD.23.011","DOIUrl":"https://doi.org/10.15259/PCACD.23.011","url":null,"abstract":"The problem of the deficiency of dietary fibre and mineral substances in the diet of modern man is well known. This problem is proposed to be solved by making a food product - fishballs - based on a combination of minced fish meat from pollock and salmon belly, containing the biologically active chitin mineral food supplement \"Hizitel\". Dietary supplementation is derived from the waste of processing shrimp shells. The influence of chitin-mineral nutritional supplement on the rheological properties of minced fish and the biological value of products based on it has been studied. The optimum modes of mixing minced fish compositions were identified and the nutritional and biological value of the functional foods developed were defined.","PeriodicalId":44461,"journal":{"name":"Progress on Chemistry and Application of Chitin and its Derivatives","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2018-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48037841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
PHARMACEUTICAL ASSESSMENT OF GYNAECOLOGICAL POWDERS WITH SODIUM ALGINATE CONTAINING A LACTIC ACID-CHITOSAN COMPLEX 含有乳酸-壳聚糖复合物的海藻酸钠妇科粉剂的药理学评价
IF 0.6
Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2018-09-10 DOI: 10.15259/PCACD.23.13
K. Małolepsza-Jarmołowska
{"title":"PHARMACEUTICAL ASSESSMENT OF GYNAECOLOGICAL POWDERS WITH SODIUM ALGINATE CONTAINING A LACTIC ACID-CHITOSAN COMPLEX","authors":"K. Małolepsza-Jarmołowska","doi":"10.15259/PCACD.23.13","DOIUrl":"https://doi.org/10.15259/PCACD.23.13","url":null,"abstract":"The insufficient duration of the drug’s contact with the vaginal mucosa does not provide adequate pH, conditioning the physiological biocenosis of the organ. This effect is hampered by numerous anatomic and physiological conditions which do not facilitate prolonged contact of the drug with the application site. This study has shown the impact of the used excipients and the ratio of lactic acid to chitosan on pH, dynamic viscosity and adhesiveness of methylcellulose gels obtained from powders. The addition of sodium alginate and excipients to these complexes allows various formulations to be obtained over a wide range of pH. Rheological investigations revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and sodium alginate in comparison to gels without sodium alginate. Studies of the work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentrations on the value of the work of adhesion.","PeriodicalId":44461,"journal":{"name":"Progress on Chemistry and Application of Chitin and its Derivatives","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2018-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46749035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DETERMINATION OF THE HYDROLYTIC ACTIVITY OF WHOLE SALIVA USING CHITOSAN ASCORBATE AS A SUBSTRATE 壳聚糖抗坏血酸作为底物测定全唾液的水解活性
IF 0.6
Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2018-09-10 DOI: 10.15259/PCACD.23.009
B. Kochańska, Mirela Łukaszewska, Jolanta Ochocińska
{"title":"DETERMINATION OF THE HYDROLYTIC ACTIVITY OF WHOLE SALIVA USING CHITOSAN ASCORBATE AS A SUBSTRATE","authors":"B. Kochańska, Mirela Łukaszewska, Jolanta Ochocińska","doi":"10.15259/PCACD.23.009","DOIUrl":"https://doi.org/10.15259/PCACD.23.009","url":null,"abstract":"The aim of this work was to evaluate of hydrolytic activity of whole saliva using chitosan ascorbate as a substrate. In this aim, the concentrations of N-acetyl-D-glucosamine were determined in saliva before addition of chitosan ascorbate, directly after addition and during incubation with chitosan ascorbate by 20 hrs. In this in vitro study were used sterile chitosan ascorbate in the form of powder. Chitosan was obtained from krill chitin. The ratio of ascorbic acid to chitosan was 1:1. The unstimulated whole saliva showed the hydrolytic activity in the presence of the chitosan ascorbate as a substrate.","PeriodicalId":44461,"journal":{"name":"Progress on Chemistry and Application of Chitin and its Derivatives","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2018-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46805359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
APPLICATIONS OF CHITOSAN–GRAPHENE OXIDE NANOCOMPOSITES IN MEDICAL SCIENCE: A REVIEW 壳聚糖-氧化石墨烯纳米复合材料在医学中的应用综述
IF 0.6
Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2018-09-10 DOI: 10.15259/PCACD.23.001
K. Pieklarz, M. Tylman, Z. Modrzejewska
{"title":"APPLICATIONS OF CHITOSAN–GRAPHENE OXIDE NANOCOMPOSITES IN MEDICAL SCIENCE: A REVIEW","authors":"K. Pieklarz, M. Tylman, Z. Modrzejewska","doi":"10.15259/PCACD.23.001","DOIUrl":"https://doi.org/10.15259/PCACD.23.001","url":null,"abstract":"Combinations of biopolymers with nanostructured carbon materials have been the subject of interest of many scientists in recent years. Particularly significant are nanocomposites made of chitosan, which is a linear aminopolysaccharide obtained in the process of deacetylation of chitin, and graphene oxide (GO).\u0000These systems, due to the atypical properties of both components such as non-toxicity, biocompatibility with human tissues and organs as well as bacteriostaticity, are characterised by a wide range of biomedical applications.\u0000They may be used in emergency medicine as dressing materials which accelerate wound healing, as well as carriers of drugs/genes and biological macromolecules, for example proteins, peptides and nucleic acids. In addition, CS-GO systems can potentially be used in regenerative medicine as scaffolds for cell culture.\u0000For this reason, the current publication presents the possibilities of the application of chitosan–graphene oxide nanocomposites in medicine considering the characteristics of the system components.","PeriodicalId":44461,"journal":{"name":"Progress on Chemistry and Application of Chitin and its Derivatives","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2018-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47133566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
THE EFFECT OF A CARBOXYMETHYLCELLULOSE SODIUM SALT ON THE PROPERTIES OF HYDROPHILIC POWDERS CONTAINING A LACTIC ACID-CHITOSAN COMPLEX 羧甲基纤维素钠盐对乳酸-壳聚糖复合物亲水性粉末性能的影响
IF 0.6
Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2018-09-10 DOI: 10.15259/PCACD.23.012
K. Małolepsza-Jarmołowska
{"title":"THE EFFECT OF A CARBOXYMETHYLCELLULOSE SODIUM SALT ON THE PROPERTIES OF HYDROPHILIC POWDERS CONTAINING A LACTIC ACID-CHITOSAN COMPLEX","authors":"K. Małolepsza-Jarmołowska","doi":"10.15259/PCACD.23.012","DOIUrl":"https://doi.org/10.15259/PCACD.23.012","url":null,"abstract":"The investigated powders on a methylcellulose base revealed good adhesion to the vaginal mucosa and were present on it throughout the daily activities of the patient. This property enabled the continuity of the 24-hour action of the drug. The treatment of vagina inflammatory conditions is usually long and difficult because of the frequent relapse.\u0000Powders were transformed into gels and were tested for their properties. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of lactic acid to chitosan of 1:1 and 2:1 showed a pH in the physiological range at 37°C. Additionally, carboxymethylcellulose sodium salt and excipients allow various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and carboxymethylcellulose sodium salt in comparison to gels without carboxymethylcellulose sodium salt.","PeriodicalId":44461,"journal":{"name":"Progress on Chemistry and Application of Chitin and its Derivatives","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2018-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42016795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
CHARACTERISTICS OF ASCORBIC ACID RELEASE FROM TPP-CROSSLINKED CHITOSAN/ALGINATE POLYELECTROLYTE COMPLEX MEMBRANES TPP交联壳聚糖/海藻酸盐复合电解质膜的抗坏血酸释放特性
IF 0.6
Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2018-09-10 DOI: 10.15259/PCACD.23.007
M. Gierszewska, J. Ostrowska-Czubenko, Ewelina Chrzanowska
{"title":"CHARACTERISTICS OF ASCORBIC ACID RELEASE FROM TPP-CROSSLINKED CHITOSAN/ALGINATE POLYELECTROLYTE COMPLEX MEMBRANES","authors":"M. Gierszewska, J. Ostrowska-Czubenko, Ewelina Chrzanowska","doi":"10.15259/PCACD.23.007","DOIUrl":"https://doi.org/10.15259/PCACD.23.007","url":null,"abstract":"Chitosan/alginate polyelectrolyte complex membranes (Ch/Alg) additionally cross-linked with tripolyphosphate (TPP) and containing ascorbic acid (AA) were prepared. The dynamic swelling behaviour of Ch/Alg/TPP and ascorbic acid release from the membrane were characterised in different buffer solutions. It has been found that the pH of the buffer solution affects the swelling and release behaviour of AA. Ascorbic acid release, observed over a period of 360 min, exhibited a biphasic pattern, characterised by a fast initial burst release, followed by a slow, sustained release. Different mathematical models were used to study the kinetics and transport mechanism of AA from Ch/Alg/TPP hydrogels. Drug release data were fitted to the zero order kinetic model and first order kinetic model. To characterise the drug mechanism, the release data were fitted to the Higuchi and Korsmeyer-Peppas equations. The initial burst AA release followed zero order kinetics and was quasi-Fickian in nature. The second step of AA release followed first order kinetics.","PeriodicalId":44461,"journal":{"name":"Progress on Chemistry and Application of Chitin and its Derivatives","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2018-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47153070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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